A novel type of bifunctional inhibitor directed against proteolytic activity and receptor/ligand interaction. Cystatin with a urokinase receptor binding site

scientific article published on 01 October 2000

A novel type of bifunctional inhibitor directed against proteolytic activity and receptor/ligand interaction. Cystatin with a urokinase receptor binding site is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.C000383200
P698PubMed publication ID10913110

P2093author name stringSchmitt M
Machleidt W
Magdolen V
Auerswald EA
Creutzburg S
Assfalg-Machleidt I
Bürgle M
Muehlenweg B
Parrado SG
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A bifunctional hybrid molecule of the amino-terminal fragment of urokinase and domain II of bikunin efficiently inhibits tumor cell invasion and metastasisQ38335766
Hybrids of chicken cystatin with human kininogen domain 2 sequences exhibit novel inhibition of calpain, improved inhibition of actinidin and impaired inhibition of papain, cathepsin L and cathepsin B.Q38362165
Reduction of breast carcinoma tumor growth and lung colonization by overexpression of the soluble urokinase-type plasminogen activator receptor (CD87).Q40886059
Modulation of invasive properties of murine squamous carcinoma cells by heterologous expression of cathepsin B and cystatin C.Q40925415
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Blockage of the urokinase receptor on the cell surface: construction and characterization of a hybrid protein consisting of the N-terminal fragment of human urokinase and human albuminQ41411673
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Recombinant chicken egg white cystatin variants of the QLVSG regionQ48150578
Determination of rate and equilibrium binding constants for macromolecular interactions using surface plasmon resonance: use of nonlinear least squares analysis methods.Q52392958
Analysis of serpin inhibitory function by mutagenesis of ovalbumin and generation of chimeric ovalbumin/PAI-2 fusion proteins.Q53970737
Expression of the human urokinase‐type plasminogen activator receptor in E. coli and Chinese hamster ovary cells: Purification of the recombinant proteins and generation of polyclonal antibodies in chickenQ54613402
Production, inhibitory activity, folding and conformational analysis of an N-terminal and an internal deletion variant of chicken cystatin.Q54627972
Conformational Variability of Chicken CystatinQ57902438
Chemical synthesis of a gene for human cystatin C and its expression in E. coliQ70232353
Temporary inhibition of papain by hairpin loop mutants of chicken cystatin. Distorted binding of the loops results in cleavage of the Gly(9)-Ala10 bondQ72114107
Inhibition of the interaction of urokinase-type plasminogen activator (uPA) with its receptor (uPAR) by synthetic peptidesQ73370257
Modularity of serpins. A bifunctional chimera possessing alpha1-proteinase inhibitor and thyroxine-binding globulin propertiesQ77754837
Inhibition of mammalian legumain by some cystatins is due to a novel second reactive siteQ77926967
P433issue43
P407language of work or nameEnglishQ1860
P921main subjectproteolysisQ33123
P304page(s)33562-33566
P577publication date2000-10-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleA novel type of bifunctional inhibitor directed against proteolytic activity and receptor/ligand interaction. Cystatin with a urokinase receptor binding site
P478volume275

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cites work (P2860)
Q373532883D/4D functional imaging of tumor-associated proteolysis: impact of microenvironment
Q38072054Cathepsin B as a cancer target
Q41908264Challenges for drug discovery - a case study of urokinase receptor inhibition
Q37808863Cysteine peptidases and their inhibitors in breast and genital cancer
Q36311494RNA interference: ready to silence cancer?
Q34464911Survey of the year 2000 commercial optical biosensor literature
Q38657144The role of lysosome in cell death regulation

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