2-acetaminofluorene blocks cell cycle progression after hepatectomy by p21 induction and lack of cyclin E expression

scientific article published on 01 November 1999

2-acetaminofluorene blocks cell cycle progression after hepatectomy by p21 induction and lack of cyclin E expression is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1049086031
P356DOI10.1038/SJ.ONC.1203045
P698PubMed publication ID10597246

P2093author name stringManns MP
Trautwein C
Flemming P
Will M
Kubicka S
Rakemann T
P2860cites workNew functional activities for the p21 family of CDK inhibitorsQ24313427
The retinoblastoma protein binds to a family of E2F transcription factorsQ24320199
Cyclin A is required at two points in the human cell cycleQ24329048
A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiationQ24568092
The retinoblastoma protein and cell cycle controlQ27860722
Differential regulation of E2F transactivation by cyclin/cdk2 complexesQ28612933
Cancer cell cyclesQ29547756
Principles of CDK regulationQ29547820
Inhibitors of mammalian G1 cyclin-dependent kinasesQ29547907
Liver regenerationQ29614743
G1 events and regulation of cell proliferationQ29618317
Mammalian G1 cyclinsQ29618855
A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1Q33265379
Regulation of the cyclin E gene by transcription factor E2F1Q33651067
Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.Q34223352
Inhibition of cyclin-dependent kinases by p21Q34447738
Multiple members of the E2F transcription factor family are the products of oncogenesQ34610790
The liver as a stem cell and lineage systemQ35232505
Retinoblastoma-repression of E2F-dependent transcription depends on the ability of the retinoblastoma protein to interact with E2F and is abrogated by the adenovirus E1A oncoproteinQ35934834
Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptorQ35997495
Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblastsQ36559514
Accumulation of p53 in a mutant cell line defective in the ubiquitin pathwayQ36648425
A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoterQ36676009
Rapid induction in regenerating liver of RL/IF-1 (an I kappa B that inhibits NF-kappa B, RelB-p50, and c-Rel-p50) and PHF, a novel kappa B site-binding complexQ36817938
Insulinlike growth factor II expression and oval cell proliferation associated with hepatocarcinogenesis in woodchuck hepatitis virus carriersQ36872573
G1 arrest and down-regulation of cyclin E/cyclin-dependent kinase 2 by the protein kinase inhibitor staurosporine are dependent on the retinoblastoma protein in the bladder carcinoma cell line 5637.Q37564092
Hepatocyte differentiation and liver progenitor cellsQ37574146
Acute-phase response factor, increased binding, and target gene transcription during liver regeneration.Q38356947
Concanavalin A-induced liver injury triggers hepatocyte proliferationQ39803692
CREB controls LAP/C/EBP beta transcriptionQ40022530
Current pathogenetic and molecular concepts in viral liver carcinogenesis.Q40708390
Hepatic oval cells express the hematopoietic stem cell marker Thy-1 in the rat.Q40869986
Pluripotential liver stem cells: facultative stem cells located in the biliary treeQ41179386
Viewpoint: putting the cell cycle in orderQ41293401
Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA.Q41358760
Bcl-2 blocks p53-dependent apoptosisQ41476333
Linking protein kinase C to cell-cycle controlQ41601708
Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domainQ43498366
A preS mutation isolated from a patient with chronic hepatitis B infection leads to virus retention and misassemblyQ44969179
p53-mediated accumulation of hypophosphorylated pRb after the G1 restriction point fails to halt cell cycle progressionQ46434050
Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice.Q52522262
New principle for the analysis of chemical carcinogenesisQ59089097
A precursor-product relationship exists between oval cells and hepatocytes in rat liverQ69419863
Proliferation, apoptosis, and induction of hepatic transcription factors are characteristics of the early response of biliary epithelial (oval) cells to chemical carcinogensQ70869719
Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regenerationQ70988072
C/EBP-beta/LAP controls down-regulation of albumin gene transcription during liver regenerationQ71246722
E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activityQ71584675
Regulation of cyclin-dependent kinase inhibitor p21(WAF1/Cip1/Sdi1) gene expression in hepatic regenerationQ73107788
Involvement of p21 and p27 in the regulation of CDK activity and cell cycle progression in the regenerating liverQ74510381
Unusual Defense Movements in Scorpaena plumieri mystesQ95621174
P433issue47
P407language of work or nameEnglishQ1860
P921main subjecthepatectomyQ1514021
P304page(s)6443-6453
P577publication date1999-11-01
P1433published inOncogeneQ1568657
P1476title2-acetaminofluorene blocks cell cycle progression after hepatectomy by p21 induction and lack of cyclin E expression
P478volume18

Reverse relations

cites work (P2860)
Q35595837ATP binding cassette transporter gene expression in rat liver progenitor cells
Q40745336Acute cytotoxicity of the chemical carcinogen 2-acetylaminofluorene in cultured rat liver epithelial cells.
Q40701811After portal branch ligation in the rat, cellular proliferation is associated with selective induction of c-Ha-ras, p53, cyclin E, and Cdk2.
Q53358254An inhibitor of cyclin-dependent kinase, stress-induced p21Waf-1/Cip-1, mediates hepatocyte mito-inhibition during the evolution of cirrhosis.
Q28567132Blunted DNA synthesis and delayed S-phase entry following inhibition of Cdk2 activity in the regenerating rat liver
Q38435503Combined systemic elimination of MET and epidermal growth factor receptor signaling completely abolishes liver regeneration and leads to liver decompensation
Q35223537Evidence against a stem cell origin of new hepatocytes in a common mouse model of chronic liver injury
Q28574325Histone acetyltransferase MOZ acts as a co-activator of Nrf2-MafK and induces tumour marker gene expression during hepatocarcinogenesis
Q38567711Liver Stem Cells: Experimental Findings and Implications for Human Liver Disease.
Q38879963Liver regeneration - mechanisms and models to clinical application
Q98238191Liver regeneration: biological and pathological mechanisms and implications
Q34347580Principles of liver regeneration and growth homeostasis
Q43728203Ras adenoviruses modulate cyclin E protein expression and DNA synthesis after partial hepatectomy.
Q52728962Replicative stress and alterations in cell cycle checkpoint controls following acetaminophen hepatotoxicity restrict liver regeneration.
Q37512367Signals and cells involved in regulating liver regeneration
Q36464940Subhepatotoxic exposure to arsenic enhances lipopolysaccharide-induced liver injury in mice
Q36450461The origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells

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