Hirudin: Its Biology and Clinical Use

scientific article published on 01 January 1994

Hirudin: Its Biology and Clinical Use is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/BF01061994
P698PubMed publication ID10603506

P2093author name stringCannon CP
Becker RC
P2860cites workExperimental studies on a recombinant hirudin, CGP 39393Q70202668
Pharmacological studies on the antithrombotic action of hirudin in experimental animalsQ70439861
Inhibition of the thrombin-platelet reaction by hirudinQ71392199
Isolation of hirudin from medicinal leechQ71987833
A quantitative thrombin time for determining levels of hirudin and HirulogQ72262042
A pilot trial of recombinant desulfatohirudin compared with heparin in conjunction with tissue-type plasminogen activator and aspirin for acute myocardial infarction: results of the Thrombolysis in Myocardial Infarction (TIMI) 5 trialQ72332452
Recombinant hirudin for unstable angina pectoris. A multicenter, randomized angiographic trialQ72344112
Initial experience with hirudin and streptokinase in acute myocardial infarction: results of the Thrombolysis in Myocardial Infarction (TIMI) 6 trialQ72360950
Recombinant hirudin in patients with chronic, stable coronary artery disease. Safety, half-life, and effect on coagulation parametersQ72560551
Safety and efficacy of recombinant hirudin (CGP 39 393) versus heparin in patients with stable angina undergoing coronary angioplastyQ72560573
An international collaborative study to investigate standardisation of hirudin potencyQ72808552
[Studies on the mechanism of the anticoagulant effect of hirudin]Q74342146
[Isolation and chemical characterization of hirudin]Q74652077
[Purification of hirudin.]Q79539876
[Use of hirudin in clinical coagulation laboratories]Q93693805
Hemorrhagic events during therapy with recombinant tissue-type plasminogen activator, heparin, and aspirin for acute myocardial infarction. Results of the Thrombolysis in Myocardial Infarction (TIMI), Phase II TrialQ33382347
Biochemistry and genetic engineering of hirudinQ38735186
Purification of hirudin by the method of isoelectric focusingQ39143577
Comparison of the inhibition of thrombin by three plasma protease inhibitorsQ39500526
A large fragment approach to DNA synthesis: total synthesis of a gene for the protease inhibitor eglin c from the leech Hirudo medicinalis and its expression in E. coli.Q40461418
Binding of thrombin to human platelet plasma membranesQ41947098
Fibrin, red cell and platelet interactions in an experimental model of thrombosisQ42063747
Binding of thrombin to human platelets and its possible significanceQ44612319
Preparation of monoclonal antibodies to hirudin and hirudin peptides. A method for studying the hirudin-thrombin interactionQ45083166
Kinetics of the thrombin-induced release of calcium(II) by plateletsQ48017967
The complete covalent structure of hirudin. Localization of the disulfide bondsQ49239525
Kinetics of the inhibition of thrombin by hirudin.Q52630061
The Thrombolysis in Myocardial Infarction (TIMI) trial. Phase I findings.Q53824140
Purification and analysis of the thrombin inhibitor hirudinQ53878501
Purification and biochemical characterization of recombinant hirudin produced by Saccharomyces cerevisiae.Q54731380
Use of site-directed mutagenesis to investigate the basis for the specificity of hirudin.Q54743556
Differentiation of platelet-aggregating effects of human tumor cell lines based on inhibition studies with apyrase, hirudin, and phospholipaseQ55489690
Biologic effects of recombinant hirudin (CGP 39393) in human volunteers. European Hirudin in Thrombosis GroupQ58898563
The structural elements of hirudin which bind to the fibrinogen recognition site of thrombin are exclusively located within its acidic C-terminal tailQ67275722
Analysis of the secondary structure of hirudin and the mechanism of its interaction with thrombinQ67976386
Clinico-pharmacological studies with recombinant hirudinQ68026562
Pharmacology of r-hirudin in renal impairmentQ68037221
The influence of GAP promoter variants on hirudin production, average plasmid copy number and cell growth in Saccharomyces cerevisiaeQ68579429
Inhibition by recombinant hirudins of experimental venous thrombosis and disseminated intravascular coagulation induced by tissue factor in ratsQ68837645
Prevention of experimental coronary thrombosis by hirudinQ69041714
Quantitative enzyme-linked immunosorbent assay (ELISA) for hirudinQ70018756
Assay of hirudin in plasma using a chromogenic thrombin substrateQ70066031
Hirudin insensitive thrombin-stimulated platelet releaseQ70079764
P433issue1
P921main subjecthirudinQ386715
P304page(s)7-16
P577publication date1994-01-01
P1433published inJournal of Thrombosis and ThrombolysisQ15766541
P1476titleHirudin: Its Biology and Clinical Use
P478volume1

Reverse relations

cites work (P2860)
Q73364778Antithrombotic Therapy during Percutaneous Coronary Intervention
Q73681259Thrombin Generation in Patients with Acute Myocardial Infarction Treated with Front-Loaded rt-PA and Recombinant Hirudin (HBW 023)

Search more.