Eukaryotic translation initiation factor 2 alpha kinase 2

mammalian protein found in Homo sapiens

Wikidata entity: Q7251483



P682 biological process ... Q211935 (protein biosynthesis) protein biosynthesis
P682 biological process ... Q242736 (phosphorylation) phosphorylation
P682 biological process ... Q14330803 (response to toxic substance) response to toxic substance
P682 biological process ... Q14330986 (peptidyl-tyrosine phosphorylation) peptidyl-tyrosine phosphorylation
P682 biological process ... Q14599399 (negative regulation of cell population proliferation) negative regulation of cell population proliferation
P682 biological process ... Q14599533 (negative regulation of apoptotic process) negative regulation of apoptotic process
P682 biological process ... Q14633883 (regulation of transcription, DNA-templated) regulation of transcription, DNA-templated
P682 biological process ... Q14633894 (negative regulation of translation) negative regulation of translation
P682 biological process ... Q14633900 (endoplasmic reticulum unfolded protein response) endoplasmic reticulum unfolded protein response
P682 biological process ... Q428253 (innate immune response) innate immune response
P682 biological process ... Q3630494 (protein autophosphorylation) protein autophosphorylation
P682 biological process ... Q7251493 (protein phosphorylation) protein phosphorylation
P682 biological process ... Q14633911 (regulation of apoptotic process) regulation of apoptotic process
P682 biological process ... Q14761969 (positive regulation of NF-kappaB transcription factor activity) positive regulation of NF-kappaB transcription factor activity
P682 biological process ... Q14763010 (transcription, DNA-templated) transcription, DNA-templated
P682 biological process ... Q14851900 (positive regulation of cytokine production) positive regulation of cytokine production
P682 biological process ... Q14863407 (negative regulation of osteoblast proliferation) negative regulation of osteoblast proliferation
P682 biological process ... Q14863428 (defense response to virus) defense response to virus
P682 biological process ... Q14864136 (positive regulation of stress-activated MAPK cascade) positive regulation of stress-activated MAPK cascade
P682 biological process ... Q14864931 (response to virus) response to virus
P682 biological process ... Q14865169 (viral process) viral process
P682 biological process ... Q21102118 (cellular response to amino acid starvation) cellular response to amino acid starvation
P682 biological process ... Q21105860 (regulation of translational initiation by eIF2 alpha phosphorylation) regulation of translational initiation by eIF2 alpha phosphorylation
P682 biological process ... Q14865219 (positive regulation of chemokine production) positive regulation of chemokine production
P682 biological process ... Q14877419 (negative regulation of viral genome replication) negative regulation of viral genome replication
P682 biological process ... Q14905684 (response to interferon-alpha) response to interferon-alpha
P682 biological process ... Q14905685 (regulation of NLRP3 inflammasome complex assembly) regulation of NLRP3 inflammasome complex assembly
P682 biological process ... Q14905686 (positive regulation of NIK/NF-kappaB signaling) positive regulation of NIK/NF-kappaB signaling
P682 biological process ... Q14905687 (regulation of hematopoietic progenitor cell differentiation) regulation of hematopoietic progenitor cell differentiation
P682 biological process ... Q14905688 (regulation of hematopoietic stem cell proliferation) regulation of hematopoietic stem cell proliferation
P682 biological process ... Q14905689 (regulation of hematopoietic stem cell differentiation) regulation of hematopoietic stem cell differentiation
P682 biological process ... Q14908111 (regulation of phosphoprotein phosphatase activity) regulation of phosphoprotein phosphatase activity
P682 biological process ... Q14916317 (immune system process) immune system process
P681 cell component ... Q40260 (nucleus) nucleus
P681 cell component ... Q42244 (ribosome) ribosome
P681 cell component ... Q79899 (cytoplasm) cytoplasm
P681 cell component ... Q220599 (cytosol) cytosol
P681 cell component ... Q14349455 (membrane) membrane
P681 cell component ... Q14330632 (perinuclear region of cytoplasm) perinuclear region of cytoplasm
P681 cell component ... Q14910925 (cytosolic ribosome) cytosolic ribosome
P591 EC enzyme number String 2.7.10.2 ???
P702 encoded by ... Q14905690 (EIF2AK2) EIF2AK2
P703 found in taxon ... Q15978631 (Homo sapiens) Homo sapiens
P692 Gene Atlas image CommonsMedia http://commons.wikimedia.org/wiki/Special:FilePath/PBB%20GE%20EIF2AK2%20204211%20x%20at%20fs.png ???
P527 has part(s) ... Q24768234 (protein kinase domain) protein kinase domain
P527 has part(s) ... Q24769051 (protein kinase, ATP binding site) protein kinase, ATP binding site
P527 has part(s) ... Q24773388 (Double-stranded RNA-binding domain) Double-stranded RNA-binding domain
P527 has part(s) ... Q24787419 (serine/threonine-protein kinase, active site) serine/threonine-protein kinase, active site
P31 instance of ... Q8054 (protein) protein
P680 molecular function ... Q167149 (protein binding) protein binding
P680 molecular function ... Q14330639 (RNA binding) RNA binding
P680 molecular function ... Q14326094 (protein serine/threonine kinase activity) protein serine/threonine kinase activity
P680 molecular function ... Q14762994 (identical protein binding) identical protein binding
P680 molecular function ... Q14817981 (ATP binding) ATP binding
P680 molecular function ... Q14820641 (protein kinase activity) protein kinase activity
P680 molecular function ... Q14840131 (transferase activity) transferase activity
P680 molecular function ... Q14860365 (nucleotide binding) nucleotide binding
P680 molecular function ... Q14863082 (kinase activity) kinase activity
P680 molecular function ... Q14863338 (protein tyrosine kinase activity) protein tyrosine kinase activity
P680 molecular function ... Q21110886 (protein phosphatase regulator activity) protein phosphatase regulator activity
P680 molecular function ... Q14866204 (double-stranded RNA binding) double-stranded RNA binding
P680 molecular function ... Q14873985 (non-membrane spanning protein tyrosine kinase activity) non-membrane spanning protein tyrosine kinase activity
P680 molecular function ... Q14905679 (eukaryotic translation initiation factor 2alpha kinase activity) eukaryotic translation initiation factor 2alpha kinase activity
P361 part of ... Q24726164 (Protein kinase-like domain superfamily) Protein kinase-like domain superfamily
P361 part of ... Q83138186 (Protein kinase domain, protein family) Protein kinase domain, protein family
P361 part of ... Q83141126 (Double-stranded RNA-binding domain, protein family) Double-stranded RNA-binding domain, protein family
P361 part of ... Q95353644 (Serine/threonine-protein kinase, active site, protein family) Serine/threonine-protein kinase, active site, protein family
P361 part of ... Q95354221 (Protein kinase, ATP binding site, protein family) Protein kinase, ATP binding site, protein family
P129 physically interacts with ... Q5007568 (PKR inhibitor) PKR inhibitor

External Ids
P705Ensembl protein IDENSP00000233057
P705Ensembl protein IDENSP00000497534
P705Ensembl protein IDENSP00000378559
P705Ensembl protein IDENSP00000393921
P705Ensembl protein IDENSP00000385014
P705Ensembl protein IDENSP00000374663
P638PDB structure ID1QU6
P638PDB structure ID2A19
P638PDB structure ID2A1A
P638PDB structure ID3UIU
P637RefSeq protein IDNP_001129123
P637RefSeq protein IDNP_001129124
P637RefSeq protein IDNP_002750
P637RefSeq protein IDXP_011531289
P637RefSeq protein IDXP_016859992
P352UniProt protein IDP19525

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log id: 5119779