| scholarly article | Q13442814 |
| P50 | author | Mark Marsh | Q37383678 |
| P2093 | author name string | Pelchen-Matthews A | |
| Parsons IJ | |||
| P2860 | cites work | Molecular biology and function of CD4 and CD8 | Q24299317 |
| A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains | Q27913878 | ||
| Internalization of HIV glycoprotein gp120 is associated with down-modulation of membrane CD4 and p56lck together with impairment of T cell activation | Q28280619 | ||
| Lymphocyte mitogenesis and CD4 modulation induced by different phorbol esters: comparative studies | Q28332851 | ||
| Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases | Q29617542 | ||
| Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts | Q33396990 | ||
| Class II MHC molecules and the HIV gp 120 envelope protein interact with functionally distinct regions of the CD4 molecule | Q33584112 | ||
| Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs | Q34149224 | ||
| The distribution of 215-kilodalton mannose 6-phosphate receptors within cis (heavy) and trans (light) Golgi subfractions varies in different cell types | Q34378128 | ||
| Morphological analysis of the regulation of CD4 endocytosis by p56lck | Q35276394 | ||
| Phorbol esters and horseradish peroxidase stimulate pinocytosis and redirect the flow of pinocytosed fluid in macrophages | Q36211893 | ||
| Inhibition of receptor-mediated but not fluid-phase endocytosis in polymorphonuclear leukocytes | Q36213773 | ||
| A quantitative analysis of the endocytic pathway in baby hamster kidney cells | Q36222043 | ||
| Novel anti-CD4 monoclonal antibodies separate human immunodeficiency virus infection and fusion of CD4+ cells from virus binding | Q36353569 | ||
| Fc receptor endocytosis is controlled by a cytoplasmic domain determinant that actively prevents coated pit localization | Q36530975 | ||
| Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinase | Q36707725 | ||
| Disruption of the CD4-p56lck complex is required for rapid internalization of CD4 | Q37154861 | ||
| The roles of CD4 and CD8 in T cell activation | Q37354693 | ||
| The lymphocyte-specific tyrosine protein kinase p56lck | Q37354700 | ||
| CD4 and CD8 act as co-receptors during thymic selection of the T cell repertoire | Q37354705 | ||
| CD4: collaborator in immune recognition and HIV infection | Q37808725 | ||
| Gangliosides induce selective modulation of CD4 from helper T lymphocytes | Q38348392 | ||
| The CD4 antigen: physiological ligand and HIV receptor | Q39184539 | ||
| Internalization and recycling of CD4 transfected into HeLa and NIH3T3 cells | Q40822207 | ||
| Phosphorylation-dependent down-modulation of CD4 requires a specific structure within the cytoplasmic domain of CD4. | Q41134259 | ||
| Structural features of the cytoplasmic region of CD4 required for internalization | Q41202305 | ||
| Phorbol myristate acetate stimulates pinocytosis and membrane spreading in mouse peritoneal macrophages | Q41339430 | ||
| Two threshold values of low pH block endocytosis at different stages. | Q41355768 | ||
| Acidification of the cytosol inhibits endocytosis from coated pits | Q41531985 | ||
| Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation | Q41570746 | ||
| Mechanism of action of the monosialoganglioside GM1 as a modulator of CD4 expression. Evidence that GM1-CD4 interaction triggers dissociation of p56lck from CD4, and CD4 internalization and degradation | Q41578766 | ||
| A lymphocyte-specific protein tyrosine kinase, p56lck, regulates the PMA-induced internalization of CD4 | Q41594028 | ||
| The cytoplasmic tail of the mannose 6-phosphate/insulin-like growth factor-II receptor has two signals for lysosomal enzyme sorting in the Golgi | Q41600770 | ||
| The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits | Q41632663 | ||
| Effect of human immunodeficiency virus gp120 glycoprotein on the association of the protein tyrosine kinase p56lck with CD4 in human T lymphocytes | Q41679180 | ||
| Differential endocytosis of CD4 in lymphocytic and nonlymphocytic cells | Q41692782 | ||
| Phosphorylation of the polymeric immunoglobulin receptor required for its efficient transcytosis | Q41734406 | ||
| Endocytosis and recycling of CD4. | Q41737817 | ||
| Degradation of CD4 following phorbol-induced internalization in human T lymphocytes. Evidence for distinct endocytic routing of CD4 and CD3 | Q41939503 | ||
| Internalization, lysosomal degradation and new synthesis of surface membrane CD4 in phorbol ester-activated T-lymphocytes and U-937 cells | Q41939881 | ||
| Down-regulation of protein kinase C is due to an increased rate of degradation | Q42856236 | ||
| The cytoplasmic tail of CD4 targets chimeric molecules to a degradative pathway | Q43700299 | ||
| Internalization of the human immunodeficiency virus does not require the cytoplasmic domain of CD4. | Q44534068 | ||
| Human immunodeficiency virus infection of monocytic and T-lymphocytic cells: receptor modulation and differentiation induced by phorbol ester | Q44890078 | ||
| HIV infection does not require endocytosis of its receptor, CD4. | Q45149382 | ||
| Adsorptive endocytosis of Semliki Forest virus | Q45790815 | ||
| Regulation of CD4 and CD8 surface expression on human thymocyte subpopulations by triggering through CD2 and the CD3-T cell receptor. | Q50890609 | ||
| Phosphorylation of CD4 and CD8 molecules following T cell triggering. | Q50899650 | ||
| T4 endocytosis and phosphorylation induced by phorbol esters but not by mitogen or HIV infection. | Q54389507 | ||
| Transient modulation and internalization of T4 antigen induced by phorbol esters. | Q54424003 | ||
| The mannose 6-phosphate receptor and the biogenesis of lysosomes | Q57960197 | ||
| Surface membrane CD4 turnover in phorbol ester stimulated T-lymphocytes | Q61763897 | ||
| Phorbol esters down-regulate transcription and translation of the CD4 gene | Q67687104 | ||
| Mutational analysis of the interaction between CD4 and class II MHC: class II antigens contact CD4 on a surface opposite the gp120-binding site | Q67969096 | ||
| Cell surface comodulation of CD4 and T cell receptor by anti-CD4 monoclonal antibody | Q69740306 | ||
| Activators of protein kinase C induce dissociation of CD4, but not CD8, from p56lck | Q69742196 | ||
| Rapid phosphorylation and modulation of the T4 antigen on cloned helper T cells induced by phorbol myristate acetate or antigen | Q70017245 | ||
| CD4 molecules are associated with the antigen receptor complex on activated but not resting T cells | Q70052178 | ||
| Alterations in T4 (CD4) protein and mRNA synthesis in cells infected with HIV | Q70310627 | ||
| Modulation of CD4 by antigenic activation | Q70322737 | ||
| The structure of an endocytosis signal | Q75292693 | ||
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 1209-1222 | |
| P577 | publication date | 1993-10-01 | |
| P1433 | published in | Journal of Experimental Medicine | Q3186912 |
| P1476 | title | Phorbol ester-induced downregulation of CD4 is a multistep process involving dissociation from p56lck, increased association with clathrin-coated pits, and altered endosomal sorting | |
| P478 | volume | 178 |
| Q27642200 | A Zinc Clasp Structure Tethers Lck to T Cell Coreceptors CD4 and CD8 |
| Q33223969 | Anti-HIV agents targeting the interaction of gp120 with the cellular CD4 receptor |
| Q38701188 | Arf6 and Rab22 mediate T cell conjugate formation by regulating clathrin-independent endosomal membrane trafficking. |
| Q90080188 | BTLA Expression on Th1, Th2 and Th17 Effector T-Cells of Patients with Systemic Lupus Erythematosus Is Associated with Active Disease |
| Q40791780 | CD3 gamma contains a phosphoserine-dependent di-leucine motif involved in down-regulation of the T cell receptor |
| Q35991137 | CD4 Receptor is a Key Determinant of Divergent HIV-1 Sensing by Plasmacytoid Dendritic Cells. |
| Q40912848 | Cell surface stability of gamma-aminobutyric acid type A receptors. Dependence on protein kinase C activity and subunit composition. |
| Q28187665 | Cell-cell fusion and internalization of the CNS-based, HIV-1 co-receptor, APJ |
| Q37945208 | Cell-to-Cell Spread of Retroviruses |
| Q74494494 | Cellular interactions in the thymus regulate the protein kinase C signaling pathway |
| Q37383714 | Characterization of a CD38-like 78-kilodalton soluble protein released from B cell lines derived from patients with X-linked agammaglobulinemia |
| Q53036467 | Clostridium difficile recurrence is characterized by pro-inflammatory peripheral blood mononuclear cell (PBMC) phenotype. |
| Q36845470 | Cluster of differentiation antigen 4 (CD4) endocytosis and adaptor complex binding require activation of the CD4 endocytosis signal by serine phosphorylation |
| Q24532862 | Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation |
| Q40653272 | Constitutive GABAA receptor endocytosis is dynamin-mediated and dependent on a dileucine AP2 adaptin-binding motif within the beta 2 subunit of the receptor. |
| Q30583336 | Defective neutrophil recruitment in leukocyte adhesion deficiency type I disease causes local IL-17-driven inflammatory bone loss |
| Q37368340 | Degradation of origin recognition complex large subunit by the anaphase-promoting complex in Drosophila |
| Q37152214 | Determination of intracellular cytokines IFN-gamma and IL-4 in canine T lymphocytes by flow cytometry following whole-blood culture. |
| Q51560560 | Differences in Type 1 and Type 2 intracytoplasmic cytokines, detected by flow cytometry, according to immunosuppression (cyclosporine A vs. tacrolimus) in stable renal allograft recipients. |
| Q40014256 | Differential control of CXCR4 and CD4 downregulation by HIV-1 Gag. |
| Q39505228 | Differential level in co-down-modulation of CD4 and CXCR4 primed by HIV-1 gp120 in response to phorbol ester, PMA, among HIV-1 isolates |
| Q36854921 | Differential modulation by delta9-tetrahydrocannabinol (∆9)-THC) of CD40 ligand (CD40L) expression in activated mouse splenic CD4+ T cells |
| Q33942231 | Differential modulation of surface and intracellular protein expression by T cells after stimulation in the presence of monensin or brefeldin A. |
| Q34110093 | Differential subcellular localization of the regulatory T-cell protein LAG-3 and the coreceptor CD4. |
| Q35745437 | Dynasore disrupts trafficking of herpes simplex virus proteins |
| Q42547430 | Elevated profile of Th17, Th1 and Tc1 cells in patients with immune thrombocytopenic purpura |
| Q44650819 | Epigallocatechin gallate, the main component of tea polyphenol, binds to CD4 and interferes with gp120 binding |
| Q34032203 | Flow cytometric measurement of intracellular cytokines. |
| Q57259193 | Galactosyl ceramide expressed on dendritic cells can mediate HIV-1 transfer from monocyte derived dendritic cells to autologous T cells |
| Q34033122 | HIV accessory proteins: multifunctional components of a complex system. |
| Q52510516 | HIV-1 glycoprotein gp120 disrupts CD4-p56lck/CD3-T cell receptor interactions and inhibits CD3 signaling. |
| Q34550922 | High level of coreceptor-independent HIV transfer induced by contacts between primary CD4 T cells |
| Q35600803 | High-Throughput HIV-Cell Fusion Assay for Discovery of Virus Entry Inhibitors |
| Q35105679 | Highly active antiretroviral therapies are effective against HIV-1 cell-to-cell transmission |
| Q24310700 | Human immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tail |
| Q39868503 | Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes |
| Q33850973 | Human immunodeficiency virus type 1 Nef-induced CD4 cell surface downregulation is inhibited by ikarugamycin |
| Q36499676 | Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathways |
| Q92086751 | IL-22 production of effector CD4+ T-cells is altered in SLE patients |
| Q35083879 | Immune regulatory mechanisms influence early pathology in spinal cord injury and in spontaneous autoimmune encephalomyelitis |
| Q44485027 | Immunodeficiency viruses. Not enough sans Nef. |
| Q30822437 | Immunoelectron microscopic investigations of patching, capping, endocytotic and shedding processes in T and B lymphocytes |
| Q33415798 | Increased interleukin-27 promotes Th1 differentiation in patients with chronic immune thrombocytopenia |
| Q33767582 | Intracellular protein traffic in lymphocytes: "how do I get THERE from HERE"? |
| Q40655454 | Involvement of CD4 D3-D4 membrane proximal extracellular domain for the inhibitory effect of oxidative stress on activation-induced CD4 down-regulation and its possible role for T cell activation. |
| Q59326302 | Is ageing associated with a shift in the balance between Type 1 and Type 2 cytokines in humans? |
| Q77356520 | Kinetics of intracytoplasmic Th1 and Th2 cytokine production assessed by flow cytometry following in vitro activation of peripheral blood mononuclear cells |
| Q40990044 | Lack of p56lck expression correlates with CD4 endocytosis in primary lymphoid and myeloid cells |
| Q40637282 | Ligand binding determines whether CD46 is internalized by clathrin-coated pits or macropinocytosis |
| Q74299664 | Linkage of protein kinase C-beta activation and intracellular interleukin-2 accumulation in human naive CD4 T cells |
| Q40509085 | Mechanisms of HIV receptor and co-receptor down-regulation by prostratin: role of conventional and novel PKC isoforms |
| Q45119982 | Mitogen-induced modulation of CD3, CD4, and CD8(1). |
| Q35896933 | Modeling Bone Marrow Progenitor Cell Differentiation and Susceptibility to HIV-1 Infection |
| Q35845424 | Myxoma virus induces extensive CD4 downregulation and dissociation of p56lck in infected rabbit CD4+ T lymphocytes |
| Q24336240 | Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain |
| Q34468033 | Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules |
| Q33911849 | Nef proteins from diverse groups of primate lentiviruses downmodulate CXCR4 to inhibit migration to the chemokine stromal derived factor 1. |
| Q39852042 | Nef-induced CD4 endocytosis in human immunodeficiency virus type 1 host cells: role of p56lck kinase |
| Q47232433 | Novel TCR-Mediated Mechanisms of Notch Activation and Signaling. |
| Q54096893 | Phorbol ester-induced disruption of the CD4-Lck complex occurs within a detergent-resistant microdomain of the plasma membrane. Involvement of the translocation of activated protein kinase C isoforms. |
| Q35847790 | Phorbol ester-induced down modulation of tailless CD4 receptors requires prior binding of gp120 and suggests a role for accessory molecules. |
| Q36276570 | Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4. |
| Q36655072 | Protein kinase C and NF-κB-dependent CD4 downregulation in macrophages induced by T cell-derived soluble factors: consequences for HIV-1 infection |
| Q28477747 | Proteomic-based identification of CD4-interacting proteins in human primary macrophages |
| Q53652968 | Quantification of Th1 and Th17 Cells with Intracellular Staining Following PMA/Ionomycin Stimulation. |
| Q52932457 | Rapid whole blood flow cytometric test to detect ICOS deficiency in patients with common variable immunodeficiency. |
| Q39873046 | Receptor (CD46) modulation and complement-mediated lysis of uninfected cells after contact with measles virus-infected cells |
| Q30494182 | Regulated movement of CD4 in and out of the immunological synapse |
| Q48085097 | Regulation of CD4 expression via recycling by HRES-1/RAB4 controls susceptibility to HIV infection |
| Q34504961 | Regulation of endosome sorting by a specific PP2A isoform |
| Q39872888 | Role of CD4 endocytosis in human immunodeficiency virus infection. |
| Q28542401 | Signal peptide-binding drug as a selective inhibitor of co-translational protein translocation |
| Q34354324 | Similar regulation of cell surface human T-cell leukemia virus type 1 (HTLV-1) surface binding proteins in cells highly and poorly transduced by HTLV-1-pseudotyped virions |
| Q40328292 | Single-cell analysis of siRNA-mediated gene silencing using multiparameter flow cytometry |
| Q33946678 | T-cell-stimulating protein A elicits immune responses during meningococcal carriage and human disease. |
| Q34418242 | The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane |
| Q33961280 | The Rous sarcoma virus Env glycoprotein contains a highly conserved motif homologous to tyrosine-based endocytosis signals and displays an unusual internalization phenotype |
| Q30176171 | The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes |
| Q33683328 | The downregulation of CD4 and MHC-I by primate lentiviruses: a paradigm for the modulation of cell surface receptors |
| Q36669879 | The human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection. |
| Q41338308 | The multifaceted role of HIV Nef. |
| Q36234765 | Trans-infection but not infection from within endosomal compartments after cell-to-cell HIV-1 transfer to CD4+ T cells |
| Q33890912 | Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis |
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