Residues 484-508 contain a major determinant of the inhibitory epitope in the A2 domain of human factor VIII

scientific article published on 01 June 1995

Residues 484-508 contain a major determinant of the inhibitory epitope in the A2 domain of human factor VIII is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.270.24.14505
P698PubMed publication ID7540171

P2093author name stringH Nakai
P Lollar
L W Hoyer
E L Saenko
J F Healey
D Scandella
I M Lubin
P2860cites workDNA sequencing with chain-terminating inhibitorsQ22066207
Molecular cloning of a cDNA encoding human antihaemophilic factorQ28268498
A hot spot of binding energy in a hormone-receptor interfaceQ29547547
On the attribution of binding energy in antigen-antibody complexes McPC 603, D1.3, and HyHEL-5.Q30195996
Epitope mapping of human factor VIII inhibitor antibodies by deletion analysis of factor VIII fragments expressed in Escherichia coliQ33641665
Inhibition of human factor VIIIa by anti-A2 subunit antibodiesQ34151336
A simple method for the preparation of homogeneous phospholipid vesiclesQ34405356
Molecular basis of factor VIII inhibition by human antibodies. Antibodies that bind to the factor VIII light chain prevent the interaction of factor VIII with phospholipidQ34575122
Epitopes on protein antigens: misconceptions and realities.Q36576238
Localization of human factor FVIII inhibitor epitopes to two polypeptide fragmentsQ37555695
Antibody-antigen complexesQ37943232
The antigenic structure of proteins: a reappraisal.Q40076398
Identification of critical contact residues in the NC41 epitope of a subtype N9 influenza virus neuraminidase.Q45787056
Thermodynamic analysis of an antibody functional epitopeQ46460317
Additivity of mutational effects in proteinsQ46528565
Receptor and antibody epitopes in human growth hormone identified by homolog-scanning mutagenesis.Q52485676
High resolution functional analysis of antibody-antigen interactionsQ67541557
Gene splicing by overlap extensionQ70662421
P433issue24
P407language of work or nameEnglishQ1860
P304page(s)14505-14509
P577publication date1995-06-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleResidues 484-508 contain a major determinant of the inhibitory epitope in the A2 domain of human factor VIII
P478volume270

Reverse relations

cites work (P2860)
Q48152338A discontinuous autoinhibitory module masks the A1 domain of von Willebrand factor.
Q36250957A major determinant of the immunogenicity of factor VIII in a murine model is independent of its procoagulant function
Q36825812A subset of high-titer anti-factor VIII A2 domain antibodies is responsive to treatment with factor VIII.
Q45884403Analysis of the human factor VIII A2 inhibitor epitope by alanine scanning mutagenesis
Q37382199B-cell and T-cell epitopes in anti-factor VIII immune responses
Q37378510Characteristics, mechanisms of action, and epitope mapping of anti-factor VIII antibodies.
Q36412125Characterization of factor VIII inhibitors
Q73693365Cleavage of factor VIII heavy chain is required for the functional interaction of a2 subunit with factor IXA
Q34304145Clustered basic residues within segment 484-510 of the factor VIIIa A2 subunit contribute to the catalytic efficiency for factor Xa generation.
Q36851942Contribution of A1 subunit residue Q316 in thrombin-activated factor VIII to A2 subunit dissociation
Q30481770Covalent inactivation of factor VIII antibodies from hemophilia A patients by an electrophilic FVIII Analog
Q38632876Engineering less immunogenic and antigenic FVIII proteins
Q38735281Evidence That Factor VIII Forms a Bivalent Complex with the Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1): IDENTIFICATION OF CLUSTER IV ON LRP1 AS THE MAJOR BINDING SITE.
Q34964772Expanding the ortholog approach for hemophilia treatment complicated by factor VIII inhibitors
Q36412120Factor VIII structure and function
Q45867739Frequency and epitope specificity of anti-factor VIII C1 domain antibodies in acquired and congenital hemophilia A.
Q30577011High-resolution mapping of epitopes on the C2 domain of factor VIII by analysis of point mutants using surface plasmon resonance
Q73066606Human inhibitor antibodies specific for the factor VIII A2 domain disrupt the interaction between the subunit and factor IXa
Q51831475Identification of porcine coagulation factor VIII domains responsible for high level expression via enhanced secretion.
Q45876257In hemophilia A and autoantibody inhibitor patients: the factor VIII A2 domain and light chain are most immunogenic
Q44274593Low density lipoprotein receptor-related protein and factor IXa share structural requirements for binding to the A3 domain of coagulation factor VIII.
Q31056138Low molecular weight peptides restore the procoagulant activity of factor VIII in the presence of the potent inhibitor antibody ESH8.
Q30707748Mapping of the minimal domain encoding a conformational epitope by lambda phage surface display: factor VIII inhibitor antibodies from haemophilia A patients
Q34983308Optimization of factor VIII replacement therapy: can structural studies help in evading antibody inhibitors?
Q35793113PEGylation of a factor VIII-phosphatidylinositol complex: pharmacokinetics and immunogenicity in hemophilia A mice
Q36951675Passive transfer of polyethylene glycol to liposomal-recombinant human FVIII enhances its efficacy in a murine model for hemophilia A.
Q41665286Potentiation of thrombin generation in hemophilia A plasma by coagulation factor VIII and characterization of antibody-specific inhibition
Q80273707Relationship between the binding sites for von Willebrand factor, phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain
Q84156772The comparative immunogenicity of human and porcine factor VIII in haemophilia A mice
Q36743356The diversity of the immune response to the A2 domain of human factor VIII
Q27648918The tertiary structure and domain organization of coagulation factor VIII
Q42864630Use of affinity-directed liquid chromatography-mass spectrometry to map the epitopes of a factor VIII inhibitor antibody fraction
Q33650193Why do inhibitors arise in patients with haemophilia A?

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