Linkage of protein kinase C-beta activation and intracellular interleukin-2 accumulation in human naive CD4 T cells

scientific article published on 01 December 1997

Linkage of protein kinase C-beta activation and intracellular interleukin-2 accumulation in human naive CD4 T cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1046/J.1365-2567.1997.00375.X
P932PMC publication ID1364151
P698PubMed publication ID9497487

P50authorJaythoon HassanQ42766065
P2093author name stringD J Reen
E Rainsford
P2860cites workIntracellular signaling by hydrolysis of phospholipids and activation of protein kinase CQ29620247
Role of CD4 molecule in the induction of interleukin 2 and interleukin 2 receptor in class II major histocompatibility complex-restricted antigen-specific T helper clones. T cell receptor/CD3 complex transmits CD4-dependent and CD4-independent signaQ34220264
T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expressionQ34553481
Stimulation of lymphokine release from T lymphoblasts. Requirement for mRNA synthesis and inhibition by cyclosporin AQ36349721
T cell responses in calcineurin A alpha-deficient miceQ36366258
Mechanisms of transactivation by nuclear factor of activated T cells-1.Q36367061
Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 productionQ37424143
Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcriptionQ37564002
Activation of resting human T cells requires prolonged stimulation of protein kinase CQ37722051
Pharmacology of cyclosporine (sandimmune). IV. Pharmacological properties in vivo.Q37920039
T-cell antigen receptor-induced signal-transduction pathways--activation and function of protein kinases C in T lymphocytesQ40608240
Neonatal CD4+ CD45RA+ T cells: precursors of adult CD4+ CD45RA+ T cells?Q40710650
An enhanced immune response in mice lacking the transcription factor NFAT1.Q41199166
Development and characterization of a protein kinase C beta-isozyme-deficient T-cell lineQ41628081
Heterogeneity of protein kinase C expression and regulation in T lymphocytesQ41747842
Internalization, lysosomal degradation and new synthesis of surface membrane CD4 in phorbol ester-activated T-lymphocytes and U-937 cellsQ41939881
CD3 antigen-mediated calcium signals and protein kinase C activation are higher in CD45R0+ than in CD45RA+ human T lymphocyte subsetsQ42509393
Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976.Q42558480
Phorbol ester-induced downregulation of CD4 is a multistep process involving dissociation from p56lck, increased association with clathrin-coated pits, and altered endosomal sortingQ42805965
Interleukin-1 augments the diminished interleukin-2 mRNA expression and proliferative response of neonatal T lymphocytes to anti-CD2 antibodiesQ43788521
Induction of Interleukin 2 Messenger RNA Inhibited by Cyclosporin AQ43914114
T cell activation induced by anti-CD3 antibodies requires prolonged stimulation of protein kinase C.Q43935529
FK-506 and cyclosporin A inhibit highly similar signal transduction pathways in human T lymphocytesQ44729971
IL-2 gene inducibility in T cells before T cell receptor expression. Changes in signaling pathways and gene expression requirements during intrathymic maturation.Q45965791
Phorbol ester synergizes with Ca2+ ionophore in activation of protein kinase C (PKC)alpha and PKC beta isoenzymes in human T cells and in induction of related cellular functionsQ46114447
12-Deoxyphorbol-13-O-phenylacetate 20 acetate [an agonist of protein kinase C beta 1 (PKC beta 1)] induces DNA synthesis, interleukin-2 (IL-2) production, IL-2 receptor alpha-chain (CD25) and beta-chain (CD122) expression, and translocation of PKC bQ46447848
Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin AQ46979889
Protein kinase C isoform expression in CD45RA+ and CD45RO+ T lymphocytesQ52052930
Increased protein kinase C activity in human memory T cells.Q52062288
Activation of cord T lymphocytes. II. Cellular and molecular analysis of the defective response induced by anti-CD3 monoclonal antibodyQ68415983
Activation of cord T lymphocytes. I. Evidence for a defective T cell mitogenesis induced through the CD2 moleculeQ69368586
Cyclosporin A inhibits T cell receptor-induced interleukin-2 synthesis of human T lymphocytes by selectively preventing a transmembrane signal transduction pathway leading to sustained activation of a protein kinase C isoenzyme, protein kinase C-betQ72650418
Cord blood CD4+ CD45RA+ T cells achieve a lower magnitude of activation when compared with their adult counterpartsQ73347835
P433issue4
P304page(s)465-471
P577publication date1997-12-01
P1433published inImmunologyQ15754984
P1476titleLinkage of protein kinase C-beta activation and intracellular interleukin-2 accumulation in human naive CD4 T cells
P478volume92

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cites work (P2860)
Q44792682Biochemical and functional assessment of equine lymphocyte phosphodiesterases and protein kinase C.
Q31910466Cellular responses of NG108-15 and SK-N-MC lines to sweet and bitter tastants as measured by extracellular acidification rates
Q74578812Inhibition of protein kinase C alpha expression by antisense RNA in transfected Jurkat cells

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