Nuclear relocation of normal huntingtin

scientific article published on 01 June 2001

Nuclear relocation of normal huntingtin is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1034/J.1600-0854.2001.002006385.X
P698PubMed publication ID11389766

P50authorTerence TaoQ102141031
P2093author name stringA M Tartakoff
P2860cites workThe Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcriptionQ22254119
Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicalsQ24310136
Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neuronsQ24317574
A proteolytic pathway that controls the cholesterol content of membranes, cells, and bloodQ24614744
Intracellular localization of the P21rho proteinsQ24642838
Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing.Q27937925
Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's diseaseQ28114818
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutationQ28246858
Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tractQ28267110
Roles for proteolysis and trafficking in notch maturation and signal transductionQ28281399
Rab7 and Rab9 are recruited onto late endosomes by biochemically distinguishable processesQ28291798
Distinction of apoptotic and necrotic cell death by in situ labelling of fragmented DNAQ28306970
Life without huntingtin: normal differentiation into functional neuronsQ28590704
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic miceQ29615357
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brainQ29617982
Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNAQ29620175
Localization of rabbit huntingtin using a new panel of monoclonal antibodiesQ30640638
Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cellsQ30779186
Altered neurotransmitter receptor expression in transgenic mouse models of Huntington's diseaseQ33703899
Regulation of nuclear localization: a key to a doorQ33804320
Reversing neurodegeneration: a promise unfoldsQ33897927
Review: dynamic stability of the interphase nucleus in health and diseaseQ33915698
Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodiesQ33920421
Incorporation of glutamine repeats makes protein oligomerize: implications for neurodegenerative diseasesQ34133850
Regulation of expanded polyglutamine protein aggregation and nuclear localization by the glucocorticoid receptorQ34973238
A requirement for NF-kappaB activation in Bcr-Abl-mediated transformationQ35195588
Identification of two lysosomal membrane glycoproteinsQ36212360
Recruitment and the role of nuclear localization in polyglutamine-mediated aggregationQ36255989
Subcellular localization of the Huntington's disease gene product in cell lines by immunofluorescence and biochemical subcellular fractionationQ36823776
Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture.Q40858681
Analysis of the subcellular localization of huntingtin with a set of rabbit polyclonal antibodies in cultured mammalian cells of neuronal origin: comparison with the distribution of huntingtin in Huntington's disease autopsy brainQ40859417
Wild-type huntingtin protects from apoptosis upstream of caspase-3.Q40880907
Caspase activation during apoptotic cell death induced by expanded polyglutamine in N2a cells.Q40916040
Forskolin and dopamine D1 receptor activation increase huntingtin's association with endosomes in immortalized neuronal cells of striatal origin.Q40949615
In vitro evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease.Q40981007
Expression of polyglutamine-expanded Huntingtin activates the SEK1-JNK pathway and induces apoptosis in a hippocampal neuronal cell lineQ41000432
A cellular model that recapitulates major pathogenic steps of Huntington's diseaseQ41017315
The influence of huntingtin protein size on nuclear localization and cellular toxicity.Q41035353
Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tractQ41182414
Heat shock proteins increase resistance to apoptosis.Q41226590
The identification of a functional nuclear localization signal in the Huntington disease proteinQ41285600
Transcriptional activation modulated by homopolymeric glutamine and proline stretchesQ41488003
Expanded polyglutamine peptides alone are intrinsically cytotoxic and cause neurodegeneration in DrosophilaQ41705884
A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein responseQ41711854
Cytoplasmic localization and the choice of ligand determine aggregate formation by androgen receptor with amplified polyglutamine stretchQ41860888
Huntington's disease intranuclear inclusions contain truncated, ubiquitinated huntingtin proteinQ42598739
Huntington's disease gene product, huntingtin, associates with microtubules in vitroQ45295496
Transglutaminase action imitates Huntington's disease: selective polymerization of Huntingtin containing expanded polyglutamine.Q45296134
Intranuclear neuronal inclusions in Huntington's disease and dentatorubral and pallidoluysian atrophy: correlation between the density of inclusions and IT15 CAG triplet repeat lengthQ45296163
Huntingtin: a single bait hooks many speciesQ45296265
Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA.Q45296558
Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtinQ45297223
Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.Q45297497
Formation of polyglutamine inclusions in non-CNS tissueQ45298039
A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.Q45298582
Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectorsQ45299117
Decreased expression of striatal signaling genes in a mouse model of Huntington's diseaseQ45300376
Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy.Q45301281
Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in DrosophilaQ47945602
Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition.Q48298684
Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.Q48373564
Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic miceQ48373570
Ectopically expressed CAG repeats cause intranuclear inclusions and a progressive late onset neurological phenotype in the mouseQ48574817
Inhibition of drug-induced apoptosis by survival factors in PC12 cellsQ72557651
Expression of extended polyglutamine sequentially activates initiator and effector caspasesQ77341954
Cellular defects and altered gene expression in PC12 cells stably expressing mutant huntingtinQ77906721
P433issue6
P304page(s)385-394
P577publication date2001-06-01
P1433published inTrafficQ1572846
P1476titleNuclear relocation of normal huntingtin
P478volume2

Reverse relations

cites work (P2860)
Q59799803A discontinuous Galerkin model for fluorescence loss in photobleaching of intracellular polyglutamine protein aggregates
Q36647206An N-terminal nuclear export signal regulates trafficking and aggregation of Huntingtin (Htt) protein exon 1.
Q30425063Deletion of the huntingtin proline-rich region does not significantly affect normal huntingtin function in mice
Q35867566Huntingtin Subcellular Localisation Is Regulated by Kinase Signalling Activity in the StHdhQ111 Model of HD.
Q40717667Huntingtin is required for ciliogenesis and neurogenesis during early Xenopus development
Q24294765Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis
Q33826159Huntingtin localisation studies - a technical review
Q57839949Huntingtin proteolysis in Huntington disease
Q30480364Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease
Q34145515Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization
Q28247421Interaction between importin 13 and myopodin suggests a nuclear import pathway for myopodin
Q52102715Nucleocytoplasmic shuttling of lgl2 is developmentally regulated in fetal lung.
Q35575850Role of proteolysis in polyglutamine disorders
Q36597920Selective neuronal degeneration in Huntington's disease
Q41154714The huntingtin N17 domain is a multifunctional CRM1 and Ran-dependent nuclear and cilial export signal
Q37339087The roles of multiple importins for nuclear import of murine aristaless-related homeobox protein
Q36003871The roles of proteolysis and nuclear localisation in the toxicity of the polyglutamine diseases. A review

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