Elimination of synapses in the developing nervous system

scientific article published on 01 October 1980

Elimination of synapses in the developing nervous system is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1126/SCIENCE.7414326
P698PubMed publication ID7414326

P50authorJeff W. LichtmanQ60686974
P2093author name stringD Purves
P2860cites workReduction of multiaxonal innervation at the neuromuscular junction of the rat during developmentQ67676792
P433issue4466
P407language of work or nameEnglishQ1860
P921main subjectnervous systemQ9404
P304page(s)153-157
P577publication date1980-10-01
P1433published inScienceQ192864
P1476titleElimination of synapses in the developing nervous system
P478volume210

Reverse relations

cites work (P2860)
Q358445071-Methyl-4-phenylpyridinium induces synaptic dysfunction through a pathway involving caspase and PKCdelta enzymatic activities.
Q52203834A developmental and component analysis of active sleep.
Q70969463A new type of lesion-induced synaptogenesis: I. Synaptic turnover in non-denervated zones of the dentate gyrus in young adult rats
Q38474729A quantitative analysis of the synaptic development of the lobus parolfactorius of the chick (Gallus domesticus).
Q36118276A role for glial cells in activity-dependent central nervous plasticity? Review and hypothesis.
Q36764491A role for synaptic plasticity in the adolescent development of executive function
Q48381862A.E. Bennett Research Award. Toward a neurodevelopmental model of of obsessive--compulsive disorder
Q24658180Abnormal development of the neuromuscular junction in Nedd4-deficient mice
Q42043238Activity affects dendritic shape and synapse elimination during steroid controlled dendritic retraction in Manduca sexta.
Q41483444Activity and synapse elimination at the neuromuscular junction
Q44321307Activity blockade increases the number of functional synapses in the hippocampus of newborn rats
Q47955970Activity sharpens the map during the regeneration of the retinotectal projection in goldfish
Q33586540Activity-Dependent Synaptic Refinement: New Insights from Drosophila
Q40556169Activity-dependent neurite outgrowth and neural network development
Q38707299Activity-dependent regulation of gene expression in muscle and neuronal cells
Q44520396Activity-dependent remodeling of presynaptic inputs by postsynaptic expression of activated CaMKII.
Q33772408Activity-driven synapse elimination leads paradoxically to domination by inactive neurons.
Q52282540Activity-mediated neural change.
Q55072540Adenosine Receptors in Developing and Adult Mouse Neuromuscular Junctions and Functional Links With Other Metabotropic Receptor Pathways.
Q48526876Age-related changes in binding to excitatory amino acid uptake site in temporal cortex of human brain
Q48482115Age-related changes in binding to excitatory amino acid uptake sites in human cerebellum
Q49037135An electron microscopical study of neuronal cell clustering in postnatal mouse striatum, with special emphasis on neuronal cell death
Q48356085An electrophysiological study of a transient ipsilateral interpositorubral projection in neonatal cats.
Q36635073Apportionment of the terminals from single preganglionic axons to target neurones in the rabbit ciliary ganglion.
Q41779911Arc/Arg3.1 is a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum.
Q43594444As the gut ages: timetables for aging of innervation vary by organ in the Fischer 344 rat.
Q52934023Asynchronous synapse elimination in neonatal motor units: studies using GFP transgenic mice.
Q35172122Axon pruning: an essential step underlying the developmental plasticity of neuronal connections
Q33680963Axonal atrophy: the retraction reaction
Q48561365Bilateral neuropathologic changes in a child with hemimegalencephaly
Q48500375Brain maturation in adolescence: concurrent changes in neuroanatomy and neurophysiology
Q34026226Cadherins: molecular codes for axon guidance and synapse formation
Q38077528Calcium-dependent regulation of climbing fibre synapse elimination during postnatal cerebellar development
Q37779441Cerebral dysplasias as expressions of altered maturational processes
Q37129211Chapter 7: GAP-43 and neuronal remodeling
Q49106180Chapter 8 The Neuroembryological Study of Behavior: Progress, Problems, Perspectives
Q50896102Characterization of transient cortical projections from auditory, somatosensory, and motor cortices to visual areas 17, 18, and 19 in the kitten.
Q35019733Childhood adversity and neural development: deprivation and threat as distinct dimensions of early experience
Q70255364Chronic hypotension
Q34505511Colloquium paper: a role for relaxed selection in the evolution of the language capacity
Q38893801Common and Divergent Mechanisms in Developmental Neuronal Remodeling and Dying Back Neurodegeneration
Q35609139Comparison of Cannabinoid CB(1) Receptor Binding in Adolescent and Adult Rats: A Positron Emission Tomography Study Using [F]MK-9470.
Q49072578Comparison of plasticity in sensory and cognitive processing systems.
Q51646393Competition for neurotrophic factor in the development of nerve connections.
Q35974456Competition in neurite outgrowth and the development of nerve connections
Q30486561Connections and synaptic function in the posteroventral cochlear nucleus of deaf jerker mice.
Q68333876Control of number and distribution of synapses during ectopic synapse formation in adult rat soleus muscles
Q36536101Correlates of intellectual ability with morphology of the hippocampus and amygdala in healthy adults
Q47970656Cortical hemispheric asymmetries are present at young ages and further develop into adolescence.
Q52167433Critical period for activity-dependent synapse elimination in developing cerebellum.
Q71346462Cytodifferentiation and synaptogenesis in the neostriatum of fetal and neonatal rhesus monkeys
Q47611412Death of an axon: studying axon loss in development and disease
Q42619183Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects
Q33556276Defining the transcriptomic landscape of the developing enteric nervous system and its cellular environment
Q36970361Dendritic translocation establishes the winner in cerebellar climbing fiber synapse elimination
Q48644402Development of X- and Y-cell retinogeniculate terminations in kittens
Q72635921Development of a transient retino-retinal pathway in hooded and albino rats
Q42455556Development of basal lamina in synaptic and extrasynaptic portions of embryonic rat muscle
Q72255125Development of corticotectal synaptic terminals in the cat: a quantitative electron microscopic analysis
Q59048424Development of glomerular pattern visualized in the olfactory bulbs of living mice
Q27302840Development of neural circuitry for precise temporal sequences through spontaneous activity, axon remodeling, and synaptic plasticity
Q52279556Development of sensory-motor synapses in the spinal cord of the frog
Q48302097Development of the principal sensory nucleus of the trigeminal nerve of the rat and evidence for a transient synaptic field in the trigeminal sensory tract
Q48391037Development of the sympathetic innervation to the cerebral arterial system in neonatal rats as revealed by anterograde labeling with wheatgerm agglutinin-horseradish peroxidase
Q49465477Developmental Changes in HCN Channel Modulation of Neocortical Layer 1 Interneurons
Q49222032Developmental changes of synaptojanin expression in the human cerebrum and cerebellum
Q37495797Developmental differences in EEG and sleep responses to acute ethanol administration and its withdrawal (hangover) in adolescent and adult Wistar rats
Q40873406Developmental mechanisms that generate precise patterns of neuronal connectivity
Q34140782Developmental neurobiology of childhood stress and trauma
Q47702791Developmental regulation of the serpin, protease nexin I, localization during activity-dependent polyneuronal synapse elimination in mouse skeletal muscle
Q49063133Developmental remodeling of the retinogeniculate synapse
Q48631045Developmental study of afferented and deafferented bee antennal lobes
Q35197180Developmental time windows for axon growth influence neuronal network topology
Q33907518Developmental trajectories during adolescence in males and females: a cross-species understanding of underlying brain changes
Q64948325Differences in the constituent fiber types contribute to the intermuscular variation in the timing of the developmental synapse elimination.
Q36510594Differential effects of acute alcohol on EEG and sedative responses in adolescent and adult Wistar rats
Q36619189Differentiation of cerebellar mossy fiber synapses in the rat: a quantitative electron microscope study
Q40623763Diverse distribution and function of fibrous microtubule-associated proteins in the nervous system.
Q42527767Dopamine-dependent desensitization of dopaminergic signaling in the developing mouse striatum.
Q48114795Early polyamine treatment enhances survival of sympathetic neurons after postnatal axonal injury or immunosympathectomy
Q77486335Effect of gravity on vestibular neural development
Q69800385Effects of chronic ethanol consumption beginning at adolescence: increased numbers of dendritic spines on cortical pyramidal cells in the adulthood
Q48819495Effects of monosodium glutamate on the development of intraventricular axons in the rat hypothalamus
Q40473040Electrical Activity, Growth Cone Motility And The Cytoskeleton
Q34099929Electrical activity and development of neural circuits
Q55645208Elimination of all redundant climbing fiber synapses requires granule cells in the postnatal cerebellum.
Q48824698Elimination of synapses during the development of the central nervous system
Q52443946Embryonic development of a population of spiking local interneurones in the locust (Schistocerca gregaria).
Q33565222Emergence of order in visual system development
Q73262145Emergence of order in visual system development
Q37546491Evidence for active synapse formation or altered postsynaptic metabolism in visual cortex of rats reared in complex environments
Q28710415Evolutionary Developmental Biology and Human Language Evolution: Constraints on Adaptation
Q34203392Extraordinary neoteny of synaptic spines in the human prefrontal cortex.
Q48663951Formation of an ipsilateral corticospinal tract after ablation of cerebral cortex in neonatal rat
Q48230585Formation of chemical synapses by adult Aplysia neurons in vitro is facilitated by the presence of juvenile neurons
Q48485223Formation of retinotopic connections: selective stabilization by an activity-dependent mechanism
Q27322361From spontaneous motor activity to coordinated behaviour: a developmental model
Q44472356Functional differentiation of multiple climbing fiber inputs during synapse elimination in the developing cerebellum
Q52281224Functional elimination of afferent pathways and decreased safety factor during postembryonic development of cockroach giant interneurons
Q36215528Functions and mechanisms of retrograde neurotrophin signalling
Q52168639Further evidence for a central reorganisation of synaptic connectivity in patients with hypoglossal-facial anastomosis in man.
Q71012689Geometry of neonatal neurones and the regulation of synapse elimination
Q34253593HBL-1 patterns synaptic remodeling in C. elegans
Q36941500Histone methyltransferase Ash1L mediates activity-dependent repression of neurexin-1α.
Q71006910Histopathological reactions and axonal regeneration in the transected spinal cord of hibernating squirrels
Q47577142Homeostatic Plasticity Shapes Cell-Type-Specific Wiring in the Retina
Q40159264Human behavioral development and genetics
Q48983066Human cyclic motility: fetal-newborn continuities and newborn state differences
Q91976703Improved prediction of brain age using multimodal neuroimaging data
Q41649852In vivo approaches to neuromuscular structure and function
Q36684191In vivo imaging of cerebral microvascular plasticity from birth to death
Q42167026In vivo quantitative proton MRSI study of brain development from childhood to adolescence
Q30428647In vivo time-lapse imaging and serial section electron microscopy reveal developmental synaptic rearrangements
Q78789949In vivo time-lapse imaging of synaptic takeover associated with naturally occurring synapse elimination
Q48233943Increased expression of insulin-like growth factor I augments the progressive phase of synaptogenesis without preventing synapse elimination in the hypoglossal nucleus
Q43581707Lack of neurotrophin-4 causes selective structural and chemical deficits in sympathetic ganglia and their preganglionic innervation.
Q50694253Large-scale somatotopic refinement via functional synapse elimination in the sensory thalamus of developing mice.
Q48343973Latency jump of “relaxed” versus “contracted” motor evoked potentials as a marker of cortico-spinal maturation
Q42370251Limited synapse overproduction can speed development but sometimes with long-term energy and discrimination penalties.
Q36355556Local brain connectivity across development in autism spectrum disorder: A cross-sectional investigation
Q42562266Losing the battle but winning the war: game theoretic analysis of the competition between motoneurons innervating a skeletal muscle
Q28246677Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits
Q30488108Lysosomal activity associated with developmental axon pruning
Q41103244Mechanism of synapse disassembly at the developing neuromuscular junction
Q35558414Mechanisms of synapse assembly and disassembly
Q41352507Membrane Receptor-Induced Changes of the Protein Kinases A and C Activity May Play a Leading Role in Promoting Developmental Synapse Elimination at the Neuromuscular Junction.
Q38549720Microglia Function in Central Nervous System Development and Plasticity
Q72681112Modeling and competition in the nervous system: clues from the sensory innervation of skin
Q48873653Monocular deprivation affects X- and Y-cell retinogeniculate terminations in cats
Q36597707Morphological and electrophysiological properties of giant interneurons during the postembryonic development of the cockroach CNS
Q52255747Morphological and physiological studies of development of the monosynaptic reflex pathway in the rat lumbar spinal cord.
Q37581176Morphology of a sensory neuron in Drosophila is abnormal in memory mutants and changes during aging
Q48300526Morphology of retinogeniculate X and Y axon arbors in monocularly enucleated cats
Q37807643Motor problems in Prader–Willi syndrome: A systematic review on body composition and neuromuscular functioning
Q92130414Multicolor lineage tracing using in vivo time-lapse imaging reveals coordinated death of clonally related cells in the developing vertebrate brain
Q42776147Multiple forms of activity-dependent competition refine hippocampal circuits in vivo
Q70077296Multiple innervation of tonic endplates revealed by activity-dependent uptake of fluorescent probes
Q49951069Myelination of Purkinje axons is critical for resilient synaptic transmission in the deep cerebellar nucleus
Q32874792Myrf ER-Bound Transcription Factors Drive C. elegans Synaptic Plasticity via Cleavage-Dependent Nuclear Translocation
Q39229953Neglect as a Violation of Species-Expectant Experience: Neurodevelopmental Consequences
Q37981491Neuroglialpharmacology: myelination as a shared mechanism of action of psychotropic treatments
Q34183712Neuronal activity-regulated gene transcription in synapse development and cognitive function
Q72047820Neuropathology
Q52203203Neurotransmission and the ontogeny of human brain.
Q48396506Non-cholinergic afferents determine the distribution of the cholinergic septohippocampal projection: a study of the AChE staining pattern in the rat fascia dentata and hippocampus after lesions, X-irradiation, and intracerebral grafting
Q72573227On the two subdivisions and intrinsic synaptic connexions in the submandibular ganglion of the rat
Q90696318Ontogenesis of learning and memory: Biopsychosocial and dynamical systems perspectives
Q36201412Opiate drug use and the pathophysiology of neuroAIDS.
Q35083343Overlapping structures in sensory-motor mappings
Q42320581Pan-neurexin perturbation results in compromised synapse stability and a reduction in readily releasable synaptic vesicle pool size
Q48819879Persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking mGluR1.
Q48498028Phosphorus-31 magnetic resonance brain spectroscopy of children at risk for a substance use disorder: preliminary results
Q52251273Post-natal disappearance of transient calcium channels in mouse skeletal muscle: effects of denervation and culture.
Q47278877Post-natal reduction of neural unit size in the rabbit ciliary ganglion
Q35871698Postnatal changes in N-methyl-D-aspartate receptor binding and stimulation by glutamate and glycine of [3H]-MK-801 binding in human temporal cortex
Q48417292Postnatal changes in the numerical density and total number of asymmetric and symmetric synapses in the hypoglossal nucleus of the rat.
Q41322172Postnatal development of the feline lateral cervical nucleus: I. A quantitative light and electron microscopic study
Q35049248Postsynaptic P/Q-type Ca2+ channel in Purkinje cell mediates synaptic competition and elimination in developing cerebellum
Q34694478Postsynaptic inositol 1,4,5-trisphosphate signaling maintains presynaptic function of parallel fiber-Purkinje cell synapses via BDNF
Q48257665Pre- and postnatal development of the primary visual cortex of the common marmoset. II. Formation, remodelling, and elimination of synapses as overlapping processes.
Q48684105Prenatal development of individual retinogeniculate axons during the period of segregation
Q39658911Presynaptic muscarinic acetylcholine autoreceptors (M1, M2 and M4 subtypes), adenosine receptors (A1 and A2A) and tropomyosin-related kinase B receptor (TrkB) modulate the developmental synapse elimination process at the neuromuscular junction
Q35922023Progression of Neuronal Damage in an In Vitro Model of the Ischemic Penumbra
Q52250956Projection neurons within a vocal motor pathway are born during song learning in zebra finches
Q40141717Protein Diffusion in Cell Membranes: Some Biological Implications
Q48967112Protein synthesis and fast axonal transport in regenerating goldfish retinal ganglion cells
Q35993323Protocadherin-dependent dendritic self-avoidance regulates neural connectivity and circuit function.
Q69149374Quantitative aspects of synaptic ribbon formation in the outer plexiform layer of the developing cat retina
Q40903000Reconstruction of the neuromuscular junction connectome
Q71171354Reduced activity during development delays the normal rearrangement of synapses in the rabbit ciliary ganglion
Q43141019Refinement of the retinogeniculate synapse by bouton clustering.
Q70986683Regenerating Axons Reclaim Sensory Targets from Collateral Nerve Sprouts
Q52208006Regressive development in neuronal structure during song learning in birds
Q48165456Reinnervation of late postnatal Purkinje cells by climbing fibers: neosynaptogenesis without transient multi-innervation
Q33572175Remodeling of synaptic architecture during hippocampal "kindling"
Q88264776Removing 4E-BP Enables Synapses to Refine without Postsynaptic Activity
Q41244124Retrograde BDNF to TrkB signaling promotes synapse elimination in the developing cerebellum.
Q27319233Reversing the outcome of synapse elimination at developing neuromuscular junctions in vivo: evidence for synaptic competition and its mechanism
Q88515019Roles for neuronal and glial autophagy in synaptic pruning during development
Q35898741Schizophrenia, myelination, and delayed corollary discharges: a hypothesis
Q30431179Schizophrenia: the illness that made us human
Q52130705Seeing is believing: GFP transgenics illuminate synapse elimination.
Q48921319Selective collateral elimination in early postnatal development restricts cortical distribution of rat pyramidal tract neurones
Q41605671Selective stabilization of muscle innervation during development: a mathematical model.
Q36005276Self-destruct programs in the processes of developing neurons
Q37227670Semaphorin 5B mediates synapse elimination in hippocampal neurons
Q92609059Sequence and hierarchy in vocal rhythms and phonology
Q46925125Sequential development of electrical and chemical synaptic connections generates a specific behavioral circuit in the leech.
Q47171902Serotonin Receptor 5-HT3A Affects Development of Bladder Innervation and Urinary Bladder Function.
Q37403805Spike timing-dependent selective strengthening of single climbing fibre inputs to Purkinje cells during cerebellar development
Q35809343Spinal cord injury: reversing the incorrect cortical maps by inductive lability procedure
Q48714583Spine formation and maturation of type 1 synapses on spiny stellate neurons in primate visual cortex
Q48098776Staining of regenerated optic arbors in goldfish tectum: Progressive changes in immature arbors and a comparison of mature regenerated arbors with normal arbors
Q42484951Stereotyped axon pruning via plexin signaling is associated with synaptic complex elimination in the hippocampus.
Q40597638Structural change and development in real and artificial neural networks
Q43540483Symmetry, stereotypy, and topography of odorant representations in mouse olfactory bulbs.
Q33864501Synapse elimination and indelible memory
Q59085017Synapse elimination in neonatal rat muscle is sensitive to pattern of muscle use
Q26864382Synapse elimination in the developing cerebellum
Q78166015Synapse formation molecules in muscle and autonomic ganglia: the dual constraint hypothesis
Q70195997Synapse repression in cell culture
Q97676626Synaptic and intrinsic mechanisms underlying development of cortical direction selectivity
Q69395274Synaptic changes in the terminals of rod photoreceptors of albino mice after partial visual cell loss induced by brief exposure to constant light
Q48940560Synaptic excitation of the second and third order auditory neurons in the avian brain stem
Q57042947Synaptic innervation density is regulated by neuron-derived BDNF
Q37076301Synaptic inputs compete during rapid formation of the calyx of Held: a new model system for neural development
Q35537394Synaptic reorganization in developing and adult nervous systems
Q33868339Synaptogenesis in visual cortex of normal and preterm monkeys: evidence for intrinsic regulation of synaptic overproduction
Q91825785Terminal Schwann cell and vacant site mediated synapse elimination at developing neuromuscular junctions
Q26752306The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration
Q64093176The Protracted Maturation of Associative Layer IIIC Pyramidal Neurons in the Human Prefrontal Cortex During Childhood: A Major Role in Cognitive Development and Selective Alteration in Autism
Q52276143The activation patterns of embryonic chick motoneurones projecting to inappropriate muscles.
Q41849395The allocation of attention to learning of goal-directed actions: a cognitive neuroscience framework focusing on the Basal Ganglia
Q48824689The corticostriatal fiber system in the rhesus monkey: organization and development
Q36222066The cytomechanics of axonal elongation and retraction
Q71833232The effects of deafferentation and spinal cord transection on synapse elimination in developing rat muscles
Q72646560The effects of protein deprivation on the nucleus raphe dorsalis: A morphometric golgi study in rats of three age groups
Q34185846The emergence of somatotopic maps of the body in S1 in rats: the correspondence between functional and anatomical organization
Q58690959The interplay between electrical and chemical synaptogenesis
Q30858380The interscutularis muscle connectome
Q30679309The lesion methodology: contrasting views from adult and child studies
Q35121766The neurobiological consequences of early stress and childhood maltreatment
Q51824856The post-natal development of cutaneous afferent fibre input and receptive field organization in the rat dorsal horn.
Q71833258The relation of neuromuscular synapse elimination to spinal position of rabbit and rat soleus motoneurones
Q44455226The role of interactions in determining cell fate of two identified motoneurons in the embryonic zebrafish
Q59085013The role of neuronal identity in synaptic competition
Q30369766Thoughts and feelings and things: A new psychiatric epistemology
Q42538907Thyroid hormone-dependent development of early cortical networks: temporal specificity and the contribution of trkB and mTOR pathways
Q71833260Tonic and reflex synaptic activity recorded in ciliary ganglion cells of anaesthetized rabbits
Q34100780Toward a comprehensive neurobiology of IGF-I.
Q35121756Trajectories of brain development: point of vulnerability or window of opportunity?
Q34313942Transient projection from the superior temporal sulcus to area 17 in the newborn macaque monkey
Q50925125Transient projections from the fronto-parietal and temporal cortex to areas 17, 18 and 19 in the kitten.
Q26849273Twitching in sensorimotor development from sleeping rats to robots
Q37109787Type-1 metabotropic glutamate receptor in cerebellar Purkinje cells: a key molecule responsible for long-term depression, endocannabinoid signalling and synapse elimination
Q42096924Uncorrelated Neural Firing in Mouse Visual Cortex during Spontaneous Retinal Waves.
Q91723257Vaccinia-related kinase 2 plays a critical role in microglia-mediated synapse elimination during neurodevelopment
Q48275480Variability of axonal arborizations hides simple rules of construction: a topological study from HRP intracellular injections.
Q50897780Withdrawal of collaterals of sympathetic axons to the rat eye during postnatal development: the role of function
Q74123871[Development of the central nervous system in mammals]
Q46112880lin-14 regulates the timing of synaptic remodelling in Caenorhabditis elegans

Search more.