Distinct sets of gene alterations in endometrial carcinoma implicate alternate modes of tumorigenesis

scientific article published on 01 May 2002

Distinct sets of gene alterations in endometrial carcinoma implicate alternate modes of tumorigenesis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/CNCR.10498
P698PubMed publication ID12015762

P50authorMef NilbertQ42752494
Pär-Ola BendahlQ92965822
P2093author name stringAke Borg
Roger Willén
Anjila Koul
P2860cites workAltered PTEN expression as a diagnostic marker for the earliest endometrial precancersQ28145813
PTEN1 is frequently mutated in primary endometrial carcinomasQ28250937
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinaseQ30439814
Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activityQ33774967
Two pathogenetic types of endometrial carcinomaQ34713298
Alteration of p16 and p15 genes in human uterine tumoursQ36617950
beta- Catenin mutations and aberrant nuclear expression during endometrial tumorigenesisQ36622495
Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor geneQ40896708
Alterations of the Rb gene and its association with Ki-ras activation and p53 inactivation in endometrial adenocarcinomaQ41585955
p53 in endometrial cancer and its putative precursors: evidence for diverse pathways of tumorigenesisQ41672720
Microsatellite instability in sporadic endometrial carcinomaQ46250416
Somatic Mutations of the PTEN/MMAC1 Gene in Fifteen Japanese Endometrial Cancers: Evidence for Inactivation of Both AllelesQ48379390
Histologic correlates and virulence implications of endometrial carcinoma associated with adenomatous hyperplasiaQ49275056
Abnormal structure and expression of PTEN/MMAC1 gene in human uterine cancersQ52537916
Clinical significance of microsatellite instability in endometrial carcinomaQ53331560
Endometrial carcinoma associated with hyperplasia--immunohistochemical study of angiogenesis and p53 expressionQ53427314
Mutations of the beta-catenin gene in endometrial carcinomas.Q54994747
The clinicopathological significance of K-RAS point mutation and gene amplification in endometrial cancerQ57240098
CLINICO-PATHOLOGICAL FEATURES AND p53 EXPRESSION IN LEFT-SIDED SPORADIC COLORECTAL CANCERS WITH AND WITHOUT MICROSATELLITE INSTABILITYQ57337219
Mutational Analysis of thePTENGene in Endometrial Carcinoma and HyperplasiaQ63199224
p16INK4andp15INK4BAlterations in Primary Gynecologic MalignancyQ63641166
Prognostic value of steroid receptor concentration and flow cytometrical DNA measurements in stage I-II endometrial carcinomaQ69745069
Endometrial carcinoma associated with hyperplasiaQ70888771
K-ras point mutations in endometrial carcinoma: effect on outcome is dependent on age of patientQ71763535
Low frequency of CDKN2 mutation in endometrial carcinomasQ71988088
Colorectal cancer with and without microsatellite instability involves different genesQ73031255
Mutational analysis of the CTNNB1 and APC genes in uterine endometrioid carcinomaQ73117118
Alteration of p16 and p15 genes in common epithelial ovarian tumorsQ73302855
PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinomaQ73374555
K-ras mutations in endometrial carcinomas with microsatellite instabilityQ73444099
Favorable survival associated with microsatellite instability in endometrioid endometrial cancersQ73588824
PTEN mutations in endometrial carcinomas: a molecular and clinicopathologic analysis of 38 casesQ73622060
Identification of TP53 Gene Mutations in Uterine Corpus Cancer with Short Follow-upQ74087825
Concomitant Endometrial Hyperplasia in Patients with Endometrial CarcinomaQ74506996
Microsatellite instability and somatic mutations in endometrial carcinomasQ77450372
K-ras gene point mutations in human endometrial carcinomas: correlation with clinicopathological features and patients' outcomeQ77763896
Differences in patterns of TP53 and KRAS2 mutations in a large series of endometrial carcinomas with or without microsatellite instabilityQ77916764
Nuclear localization of beta-catenin in normal and carcinogenic endometriumQ78015141
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectendometrial carcinomaQ18555222
P304page(s)2369-2379
P577publication date2002-05-01
P1433published inCancerQ326041
P1476titleDistinct sets of gene alterations in endometrial carcinoma implicate alternate modes of tumorigenesis
P478volume94

Reverse relations

cites work (P2860)
Q34082455Alteration of the k-ras gene expression in atypical and nonatypical hyperplastic endometrium
Q37854068Aromatase inhibition: a potential target for the management of recurrent or metastatic endometrial cancer by letrozole: more questions than answers?
Q35085296Capillary electrophoresis and its application in the clinical laboratory
Q39668107Clinicopathologic Significance of Mismatch Repair Defects in Endometrial Cancer: An NRG Oncology/Gynecologic Oncology Group Study
Q36410067Early endometrial carcinoma: clinicopathology, hormonal aspects, molecular genetics, diagnosis, and treatment
Q37827340Emerging therapeutic targets in endometrial cancer
Q33781274Genetics of endometrial cancers
Q83855411Image cytometry DNA ploidy correlates with histological subtypes in endometrial carcinomas
Q33750187MGMT promoter hypermethylation and K-RAS, PTEN and TP53 mutations in tamoxifen-exposed and non-exposed endometrial cancer cases
Q37225495Mitochondrial ribosomal protein S18-2 is highly expressed in endometrial cancers along with free E2F1.
Q36772096Molecular carcinogenesis of endometrial cancer
Q44771919Molecular characterization of uterine clear cell carcinoma
Q40252326Molecular genetic defects in endometrial carcinomas: microsatellite instability, PTEN and beta-catenin (CTNNB1) genes mutations
Q35640925Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification
Q35065032Molecular pathogenesis and prognostic factors in endometrial carcinoma
Q47131591Mutation status coupled with RNA-sequencing data can efficiently identify important non-significantly mutated genes serving as diagnostic biomarkers of endometrial cancer
Q42796769Novel TP53 gene mutation and correlation with p53 immunohistochemistry in a mixed epithelial carcinoma of the endometrium.
Q34396070Opposite alterations of DNA methyltransferase gene expression in endometrioid and serous endometrial cancers
Q28181035PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms
Q37270432PTEN: a new guardian of the genome.
Q36276560Patterns of CTCF and ZFHX3 Mutation and Associated Outcomes in Endometrial Cancer
Q35911350Personalized therapy in endometrial cancer: Challenges and opportunities
Q36731185Rational selection of biomarker driven therapies for gynecologic cancers: The more we know, the more we know we don't know
Q90778927Safety lead-in of the MEK inhibitor trametinib in combination with GSK2141795, an AKT inhibitor, in patients with recurrent endometrial cancer: An NRG Oncology/GOG study
Q39454208Targeted Endometrial Cancer Therapy as a Future Prospect
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Q45410745Three-dimensional nuclear telomere architecture changes during endometrial carcinoma development
Q47686988p16INK4A alterations are accompanied by aberrant protein immunostaining in endometrial carcinomas

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