Huntingtin localisation studies - a technical review

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Huntingtin localisation studies - a technical review is …
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scholarly articleQ13442814

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P356DOI10.1371/CURRENTS.RRN1211
P932PMC publication ID3037564
P698PubMed publication ID21339845

P2093author name stringLesley Jones
Alis Hughes
P2860cites workHuntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice.Q45304186
Heterogeneous topographic and cellular distribution of huntingtin expression in the normal human neostriatum.Q48723938
Huntingtin immunoreactivity in the rat neostriatum: differential accumulation in projection and interneuronsQ48736244
Partial characterisation of murine huntingtin and apparent variations in the subcellular localisation of huntingtin in human, mouse and rat brainQ49020588
Nuclear relocation of normal huntingtinQ73965077
Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzymeQ24311567
Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neuronsQ24317574
Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutationQ28246858
Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathwaysQ28277799
Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in miceQ28505664
Neurological abnormalities in a knock-in mouse model of Huntington's diseaseQ28508179
Expression of normal and mutant huntingtin in the developing brainQ28508248
Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated formQ28509836
Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's diseaseQ28589793
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brainQ29617982
Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragmentQ30490726
Localization of rabbit huntingtin using a new panel of monoclonal antibodiesQ30640638
Huntingtin interacts with cystathionine beta-synthaseQ32120855
Overview of cell fixatives and cell membrane permeantsQ33546660
Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington diseaseQ33726473
Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodiesQ33920421
Characterization and localization of the Huntington disease gene productQ34662553
Normal and expanded Huntington's disease gene alleles produce distinguishable proteins due to translation across the CAG repeat.Q36437616
Subcellular localization of the Huntington's disease gene product in cell lines by immunofluorescence and biochemical subcellular fractionationQ36823776
Is my antibody-staining specific? How to deal with pitfalls of immunohistochemistry.Q37352171
Neuroanatomic profile of polyglutamine immunoreactivity in Huntington disease brains.Q37372681
Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcriptionQ40764541
Analysis of the subcellular localization of huntingtin with a set of rabbit polyclonal antibodies in cultured mammalian cells of neuronal origin: comparison with the distribution of huntingtin in Huntington's disease autopsy brainQ40859417
The influence of huntingtin protein size on nuclear localization and cellular toxicity.Q41035353
Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregatesQ41065635
The identification of a functional nuclear localization signal in the Huntington disease proteinQ41285600
Specificity of immunoreactions: the importance of testing specificity in each methodQ41977995
New anti-huntingtin monoclonal antibodies: implications for huntingtin conformation and its binding proteinsQ42664318
Widespread expression of Huntington's disease gene (IT15) protein productQ42684112
Nuclear localization of N-terminal mutant huntingtin is cell cycle dependentQ44095469
Huntingtin localization in brains of normal and Huntington's disease patientsQ45295341
Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA.Q45296558
Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtinQ45297223
A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.Q45298582
P304page(s)RRN1211
P577publication date2011-02-16
P1433published inPLOS CurrentsQ7119653
P1476titleHuntingtin localisation studies - a technical review
P478volume3