A fungal metabolite which inhibits the interaction of CD4 with major histocompatibility complex-encoded class II molecules

scientific article published on 01 April 1994

A fungal metabolite which inhibits the interaction of CD4 with major histocompatibility complex-encoded class II molecules is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/EJI.1830240432
P698PubMed publication ID8149967

P2093author name stringMoore M
Moore J
Sinigaglia F
Cammarota G
Depledge P
Gammon G
Elcock C
Chandler G
Wrigley S
P2860cites workThe CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complexQ24293680
Interaction between CD4 and class II MHC molecules mediates cell adhesionQ24339626
The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytesQ24653345
Crystal structure of domains 3 and 4 of rat CD4: relation to the NH2-terminal domainsQ27732164
The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirusQ28259668
The immunoglobulin superfamily--domains for cell surface recognitionQ28294978
Preparation and anti-HIV activities of aurintricarboxylic acid fractions and analogues: direct correlation of antiviral potency with molecular weightQ28323658
The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lckQ28506433
Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lckQ28511623
Binding of HTLV-III/LAV to T4+ T cells by a complex of the 110K viral protein and the T4 moleculeQ28646808
T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAVQ28646817
The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brainQ29618472
Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domainsQ30195771
CD4-T-cell antigen receptor complexes on human leukemia T cellsQ33658291
Specific interaction of aurintricarboxylic acid with the human immunodeficiency virus/CD4 cell receptorQ33854208
Structure and expression of the human and mouse T4 genesQ34380179
Crystal structure of an HIV-binding recombinant fragment of human CD4.Q34637157
Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigenQ34685578
A soluble form of CD4 (T4) protein inhibits AIDS virus infectionQ34686801
CD4: its structure, role in immune function and AIDS pathogenesis, and potential as a pharmacological targetQ35290853
Novel anti-CD4 monoclonal antibodies separate human immunodeficiency virus infection and fusion of CD4+ cells from virus bindingQ36353569
MHC class II interaction with CD4 mediated by a region analogous to the MHC class I binding site for CD8Q38329233
The biologic roles of CD2, CD4, and CD8 in T-cell activationQ38624492
Selective Tropism of Lymphadenopathy Associated Virus (LAV) for Helper-Inducer T LymphocytesQ39140204
Investigations into the mechanism by which sulfated polysaccharides inhibit HIV infection in vitroQ41650013
A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2.Q41734593
The major histocompatibility complex-restricted antigen receptor on T cells. II. Role of the L3T4 productQ41764902
Polyionic compounds selectively alter availability of CD4 receptors for HIV coat protein rgp120.Q43802431
Substitution at residue 227 of H-2 class I molecules abrogates recognition by CD8-dependent, but not CD8-independent, cytotoxic T lymphocytesQ44026639
19 Selection of T cell epitopes and vaccine engineeringQ47864230
The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene familyQ48376775
CD4-binding compounds: an assay to detect new classes of immunopharmacological agents.Q50783628
Identification of a CD4 binding site on the beta 2 domain of HLA-DR molecules.Q52443678
Isolation and structure elucidation of polivione, a polyketide co-metabolite of citromycetin in Penicillium frequentansQ57834689
Biochemical identification of a direct physical interaction between the CD4: p56lck and Ti(TcR)/CD3 complexesQ58180242
Expression and function of CD4 in a murine T-cell hybridomaQ58974630
Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56 lckQ59025223
Mutational analysis of the interaction between CD4 and class II MHC: class II antigens contact CD4 on a surface opposite the gp120-binding siteQ67969096
Simple methods for monitoring HIV-1 and HIV-2 gp120 binding to soluble CD4 by enzyme-linked immunosorbent assay: HIV-2 has a 25-fold lower affinity than HIV-1 for soluble CD4Q68515930
The MHC-binding and gp120-binding functions of CD4 are separableQ69355384
Structure of a novel phospholipase C inhibitor, vinaxanthone (Ro 09-1450), produced by penicillium vinaceumQ104103719
P433issue4
P921main subjectPenicillium glabrumQ7162864
citromycetinQ15410873
VinaxanthoneQ77518780
Anhydrofulvic acidQ105219122
P304page(s)991-998
P577publication date1994-04-01
P1433published inEuropean Journal of ImmunologyQ5412727
P1476titleA fungal metabolite which inhibits the interaction of CD4 with major histocompatibility complex-encoded class II molecules
P478volume24

Reverse relations

cites work (P2860)
Q61451099Carboxyxanthones: Bioactive Agents and Molecular Scaffold for Synthesis of Analogues and Derivatives
Q71108237Human recombinant CD4 and CD4-derived synthetic peptides agglutinate immunoglobulin-coated latex particles. Evidence that residues 25-28 and 35-38 of human CD4 form two separate immunoglobulin binding sites
Q41685247Novel screen methodologies for identification of new microbial metabolites with pharmacological activity
Q38235876Semaphorins and plexins as therapeutic targets
Q112080871Vinaxanthone inhibits Semaphorin3A induced axonal growth cone collapse in embryonic neurons but fails to block its growth promoting effects on adult neurons
Q34961853Vinaxanthone, a new FabI inhibitor from Penicillium sp.
Q78429437Xanthofulvin, a Novel Semaphorin Inhibitor Produced by a Strain of Penicillium
Q36297759Xanthone derivatives: new insights in biological activities.

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