| scholarly article | Q13442814 |
| P356 | DOI | 10.1126/SCIENCE.2425436 |
| P698 | PubMed publication ID | 2425436 |
| P2093 | author name string | R A Frizzell | |
| G Rechkemmer | |||
| R L Shoemaker | |||
| P433 | issue | 4763 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | cystic fibrosis | Q178194 |
| P304 | page(s) | 558-560 | |
| P577 | publication date | 1986-08-01 | |
| P1433 | published in | Science | Q192864 |
| P1476 | title | Altered regulation of airway epithelial cell chloride channels in cystic fibrosis | |
| P478 | volume | 233 |
| Q40341688 | A Cl- channel activated by parathyroid hormone in rabbit renal proximal tubule cells |
| Q60928130 | A Comparison between Two Pathophysiologically Different yet Microbiologically Similar Lung Diseases: Cystic Fibrosis and Chronic Obstructive Pulmonary Disease |
| Q69036979 | A chloride conductance activated by adenosine 3',5'-cyclic monophosphate in the apical membrane of Necturus enterocytes |
| Q28300686 | A clue to the basic defect in cystic fibrosis from cloning the CF antigen gene |
| Q33598519 | A cystic fibrosis pancreatic adenocarcinoma cell line |
| Q53042258 | A low-salt diet facilitates Cl secretion in hen lower intestine |
| Q34141568 | A novel exon in the cystic fibrosis transmembrane conductance regulator gene activated by the nonsense mutation E92X in airway epithelial cells of patients with cystic fibrosis |
| Q41597684 | A transformed human epithelial cell line that retains tight junctions post crisis |
| Q33209490 | Abnormal secretagogue-induced intracellular free Ca2+ regulation in cystic fibrosis nasal epithelial cells |
| Q69901664 | Absence of secretory response in jejunal biopsy samples from children with cystic fibrosis |
| Q28142263 | Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity |
| Q44469047 | Activation of K+ and Cl- channels by Ca2+ and cyclic AMP in dissociated kidney epithelial (MDCK) cells |
| Q45948349 | Activation of chloride channels in normal and cystic fibrosis airway epithelial cells by multifunctional calcium/calmodulin-dependent protein kinase |
| Q34573926 | Activation of ion transport pathways by changes in cell volume |
| Q35870871 | Adenosine receptors on human airway epithelia and their relationship to chloride secretion |
| Q33715133 | Adult stem cells from bone marrow stroma differentiate into airway epithelial cells: potential therapy for cystic fibrosis |
| Q36637394 | Alginate synthesis by Pseudomonas aeruginosa: a key pathogenic factor in chronic pulmonary infections of cystic fibrosis patients |
| Q67704096 | Altered Biochemical Regulation of Secretion in Cystic Fibrosis Epithelial Cells |
| Q34561780 | Altered binding of 125I-labeled calmodulin to a 46.5-kilodalton protein in skin fibroblasts cultured from patients with cystic fibrosis |
| Q34620126 | Altered chloride metabolism in cultured cystic fibrosis skin fibroblasts |
| Q67504823 | Altered membrane ionic permeability in a rat model of chronic renal failure |
| Q67488623 | Alternate pathways for chloride conductance activation in normal and cystic fibrosis airway epithelial cells |
| Q68362657 | Analysis of cell surface glycoconjugates in fibroblasts from patients with cystic fibrosis |
| Q46388400 | Anion channels activated by adrenaline in cardiac myocytes |
| Q48649717 | Anion channels from rat brain synaptosomal membranes incorporated into planar bilayers |
| Q44969171 | Anion channels in a leaky epithelium. A patch-clamp study of choroid plexus |
| Q24293563 | Anoctamin 6 is an essential component of the outwardly rectifying chloride channel |
| Q24645272 | Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels |
| Q37587534 | Antisense oligodeoxynucleotide to the cystic fibrosis gene inhibits anion transport in normal cultured sweat duct cells |
| Q40303900 | Antisense oligodeoxynucleotide to the cystic fibrosis transmembrane conductance regulator inhibits cyclic AMP-activated but not calcium-activated cell volume reduction in a human pancreatic duct cell line |
| Q42615423 | Apical membrane Cl- channels in airway epithelia: anion selectivity and effect of an inhibitor |
| Q36678514 | Basic Aspects of Cystic Fibrosis |
| Q35438966 | Bicarbonate conductance and pH regulatory capability of cystic fibrosis transmembrane conductance regulator |
| Q41698244 | Bicarbonate permeability of epithelial chloride channels |
| Q69129792 | Bicarbonate permeability of the outwardly rectifying anion channel |
| Q35834782 | Bimodal control of a Ca(2+)-activated Cl(-) channel by different Ca(2+) signals |
| Q41344470 | Biochemical and genetic exclusion of calmodulin as the site of the basic defect in cystic fibrosis. |
| Q34500723 | Biology of sweat glands and their disorders. I. Normal sweat gland function |
| Q42809539 | CFTR and outward rectifying chloride channels are distinct proteins with a regulatory relationship |
| Q33595872 | CFTR transcripts are undetectable in lymphocytes and respiratory epithelial cells of a CF patient homozygous for the nonsense mutation R553X |
| Q67707881 | Ca2+-dependent chloride conductance inNecturus taste cells |
| Q41690086 | CaMKII mediates stimulation of chloride conductance by calcium in T84 cells |
| Q35754806 | Calcium- and cyclic AMP-dependent chloride secretion in human colonic epithelia |
| Q68264881 | Calcium- and cyclic-AMP-mediated secretory responses in isolated colonic crypts |
| Q67543680 | Cell swelling activates K+ and Cl- channels as well as nonselective, stretch-activated cation channels in Ehrlich ascites tumor cells |
| Q69100994 | Characteristics and regulation of a high conductance anion channel in GBK kidney epithelial cells |
| Q54073333 | Characterization of a Ca(2+)-dependent anion channel from sheep tracheal epithelium incorporated into planar bilayers. |
| Q69124508 | Characterization of a phosphorylation-activated Cl-selective channel in isolated Necturus enterocytes |
| Q41464034 | Characterization of an outwardly rectifying chloride channel in a human submandibular gland duct cell line (HSG). |
| Q69055938 | Characterization of chloride channels in membrane vesicles from the kidney outer medulla |
| Q48822639 | Characterization of epithelial cell cultures derived from human tracheal glands |
| Q44265565 | Characterization of human sweat duct chloride conductance by chloride channel blockers |
| Q33639673 | Characterization of human tracheal epithelial cells transformed by an origin-defective simian virus 40. |
| Q37047526 | Characterization of immortal cystic fibrosis tracheobronchial gland epithelial cells |
| Q54171293 | Characterization of two distinct Cl- conductances in fused human respiratory epithelial cells. I. Anion selectivities, stimulation and intermeshing signal transduction pathways. |
| Q54172223 | Characterization of two distinct Cl- conductances in fused human respiratory epithelial cells. II. Relation to cystic fibrosis gene product. |
| Q41733415 | Chloride and potassium channels in U937 human monocytes |
| Q28285616 | Chloride channel inhibition by the venom of the scorpion Leiurus quinquestriatus |
| Q42103048 | Chloride channels activated by osmotic stress in T lymphocytes |
| Q36574693 | Chloride channels of biological membranes |
| Q58113228 | Chloride conductance regulated by cyclic AMP-dependent protein kinase in cardiac myocytes |
| Q54330704 | Chloride conductive and cotransport mechanisms in cultures of canine tracheal epithelial cells measured by an entrapped fluorescent indicator. |
| Q69364353 | Chloride current activated by cyclic AMP and parathyroid hormone in rat osteoblasts |
| Q67660592 | Chloride permeability regulation via a cyclic AMP pathway in cultured human sweat duct cells |
| Q34578485 | Chloride secretory response of cystic fibrosis human airway epithelia. Preservation of calcium but not protein kinase C- and A-dependent mechanisms |
| Q46262366 | Chloride transport in apical membrane vesicles from bovine tracheal epithelium: characterization using a fluorescent indicator |
| Q41822031 | Chloride transport in cultured nasal epithelium of cystic fibrosis patients |
| Q44094246 | Chloride-sensitive nature of the adrenaline-induced current in guinea-pig cardiac myocytes |
| Q34327328 | Cl- permeability of human sweat duct cells monitored with fluorescence-digital imaging microscopy: evidence for reduced plasma membrane Cl- permeability in cystic fibrosis |
| Q36947611 | Comparison of adherence of Pseudomonas aeruginosa to respiratory epithelial cells from cystic fibrosis patients and healthy subjects |
| Q68263073 | Conductance Pathways Involved in Chloride Secretion and Their Regulation |
| Q41721279 | Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer |
| Q71787661 | Cyclic AMP-Related and Cation-Affected Human Platelet Chloride Transport Regulation |
| Q58113448 | Cyclic AMP-dependent protein kinase opens chloride channels in normal but not cystic fibrosis airway epithelium |
| Q30989236 | Cyclic AMP-independent secretion of mucin by SW1116 human colon carcinoma cells. Differential control by Ca2+ ionophore A23187 and arachidonic acid |
| Q35584011 | Cyclic adenosine monophosphate-dependent kinase in cystic fibrosis tracheal epithelium |
| Q39017146 | Cystic Fibrosis and the Nervous System. |
| Q36696232 | Cystic Fibrosis, the CFTR, and Rectifying Cl- Channels |
| Q22306467 | Cystic Fibrosis: Lessons from the Sweat Gland |
| Q68204729 | Cystic fibrosis |
| Q37532597 | Cystic fibrosis gene expression is not correlated with rectifying Cl- channels |
| Q33615206 | Cystic fibrosis--on the threshold of a rational therapy. |
| Q36639844 | Cystic fibrosis. 4. Abnormalities of airway epithelial function and the implications of the discovery of the cystic fibrosis gene |
| Q33664918 | Cystic fibrosis: exploiting its genetic basis in the hunt for new therapies |
| Q68977033 | Defective beta-adrenergic secretory responses in submandibular acinar cells from cystic fibrosis patients |
| Q38208071 | Defective regulation of epithelial Cl- permeability and protein secretion in cystic fibrosis: the putative basic defect |
| Q34124030 | Determinants of mild clinical symptoms in cystic fibrosis patients. Residual chloride secretion measured in rectal biopsies in relation to the genotype |
| Q35824033 | Diversity of airway epithelial cell targets for in vivo recombinant adenovirus-mediated gene transfer |
| Q95811332 | Drug Therapy in the 1990s : What Can We Expect for Cystic Fibrosis? |
| Q39629752 | Effect of duramycin on chloride transport and intracellular calcium concentration in cystic fibrosis and non‐cystic fibrosis epithelia |
| Q34390399 | Effects of cystic fibrosis and congenital bilateral absence of the vas deferens-associated mutations on cystic fibrosis transmembrane conductance regulator-mediated regulation of separate channels |
| Q36410508 | Effects of insulin and phosphatase on a Ca2(+)-dependent Cl- channel in a distal nephron cell line (A6). |
| Q46921811 | Effects of stilbenedisulfonic acid derivatives on the cAMP-regulated chloride current in cardiac myocytes |
| Q41688873 | Efficient CFTR expression from AAV vectors packaged with promoters--the second generation |
| Q36287507 | Efficient expression of CFTR function with adeno-associated virus vectors that carry shortened CFTR genes |
| Q45265943 | Evidence for a cytosolic inhibitor of epithelial chloride channels |
| Q54373452 | Evidence for reduced Cl- and increased Na+ permeability in cystic fibrosis human primary cell cultures. |
| Q24675847 | Exclusion of catalytic and regulatory subunits of cAMP-dependent protein kinase as candidate genes for the defect causing cystic fibrosis |
| Q41838750 | Expression and characterization of the cystic fibrosis transmembrane conductance regulator. |
| Q59073603 | Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells |
| Q35786183 | Expression of the cystic fibrosis transmembrane conductance regulator gene in cells of non-epithelial origin |
| Q35072251 | Expression of the human cystic fibrosis transmembrane conductance regulator gene in the mouse lung after in vivo intratracheal plasmid-mediated gene transfer |
| Q35821409 | Extensive posttranscriptional deletion of the coding sequences for part of nucleotide-binding fold 1 in respiratory epithelial mRNA transcripts of the cystic fibrosis transmembrane conductance regulator gene is not associated with the clinical manif |
| Q34557042 | Extracellular calcium affects the membrane currents of cultured human keratinocytes |
| Q41985605 | Failure to induce secretion in jejunal biopsies from children with cystic fibrosis |
| Q33807711 | Fatty acids inhibit apical membrane chloride channels in airway epithelia |
| Q34125265 | Fluorescence measurement of chloride transport in monolayer cultured cells. Mechanisms of chloride transport in fibroblasts |
| Q69839496 | Forskolin effects on the voltage-gated K+ conductance of human T cells |
| Q67679629 | G-proteins mediate intestinal chloride channel activation |
| Q33676661 | Genetic markers on chromosome 7. |
| Q42966018 | Glucose intolerance in cystic fibrosis |
| Q50796739 | Halide transport in Xenopus oocytes |
| Q41661082 | High intracellular pH in CFPAC: A pancreas cell line from a patient with cystic fibrosis is lowered by retrovirus-mediated CFTR gene transfer |
| Q67690102 | Histamine-induced chloride channels in apical membrane of isolated rabbit parietal cells |
| Q44524539 | Hormonal regulation of Cl transport in polar airway epithelia measured by a fluorescent indicator |
| Q67468984 | Human cystic fibrosis transmembrane conductance regulator directed to respiratory epithelial cells of transgenic mice |
| Q30501218 | Identification and regional localization of DNA markers on chromosome 7 for the cloning of the cystic fibrosis gene |
| Q52497284 | Identification of a voltage- and calcium-dependent non-selective cation channel in cultured adult and fetal human nasal epithelial cells |
| Q40593816 | Identification of an N-terminal amino acid of the CLC-3 chloride channel critical in phosphorylation-dependent activation of a CaMKII-activated chloride current |
| Q33500509 | Identification of sequences of chromosome 7 that are expressed in sweat gland epithelial cells |
| Q22010475 | Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea |
| Q37023795 | Imaging CFTR in its native environment |
| Q37609030 | Immunocytochemical localization of the cystic fibrosis gene product CFTR |
| Q39627509 | Immunoglobulin G and its function in the human respiratory tract |
| Q36287753 | In vitro bioelectric properties of bronchial epithelium from transplanted lungs in recipients with cystic fibrosis |
| Q68315223 | In vivo evidence of altered chloride but not potassium secretion in cystic fibrosis rectal mucosa |
| Q36530501 | Increased calcium influx in dystrophic muscle |
| Q43891472 | Increased expression of G protein-coupled receptor kinases in cystic fibrosis lung. |
| Q68320717 | Increased sulfate uptake in skin fibroblasts isolated from cystic fibrosis patients |
| Q34576404 | Increased sulfation of glycoconjugates by cultured nasal epithelial cells from patients with cystic fibrosis |
| Q42489244 | Inhibition by chloride channel blockers of anion secretion in cultured epididymal epithelium and intact epididymis of rats |
| Q68253613 | Inhibition of epithelial chloride channels by cytosol |
| Q70342048 | Intracellular ion concentrations in the frog cornea epithelium during stimulation and inhibition of Cl secretion |
| Q42505530 | Intracellular pH measurement in primary monolayer cultures of rat epididymal cells |
| Q34311621 | Ion channel associated diseases: overview of molecular mechanisms |
| Q51534237 | Ion transport across the murine intestine in the absence and presence of CFTR. |
| Q42223112 | Ion transport in cultured epithelia from human sweat glands: comparison of normal and cystic fibrosis tissues |
| Q35555012 | Isolation of additional polymorphic clones from the cystic fibrosis region, using chromosome jumping from D7S8. |
| Q34619106 | Isolation of cDNA clones for the catalytic gamma subunit of mouse muscle phosphorylase kinase: expression of mRNA in normal and mutant Phk mice |
| Q67767969 | Longitudinal studies of virulence factors of Pseudomonas aeruginosa in cystic fibrosis |
| Q41721337 | Low-conductance chloride channel activated by cAMP in the epithelial cell line T84 |
| Q48481510 | Macroscopic and single-channel chloride currents in neuropile glial cells of the leech central nervous system |
| Q33614906 | Mapping approaches to gene identification in humans |
| Q35198958 | Mapping of DNA markers linked to the cystic fibrosis locus on the long arm of chromosome 7 |
| Q34394060 | Measurement of intracellular mediators in enterocytes isolated from jejunal biopsy specimens of control and cystic fibrosis patients |
| Q40413648 | Membrane mechanisms and intracellular signalling in cell volume regulation. |
| Q36636914 | Microbiology of airway disease in patients with cystic fibrosis |
| Q40473234 | Molecular basis of epithelial Cl channels. |
| Q38113091 | Molecular functions of anoctamin 6 (TMEM16F): a chloride channel, cation channel, or phospholipid scramblase? |
| Q33829610 | Neuronal Ca2+ -activated Cl- channels--homing in on an elusive channel species |
| Q72505337 | New respiratory therapies in cystic fibrosis |
| Q68480435 | Outward-rectifying chloride channels in cultured adult and fetal human nasal epithelial cells |
| Q40485139 | Outwardly rectifying chloride channels and CF: A divorce and remarriage |
| Q41938196 | Patch clamp on the luminal membrane of exocrine gland acini from frog skin (Rana esculenta) reveals the presence of cystic fibrosis transmembrane conductance regulator-like Cl- channels activated by cyclic AMP |
| Q42523261 | Permeability properties of cell membranes and tight junctions of normal and cystic fibrosis sweat ducts |
| Q68969434 | Physiology. Chloride ions and cystic fibrosis |
| Q36724262 | Probing the basic defect in cystic fibrosis |
| Q54104161 | Properties and regulation of chloride channels in cystic fibrosis and normal airway cells. |
| Q44571365 | Properties of an anion-selective channel from rat colonic enterocyte plasma membranes reconstituted into planar phospholipid bilayers |
| Q54023406 | Protein kinase A-regulated Cl- channel in ML-1 human hematopoietic myeloblasts. |
| Q39606715 | Recent advances in cystic fibrosis |
| Q36696191 | Regulation of Absorption in the Human Sweat Duct |
| Q41689572 | Regulation of CI− channels by multifunctional CaM kinase |
| Q33900084 | Regulation of Cl- transport in T84 cell clones expressing a mutant regulatory subunit of cAMP-dependent protein kinase |
| Q36696203 | Regulation of Epithelial Chloride Channels: Roles of Protein Kinases and Arachidonic Acid |
| Q67704107 | Regulation of Expression of CFTR in Human Intestinal Epithelial Cells |
| Q41706424 | Regulation of Lymphocyte Chloride Channels |
| Q58113284 | Regulation of chloride channels by protein kinase C in normal and cystic fibrosis airway epithelia |
| Q54077836 | Regulation of epithelial chloride channels by protein phosphatase |
| Q41188824 | Regulation of epithelial ion channels by the cystic fibrosis transmembrane conductance regulator |
| Q53729790 | Regulation of intracellular calcium by extracellular nucleotides in pig tracheal submucosal gland cells. |
| Q90482448 | Renal Chloride Channels in Relation to Sodium Chloride Transport |
| Q93739851 | Reply |
| Q46412929 | Retention of basic electrophysiologic properties by human sweat duct cells in primary culture |
| Q44302361 | Roles of Ca and cAMP on Cl Channel Activity in Cystic Fibrosis Sweat Clear Cells as Studied by Microsuperfusion and Cell Volume Analysis |
| Q41964049 | Secondhand smoke inhibits both Cl- and K+ conductances in normal human bronchial epithelial cells. |
| Q69051907 | Secretin-regulated chloride channel on the apical plasma membrane of pancreatic duct cells |
| Q34213495 | Severe deficiency of cystic fibrosis transmembrane conductance regulator messenger RNA carrying nonsense mutations R553X and W1316X in respiratory epithelial cells of patients with cystic fibrosis |
| Q69352321 | Single chloride channels in colon mucosa and isolated colonic enterocytes of the rat |
| Q41530928 | Small and intermediate conductance chloride channels in HT29 cells |
| Q37481348 | Sodium-coupled glycine uptake by Ehrlich ascites tumor cells results in an increase in cell volume and plasma membrane channel activities |
| Q67704093 | Some Properties of Sodium and Chloride Channels in Respiratory Epithelia of CF- and Non-CF-Patients |
| Q35874742 | Stimulation of chloride secretion by P1 purinoceptor agonists in cystic fibrosis phenotype airway epithelial cell line CFPEo- |
| Q67469589 | Submucosal glands are the predominant site of CFTR expression in the human bronchus |
| Q42798991 | The chloride channel blocker anthracene 9-carboxylate inhibits fatty acid incorporation into phospholipid in cultured human airway epithelial cells |
| Q36714231 | The cystic fibrosis heterozygote — Advantage in surviving cholera? |
| Q69444781 | The effect of nicardipine, a calcium channel blocker, on the sweat test in adult patients with cystic fibrosis |
| Q41078930 | The membrane transporters regulating epithelial NaCl secretion |
| Q67467350 | The outwardly rectifying Cl? channel is not involved in cAMP-mediated Cl? secretion in HT-29 cells: evidence for a very-low-conductance Cl? channel |
| Q33637654 | The regulation of epithelial cell cAMP- and calcium-dependent chloride channels |
| Q62583358 | Transcript analysis of CFTR nonsense mutations in lymphocytes and nasal epithelial cells from cystic fibrosis patients |
| Q41518228 | Transfection of wild-type CFTR into cystic fibrosis lymphocytes restores chloride conductance at G1 of the cell cycle |
| Q35925248 | Variable deletion of exon 9 coding sequences in cystic fibrosis transmembrane conductance regulator gene mRNA transcripts in normal bronchial epithelium |
| Q45126262 | Voltage-gated chloride currents in cultured canine tracheal epithelial cells |
| Q77366685 | What we know and what we do not know about cystic fibrosis transmembrane conductance regulator |
| Q36434761 | Whole-cell and single channel K+ and Cl- currents in epithelial cells of frog skin |
| Q38749495 | Why is the cystic fibrosis gene so frequent? |
| Q42465429 | cAMP-activated chloride channel in the basolateral membrane of the thick ascending limb of the mouse kidney. |
| Q41621909 | cAMP-dependent activation of small-conductance Cl- channels in HT29 colon carcinoma cells |
| Q28212490 | pCLCA1 becomes a cAMP-dependent chloride conductance mediator in Caco-2 cells |
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