tRNA thiolation links translation to stress responses in Saccharomyces cerevisiae

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tRNA thiolation links translation to stress responses in Saccharomyces cerevisiae is …
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scholarly articleQ13442814

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P356DOI10.1091/MBC.E14-06-1145
P8608Fatcat IDrelease_llomuzj2j5cblpqxsu3fgnqxoi
P932PMC publication ID4294674
P698PubMed publication ID25392298
P5875ResearchGate publication ID268232551

P50authorHidde PloeghQ1617296
P2093author name stringDavid Pincus
Jadyn R Damon
P2860cites workNIH Image to ImageJ: 25 years of image analysisQ23319322
N6-methyladenosine-dependent regulation of messenger RNA stabilityQ24310545
A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathwayQ24315993
The sulfurtransferase activity of Uba4 presents a link between ubiquitin-like protein conjugation and activation of sulfur carrier proteinsQ27650647
Structural and Mechanistic Basis for Enhanced Translational Efficiency by 2-Thiouridine at the tRNA Anticodon Wobble PositionQ27678443
Genomic expression programs in the response of yeast cells to environmental changesQ27860823
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiaeQ27861085
High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosisQ27930684
Novel methyltransferase for modified uridine residues at the wobble position of tRNA.Q27931852
A protein conjugation system in yeast with homology to biosynthetic enzyme reaction of prokaryotesQ27932025
Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA.Q27932043
Urmylation: A Ubiquitin-like Pathway that Functions during Invasive Growth and Budding in YeastQ27932517
Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifierQ27932686
Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic-leucine zipper motif is required for the unfolded protein-response pathwayQ27932953
Evidence for an adaptation mechanism of mitochondrial translation via tRNA import from the cytosol.Q27933283
Analysis of quality control substrates in distinct cellular compartments reveals a unique role for Rpn4p in tolerating misfolded membrane proteins.Q27933335
Thio-modification of yeast cytosolic tRNA requires a ubiquitin-related system that resembles bacterial sulfur transfer systemsQ27933952
Elevated levels of two tRNA species bypass the requirement for elongator complex in transcription and exocytosis.Q27934002
Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAsQ27934109
A conserved modified wobble nucleoside (mcm5s2U) in lysyl-tRNA is required for viability in yeastQ27934519
An early step in wobble uridine tRNA modification requires the Elongator complexQ27934531
Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteinsQ27936377
A genome-wide screen identifies genes required for formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiaeQ27936390
RNA Methylation by the MIS Complex Regulates a Cell Fate Decision in YeastQ27936524
Attachment of the ubiquitin-related protein Urm1p to the antioxidant protein Ahp1pQ27936831
A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein responseQ27938493
Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseasesQ27939299
Isolation of the gene encoding the S. cerevisiae heat shock transcription factorQ27939979
The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element (STRE)Q27940320
Multifunctional yeast high-copy-number shuttle vectorsQ28131605
Optimized protein extraction for quantitative proteomics of yeastsQ28469329
A quantitative systems approach reveals dynamic control of tRNA modifications during cellular stressQ28476548
Loss of a conserved tRNA anticodon modification perturbs cellular signalingQ28535022
rRNA modifications and ribosome functionQ28610126
Solution structure of Urm1 and its implications for the origin of protein modifiersQ28768369
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiaeQ29546523
tRNA biology charges to the frontQ29616318
tRNA's wobble decoding of the genome: 40 years of modificationQ29618115
A 22 bp cis-acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteinsQ33938056
Defects in tRNA processing and nuclear export induce GCN4 translation independently of phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2Q33962665
A comprehensive analysis of translational missense errors in the yeast Saccharomyces cerevisiae.Q34075919
Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeastQ34490441
Modification of tRNA(Lys) UUU by elongator is essential for efficient translation of stress mRNAs.Q34846015
rRNA pseudouridylation defects affect ribosomal ligand binding and translational fidelity from yeast to human cells.Q35569577
Ribosome Deficiency Protects Against ER Stress in Saccharomyces cerevisiaeQ35917326
Translational control of cell division by ElongatorQ36073480
Coordination of growth rate, cell cycle, stress response, and metabolic activity in yeastQ36325907
Increased tRNA modification and gene-specific codon usage regulate cell cycle progression during the DNA damage responseQ36338771
Translational infidelity-induced protein stress results from a deficiency in Trm9-catalyzed tRNA modificationsQ36391935
Crystal structure of Δ(185-243)ApoA-I suggests a mechanistic framework for the protein adaptation to the changing lipid load in good cholesterol: from flatland to sphereland via double belt, belt buckle, double hairpin and trefoil/tetrafoilQ36501281
Three-dimensional structure of the AAH26994.1 protein from Mus musculus, a putative eukaryotic Urm1Q36518080
Cotranslational response to proteotoxic stress by elongation pausing of ribosomesQ36604984
Widespread Regulation of Translation by Elongation Pausing in Heat ShockQ36605333
Identification of cis and trans components of a novel heat shock stress regulatory pathway in Saccharomyces cerevisiaeQ36658896
Cap-dependent and cap-independent translation by internal initiation of mRNAs in cell extracts prepared from Saccharomyces cerevisiaeQ36669457
Multicopy tRNA genes functionally suppress mutations in yeast eIF-2 alpha kinase GCN2: evidence for separate pathways coupling GCN4 expression to unchanged tRNAQ36671377
Transcriptional regulation of an hsp70 heat shock gene in the yeast Saccharomyces cerevisiaeQ36840682
tRNA tKUUU, tQUUG, and tEUUC wobble position modifications fine-tune protein translation by promoting ribosome A-site binding.Q37049384
Slow growth induces heat-shock resistance in normal and respiratory-deficient yeastQ37078633
Sulfur amino acids regulate translational capacity and metabolic homeostasis through modulation of tRNA thiolationQ37133127
tRNA genes rapidly change in evolution to meet novel translational demands.Q37405617
Evidence for translational regulation of the activator of general amino acid control in yeastQ37573526
Biosynthesis and function of posttranscriptional modifications of transfer RNAsQ38035925
Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5'-3' exonucleases Rat1 and Xrn1.Q38310518
Misfolded proteins are competent to mediate a subset of the responses to heat shock in Saccharomyces cerevisiaeQ38362814
Eukaryotic wobble uridine modifications promote a functionally redundant decoding system.Q39024470
Saccharomyces cerevisiae IRE2/HAC1 is involved in IRE1-mediated KAR2 expressionQ39718036
Novel small-molecule inhibitors of RNA polymerase III.Q39751935
Eukaryotic ribosomal RNA determinants of aminoglycoside resistance and their role in translational fidelity.Q41355898
Multiple independent regulatory pathways control UBI4 expression after heat shock in Saccharomyces cerevisiaeQ41609771
The yeast rapid tRNA decay pathway primarily monitors the structural integrity of the acceptor and T-stems of mature tRNA.Q41959880
The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulumQ42083502
Trm9-catalyzed tRNA modifications link translation to the DNA damage responseQ42134963
Interaction of tRNAs and of phosphorothioate-substituted nucleic acids with an organomercurial. Probing the chemical environment of thiolated residues by affinity electrophoresisQ42206812
Loss of rRNA modifications in the decoding center of the ribosome impairs translation and strongly delays pre-rRNA processingQ42554055
tRNAHis 5-methylcytidine levels increase in response to several growth arrest conditions in Saccharomyces cerevisiae.Q42704036
The Kluyveromyces lactis gamma-toxin targets tRNA anticodons.Q42730994
Accurate translation of the genetic code depends on tRNA modified nucleosides.Q43893359
The role of modifications in codon discrimination by tRNA(Lys)UUU.Q45159086
Preparation of yeast RNA.Q46761146
A regulatory upstream promoter element in the Drosophila hsp 70 heat-shock geneQ52527826
RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis.Q52628551
Rapid tRNA decay can result from lack of nonessential modificationsQ54342180
Heat shock factor-independent heat control of transcription of the CTT1 gene encoding the cytosolic catalase T of Saccharomyces cerevisiaeQ70214070
Degradation of proteins from the ER of S. cerevisiae requires an intact unfolded protein response pathwayQ73958524
Palindrome with Spacer of One Nucleotide Is Characteristic of the cis-Acting Unfolded Protein Response Element in Saccharomyces cerevisiaeQ74450519
Urmylation controls Nil1p and Gln3p-dependent expression of nitrogen-catabolite repressed genes in Saccharomyces cerevisiaeQ79664248
P4510describes a project that usesImageJQ1659584
P433issue2
P921main subjectSaccharomyces cerevisiaeQ719725
P304page(s)270-282
P577publication date2014-11-12
P1433published inMolecular Biology of the CellQ2338259
P1476titletRNA thiolation links translation to stress responses in Saccharomyces cerevisiae
P478volume26

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cites work (P2860)
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Q92058511Genomewide and Enzymatic Analysis Reveals Efficient d-Galacturonic Acid Metabolism in the Basidiomycete Yeast Rhodosporidium toruloides
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Q26749584Multiple Layers of Stress-Induced Regulation in tRNA Biology
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Q42220024Sulfur transfer and activation by ubiquitin-like modifier system Uba4•Urm1 link protein urmylation and tRNA thiolation in yeast
Q46324562TRMT1-Catalyzed tRNA Modifications Are Required for Redox Homeostasis To Ensure Proper Cellular Proliferation and Oxidative Stress Survival.
Q42127112The emerging role of complex modifications of tRNA(Lys)UUU in signaling pathways
Q58574241Unfolded Protein Response Suppression in Yeast by Loss of tRNA Modifications
Q37589999Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response
Q39170989Wobble uridine modifications-a reason to live, a reason to die?!
Q38874192tRNA wobble modifications and protein homeostasis

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