Failure of RNA synthesis to recover after UV irradiation: an early defect in cells from individuals with Cockayne's syndrome and xeroderma pigmentosum

scientific article published on 01 April 1982

Failure of RNA synthesis to recover after UV irradiation: an early defect in cells from individuals with Cockayne's syndrome and xeroderma pigmentosum is …
instance of (P31):
scholarly articleQ13442814

External links are
P953full work available at URLhttp://cancerres.aacrjournals.org/cgi/content/abstract/42/4/1473
P698PubMed publication ID6174225

P2093author name stringLehmann AR
Mayne LV
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectxeroderma pigmentosumQ612693
P304page(s)1473-1478
P577publication date1982-04-01
P1433published inCancer ResearchQ326097
P1476titleFailure of RNA synthesis to recover after UV irradiation: an early defect in cells from individuals with Cockayne's syndrome and xeroderma pigmentosum
P478volume42

Reverse relations

cites work (P2860)
Q41352478A Novel Mutation in ERCC8 Gene Causing Cockayne Syndrome
Q36552711A UV-responsive G2 checkpoint in rodent cells
Q27318209A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome
Q42177676A rapid, comprehensive system for assaying DNA repair activity and cytotoxic effects of DNA-damaging reagents
Q39694111A ubiquitin-binding domain in Cockayne syndrome B required for transcription-coupled nucleotide excision repair
Q37021545A ubiquitylation site in Cockayne syndrome B required for repair of oxidative DNA damage, but not for transcription-coupled nucleotide excision repair
Q37219471Accumulation of (5'S)-8,5'-cyclo-2'-deoxyadenosine in organs of Cockayne syndrome complementation group B gene knockout mice
Q86630527Age-associated decreases in human DNA repair capacity: Implications for the skin
Q38721258Amplification of unscheduled DNA synthesis signal enables fluorescence-based single cell quantification of transcription-coupled nucleotide excision repair.
Q37488658BHK cell lines with increased rates of gene amplification are hypersensitive to ultraviolet light
Q24302667BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II.
Q34554610Blinded by the UV light: how the focus on transcription-coupled NER has distracted from understanding the mechanisms of Cockayne syndrome neurologic disease
Q37418002Blurring the line between the DNA damage response and transcription: the importance of chromatin dynamics
Q30854865Chromatin restoration following nucleotide excision repair involves the incorporation of ubiquitinated H2A at damaged genomic sites
Q38339920Cisplatin- and UV-damaged DNA lure the basal transcription factor TFIID/TBP.
Q69109211Clinical and biochemical studies in three patients with severe early infantile Cockayne syndrome
Q37638150Cockayne Syndrome group B protein stimulates NEIL2 DNA glycosylase activity.
Q34590427Cockayne syndrome B protein regulates the transcriptional program after UV irradiation
Q28306117Cockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediates
Q24317053Cockayne syndrome group B protein enhances elongation by RNA polymerase II
Q24318851Cockayne syndrome protein B interacts with and is phosphorylated by c-Abl tyrosine kinase
Q38923380Cockayne syndrome: Clinical features, model systems and pathways
Q34232807Cockayne syndrome: Review of 140 cases
Q36433210Cockayne syndrome: magnetic resonance images of the brain in a severe form with early onset
Q28537642Cockayne syndrome: varied requirement of transcription-coupled nucleotide excision repair for the removal of three structurally different adducts from transcribed DNA
Q41653440Cockayne's syndrome: correlation of clinical features with cellular sensitivity of RNA synthesis to UV irradiation
Q37593459Complete absence of Cockayne syndrome group B gene product gives rise to UV-sensitive syndrome but not Cockayne syndrome
Q89722956Continuous transcription initiation guarantees robust repair of all transcribed genes and regulatory regions
Q28238854DNA repair diseases: What do they tell us about cancer and aging?
Q36078695DNA transcription and repair: a confluence
Q50106852Deep intronic variation in splicing regulatory element of the ERCC8 gene associated with severe but long-term survival Cockayne syndrome
Q34348395Deficient repair of the transcribed strand of active genes in Cockayne's syndrome cells
Q28594975Developmental defects and male sterility in mice lacking the ubiquitin-like DNA repair gene mHR23B
Q28509765Different effects of CSA and CSB deficiency on sensitivity to oxidative DNA damage
Q36850507Differential repair of DNA damage in the human metallothionein gene family
Q40450525Differential repair of UV damage in Saccharomyces cerevisiae
Q43183885Differential repair of UV damage in rad mutants of Saccharomyces cerevisiae: a possible function of G2 arrest upon UV irradiation
Q33559326Differential requirement for the ATPase domain of the Cockayne syndrome group B gene in the processing of UV-induced DNA damage and 8-oxoguanine lesions in human cells
Q28593341Differential role of transcription-coupled repair in UVB-induced G2 arrest and apoptosis in mouse epidermis
Q35006896Disorders of nucleotide excision repair: the genetic and molecular basis of heterogeneity
Q33603063Dissociation of CAK from core TFIIH reveals a functional link between XP-G/CS and the TFIIH disassembly state
Q34407717Dysregulation of gene expression as a cause of Cockayne syndrome neurological disease
Q33592846Early onset Cockayne's syndrome: case reports with neuropathological and fibroblast studies
Q34503412Elements That Regulate the DNA Damage Response of Proteins Defective in Cockayne Syndrome
Q36690666Evidence from mutation spectra that the UV hypermutability of xeroderma pigmentosum variant cells reflects abnormal, error-prone replication on a template containing photoproducts
Q64230140Fluorescently-labelled CPD and 6-4PP photolyases: new tools for live-cell DNA damage quantification and laser-assisted repair
Q38210260Gearing up chromatin: A role for chromatin remodeling during the transcriptional restart upon DNA damage
Q43599752Gene-specific DNA repair in terminally differentiating rat myoblasts
Q40819236Genomic damage and its repair in young and aging brain
Q40019757HHR23B, a human Rad23 homolog, stimulates XPC protein in nucleotide excision repair in vitro
Q33808192Hypomorphic PCNA mutation underlies a human DNA repair disorder.
Q42512985Local UV-induced DNA damage in cell nuclei results in local transcription inhibition
Q27022616Mammalian transcription-coupled excision repair
Q40693785Mechanisms of transcription-repair coupling and mutation frequency decline
Q89393146Mechanistic insights in transcription-coupled nucleotide excision repair of ribosomal DNA
Q90387567Mechanistic insights into the regulation of transcription and transcription-coupled DNA repair by Cockayne syndrome protein B
Q35943160Mfd is required for rapid recovery of transcription following UV-induced DNA damage but not oxidative DNA damage in Escherichia coli
Q36874609Mitochondrial deficiency in Cockayne syndrome
Q24538671Molecular analysis of mutations in the CSB (ERCC6) gene in patients with Cockayne syndrome
Q33758049Molecular characterization of an acidic region deletion mutant of Cockayne syndrome group B protein
Q39762223Multiomic Analysis of the UV-Induced DNA Damage Response
Q24310583Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair
Q38880991NELF-E is recruited to DNA double-strand break sites to promote transcriptional repression and repair.
Q49689803Non-coding RNA networks in cancer.
Q40557149Nuclear matrix associated DNA is preferentially repaired in normal human fibroblasts, exposed to a low dose of ultraviolet light but not in Cockayne's syndrome fibroblasts
Q37308518Nucleic acid binding activity of human Cockayne syndrome B protein and identification of Ca(2+) as a novel metal cofactor
Q72236445Nucleotide excision repair in yeast
Q28238547Physiological consequences of defects in ERCC1-XPF DNA repair endonuclease
Q91859408Poly(ADP-ribose) polymerase 1 (PARP1) promotes oxidative stress-induced association of Cockayne syndrome group B protein with chromatin
Q38125728Post-transcriptional regulation of DNA damage-responsive gene expression
Q34660120Preferential DNA repair in expressed genes
Q37408662Preferential DNA repair of an active gene in human cells
Q34025252Premature aging and cancer in nucleotide excision repair-disorders
Q37229309Progeroid syndromes: probing the molecular basis of aging?
Q36458801Protein oxidative damage is associated with life expectancy of houseflies
Q38741213RNA Processing and Genome Stability: Cause and Consequence
Q39721529Recovery of RNA polymerase II synthesis following DNA damage in mutants of Saccharomyces cerevisiae defective in nucleotide excision repair
Q24644162Recruitment of the putative transcription-repair coupling factor CSB/ERCC6 to RNA polymerase II elongation complexes
Q36191704Regulation of active genome integrity and expression by Rad26p
Q90110326Regulation of the RNAPII Pool Is Integral to the DNA Damage Response
Q33695867Regulation of ultraviolet light-induced gene expression by gene size
Q34636957Role of transcription-coupled DNA repair in susceptibility to environmental carcinogenesis
Q54959914Similarity in the effect of caffeine on DNA synthesis after UV irradiation between xeroderma pigmentosum variant cells and mouse cells.
Q36545639Sirt1 suppresses RNA synthesis after UV irradiation in combined xeroderma pigmentosum group D/Cockayne syndrome (XP-D/CS) cells
Q41331200Somatic cell mutation frequency at the HPRT, T-cell antigen receptor and glycophorin A loci in Cockayne syndrome
Q35953606Special issue on the segmental progeria Cockayne syndrome
Q41992139Stabilization of Ultraviolet (UV)-stimulated Scaffold Protein A by Interaction with Ubiquitin-specific Peptidase 7 Is Essential for Transcription-coupled Nucleotide Excision Repair
Q35804859Strand specificity for UV-induced DNA repair and mutations in the Chinese hamster HPRT gene
Q22010799The ATPase domain but not the acidic region of Cockayne syndrome group B gene product is essential for DNA repair
Q38815648The C-terminal Region and SUMOylation of Cockayne Syndrome Group B Protein Play Critical Roles in Transcription-coupled Nucleotide Excision Repair
Q52560605The Cellular Response to Transcription-Blocking DNA Damage.
Q36871119The Cockayne Syndrome Natural History (CoSyNH) study: clinical findings in 102 individuals and recommendations for care.
Q33887586The Cockayne syndrome B protein, involved in transcription-coupled DNA repair, resides in an RNA polymerase II-containing complex
Q28240933The cockayne syndrome B protein is essential for neuronal differentiation and neuritogenesis
Q33640104The genetic defect in Cockayne syndrome is associated with a defect in repair of UV-induced DNA damage in transcriptionally active DNA.
Q34609713The human CSB (ERCC6) gene corrects the transcription-coupled repair defect in the CHO cell mutant UV61
Q37593710The many faces of Cockayne syndrome
Q35907237The residual repair capacity of xeroderma pigmentosum complementation group C fibroblasts is highly specific for transcriptionally active DNA
Q34649133The role of genetics in the establishment and maintenance of the epigenome.
Q40019597The sensitivity of Cockayne's syndrome cells to DNA-damaging agents is not due to defective transcription-coupled repair of active genes
Q39718264The sensitivity of human fibroblasts to N-acetoxy-2-acetylaminofluorene is determined by the extent of transcription-coupled repair, and/or their capability to counteract RNA synthesis inhibition
Q40605912The ultraviolet sensitivity of Cockayne syndrome cells is not a consequence of reduced cellular NAD content
Q34640431Transcription and DNA damage: a link to a kink
Q53801893Transcription-associated events affecting genomic integrity.
Q35195489Transcription-coupled repair in yeast is independent from ubiquitylation of RNA pol II: implications for Cockayne's syndrome
Q39607390Transcription-coupled repair is inducible in hamster cells
Q33594900Transcription-coupled repair of DNA damage: unanticipated players, unexpected complexities
Q42951445Transcription-related human disorders.
Q38690465Transcriptional Signatures of Aging.
Q38715789UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene
Q37249463UV-induced inhibition of transcription involves repression of transcription initiation and phosphorylation of RNA polymerase II.
Q36458963Ultraviolet-induced mutations in Cockayne syndrome cells are primarily caused by cyclobutane dimer photoproducts while repair of other photoproducts is normal.
Q39393194Uncommon nucleotide excision repair phenotypes revealed by targeted high-throughput sequencing
Q35195587Xeroderma pigmentosum and Cockayne syndrome: overlapping clinical and biochemical phenotypes
Q36728551Xeroderma pigmentosum complementation group C cells remove pyrimidine dimers selectively from the transcribed strand of active genes
Q35194613Xeroderma pigmentosum complementation group G associated with Cockayne syndrome

Search more.