Antipyrine, theophylline, and hexobarbital as in vivo P450 probe drugs

scientific article published on 01 January 1996

Antipyrine, theophylline, and hexobarbital as in vivo P450 probe drugs is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0076-6879(96)72021-9
P698PubMed publication ID8791775

P2093author name stringD D Breimer
K Groen
P2860cites workCharacterisation of theophylline metabolism in human liver microsomesQ34416806
Relationship between the metabolism of antipyrine, hexobarbitone and theophylline in man as assessed by a 'cocktail' approachQ34418061
Prediction of xenobiotic metabolism by non-invasive methodsQ37829237
A 'cocktail' strategy to assess in vivo oxidative drug metabolism in humansQ37946157
Therapeutic Drug Monitoring in SalivaQ38243033
Disposition of hexobarbital: 15 years of an intriguing model substrateQ39567059
Studies on the Different Metabolic Pathways of Antipyrine in Rats: Influence of Phenobarbital and 3-Methylcholanthrene TreatmentQ39710232
Influence of endogenous and exogenous effectors on the pharmacokinetics of theophylline. Focus on biotransformation.Q40467542
Biotransformation of caffeine and theophylline in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms.Q41142887
Influence of dietary protein and carbohydrate on antipyrine and theophylline metabolism in manQ41905249
Differential effects of enzyme induction on antipyrine metabolite formationQ42021525
Studies on the different metabolic pathways of antipyrine in man. I. Oral administration of 250, 500 and 1000 mg to healthy volunteersQ42285318
Assessment of antipyrine kinetics by measurement in salivaQ43255360
Studies on the disposition of antipyrine, aminopyrine, and phenacetin using plasma, saliva, and urine.Q52869969
Age-associated stereoselective alterations in hexobarbital metabolismQ68309596
Simultaneous quantitation of d- and l-hexobarbital in rat blood by high-performance liquid chromatographyQ69425006
Theophylline: a remarkable window to the hepatic microsomal oxidasesQ70335270
Studies of the different metabolic pathways of antipyrine in man. Oral versus i.v. administration and the influence of urinary collection timeQ70336540
The relationship between phenazone (antipyrine) metabolite formation and theophylline metabolism in healthy and frail elderly womenQ70490332
Interindividual variations in drug disposition. Clinical implications and methods of investigationQ71064667
Theophylline metabolism in relation to antipyrine, debrisoquine, and sparteine metabolismQ71388580
Improved high-performance liquid chromatographic method for the simultaneous determination of caffeine and its N-demethylated metabolites in plasma using solid-phase extractionQ93616783
P304page(s)169-177
P577publication date1996-01-01
P1433published inMethods in EnzymologyQ2076903
P1476titleAntipyrine, theophylline, and hexobarbital as in vivo P450 probe drugs
P478volume272

Reverse relations

Q41916988An in vivo assay for elucidating the importance of cytochromes P450 for the ability of a wild mammalian herbivore (Neotoma lepida) to consume toxic plantscites workP2860

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