Identification and analysis of cytochrome P450IID6 antigenic sites recognized by anti‐liver‐kidney microsome type‐1 antibodies (LKM1)

scientific article published on 01 May 1993

Identification and analysis of cytochrome P450IID6 antigenic sites recognized by anti‐liver‐kidney microsome type‐1 antibodies (LKM1) is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/EJI.1830230519
P953full work available at URLhttps://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Feji.1830230519
https://onlinelibrary.wiley.com/doi/pdf/10.1002/eji.1830230519
P698PubMed publication ID7682958

P50authorFernando AlvarezQ83341984
P2093author name stringA. M. Yamamoto
F. F. Clerc
O. Boniface
D. Cresteil
P2860cites workElectrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applicationsQ24561689
Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferaseQ27860571
Vectors that facilitate the expression and purification of foreign peptides in Escherichia coli by fusion to maltose-binding proteinQ28281310
Antibodies against human cytochrome P-450db1 in autoimmune hepatitis type II.Q33665767
Characterization of the common genetic defect in humans deficient in debrisoquine metabolismQ34049056
LKM-1 autoantibodies recognize a short linear sequence in P450IID6, a cytochrome P-450 monooxygenaseQ34205552
Polyclonal B cell activation in lupus-prone mice precedes and predicts the development of autoimmune diseaseQ34261883
Major antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is cytochrome P450db1.Q34569386
Analysis of anticentromere autoantibodies using cloned autoantigen CENP-B.Q34640200
Specificities of antibodies to acetylcholine receptors in sera from myasthenia gravis patients measured by monoclonal antibodiesQ36275255
Anti-liver-kidney microsome antibody recognizes a 50,000 molecular weight protein of the endoplasmic reticulumQ36349992
Anti-liver kidney microsome antibody recognizes a cytochrome P450 from the IID subfamilyQ36351347
Systemic autoimmune disease arises from polyclonal B cell activationQ36352692
Human autoantibody-reactive epitopes of SS-B/La are highly conserved in comparison with epitopes recognized by murine monoclonal antibodiesQ36354257
Anti-liver-kidney microsome antibody type 1 recognizes human cytochrome P450 db1.Q36418262
Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22.Q36455144
Altering the antigenicity of proteinsQ36950179
Dextromethorphan phenotypes in paediatric patients with autoimmune hepatitisQ42144311
Chronic active hepatitis associated with antiliver/kidney microsome antibody type 1: a second type of "autoimmune" hepatitisQ44086661
Continuous and discontinuous protein antigenic determinantsQ47646416
Identification of the main epitope on human cytochrome P450 IID6 recognized by anti-liver kidney microsome antibodyQ50185868
Antibodies to liver/kidney microsome1 in chronic active hepatitis recognize specific forms of hepatic cytochrome P-450Q58483831
Study of CYP2D6 gene in children with autoimmune hepatitis and P450 IID6 autoantibodiesQ67513498
Autoimmune hepatitis with initial presentation as acute hepatic failure in young childrenQ68701208
Patients with type II autoimmune hepatitis express functionally intact cytochrome P-450 db1 that is inhibited by LKM-1 autoantibodies in vitro but not in vivoQ68859966
Anti-liver-kidney microsome antibody-positive autoimmune hepatitis presenting as fulminant liver failureQ68890876
Mechanisms of antibody binding to a proteinQ69766097
Liver disease associated with anti-liver-kidney microsome antibody in childrenQ70019464
Detection of anti-endoplasmic reticulum antibody-positive autoimmune hepatitis in children, using an ELISA techniqueQ70229770
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectantibody binding sitesQ71147970
P304page(s)1105-1111
P577publication date1993-05-01
P1433published inEuropean Journal of ImmunologyQ5412727
P1476titleIdentification and analysis of cytochrome P450IID6 antigenic sites recognized by anti-liver-kidney microsome type-1 antibodies (LKM1)
Identification and analysis of cytochrome P450IID6 antigenic sites recognized by anti‐liver‐kidney microsome type‐1 antibodies (LKM1)
P478volume23

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cites work (P2860)
Q84843142Adoptive transfer of ex vivo expanded regulatory T cells in an autoimmune hepatitis murine model restores peripheral tolerance
Q73017826Antigenic mapping of bacterial and animal cytochromes P-450
Q24804699Autoantibodies and autoantigens in autoimmune hepatitis: important tools in clinical practice and to study pathogenesis of the disease
Q74529379Autoantibodies and defined target autoantigens in autoimmune hepatitis: an overview
Q54939025Autoantibodies in Autoimmune Hepatitis: Can Epitopes Tell Us about the Etiology of the Disease?
Q55004958Autoantibodies in Autoimmune Liver Disease-Clinical and Diagnostic Relevance.
Q78025889Autoantibody detection in type 2 autoimmune hepatitis using a chimera recombinant protein
Q33870268Autoimmune hepatitis
Q73922527Autoimmune hepatitis
Q34371115Autoimmune hepatitis and its variant syndromes
Q33342074Autoimmune hepatitis, from mechanisms to therapy
Q28087726Autoimmune hepatitis, one disease with many faces: etiopathogenetic, clinico-laboratory and histological characteristics
Q36699786Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection
Q42986166Chronic hepatitis C associated with anti-liver/kidney microsome-1 antibody is not a subgroup of autoimmune hepatitis
Q40988911Cytochrome P450 2D6 as a model antigen
Q41438951Cytochrome P450 enzymes and UDP-glucuronosyltransferases as hepatocellular autoantigens
Q41199724Cytochromes P450 and UDP-glucuronosyl-transferases as hepatocellular autoantigens
Q77221647Epitope mapping of cytochrome P4502D6 autoantigen in patients with chronic hepatitis C during alpha-interferon treatment
Q36869203Establishment of a novel radioligand assay using eukaryotically expressed cytchrome P4502D6 for the measurement of liver kidney microsomal type 1 antibdy in patients with autoimmune hepatitis and hepatitis C virus infection
Q34606147Fulminant hepatic failure in a case of autoimmune hepatitis in hepatitis C during peg-interferon-alpha 2b plus ribavirin treatment
Q34408786Heterogeneity of liver/kidney microsomal antibody type 1 in autoimmune hepatitis and hepatitis C virus related liver disease
Q27473220Immunoglobulin GM and KM Allotypes and Prevalence of Anti-LKM1 Autoantibodies in Patients with Hepatitis C Virus Infection
Q45206647Immunological cross-reactivity to multiple autoantigens in patients with liver kidney microsomal type 1 autoimmune hepatitis.
Q28069584Immunopathogenic Mechanisms of Autoimmune Hepatitis: How Much Do We Know from Animal Models?
Q33220129LKM1 autoantibodies in chronic hepatitis C infection: a case of molecular mimicry?
Q35351021Liver/kidney microsomal antibody type 1 and liver cytosol antibody type 1 concentrations in type 2 autoimmune hepatitis
Q47809505MHC class II sequences of susceptibility and protection in Mexicans with autoimmune hepatitis
Q34308948Molecular mimicry and autoimmune liver disease: virtuous intentions, malign consequences
Q34936749New autoantibodies and autoantigens in autoimmune hepatitis
Q42980425Non-organ specific autoantibodies in children with chronic hepatitis C.
Q37607111Novel Immunotherapies for Autoimmune Hepatitis.
Q81862507Of mice and women: toward a mouse model of autoimmune hepatitis
Q58100731Overlapping but distinct specificities of anti-liver-kidney microsome antibodies in autoimmune hepatitis type II and hepatitis C revealed by recombinant native CYP2D6 and novel peptide epitopes
Q78322634Pathogenesis of autoimmune hepatitis
Q36744611Pathogenesis of autoimmune hepatitis: from break of tolerance to immune-mediated hepatocyte apoptosis
Q59354446Pathogens and autoimmune hepatitis
Q33781271Pharmacogenetics of cytochromes P450.
Q35725777Regulatory T Cells in Autoimmune and Viral Chronic Hepatitis
Q38496935Transitioning from Idiopathic to Explainable Autoimmune Hepatitis
Q34005330Xenobiotic-metabolizing enzymes as autoantigens in human autoimmune disorders. An update.

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