Enzymatic synthesis of a bacterial polyketide from acetyl and malonyl coenzyme A

scientific article published on 01 December 1993

Enzymatic synthesis of a bacterial polyketide from acetyl and malonyl coenzyme A is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1126/SCIENCE.8248801
P698PubMed publication ID8248801

P2093author name stringC R Hutchinson
B Shen
P2860cites workNucleotide sequence of the tcmII-tcmIV region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens and evidence that the tcmN gene encodes a multifunctional cyclase-dehydratase-O-methyl transferaseQ36110129
The tcmVI region of the tetracenomycin C biosynthetic gene cluster of Streptomyces glaucescens encodes the tetracenomycin F1 monooxygenase, tetracenomycin F2 cyclase, and, most likely, a second cyclaseQ36124265
Overproduction and localization of components of the polyketide synthase of Streptomyces glaucescens involved in the production of the antibiotic tetracenomycin CQ36163532
Anthracycline metabolites from baumycin-producing Streptomyces sp. D788. II. New anthracycline metabolites produced by a blocked mutant strain RPM-5Q70568332
New anthracyclines, feudomycins, produced by the mutant from Streptomyces coeruleorubidus ME130-A4.Q105010173
Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.Q115949565
P433issue5139
P407language of work or nameEnglishQ1860
P304page(s)1535-1540
P577publication date1993-12-01
P1433published inScienceQ192864
P1476titleEnzymatic synthesis of a bacterial polyketide from acetyl and malonyl coenzyme A
P478volume262

Reverse relations

cites work (P2860)
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Q36564492A yeast acetyl coenzyme A carboxylase mutant links very-long-chain fatty acid synthesis to the structure and function of the nuclear membrane-pore complex.
Q40940289Achieving natural product synthesis and diversity via catalytic networking ex vivo
Q57986106Acylation of Streptomyces type II polyketide synthase acyl carrier proteins
Q74232738Catalytic self-acylation of type II polyketide synthase acyl carrier proteins
Q44664437Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases
Q39931719Cloning, sequencing, and analysis of the griseusin polyketide synthase gene cluster from Streptomyces griseus
Q33538629Combinatorial biosynthesis for new drug discovery
Q27644463Conformational changes associated with the binding of zinc acetate at the putative active site of Xc TcmJ, a cupin from Xanthomonas campestris pv. campestris
Q28504079Crp is a global regulator of antibiotic production in streptomyces
Q33910335Cyclization of aromatic polyketides from bacteria and fungi
Q37533052Deciphering the mechanism for the assembly of aromatic polyketides by a bacterial polyketide synthase
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