Interindividual variations in drug disposition. Clinical implications and methods of investigation

scientific article published on 01 September 1983

Interindividual variations in drug disposition. Clinical implications and methods of investigation is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1021577294
P356DOI10.2165/00003088-198308050-00001
P698PubMed publication ID6627809

P2093author name stringD D Breimer
P2860cites workComparison of the in vivo and in vitro rates of formation of the three main oxidative metabolites of antipyrine in manQ34449586
Environmental factors affecting antipyrine metabolism in London factory and office workersQ34517058
Family study of antipyrine clearanceQ34746094
Genetic variation in rates of antipyrine metabolite formation: a study in uninduced twinsQ35469675
Polymorphisms of Oxidation at Carbon Centers of Drugs and Their Clinical SignificanceQ36105459
3-Hydroxymethyl antipyrine excretion in urine after an oral dose of antipyrine. A reconsideration of previously published data and synthesis of a pure reference substanceQ36645599
Factors affecting theophylline clearances: Age, tobacco, marijuana, cirrhosis, congestive heart failure, obesity, oral contraceptives, benzodiazepines, barbiturates, and ethanolQ39288636
The antipyrine test in clinical pharmacology: Conceptions and misconceptionsQ39676489
Genetic and environmental factors affecting drug disposition in manQ39708309
Individual Differences in the Disposition of Drugs Metabolised in the BodyQ39720658
Assessment of Methods to Identify Sources of Interindividual Pharmacokinetic VariationsQ40108050
Defective oxidation of drugs: pharmacokinetic and therapeutic implicationsQ40329696
Intraindividual variation in drug dispositionQ40723411
Multiplicity of mammalian microsomal cytochromes P-45Q41203588
Assay of Antipyrine and Its Primary Metabolites in Plasma, Saliva and Urine by High-Performance Liquid Chromatography and Some Preliminary Results in ManQ41705893
Factors affecting antipyrine metabolism in West African villagersQ44188540
Environmental effects on antipyrine half-life in man.Q46532923
Differential induction of antipyrine metabolism by rifampicin.Q53701115
Interindividual differences in drug oxidation: clinical importance.Q53715264
A case of deficiency of N-hydroxylation of amobarbitalQ67011355
Antipyrine kinetics in the elderly: prediction of age-related changes in benzodiazepine oxidizing capacityQ70264232
Studies of the different metabolic pathways of antipyrine in man. Oral versus i.v. administration and the influence of urinary collection timeQ70336540
E- and Z-10-hydroxylation of nortriptyline: relationship to polymorphic debrisoquine hydroxylationQ70823716
Influence of the Genetically Controlled Deficiency in Debrisoquine Hydroxylation on Antipyrine Metabolite FormationQ70887429
Antipyrine metabolism in the rat by three hepatic monooxygenasesQ71274183
Ethnic differences in drug metabolismQ71452908
Induction of hexobarbital and antipyrine metabolism by rifampicin treatment in the pigQ72521276
Pharmacokinetics of simultaneously administered hexobarbital and heptabarbital in rats: an alternative approach to metabolic correlation studiesQ72555717
P433issue5
P304page(s)371-377
P577publication date1983-09-01
P1433published inClinical PharmacokineticsQ5133788
P1476titleInterindividual variations in drug disposition. Clinical implications and methods of investigation
P478volume8

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cites work (P2860)
Q35640730"Cocktail" approaches and strategies in drug development: valuable tool or flawed science?
Q346217962-Hydroxylation of ethinyloestradiol in relation to the oxidation of sparteine and antipyrine
Q90903705ADMET Evaluation in Drug Discovery. 19. Reliable Prediction of Human Cytochrome P450 Inhibition Using Artificial Intelligence Approaches
Q68437539Antipyrine Pharmacokinetics in Women Receiving Conjugated Estrogens
Q34447041Antipyrine clearance and metabolite formation in children with congenital adrenal hyperplasia
Q42040905Antipyrine clearance and metabolite formation in patients with alcoholic cirrhosis
Q72747532Antipyrine metabolism in patients with disseminated testicular cancer and the influence of cytostatic treatment
Q43949330Antipyrine metabolite formation and excretion in patients with chronic renal failure
Q71497746Antipyrine, theophylline, and hexobarbital as in vivo P450 probe drugs
Q40191967Cigarette smoking pharmacokinetics and its relationship to smoking behaviour
Q32117273Clinical pharmacokinetics and pharmacodynamics of ifosfamide and its metabolites
Q69720901Comparison of trimethadione and antipyrine as indicators of oxidative drug metabolizing capacity in man
Q86836795Correlation between in vivo antipyrine metabolite formation and theophylline metabolism in rats
Q38716927Drug-induced agranulocytosis: review of possible mechanisms, and prospects for clozapine studies
Q51777849Effect of antipyrine coadministration on the kinetics of acetaminophen and lidocaine.
Q78019948Effect of tacrine hydrochloride on hepatic drug metabolism
Q55264312Effects of salidroside on rat CYP enzymes by a cocktail of probe drugs.
Q68358322Elimination of cotinine from body fluids
Q93534039Elimination of cotinine from body fluids: disposition in smokers and nonsmokers
Q42867703Evaluation of CYP2C9 Activity in Rats: Use of Tolbutamide Alone and in Combined with Bupropion.
Q40839213Evaluation of a novel high-throughput assay for cytochrome P450 2D6 using 7-methoxy-4-(aminomethyl)-coumarin
Q51832268Evaluation of infusion regimens for thiopentone as a primary anaesthetic agent.
Q68048932Gas chromatographic determination of sparteine and 2- and 5-dehydrosparteine in plasma and urine
Q34682168Genetically determined variability in acetylation and oxidation. Therapeutic implications
Q67927805Ifosfamide plasma clearance in relation to polymorphic debrisoquine oxidation
Q44673368Incidence of a subclinical fascioliasis on antipyrine clearance and metabolite excretion in sheep
Q40791116Individual variation in first-pass metabolism
Q41836161Induction of mixed function oxidase activity in man by rifapentine (MDL 473), a long-acting rifamycin derivative
Q70733898Influence of alaproclate on antipyrine metabolite formation in man
Q93646835Influence of cimetidine on steady state concentration and metabolite formation from antipyrine infused with a rectal osmotic mini pump
Q41170834Influence of nutrition on liver oxidative metabolism
Q34621602Influence of rifampicin treatment on antipyrine clearance and metabolite formation in patients with tuberculosis
Q61794905Inhibition and induction of metronidazole and antipyrine metabolism
Q41914937Inhibition of ethinyloestradiol and tolbutamide metabolism by quinoline derivatives in vitro
Q40845851Inhibitory effect of nicotine and its metabolites on tolbutamide hydroxylation in rat liver microsomes
Q34358130Lack of pharmacokinetic interaction between nifedipine, sparteine and phenytoin in man.
Q34448167Obesity effects on nitrazepam disposition
Q42015699Partial metabolic clearances as determinants of the oral bioavailability of propranolol
Q41919910Pharmacokinetic aspects of chloroquine-induced pruritus: influence of dose and evidence for varied extent of metabolism of the drug
Q69812035Pharmacokinetics of adriamycin, adriamycinol, and antipyrine in patients with moderate tumor involvement of the liver
Q37713715Quantifying hepatic function in the presence of liver disease with phenazone (antipyrine) and its metabolites
Q34418061Relationship between the metabolism of antipyrine, hexobarbitone and theophylline in man as assessed by a 'cocktail' approach
Q93560199Research in the Division of Pharmacology
Q64130397Risk Assessment: Extrapolation to Individual Risk
Q70028173Salivary antipyrine half-life during injectable progestagen contraception
Q68411894Selective inhibition of drug oxidation after simultaneous administration of two probe drugs, antipyrine and tolbutamide
Q34417536Simplified approaches to the determination of antipyrine pharmacokinetic parameters
Q30963437Solid phase extraction and simultaneous high performance liquid chromatographic determination of antipyrine and its major metabolites in urine
Q41323109The distribution of debrisoquine metabolic phenotypes and implications for the suggested association with lung cancer risk
Q73567801The effect of velnacrine on the mixed function oxidase system
Q42284969The effects of diltiazem on hepatic drug metabolizing enzymes in man using antipyrine, trimethadione and debrisoquine as model substrates
Q28361778The metabolism of 17 alpha-ethinyloestradiol by human liver microsomes: formation of catechol and chemically reactive metabolites
Q70490332The relationship between phenazone (antipyrine) metabolite formation and theophylline metabolism in healthy and frail elderly women
Q41647373Trimethadione as a probe drug to estimate hepatic oxidizing capacity in humans.
Q69948291Urinary excretion of 6 beta-hydroxycortisol and the time course measurement of enzyme induction in man
Q73846452Validation of the five-drug "Pittsburgh cocktail" approach for assessment of selective regulation of drug-metabolizing enzymes
Q41816741Verapamil disposition and cardiovascular effects in elderly patients after single intravenous and oral doses

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