| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1146/ANNUREV.PHYSIOL.65.092101.142426 |
| P8608 | Fatcat ID | release_5boodgtipzhj3i7zmsjwm45lxa |
| P932 | PMC publication ID | 1857313 |
| P698 | PubMed publication ID | 12524461 |
| P5875 | ResearchGate publication ID | 10954630 |
| P50 | author | John F Engelhardt | Q56999987 |
| Ryan Driskell | Q43118961 | ||
| P2093 | author name string | John F Engelhardt | |
| P2860 | cites work | Latent adeno-associated virus infection elicits humoral but not cell-mediated immune responses in a nonhuman primate model | Q24527302 |
| Adeno-associated virus type 6 (AAV6) vectors mediate efficient transduction of airway epithelial cells in mouse lungs compared to that of AAV2 vectors | Q24529153 | ||
| Adeno-associated virus serotype 4 (AAV4) and AAV5 both require sialic acid binding for hemagglutination and efficient transduction but differ in sialic acid linkage specificity | Q24529161 | ||
| Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions | Q24531466 | ||
| Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy | Q24535690 | ||
| Site-specific integration by adeno-associated virus | Q24558738 | ||
| Parvovirus replication | Q24634739 | ||
| Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics | Q28141424 | ||
| Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis | Q28213353 | ||
| Inhibition of recombinant adeno-associated virus (rAAV) transduction by bronchial secretions from cystic fibrosis patients | Q45739682 | ||
| Overcoming adeno-associated virus vector size limitation through viral DNA heterodimerization | Q45742577 | ||
| Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy | Q28297851 | ||
| Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5 | Q28303765 | ||
| In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector | Q29547503 | ||
| A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency | Q33340517 | ||
| Cystic fibrosis and the salt controversy | Q33544405 | ||
| Infectious clones and vectors derived from adeno-associated virus (AAV) serotypes other than AAV type 2. | Q33781976 | ||
| In vitro and in vivo biology of recombinant adenovirus vectors with E1, E1/E2A, or E1/E4 deleted. | Q33782356 | ||
| Successful readministration of adeno-associated virus vectors to the mouse lung requires transient immunosuppression during the initial exposure | Q33786029 | ||
| Repeat transduction in the mouse lung by using adeno-associated virus vectors with different serotypes | Q33793801 | ||
| Incorporation of adeno-associated virus in a calcium phosphate coprecipitate improves gene transfer to airway epithelia in vitro and in vivo. | Q33795565 | ||
| Impaired intracellular trafficking of adeno-associated virus type 2 vectors limits efficient transduction of murine fibroblasts | Q33796712 | ||
| Adeno-associated virus type 5 (AAV5) but not AAV2 binds to the apical surfaces of airway epithelia and facilitates gene transfer | Q33802811 | ||
| CD40 ligand-dependent activation of cytotoxic T lymphocytes by adeno-associated virus vectors in vivo: role of immature dendritic cells | Q33810726 | ||
| Generation of an adenovirus vector lacking E1, e2a, E3, and all of E4 except open reading frame 3. | Q33815920 | ||
| Repeated delivery of adeno-associated virus vectors to the rabbit airway | Q33823405 | ||
| Concatamerization of adeno-associated virus circular genomes occurs through intermolecular recombination. | Q33823450 | ||
| Jaagsiekte sheep retrovirus Env protein stabilizes retrovirus vectors against inactivation by lung surfactant, centrifugation, and freeze-thaw cycling. | Q33854928 | ||
| Airway epithelial CFTR mRNA expression in cystic fibrosis patients after repetitive administration of a recombinant adenovirus | Q33901983 | ||
| An animal model for cystic fibrosis made by gene targeting | Q33970549 | ||
| Expression of the cystic fibrosis gene in adult human lung | Q34126273 | ||
| Defective fluid transport by cystic fibrosis airway epithelia | Q34134003 | ||
| Gene therapy: trials and tribulations | Q34186665 | ||
| Gene transfer into the airway epithelium of animals by targeting the polymeric immunoglobulin receptor | Q34199152 | ||
| Ribozyme gene therapy: applications for molecular medicine | Q34234190 | ||
| Endosomal processing limits gene transfer to polarized airway epithelia by adeno-associated virus. | Q34433170 | ||
| Human fibroblast growth factor receptor 1 is a co-receptor for infection by adeno-associated virus 2. | Q34486856 | ||
| AlphaVbeta5 integrin: a co-receptor for adeno-associated virus type 2 infection | Q34486863 | ||
| Neuroepithelial bodies of pulmonary airways serve as a reservoir of progenitor cells capable of epithelial regeneration | Q34506533 | ||
| Gene repair and transposon-mediated gene therapy | Q34565709 | ||
| Noninvasive gene transfer to the lung for systemic delivery of therapeutic proteins. | Q34777289 | ||
| Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver | Q35559973 | ||
| Actin filaments mediate DNA fiber formation in chronic inflammatory airway disease | Q35774309 | ||
| Trans-splicing vectors expand the utility of adeno-associated virus for gene therapy | Q35799349 | ||
| Extensive posttranscriptional deletion of the coding sequences for part of nucleotide-binding fold 1 in respiratory epithelial mRNA transcripts of the cystic fibrosis transmembrane conductance regulator gene is not associated with the clinical manif | Q35821409 | ||
| Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses | Q35837026 | ||
| A new dual-vector approach to enhance recombinant adeno-associated virus-mediated gene expression through intermolecular cis activation | Q45742580 | ||
| Structural analysis of adeno-associated virus transduction circular intermediates. | Q45747262 | ||
| Quantitative analysis of the packaging capacity of recombinant adeno-associated virus | Q45766162 | ||
| High doses of a helper-dependent adenoviral vector yield supraphysiological levels of alpha1-antitrypsin with negligible toxicity | Q45855434 | ||
| Viral receptors and vector purification: new approaches for generating clinical-grade reagents | Q45857978 | ||
| Cationic lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis: a double-blind placebo-controlled trial. | Q45861736 | ||
| The extra- and intracellular barriers to lipid and adenovirus-mediated pulmonary gene transfer in native sheep airway epithelium | Q45862101 | ||
| Increasing epithelial junction permeability enhances gene transfer to airway epithelia In vivo. | Q45865025 | ||
| A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis | Q45866575 | ||
| Methods for construction of adenovirus vectors | Q45866700 | ||
| Increasing the size of rAAV-mediated expression cassettes in vivo by intermolecular joining of two complementary vectors | Q45867424 | ||
| Recombinant IL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung. | Q45867442 | ||
| Progenitor cells of the adult human airway involved in submucosal gland development. | Q45867961 | ||
| Prolonged transgene expression in cotton rat lung with recombinant adenoviruses defective in E2a. | Q45870000 | ||
| Inhibitory effect of cystic fibrosis sputum on adenovirus-mediated gene transfer in cultured epithelial cells | Q45871368 | ||
| Aerosol and intravenous transfection of human alpha 1-antitrypsin gene to lungs of rabbits | Q45873756 | ||
| Stem cell niches in the mouse airway. | Q45878035 | ||
| Aerosol and lobar administration of a recombinant adenovirus to individuals with cystic fibrosis. II. Transfection efficiency in airway epithelium | Q45878973 | ||
| Hepatic gene therapy: persistent expression of human alpha 1-antitrypsin in mice after direct gene delivery in vivo | Q45879739 | ||
| Expanding AAV packaging capacity with trans-splicing or overlapping vectors: a quantitative comparison | Q45880308 | ||
| Loss of binding and entry of liposome-DNA complexes decreases transfection efficiency in differentiated airway epithelial cells | Q45880343 | ||
| A placebo-controlled study of liposome-mediated gene transfer to the nasal epithelium of patients with cystic fibrosis. | Q45881607 | ||
| Evidence for safety and efficacy of DOTAP cationic liposome mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis | Q45881610 | ||
| Safety of a single aerosol administration of escalating doses of the cationic lipid GL-67/DOPE/DMPE-PEG5000 formulation to the lungs of normal volunteers | Q45884078 | ||
| Lentiviral vectors for gene therapy of cystic fibrosis. | Q45885318 | ||
| Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity. | Q45885499 | ||
| Lef1 transcription factor expression defines airway progenitor cell targets for in utero gene therapy of submucosal gland in cystic fibrosis | Q45887687 | ||
| Cellular heterogeneity of CFTR expression and function in the lung: implications for gene therapy of cystic fibrosis. | Q45889649 | ||
| Basolateral localization of fiber receptors limits adenovirus infection from the apical surface of airway epithelia | Q50109548 | ||
| Liposome-mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis | Q57416213 | ||
| Na+ and Cl? conductances in airway epithelial cells: increased Na+ conductance in cystic fibrosis | Q59278426 | ||
| Stepwise dismantling of adenovirus 2 during entry into cells | Q64377608 | ||
| Non-invasive liposome-mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice | Q64377665 | ||
| Helper-dependent adenoviral vectors | Q64379053 | ||
| Partial correction of endogenous DeltaF508 CFTR in human cystic fibrosis airway epithelia by spliceosome-mediated RNA trans-splicing | Q64379396 | ||
| A phase I study of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator gene to a lung segment of individuals with cystic fibrosis | Q64381103 | ||
| Vector-specific complementation profiles of two independent primary defects in cystic fibrosis airways | Q64382112 | ||
| Aerosol administration of a recombinant adenovirus expressing CFTR to cystic fibrosis patients: a phase I clinical trial | Q64382613 | ||
| Detailed analysis of structures and formulations of cationic lipids for efficient gene transfer to the lung | Q64382719 | ||
| Modification of nasal epithelial potential differences of individuals with cystic fibrosis consequent to local administration of a normal CFTR cDNA adenovirus gene transfer vector | Q64383094 | ||
| Submucosal glands are the predominant site of CFTR expression in the human bronchus | Q67469589 | ||
| Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis | Q71660966 | ||
| Improvements in cationic liposomes for in vivo gene transfer | Q71732071 | ||
| The inhibitory role of CpG immunostimulatory motifs in cationic lipid vector-mediated transgene expression in vivo | Q73022551 | ||
| Human alpha-defensin 1 (HNP-1) inhibits adenoviral infection in vitro | Q74338160 | ||
| Efficient and persistent gene transfer of AAV-CFTR in maxillary sinus | Q77292224 | ||
| Expression of alpha v beta 5 integrin is necessary for efficient adenovirus-mediated gene transfer in the human airway. | Q35847135 | ||
| Transient subversion of CD40 ligand function diminishes immune responses to adenovirus vectors in mouse liver and lung tissues | Q35868592 | ||
| Transduction by adeno-associated virus vectors in the rabbit airway: efficiency, persistence, and readministration. | Q35889903 | ||
| A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal | Q35915922 | ||
| Efficient expression of CFTR function with adeno-associated virus vectors that carry shortened CFTR genes | Q36287507 | ||
| Sustained secretion of human alpha-1-antitrypsin from murine muscle transduced with adeno-associated virus vectors | Q36734619 | ||
| Feline immunodeficiency virus vectors persistently transduce nondividing airway epithelia and correct the cystic fibrosis defect | Q36807130 | ||
| Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression | Q36830429 | ||
| Repeat administration of an adenovirus vector encoding cystic fibrosis transmembrane conductance regulator to the nasal epithelium of patients with cystic fibrosis | Q37353301 | ||
| Lack of high affinity fiber receptor activity explains the resistance of ciliated airway epithelia to adenovirus infection | Q37371791 | ||
| Incorporation of adenovirus in calcium phosphate precipitates enhances gene transfer to airway epithelia in vitro and in vivo | Q37387177 | ||
| Expression of the cystic fibrosis transmembrane conductance regulator gene in the respiratory tract of normal individuals and individuals with cystic fibrosis | Q37557674 | ||
| The serous cell | Q37876724 | ||
| Limited entry of adenovirus vectors into well-differentiated airway epithelium is responsible for inefficient gene transfer | Q39582545 | ||
| Influence of cell polarity on retrovirus-mediated gene transfer to differentiated human airway epithelia. | Q39583034 | ||
| Humoral immunity to adeno-associated virus type 2 vectors following administration to murine and nonhuman primate muscle | Q39589663 | ||
| Ubiquitination of both adeno-associated virus type 2 and 5 capsid proteins affects the transduction efficiency of recombinant vectors. | Q39682659 | ||
| A clinical inflammatory syndrome attributable to aerosolized lipid-DNA administration in cystic fibrosis | Q40603327 | ||
| Development of a FLP/frt system for generating helper-dependent adenoviral vectors | Q40805792 | ||
| Alpha 1-antitrypsin deficiency: an overview | Q40857527 | ||
| Repair of CFTR mRNA by spliceosome-mediated RNA trans-splicing | Q40906944 | ||
| Binding and uptake of cationic lipid:pDNA complexes by polarized airway epithelial cells | Q40972916 | ||
| Retrovirus-mediated gene transfer in lungs of living fetal sheep. | Q40980092 | ||
| The effect of mucolytic agents on gene transfer across a CF sputum barrier in vitro | Q41052060 | ||
| Advances in adenoviral vectors: from genetic engineering to their biology | Q41101850 | ||
| Recombinant adeno-associated virus (AAV-CFTR) vectors do not integrate in a site-specific fashion in an immortalized epithelial cell line. | Q41171031 | ||
| Recombinant adenovirus deleted of all viral genes for gene therapy of cystic fibrosis | Q41226051 | ||
| Targeting cell-specific gene expression with an adenovirus vector containing the lacZ gene under the control of the CFTR promoter | Q41244961 | ||
| Expression of the cystic fibrosis transmembrane conductance regulator from a novel adeno-associated virus promoter | Q41573620 | ||
| Efficiency of gene transfer for restoration of normal airway epithelial function in cystic fibrosis | Q41607205 | ||
| Adenoviral vectors for gene transfer | Q41628950 | ||
| In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium | Q41644008 | ||
| Efficient CFTR expression from AAV vectors packaged with promoters--the second generation | Q41688873 | ||
| Safety and biological efficacy of an adeno-associated virus vector-cystic fibrosis transmembrane regulator (AAV-CFTR) in the cystic fibrosis maxillary sinus. | Q41746617 | ||
| Adenovirus-mediated transfer of a recombinant alpha 1-antitrypsin gene to the lung epithelium in vivo | Q41894646 | ||
| Polarity influences the efficiency of recombinant adenoassociated virus infection in differentiated airway epithelia. | Q42466029 | ||
| Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans | Q42476540 | ||
| Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1-deleted adenoviruses. | Q42483331 | ||
| Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis. | Q42483788 | ||
| Evidence for stem-cell niches in the tracheal epithelium | Q42506114 | ||
| Safety of single-dose administration of an adeno-associated virus (AAV)-CFTR vector in the primate lung. | Q42524846 | ||
| Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis. | Q43535009 | ||
| EGTA enhancement of adenovirus-mediated gene transfer to mouse tracheal epithelium in vivo | Q43553736 | ||
| A phase I study of aerosolized administration of tgAAVCF to cystic fibrosis subjects with mild lung disease | Q43670160 | ||
| Complement activation by recombinant adenoviruses. | Q43861771 | ||
| Altered fluid transport across airway epithelium in cystic fibrosis | Q43917311 | ||
| CFTR gene transduction in neonatal rabbits using an adeno-associated virus (AAV) vector | Q45279254 | ||
| Perfluorochemical liquid enhances adeno-associated virus-mediated transgene expression in lungs | Q45739293 | ||
| P921 | main subject | gene therapy | Q213901 |
| lung disease | Q3392853 | ||
| P304 | page(s) | 585-612 | |
| P577 | publication date | 2002-05-01 | |
| P1433 | published in | Annual Review of Physiology | Q567364 |
| P1476 | title | Current status of gene therapy for inherited lung diseases | |
| P478 | volume | 65 |
| Q37393822 | A novel chimeric adenoassociated virus 2/human bocavirus 1 parvovirus vector efficiently transduces human airway epithelia. |
| Q57112729 | A potential treatment for pandemic influenza using siRNAs targeting conserved regions of influenza A |
| Q45879506 | A realistic chance for gene therapy in the near future |
| Q33864423 | A shortened adeno-associated virus expression cassette for CFTR gene transfer to cystic fibrosis airway epithelia. |
| Q37676243 | Advances in Non-Viral DNA Vectors for Gene Therapy |
| Q36079832 | Airway gene therapy and cystic fibrosis |
| Q29248141 | Barriers to inhaled gene therapy of obstructive lung diseases: A review |
| Q38124849 | Cell therapy for cystic fibrosis |
| Q45873506 | Cystic fibrosis, gene therapy, and lung inflammation: for better or worse? |
| Q35684857 | Ebola virus glycoproteins: guidance devices for targeting gene therapy vectors |
| Q45877051 | Effect of Pseudomonas-induced chronic lung inflammation on specific cytotoxic T-cell responses to adenoviral vectors in mice |
| Q58607010 | Establishment of a High Yield rAAV/HBoV Vector Production System Independent of Bocavirus Non-structural Proteins |
| Q35200182 | Ferret and pig models of cystic fibrosis: prospects and promise for gene therapy |
| Q37182894 | Gene delivery to the airway |
| Q36161211 | Gene therapeutics in Sjögren's syndrome |
| Q45422901 | High levels of persistent expression of alpha1-antitrypsin mediated by the nonhuman primate serotype rh.10 adeno-associated virus despite preexisting immunity to common human adeno-associated viruses |
| Q40207332 | Human Bocavirus Type-1 Capsid Facilitates the Transduction of Ferret Airways by Adeno-Associated Virus Genomes |
| Q36825419 | Human, Pig, and Mouse Interferon-Induced Transmembrane Proteins Partially Restrict Pseudotyped Lentiviral Vectors |
| Q35399152 | Hybrid nonviral/viral vector systems for improved piggyBac DNA transposon in vivo delivery |
| Q35228912 | In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells |
| Q33647647 | In vitro and in vivo functional characterization of gutless recombinant SV40-derived CFTR vectors |
| Q40488137 | Intrapleural administration of a serotype 5 adeno-associated virus coding for alpha1-antitrypsin mediates persistent, high lung and serum levels of alpha1-antitrypsin |
| Q36587580 | Intrapulmonary Versus Nasal Transduction of Murine Airways With GP64-pseudotyped Viral Vectors |
| Q38614351 | Lentiviral vectors and cystic fibrosis gene therapy |
| Q36012920 | Novel molecular approaches to cystic fibrosis gene therapy |
| Q41985187 | Polyethylenimine-mediated gene delivery to the lung and therapeutic applications. |
| Q37158813 | Postentry processing of recombinant adeno-associated virus type 1 and transduction of the ferret lung are altered by a factor in airway secretions. |
| Q34399258 | Pseudotyped AAV vector-mediated gene transfer in a human fetal trachea xenograft model: implications for in utero gene therapy for cystic fibrosis |
| Q34332782 | Rescuing cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by transcomplementation |
| Q27347215 | Sheep lung segmental delivery strategy demonstrates adenovirus priming of local lung responses to bacterial LPS and the role of elafin as a response modulator |
| Q50700920 | Targeted gene transfer to fetal rat lung interstitium by ultrasound-guided intrapulmonary injection. |
| Q31099925 | The ΔF508-CFTR mutation inhibits wild-type CFTR processing and function when co-expressed in human airway epithelia and in mouse nasal mucosa |
| Q37866086 | Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges |
| Q40102508 | Toxicity of fiber- and penton base-modified adenovirus type 5 vectors on lung development in newborn rats. |
| Q36448393 | Treatment of human disease by adeno-associated viral gene transfer |
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