Hypertolerance to morphine in G(z alpha)-deficient mice

scientific article published on 01 July 2000

Hypertolerance to morphine in G(z alpha)-deficient mice is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0006-8993(00)02387-8
P698PubMed publication ID10869496

P50authorAlbert S. MellickQ40461197
P2093author name stringA J Reynolds
S E Bartlett
I A Hendry
D Megirian
K I Matthaei
K J Leck
K Heydon
K L Kelleher
P2860cites workIdentification of a GTP-binding protein alpha subunit that lacks an apparent ADP-ribosylation site for pertussis toxinQ24296604
Novel localization of a G protein, Gz-alpha, in neurons of brain and retinaQ24318994
Gz-mediated hormonal inhibition of cyclic AMP accumulationQ28646144
Activation of Type II Adenylyl Cyclase by the Cloned μ‐Opioid Receptor: Coupling to Multiple G ProteinsQ28646197
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genesQ29547355
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cellsQ29614545
Diversity of G proteins in signal transductionQ29618841
Establishment of a germ-line competent C57BL/6 embryonic stem cell lineQ34991986
Morphine activates opioid receptors without causing their rapid internalizationQ41175884
Phosphorylation and agonist-specific intracellular trafficking of an epitope-tagged mu-opioid receptor expressed in HEK 293 cellsQ41290918
Regulation of multiple effectors by the cloned delta-opioid receptor: stimulation of phospholipase C and type II adenylyl cyclase.Q41338715
The human chemoattractant complement C5a receptor inhibits cyclic AMP accumulation through Gi and Gz proteinsQ41361165
Analysis by mRNA levels of the expression of six G protein alpha-subunit genes in mammalian cells and tissuesQ41665833
Interaction of opioid peptides and other drugs with multiple kappa receptors in rat and human brain. Evidence for species differencesQ44332263
Genetic influences in opioid analgesic sensitivity in miceQ44334939
Gz coupling to the rat kappa-opioid receptorQ44336007
Morphine-induced reciprocal alterations in G alpha s and opioid peptide mRNA levels in discrete brain regionsQ44336510
Chronic morphine induces tolerance and desensitization of mu-opioid receptor but not down-regulation in rabbitQ44338502
Regulation of G proteins by chronic morphine in the rat locus coeruleusQ45272898
Genetic differences in morphine sensitivity, tolerance and withdrawal in ratsQ48394749
Developmental expression of messenger RNA levels of the α subunit of the GTP-binding protein, Gz, in the mouse nervous systemQ48443207
A general role for adaptations in G-proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal functionQ48722567
Retrograde axonal transport of the alpha subunit of the GTP-binding protein Gz to the nucleus of sensory neuronsQ51588477
G proteinsQ68015193
P433issue1-2
P921main subjectmorphineQ81225
P1104number of pages10
P304page(s)10-19
P577publication date2000-07-01
P1433published inBrain ResearchQ4955782
P1476titleHypertolerance to morphine in G(z alpha)-deficient mice
P478volume870

Reverse relations

cites work (P2860)
Q28566717Activation of Gz attenuates Rap1-mediated differentiation of PC12 cells
Q34183966Analysis of candidate genes for morphine preference quantitative trait locus Mop2
Q36999713Candidate gene polymorphisms predicting individual sensitivity to opioids
Q36016914Deletion of GαZ Protein Protects against Diet-induced Glucose Intolerance via Expansion of β-Cell Mass
Q35205782Effect of KEPI (Ppp1r14c) deletion on morphine analgesia and tolerance in mice of different genetic backgrounds: when a knockout is near a relevant quantitative trait locus
Q34489831Endogenous opiates: 2000
Q46748753Enhanced effect of dopaminergic stimulation on prepulse inhibition in mice deficient in the alpha subunit of G(z).
Q24655663Essential role for RGS9 in opiate action
Q36617402Functional genomics of sex hormone-dependent neuroendocrine systems: specific and generalized actions in the CNS.
Q43991371G(z alpha) deficient mice: enzyme levels in the autonomic nervous system, neuronal survival and effect of genetic background.
Q34226030G(z) signaling: emerging divergence from G(i) signaling
Q43996585Glycosylated phosducin-like protein long regulates opioid receptor function in mouse brain
Q33895342Gαz regulates BDNF-induction of axon growth in cortical neurons
Q35878239High incidence of recurrent copy number variants in patients with isolated and syndromic Müllerian aplasia
Q34226045In vivo functions of heterotrimeric G-proteins: studies in Galpha-deficient mice.
Q37393641Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs
Q48389775Mice deficient in the alpha subunit of G(z) show changes in pre-pulse inhibition, anxiety and responses to 5-HT(1A) receptor stimulation, which are strongly dependent on the genetic background
Q35177403Molecular basis of opioid dependence: role of signal regulation by G-proteins
Q34922365Molecular mechanisms of analgesia induced by opioids and ethanol: is the GIRK channel one of the keys?
Q40626548Phosphorylation-regulated Inhibition of the Gz GTPase-activating Protein Activity of RGS Proteins by Synapsin I
Q37706673Rapid and pervasive changes in genome-wide enhancer usage during mammalian development
Q37726377Regulation of immune function by G protein-coupled receptors, trimeric G proteins, and RGS proteins.
Q50026534Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/β-catenin pathway.
Q44100463Sympathetic denervation-induced changes in G protein expression in enteric neurons of the guinea pig colon
Q35171345μ-Opioid receptor coupling to Gα(o) plays an important role in opioid antinociception

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