Relationship between the binding sites for von Willebrand factor, phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain

scientific article published on 01 May 2007

Relationship between the binding sites for von Willebrand factor, phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1014493590
P356DOI10.1532/IJH97.06192
P698PubMed publication ID17483075

P50authorMidori ShimaQ111804989
P2093author name stringAkira Yoshioka
Ichiro Tanaka
John C Giddings
Keiji Nogami
Masahiro Takeyama
P2860cites workLocations of disulfide bonds and free cysteines in the heavy and light chains of recombinant human factor VIII (antihemophilic factor A)Q24675267
Structure of the C2 domain of human factor VIII at 1.5 A resolutionQ27620583
Synthetic factor VIII peptides with amino acid sequences contained within the C2 domain of factor VIII inhibit factor VIII binding to phosphatidylserineQ28299233
Proteolytic processing of human factor VIII. Correlation of specific cleavages by thrombin, factor Xa, and activated protein C with activation and inactivation of factor VIII coagulant activityQ28630745
Structure of human factor VIIIQ28630991
Antigenicity of putative phospholipid membrane-binding residues in factor VIII.Q31775088
Stabilization of factor VIII in plasma by the von Willebrand factor. Studies on posttransfusion and dissociated factor VIII and in patients with von Willebrand's diseaseQ37046074
Surface-dependent reactions of the vitamin K-dependent enzyme complexesQ37938426
A human antibody directed to the factor VIII C1 domain inhibits factor VIII cofactor activity and binding to von Willebrand factorQ38317213
The factor VIII complex: structure and function.Q40100344
A monoclonal antibody (NMC-VIII/10) to factor VIII light chain recognizing Glu1675-Glu1684 inhibits factor VIII binding to endogenous von Willebrand factor in human umbilical vein endothelial cellsQ43405759
Interaction of factor VIII-von Willebrand Factor with phospholipid vesiclesQ44108483
Expression of active human factor VIII from recombinant DNA clonesQ45862746
Localization of epitopes for human factor VIII inhibitor antibodies by immunoblotting and antibody neutralizationQ45883781
Some human inhibitor antibodies interfere with factor VIII binding to factor IX.Q45888084
An immunogenic region within residues Val1670-Glu1684 of the factor VIII light chain induces antibodies which inhibit binding of factor VIII to von Willebrand factorQ46196321
The size of human factor VIII heterodimers and the effects produced by thrombinQ47207667
Epitope localization of monoclonal antibodies against factor VIII light chain which inhibit complex formation by factor VIII with von Willebrand factorQ67710620
The effect of thrombin on the complex between factor VIII and von Willebrand factorQ70354812
The role of phospholipid and factor VIIIa in the activation of bovine factor XQ71538444
A role for the C2 domain of factor VIII in binding to von Willebrand factorQ71618882
Residues 484-508 contain a major determinant of the inhibitory epitope in the A2 domain of human factor VIIIQ71697096
A factor VIII neutralizing monoclonal antibody and a human inhibitor alloantibody recognizing epitopes in the C2 domain inhibit factor VIII binding to von Willebrand factor and to phosphatidylserineQ72076617
Identification of a factor VIII peptide, residues 2315-2330, which neutralizes human factor VIII C2 inhibitor alloantibodies: requirement of Cys2326 and Glu2327 for maximum effectQ73079937
Role of factor VIII C2 domain in factor VIII binding to factor XaQ73083310
Factor VIII C2 domain contains the thrombin-binding site responsible for thrombin-catalyzed cleavage at Arg1689Q73834568
A novel mechanism of factor VIII protection by von Willebrand factor from activated protein C-catalyzed inactivationQ74097916
P433issue4
P304page(s)317-322
P577publication date2007-05-01
P1433published inInternational Journal of HematologyQ6051416
P1476titleRelationship between the binding sites for von Willebrand factor, phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain
P478volume85