Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs

scientific article

Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1093/NAR/GKR178
P3181OpenCitations bibliographic resource ID4315038
P932PMC publication ID3152333
P698PubMed publication ID21459853
P5875ResearchGate publication ID50988801

P50authorPhilip LijnzaadQ71623227
Valérie de Crécy-LagardQ84288090
Cosmin SaveanuQ41853772
Tineke L LenstraQ42602199
Alain JacquierQ42646103
P2093author name stringFrank C P Holstege
Domenico Libri
Marie-Claire Daugeron
Herman van Tilbeurgh
Basma El Yacoubi
Martina Frizzarin
Xipeng Liu
Agnès Baudin-Baillieu
Laurence Decourty
P2860cites workMultiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activationQ24535079
Functional anticodon architecture of human tRNALys3 includes disruption of intraloop hydrogen bonding by the naturally occurring amino acid modification, t6AQ27627952
Naturally-occurring modification restricts the anticodon domain conformational space of tRNA(Phe)Q27642648
An archaeal orthologue of the universal protein Kae1 is an iron metalloprotein which exhibits atypical DNA-binding properties and apurinic-endonuclease activity in vitroQ27647745
Atomic Structure of the KEOPS Complex: An Ancient Protein Kinase-Containing Molecular MachineQ27652648
Structure of the archaeal Kae1/Bud32 fusion protein MJ1130: a model for the eukaryotic EKC/KEOPS subcomplexQ27653522
Linear models and empirical bayes methods for assessing differential expression in microarray experimentsQ27860758
The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA.Q27931264
Fal1p is an essential DEAD-box protein involved in 40S-ribosomal-subunit biogenesis in Saccharomyces cerevisiaeQ27931519
The highly conserved eukaryotic DRG factors are required for efficient translation in a manner redundant with the putative RNA helicase Slh1Q27932287
The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A.Q27932308
Yeast homolog of a cancer-testis antigen defines a new transcription complexQ27933400
GTP hydrolysis controls stringent selection of the AUG start codon during translation initiation in Saccharomyces cerevisiaeQ27935355
Isolation and functional characterization of a temperature-sensitive mutant of the yeast Saccharomyces cerevisiae in translation initiation factor eIF5: an eIF5-dependent cell-free translation system.Q52170675
Characterization of translation initiation factor 5 (eIF5) from Saccharomyces cerevisiae. Functional homology with mammalian eIF5 and the effect of depletion of eIF5 on protein synthesis in vivo and in vitro.Q52193428
Molecular recognition of the identity-determinant set of isoleucine transfer RNA from Escherichia coli.Q54639835
47 O-sialoglycoprotease from Pasteurella haemolyticaQ72059294
The Sua5 protein is essential for normal translational regulation in yeastQ27935877
Sua5p a single-stranded telomeric DNA-binding protein facilitates telomere replicationQ27936111
Programmed translational frameshifting in a gene required for yeast telomere replicationQ27936627
A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulatorQ27938839
GCD2, a translational repressor of the GCN4 gene, has a general function in the initiation of protein synthesis in Saccharomyces cerevisiaeQ27939500
Biosynthesis of N-(purin-6-ylcarbamoyl)-l-threonine riboside. Incorporation of l-threonine in vivo into modified nucleoside of transfer ribonucleic acidQ28363530
The mechanism of eukaryotic translation initiation and principles of its regulationQ29547270
Translational regulation of GCN4 and the general amino acid control of yeastQ29615275
An improved map of conserved regulatory sites for Saccharomyces cerevisiaeQ30477138
Structure-function analysis of yeast piD261/Bud32, an atypical protein kinase essential for normal cell lifeQ31060617
'Conserved hypothetical' proteins: prioritization of targets for experimental studyQ31120471
Linking functionally related genes by sensitive and quantitative characterization of genetic interaction profilesQ33327937
Isolation and characterization of SUA5, a novel gene required for normal growth in Saccharomyces cerevisiaeQ33959700
Defects in tRNA processing and nuclear export induce GCN4 translation independently of phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2Q33962665
Molecular view of 43 S complex formation and start site selection in eukaryotic translation initiationQ33967297
Eukaryotic translation initiation factor 5 is critical for integrity of the scanning preinitiation complex and accurate control of GCN4 translation.Q34558627
A segment of GCN4 mRNA containing the upstream AUG codons confers translational control upon a heterologous yeast transcriptQ34618853
A role for the universal Kae1/Qri7/YgjD (COG0533) family in tRNA modificationQ34626470
Multicopy tRNA genes functionally suppress mutations in yeast eIF-2 alpha kinase GCN2: evidence for separate pathways coupling GCN4 expression to unchanged tRNAQ36671377
Genetic identification of yeast 18S rRNA residues required for efficient recruitment of initiator tRNA(Met) and AUG selectionQ36843520
Qri7/OSGEPL, the mitochondrial version of the universal Kae1/YgjD protein, is essential for mitochondrial genome maintenanceQ37384757
Adaptable gene-specific dye bias correction for two-channel DNA microarraysQ42145024
Biosynthesis and specific labeling of N-(purin-6-ylcarbamoyl)threonine of Escherichiacoli transfer RNAQ42233421
N-(purin-6-ylcarbamoyl)threonine: Biosynthesis in vitro in transfer RNA by an enzyme purified fromEscherichia coliQ42233720
The enzymatic synthesis of N-(purin-6-ylcarbamoyl)threonine, an anticodon-adjacent base in transfer ribonucleic acidQ42233759
Effect of threonylcarbamoyl modification (t6A) in yeast tRNA Arg III on codon-anticodon and anticodon-anticodon interactions. A thermodynamic and kinetic evaluationQ42257514
A consensus of core protein complex compositions for Saccharomyces cerevisiaeQ42974011
Modified nucleoside dependent Watson-Crick and wobble codon binding by tRNALysUUU speciesQ44874333
P275copyright licenseCreative Commons Attribution-NonCommercial 2.5 GenericQ19113746
P6216copyright statuscopyrightedQ50423863
P4510describes a project that useslimmaQ112236343
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectChromatin DNA-binding EKC/KEOPS complex subunit PCC1 YKR095W-AQ27549998
TRNA N6-adenosine threonylcarbamoyltransferase YKR038CQ27552883
P304page(s)6148-6160
P577publication date2011-04-01
P1433published inNucleic Acids ResearchQ135122
P1476titleGcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs
P478volume39

Reverse relations

cites work (P2860)
Q64044040A familial case of Galloway-Mowat syndrome due to a novel TP53RK mutation: a case report
Q34395576A genetic investigation of the KEOPS complex in halophilic Archaea
Q104073455A substrate binding model for the KEOPS tRNA modifying complex
Q36286482An extensive allelic series of Drosophila kae1 mutants reveals diverse and tissue-specific requirements for t6A biogenesis.
Q28492588Biosynthesis of threonylcarbamoyl adenosine (t6A), a universal tRNA nucleoside
Q38517893Cell polarity in Saccharomyces cerevisiae depends on proper localization of the Bud9 landmark protein by the EKC/KEOPS complex.
Q92203189Conformational communication mediates the reset step in t6A biosynthesis
Q37631233Conserved residues in yeast initiator tRNA calibrate initiation accuracy by regulating preinitiation complex stability at the start codon
Q27676736Crystal structure of the dimer of two essentialSalmonella typhimuriumproteins, YgjD & YeaZ and calorimetric evidence for the formation of a ternary YgjD-YeaZ-YjeE complex
Q41308269Crystal structures of the Gon7/Pcc1 and Bud32/Cgi121 complexes provide a model for the complete yeast KEOPS complex
Q28117728Discovery of the β-barrel-type RNA methyltransferase responsible for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs
Q27009453Diversity of the biosynthesis pathway for threonylcarbamoyladenosine (t(6)A), a universal modification of tRNA
Q37131488Essentiality of threonylcarbamoyladenosine (t(6)A), a universal tRNA modification, in bacteria
Q41833611Global translational impacts of the loss of the tRNA modification t6A in yeast.
Q34034860In vitro biosynthesis of a universal t6A tRNA modification in Archaea and Eukarya
Q92650205KAE1 Allelic Variants Affect TORC1 Activation and Fermentation Kinetics in Saccharomyces cerevisiae
Q65001675KEOPS complex promotes homologous recombination via DNA resection.
Q27972867Kinase-associated endopeptidase 1 (Kae1) participates in an atypical ribosome-associated complex in the apicoplast of Plasmodium falciparum
Q28535022Loss of a conserved tRNA anticodon modification perturbs cellular signaling
Q37698279Loss of wobble uridine modification in tRNA anticodons interferes with TOR pathway signaling
Q42182768Modulation of the Proteostasis Machinery to  Overcome Stress Caused by Diminished Levels of  t6A-Modified tRNAs in Drosophila
Q89669020Molecular basis for t6A modification in human mitochondria
Q35192105Molecular mechanism of scanning and start codon selection in eukaryotes
Q40094779Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly.
Q30375501NMR-based Structural Analysis of Threonylcarbamoyl-AMP Synthase and Its Substrate Interactions.
Q92985783Negative Regulation of the Mis17-Mis6 Centromere Complex by mRNA Decay Pathway and EKC/KEOPS Complex in Schizosaccharomyces pombe
Q27939874Plasticity and diversity of tRNA anticodon determinants of substrate recognition by eukaryotic A37 isopentenyltransferases
Q47197880Structure and mechanism of a bacterial t6A biosynthesis system
Q52591099Structure-function analysis of Sua5 protein reveals novel functional motifs required for the biosynthesis of the universal t6A tRNA modification.
Q41595438The ATP-mediated formation of the YgjD-YeaZ-YjeE complex is required for the biosynthesis of tRNA t6A in Escherichia coli
Q33728139The Drosophila EKC/KEOPS complex: roles in protein synthesis homeostasis and animal growth
Q35883879The Levels of a Universally Conserved tRNA Modification Regulate Cell Growth
Q42127112The emerging role of complex modifications of tRNA(Lys)UUU in signaling pathways
Q42274601The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME.
Q34289214The mechanism of eukaryotic translation initiation: new insights and challenges
Q47337711Transcriptome-wide Analysis of Roles for tRNA Modifications in Translational Regulation
Q27000788Transfer RNA post-transcriptional processing, turnover, and subcellular dynamics in the yeast Saccharomyces cerevisiae
Q49906097mRNA Translation Gone Awry: Translation Fidelity and Neurological Disease
Q42351643tRNA anticodon loop modifications ensure protein homeostasis and cell morphogenesis in yeast
Q34960691tRNA thiolation links translation to stress responses in Saccharomyces cerevisiae

Search more.