Efficient expression of CFTR function with adeno-associated virus vectors that carry shortened CFTR genes

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Efficient expression of CFTR function with adeno-associated virus vectors that carry shortened CFTR genes is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1998PNAS...9510158Z
P356DOI10.1073/PNAS.95.17.10158
P932PMC publication ID21478
P698PubMed publication ID9707617
P5875ResearchGate publication ID13576930

P2093author name stringD Wang
P D Fan
Y W Kan
L Zhang
H Fischer
J H Widdicombe
J Y Dong
P2860cites workIdentification of the cystic fibrosis gene: chromosome walking and jumpingQ22299423
Identification of the cystic fibrosis gene: cloning and characterization of complementary DNAQ28119124
Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid.Q34732912
Cystic fibrosis transmembrane conductance regulator: a chloride channel with novel regulationQ35318538
Cystic fibrosis: molecular biology and therapeutic implicationsQ35319385
Role of viral antigens in destructive cellular immune responses to adenovirus vector-transduced cells in mouse lungs.Q35871002
Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vectorQ35872651
Chloride channel and chloride conductance regulator domains of CFTR, the cystic fibrosis transmembrane conductance regulatorQ35935185
Abnormal regulation of ion channels in cystic fibrosis epitheliaQ36586832
Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vectorQ36663364
Epithelial cell dysfunction in cystic fibrosis: implications for airways diseaseQ38790982
The actin filament disrupter cytochalasin D activates the recombinant cystic fibrosis transmembrane conductance regulator Cl- channel in mouse 3T3 fibroblastsQ41258928
Gene transfer to freshly isolated human respiratory epithelial cells in vitro using a replication-deficient adenovirus containing the human cystic fibrosis transmembrane conductance regulator cDNA.Q41485634
Expression of the cystic fibrosis transmembrane conductance regulator from a novel adeno-associated virus promoterQ41573620
Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transferQ41721279
Expression and characterization of the cystic fibrosis transmembrane conductance regulator.Q41838750
Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis.Q42483788
Effect of deletion mutations on the function of CFTR chloride channelsQ42674559
A method for measuring Cl efflux from dispersed cells of airway epitheliumQ42829729
CFTR gene transduction in neonatal rabbits using an adeno-associated virus (AAV) vectorQ45279254
Recombinant adeno-associated virus for muscle directed gene therapyQ45764433
Quantitative analysis of the packaging capacity of recombinant adeno-associated virusQ45766162
Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: biological efficacy study.Q45866166
Gene therapy of cystic fibrosis lung disease using E1 deleted adenoviruses: a phase I trialQ45866236
Acute responses of non-human primates to airway delivery of an adenovirus vector containing the human cystic fibrosis transmembrane conductance regulator cDNA.Q45866338
Adenovirus-mediated gene transfer for cystic fibrosis: quantitative evaluation of repeated in vivo vector administration to the lungQ45867192
Safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lungs of nonhuman primates.Q45878651
Adenovirus-mediated generation of cAMP-stimulated Cl- transport in cystic fibrosis airway epithelia in vitro: effect of promoter and administration methodQ45881877
Replication of rep-cap genes is essential for the high-efficiency production of recombinant AAV.Q45952048
Fluid transport across cultures of human tracheal glands is altered in cystic fibrosisQ46064004
Cyclic AMP-dependent protein kinase opens chloride channels in normal but not cystic fibrosis airway epitheliumQ58113448
Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cellsQ59073603
Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosineQ64382406
Effect of Deleting the R Domain on CFTR-Generated Chloride ChannelsQ67694895
Altered regulation of airway epithelial cell chloride channels in cystic fibrosisQ68967044
Recombinant adeno-associated viral vectors mediate long-term transgene expression in muscleQ73254110
Efficient and persistent gene transfer of AAV-CFTR in maxillary sinusQ77292224
P433issue17
P407language of work or nameEnglishQ1860
P921main subjectvector-borne diseaseQ2083837
P304page(s)10158-10163
P577publication date1998-08-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleEfficient expression of CFTR function with adeno-associated virus vectors that carry shortened CFTR genes
P478volume95

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cites work (P2860)
Q33902133A PDZ-interacting domain in CFTR is an apical membrane polarization signal
Q48347827A combined analysis of the cystic fibrosis transmembrane conductance regulator: implications for structure and disease models
Q28256353A hybrid vector system expands adeno-associated viral vector packaging capacity in a transgene-independent manner
Q37393822A novel chimeric adenoassociated virus 2/human bocavirus 1 parvovirus vector efficiently transduces human airway epithelia.
Q33864423A shortened adeno-associated virus expression cassette for CFTR gene transfer to cystic fibrosis airway epithelia.
Q33840994AAV vectors: is clinical success on the horizon?
Q35012413Barriers to and new approaches for gene therapy and gene delivery in cystic fibrosis.
Q34016471CFTR with a partially deleted R domain corrects the cystic fibrosis chloride transport defect in human airway epithelia in vitro and in mouse nasal mucosa in vivo
Q92258204CRISPR/Cas Applications in Myotonic Dystrophy: Expanding Opportunities
Q35043830Current status of gene therapy for inherited lung diseases
Q58595420Cystic Fibrosis Gene Therapy: Looking Back, Looking Forward
Q34582621Cystic fibrosis transmembrane conductance regulator with a shortened R domain rescues the intestinal phenotype of CFTR-/- mice.
Q33664918Cystic fibrosis: exploiting its genetic basis in the hunt for new therapies
Q45162912Dual therapeutic utility of proteasome modulating agents for pharmaco-gene therapy of the cystic fibrosis airway.
Q34762614Effects of C-terminal deletions on cystic fibrosis transmembrane conductance regulator function in cystic fibrosis airway epithelia
Q51712353Efficient mouse airway transduction following recombination between AAV vectors carrying parts of a larger gene.
Q40532563Engagement of the B-cell antigen receptor (BCR) allows efficient transduction of ZAP-70-positive primary B-CLL cells by recombinant adeno-associated virus (rAAV) vectors
Q45865993Expression of a truncated cystic fibrosis transmembrane conductance regulator with an AAV5-pseudotyped vector in primates
Q35200182Ferret and pig models of cystic fibrosis: prospects and promise for gene therapy
Q39877658Functional cystic fibrosis transmembrane conductance regulator expression in cystic fibrosis airway epithelial cells by AAV6.2-mediated segmental trans-splicing
Q36925241Gene therapy for the treatment of cystic fibrosis
Q33482133Generation of novel AAV variants by directed evolution for improved CFTR delivery to human ciliated airway epithelium
Q34447817Hot topics in adeno-associated virus as a gene transfer vector
Q40207332Human Bocavirus Type-1 Capsid Facilitates the Transduction of Ferret Airways by Adeno-Associated Virus Genomes
Q40850802Localization of sequences within the C-terminal domain of the cystic fibrosis transmembrane conductance regulator which impact maturation and stability
Q36012920Novel molecular approaches to cystic fibrosis gene therapy
Q35821858Optimization of Recombinant Adeno-Associated Virus-Mediated Expression for Large Transgenes, Using a Synthetic Promoter and Tandem Array Enhancers
Q24533013Packaging capacity of adeno-associated virus serotypes: impact of larger genomes on infectivity and postentry steps
Q42425977Protein trans-splicing as a means for viral vector-mediated in vivo gene therapy
Q35111738Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system.
Q40816480Regulatory interaction between the cystic fibrosis transmembrane conductance regulator and HCO3- salvage mechanisms in model systems and the mouse pancreatic duct
Q40906944Repair of CFTR mRNA by spliceosome-mediated RNA trans-splicing
Q24791598The PEST sequence does not contribute to the stability of the cystic fibrosis transmembrane conductance regulator
Q90075755Viral Vectors, Animal Models, and Cellular Targets for Gene Therapy of Cystic Fibrosis Lung Disease

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