| scholarly article | Q13442814 |
| P2093 | author name string | Koo CH | |
| Selkoe DJ | |||
| Koo EH | |||
| Squazzo SL | |||
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | monoclonal antibody | Q422248 |
| P304 | page(s) | 991-998 | |
| P577 | publication date | 1996-05-01 | |
| P1433 | published in | Journal of Cell Science | Q1524177 |
| P1476 | title | Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody | |
| P478 | volume | 109 ( Pt 5) |
| Q37902514 | APP physiological and pathophysiological functions: insights from animal models. |
| Q30552384 | Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy |
| Q39262801 | Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes |
| Q28504667 | Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts |
| Q30666219 | Alzheimer's disease: pathophysiology and applications of magnetic nanoparticles as MRI theranostic agents. |
| Q34814145 | Amyloid-β as a Modulator of Synaptic Plasticity |
| Q35822309 | An antibody to the beta-secretase cleavage site on amyloid-beta-protein precursor inhibits amyloid-beta production. |
| Q34298548 | An early specific cell-cell interaction occurs in the production of beta-amyloid in cell cultures |
| Q39625273 | Anti-amyloid precursor protein immunoglobulins inhibit amyloid-β production by steric hindrance |
| Q35924931 | ApoER2 expression increases Abeta production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of gamma-secretase activity. |
| Q34210015 | Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target |
| Q30657683 | Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomes |
| Q35603093 | Association of ApoE and LRP mRNA levels with dementia and AD neuropathology |
| Q38940822 | Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing |
| Q33827931 | C-terminal 37 residues of LRP promote the amyloidogenic processing of APP independent of FE65 |
| Q26851244 | Caenorhabditis elegans as a model organism to study APP function |
| Q30528638 | Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport |
| Q71971007 | Cell surface amyloid beta-protein precursor colocalizes with beta 1 integrins at substrate contact sites in neural cells |
| Q34572746 | Cell surface binding and internalization of aβ modulated by degree of aggregation |
| Q35211845 | Changes in the ageing brain in health and disease |
| Q36080682 | Decreasing the expression of PICALM reduces endocytosis and the activity of β-secretase: implications for Alzheimer's disease |
| Q40086364 | Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA. |
| Q47875216 | Dysregulation of Rab5-Mediated Endocytic Pathways in Alzheimer's Disease |
| Q38229095 | Endocytic trafficking of membrane-bound cargo: a flotillin point of view. |
| Q36666647 | Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo |
| Q38027806 | Endoplasmic reticulum enrollment in Alzheimer's disease. |
| Q46004266 | FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein. |
| Q40003065 | Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons. |
| Q47398628 | GGA1 regulates signal-dependent sorting of BACE1 to recycling endosomes, which moderates Aβ production. |
| Q24336029 | GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production |
| Q26269915 | Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis |
| Q54199487 | Inhibition of death-associated protein kinase 1 attenuates the phosphorylation and amyloidogenic processing of amyloid precursor protein. |
| Q89613001 | Inhibitory effects of curcumin on H2O2-induced cell damage and APP expression and processing in SH-SY5Y cells transfected with APP gene with Swedish mutation |
| Q26999922 | Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease |
| Q24300851 | Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme |
| Q36110179 | Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons |
| Q58571807 | Justicidin A Reduces β-Amyloid via Inhibiting Endocytosis of β-Amyloid Precursor Protein |
| Q35165089 | LINGO-1 promotes lysosomal degradation of amyloid-β protein precursor |
| Q73745130 | Late compartments of amyloid precursor protein transport in SY5Y cells are involved in beta-amyloid secretion |
| Q35110927 | Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein |
| Q33568378 | Membrane localization of beta-amyloid 1-42 in lysosomes: a possible mechanism for lysosome labilization |
| Q34299120 | Mitochondrial dysfunction and cellular metabolic deficiency in Alzheimer's disease |
| Q41665323 | Modifications and Trafficking of APP in the Pathogenesis of Alzheimer's Disease |
| Q35023109 | Modulation of beta-amyloid precursor protein trafficking and processing by the low density lipoprotein receptor family |
| Q28539710 | Multiplex assay for live-cell monitoring of cellular fates of amyloid-β precursor protein (APP) |
| Q43051937 | Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo |
| Q64970966 | Packing Density of the Amyloid Precursor Protein in the Cell Membrane. |
| Q36437712 | Phorbol esters affect multiple steps in beta-amyloid precursor protein trafficking and amyloid beta-protein production |
| Q36395110 | Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis |
| Q35204147 | Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation |
| Q30494468 | Rapid and direct transport of cell surface APP to the lysosome defines a novel selective pathway |
| Q38002193 | Relationships between the amyloid precursor protein and its various proteolytic fragments and neuronal systems |
| Q33283469 | Requirement of aggregation propensity of Alzheimer amyloid peptides for neuronal cell surface binding |
| Q41381112 | Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated |
| Q46043117 | S655 phosphorylation enhances APP secretory traffic |
| Q26269904 | Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP |
| Q40219967 | Solution studies and structural model of the extracellular domain of the human amyloid precursor protein |
| Q35103335 | Subcellular topography of neuronal Abeta peptide in APPxPS1 transgenic mice |
| Q22000600 | The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid |
| Q35905454 | The Amyloid Precursor Protein of Alzheimer's Disease Clusters at the Organelle/Microtubule Interface on Organelles that Bind Microtubules in an ATP Dependent Manner |
| Q92812032 | The Challenge of Modulating Heparan Sulfate Turnover by Multitarget Heparin Derivatives |
| Q52572881 | The Drosophila beta-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction. |
| Q26750116 | The Neuroprotective Properties of the Amyloid Precursor Protein Following Traumatic Brain Injury |
| Q89741570 | The Rab5 activator RME-6 is required for amyloid precursor protein endocytosis depending on the YTSI motif |
| Q38936434 | The Role of Presenilin in Protein Trafficking and Degradation-Implications for Metal Homeostasis |
| Q36137423 | The amyloid precursor protein copper binding domain histidine residues 149 and 151 mediate APP stability and metabolism. |
| Q24680465 | The amyloid precursor protein: beyond amyloid |
| Q39665687 | The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing |
| Q47438354 | The physical approximation of APP and BACE-1: A key event in alzheimer's disease pathogenesis |
| Q26825686 | The role of APP and BACE1 trafficking in APP processing and amyloid-β generation |
| Q41882355 | The role of flotillins in regulating aβ production, investigated using flotillin 1-/-, flotillin 2-/- double knockout mice. |
| Q74552056 | The role of glycoproteins in neural development function, and disease |
| Q90463012 | The trans-Golgi network is a major site for α-secretase processing of amyloid precursor protein in primary neurons |
| Q46208166 | Three-dimensional quantitative structure-activity relationship (3D-QSAR) studies of various benzodiazepine analogues of gamma-secretase inhibitors |
| Q47592174 | Trafficking in Alzheimer's Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin. |
| Q28584304 | Trafficking of cell-surface beta-amyloid precursor protein: evidence that a sorting intermediate participates in synaptic vesicle recycling |
| Q35786031 | Transgenic mice over-expressing the C-99 fragment of betaPP with an alpha-secretase site mutation develop a myopathy similar to human inclusion body myositis |
| Q93012908 | cGMP favors the interaction between APP and BACE1 by inhibiting Rab5 GTPase activity |
Search more.