| scholarly article | Q13442814 |
| P356 | DOI | 10.1161/01.RES.84.5.562 |
| P698 | PubMed publication ID | 10082478 |
| P2093 | author name string | B O'Rourke | |
| E Marbán | |||
| G F Tomaselli | |||
| D A Kass | |||
| R Tunin | |||
| S Kääb | |||
| P433 | issue | 5 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 562-570 | |
| P577 | publication date | 1999-03-01 | |
| P1433 | published in | Circulation Research | Q2599020 |
| P1476 | title | Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, I: experimental studies | |
| P478 | volume | 84 |
| Q36097754 | A New MRI-Based Model of Heart Function with Coupled Hemodynamics and Application to Normal and Diseased Canine Left Ventricles |
| Q28714375 | A computational approach to understanding the cardiac electromechanical activation sequence in the normal and failing heart, with translation to the clinical practice of CRT |
| Q34187747 | A mathematical treatment of integrated Ca dynamics within the ventricular myocyte. |
| Q84790575 | A pharmacokinetic-pharmacodynamic model for cardiovascular safety assessment of R1551 |
| Q34048060 | Abnormal intrastore calcium signaling in chronic heart failure |
| Q41981503 | Activity profile of calpains I and II in chronically infarcted rat myocardium--influence of the calpain inhibitor CAL 9961. |
| Q73877839 | Alterations in action potential profile enhance excitation-contraction coupling in rat cardiac myocytes |
| Q42584078 | Alterations in excitation-contraction coupling in chronically ischemic or hibernating myocardium |
| Q64933029 | Altered Intracellular Calcium Homeostasis and Arrhythmogenesis in the Aged Heart. |
| Q33683757 | Altered intracellular Ca2+ handling in heart failure |
| Q33947540 | An integrative model of the cardiac ventricular myocyte incorporating local control of Ca2+ release. |
| Q90083883 | Anesthetic Agents Isoflurane and Propofol Decrease Maximal Ca2+-Activated Force and Thus Contractility in the Failing Myocardium |
| Q92512512 | Animal models of arrhythmia: classic electrophysiology to genetically modified large animals |
| Q41508055 | Astragalus Granule Prevents Ca2+ Current Remodeling in Heart Failure by the Downregulation of CaMKII. |
| Q37726503 | Ca handling during excitation-contraction coupling in heart failure |
| Q34426123 | Ca2+ clock malfunction in a canine model of pacing-induced heart failure |
| Q35898648 | Cardiac aging: from molecular mechanisms to significance in human health and disease |
| Q28075339 | Cardiac dynamics: Alternans and arrhythmogenesis |
| Q30426852 | Cardiac models in drug discovery and development: a review |
| Q40490233 | Cardiac sodium-calcium exchanger is regulated by allosteric calcium and exchanger inhibitory peptide at distinct sites |
| Q42517468 | Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter |
| Q82383980 | Cellular Mechanism Underlying Burn Serum-Generated Bidirectional Regulation of Excitation-Contraction Coupling in Isolated Rat Cardiomyocytes |
| Q42535579 | Cellular and molecular determinants of altered Ca2+ handling in the failing rabbit heart: primary defects in SR Ca2+ uptake and release mechanisms. |
| Q37640381 | Cellular mechanism of cardiac alternans: an unresolved chicken or egg problem |
| Q36554735 | Cellular mechanisms of arrhythmogenic cardiac alternans |
| Q44227858 | Cocaine downregulates cardiac SERCA2a and depresses myocardial function in the murine model |
| Q42513320 | Combined effects of reduced connexin 43, depressed active generator properties and energetic stress on conduction disturbances in canine failing myocardium. |
| Q35931464 | Comparable calcium handling of human iPSC-derived cardiomyocytes generated by multiple laboratories. |
| Q35855899 | Comparison of the effects of continuous and pulsatile left ventricular-assist devices on ventricular unloading using a cardiac electromechanics model. |
| Q37572585 | Computational Analysis of Pumping Efficacy of a Left Ventricular Assist Device according to Cannulation Site in Heart Failure with Valvular Regurgitation. |
| Q47401705 | Computational analysis of the effect of mitral and aortic regurgitation on the function of ventricular assist devices using 3D cardiac electromechanical model. |
| Q36753572 | Computational analysis of the effect of valvular regurgitation on ventricular mechanics using a 3D electromechanics model. |
| Q47422068 | Computational prediction of the effects of the intra-aortic balloon pump on heart failure with valvular regurgitation using a 3D cardiac electromechanical model |
| Q36536376 | Computational quantification of the cardiac energy consumption during intra-aortic balloon pumping using a cardiac electromechanics model |
| Q34172824 | Critical determinants of Ca(2+)-dependent inactivation within an EF-hand motif of L-type Ca(2+) channels |
| Q34977226 | Deciphering Arrhythmia Mechanisms - Tools of the Trade |
| Q30489041 | Decreased left ventricular torsion and untwisting in children with dilated cardiomyopathy |
| Q35690709 | Different subcellular populations of L-type Ca2+ channels exhibit unique regulation and functional roles in cardiomyocytes |
| Q34295777 | Disease-related cardiac troponins alter thin filament Ca2+ association and dissociation rates. |
| Q39737461 | Dual gene therapy with SERCA1 and Kir2.1 abbreviates excitation without suppressing contractility |
| Q38699788 | Dysregulated Zn2+ homeostasis impairs cardiac type-2 ryanodine receptor and mitsugumin 23 functions, leading to sarcoplasmic reticulum Ca2+ leakage. |
| Q73856300 | Early autonomic and repolarization abnormalities contribute to lethal arrhythmias in chronic ischemic heart failure: characteristics of a novel heart failure model in dogs with postmyocardial infarction left ventricular dysfunction |
| Q34017752 | Effect of nonuniform muscle contraction on sustainability and frequency of triggered arrhythmias in rat cardiac muscle. |
| Q36926268 | Effects of 4'-chlorodiazepam on cellular excitation-contraction coupling and ischaemia-reperfusion injury in rabbit heart |
| Q35044085 | Effects of cardioselective KATP channel antagonism on basal, stimulated, and ischaemic myocardial function in in vivo failing canine heart. |
| Q37190351 | Effects of thapsigargin and phenylephrine on calcineurin and protein kinase C signaling functions in cardiac myocytes |
| Q34578568 | Electrical and structural remodeling of the failing ventricle |
| Q37978197 | Electrical remodeling in dyssynchrony and resynchronization |
| Q33792957 | Electrical remodeling in the failing heart |
| Q34578536 | Electrophysiologic parameters and predisposing factors in the generation of drug-induced Torsade de Pointes arrhythmias |
| Q35239679 | Electrophysiological and structural remodeling in heart failure modulate arrhythmogenesis. 1D simulation study |
| Q37245080 | Electrophysiological consequences of dyssynchronous heart failure and its restoration by resynchronization therapy |
| Q34433124 | Electrophysiological modeling of cardiac ventricular function: from cell to organ |
| Q33887264 | Electrophysiological remodeling in heart failure |
| Q36968869 | Emerging mechanisms of T-tubule remodelling in heart failure |
| Q37858336 | Endoplasmic-reticulum calcium depletion and disease |
| Q34689299 | Endurance exercise training reduces cardiac sodium/calcium exchanger expression in animals susceptible to ventricular fibrillation |
| Q34431265 | Engineered calmodulins reveal the unexpected eminence of Ca2+ channel inactivation in controlling heart excitation |
| Q45984923 | Estimating the probabilities of rare arrhythmic events in multiscale computational models of cardiac cells and tissue. |
| Q36893596 | Excitation-contraction coupling and mitochondrial energetics |
| Q42277218 | Excitation-contraction coupling changes during postnatal cardiac development |
| Q37699474 | Expert consensus document: Mitochondrial function as a therapeutic target in heart failure |
| Q33804951 | Gene therapies for arrhythmias in heart failure |
| Q38416938 | Gene therapy to restore electrophysiological function in heart failure |
| Q45054957 | Halothane alters contractility and Ca2+ transport in ventricular myocytes from streptozotocin-induced diabetic rats |
| Q47894268 | How does pressure overload cause cardiac hypertrophy and dysfunction? High-ouabain affinity cardiac Na+ pumps are crucial |
| Q36647370 | Hydralazine and organic nitrates restore impaired excitation-contraction coupling by reducing calcium leak associated with nitroso-redox imbalance |
| Q41886404 | Image-based estimation of ventricular fiber orientations for patient-specific simulations. |
| Q91867469 | Impaired Baroreflex Function in an Ovine Model of Chronic Heart Failure Induced by Multiple Coronary Microembolizations |
| Q36968582 | In vivo and in vitro cardiac responses to beta-adrenergic stimulation in volume-overload heart failure |
| Q92077684 | Inhibition of PI3Kinase-α is pro-arrhythmic and associated with enhanced late Na+ current, contractility, and Ca2+ release in murine hearts |
| Q37826593 | Integrative systems models of cardiac excitation-contraction coupling |
| Q34680310 | Interplay of ryanodine receptor distribution and calcium dynamics |
| Q38111124 | Intracellular Na⁺ and cardiac metabolism |
| Q34093037 | Intracellular calcium and the relationship to contractility in an avian model of heart failure |
| Q96576958 | Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target |
| Q26829681 | Ion Channels in the Heart |
| Q42698783 | Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling |
| Q24300128 | KCNE2 protein is more abundant in ventricles than in atria and can accelerate hERG protein degradation in a phosphorylation-dependent manner |
| Q46002023 | Keeping the beat: life without SERCA--is it possible? |
| Q36977795 | Key pathways associated with heart failure development revealed by gene networks correlated with cardiac remodeling |
| Q33559941 | Long-term fish oil supplementation induces cardiac electrical remodeling by changing channel protein expression in the rabbit model |
| Q37101211 | Mechanisms of disease: ion channel remodeling in the failing ventricle |
| Q33771680 | Mechanisms of enhanced beta-adrenergic reserve from cardiac resynchronization therapy |
| Q34352893 | Mechanisms of excitation-contraction coupling in an integrative model of the cardiac ventricular myocyte |
| Q27024176 | Mechanisms of sudden cardiac death: oxidants and metabolism |
| Q38862807 | Mechanisms of the cyclic nucleotide cross-talk signaling network in cardiac L-type calcium channel regulation |
| Q36042518 | Mechanisms of ventricular arrhythmias: a dynamical systems-based perspective |
| Q37234954 | Mechanistic insight into prolonged electromechanical delay in dyssynchronous heart failure: a computational study |
| Q35065795 | Metabolic regulation of sodium-calcium exchange by intracellular acyl CoAs. |
| Q33896746 | Mitochondria and arrhythmias. |
| Q104130395 | Mitochondrial Ca2+ in heart failure: Not enough or too much? |
| Q104268829 | Mitochondrial Ca2+, redox environment and ROS emission in heart failure: Two sides of the same coin? |
| Q28344475 | Model study of ATP and ADP buffering, transport of Ca(2+) and Mg(2+), and regulation of ion pumps in ventricular myocyte |
| Q41649726 | Modeling Na+-Ca2+ exchange in the heart: Allosteric activation, spatial localization, sparks and excitation-contraction coupling |
| Q26824052 | Modeling cardiac electromechanics and mechanoelectrical coupling in dyssynchronous and failing hearts: insight from adaptive computer models |
| Q40150660 | Modeling gain and gradedness of Ca2+ release in the functional unit of the cardiac diadic space |
| Q92302079 | Modeling heart failure in animal models for novel drug discovery and development |
| Q34032476 | Molecular aspects and gene therapy prospects for diastolic failure |
| Q37099714 | Molecular basis of diastolic dysfunction. |
| Q37264873 | Molecular correlates of altered expression of potassium currents in failing rabbit myocardium. |
| Q37644983 | Multiple and diverse coexpression, location, and regulation of additional SERCA2 and SERCA3 isoforms in nonfailing and failing human heart. |
| Q24814382 | Myocardial contractility in the echo lab: molecular, cellular and pathophysiological basis |
| Q58746196 | Myocyte [Na] Dysregulation in Heart Failure and Diabetic Cardiomyopathy |
| Q38114737 | Na/Ca exchange and contraction of the heart. |
| Q91687514 | Neuregulin-1β Partially Improves Cardiac Function in Volume-Overload Heart Failure Through Regulation of Abnormal Calcium Handling |
| Q85112502 | Optogenetic control of heart muscle in vitro and in vivo |
| Q34573114 | Orphaned ryanodine receptors in the failing heart. |
| Q31718443 | Overexpression of the Na(+)/Ca(2+) exchanger and inhibition of the sarcoplasmic reticulum Ca(2+)-ATPase in ventricular myocytes from transgenic mice |
| Q91606069 | PI3Kα in cardioprotection: Cytoskeleton, late Na+ current, and mechanism of arrhythmias |
| Q42085293 | Partial inhibition of sodium/calcium exchange restores cellular calcium handling in canine heart failure |
| Q48448938 | Pivotal role of α2 Na+ pumps and their high affinity ouabain binding site in cardiovascular health and disease |
| Q34983537 | Positive inotropic and lusitropic effects of HNO/NO − in failing hearts: Independence from β-adrenergic signaling |
| Q28576540 | Post-transcriptional gene silencing of KChIP2 and Navbeta1 in neonatal rat cardiac myocytes reveals a functional association between Na and Ito currents |
| Q58693859 | Proarrhythmic Remodeling of Calcium Homeostasis in Cardiac Disease; Implications for Diabetes and Obesity |
| Q43876768 | Reduced level of serine(16) phosphorylated phospholamban in the failing rat myocardium: a major contributor to reduced SERCA2 activity |
| Q35037535 | Regulation of cardiac excitation-contraction coupling by action potential repolarization: role of the transient outward potassium current (I(to)). |
| Q50524937 | Regulation of sarcoplasmic reticulum Ca²⁺ leak by cytosolic Ca²⁺ in rabbit ventricular myocytes. |
| Q37272198 | Regulation of the Na+/Ca2+ exchanger by pyridine nucleotide redox potential in ventricular myocytes |
| Q27002929 | Regulation of the cardiac sodium pump |
| Q73842618 | Remodelling of ionic currents in hypertrophied and failing hearts of transgenic mice overexpressing calsequestrin |
| Q34101474 | Role of CaMKII in RyR leak, EC coupling and action potential duration: a computational model |
| Q34032413 | Role of myofilaments and calcium handling in left ventricular relaxation |
| Q34049927 | Role of sodium-calcium exchanger in modulating the action potential of ventricular myocytes from normal and failing hearts |
| Q36557850 | Role of xanthine oxidoreductase in cardiac nitroso-redox imbalance |
| Q37248371 | Ryanodine receptor-mediated arrhythmias and sudden cardiac death. |
| Q92863133 | SGLT2 Inhibitors Play a Salutary Role in Heart Failure via Modulation of the Mitochondrial Function |
| Q43264397 | Sarcoplasmic reticulum function and carnitine palmitoyltransferase-1 inhibition during progression of heart failure |
| Q33332056 | Short-term pacing in the mouse alters cardiac expression of connexin43. |
| Q34821596 | Significance and control of cardiac arrhythmias in patients with congestive cardiac failure |
| Q34197955 | Sodium/Calcium Exchanger (NCX1) Macromolecular Complex |
| Q37406349 | Spontaneous calcium release in tissue from the failing canine heart |
| Q42589353 | Subcellular structures and function of myocytes impaired during heart failure are restored by cardiac resynchronization therapy. |
| Q89235554 | Substrates and potential therapeutics of ventricular arrhythmias in heart failure |
| Q35069142 | T-tubule disruption promotes calcium alternans in failing ventricular myocytes: mechanistic insights from computational modeling |
| Q33708542 | Targeting device therapy: genomics of sudden death. |
| Q37229784 | The cardiac sarcoplasmic/endoplasmic reticulum calcium ATPase: a potent target for cardiovascular diseases |
| Q46285770 | The effects of intracellular Ca2+ on cardiac K+ channel expression and activity: novel insights from genetically altered mice |
| Q37229189 | The impact of varying autonomic states on the dynamic beat-to-beat QT-RR and QT-TQ interval relationships |
| Q42549097 | The ins and outs of calcium in heart failure |
| Q48087140 | The pump, the exchanger, and the holy spirit: origins and 40-year evolution of ideas about the ouabain-Na+ pump endocrine system |
| Q34986514 | The relationship between arrhythmogenesis and impaired contractility in heart failure: role of altered ryanodine receptor function. |
| Q37555074 | The role of CaMKII regulation of phospholamban activity in heart disease |
| Q39603611 | The role of Na dysregulation in cardiac disease and how it impacts electrophysiology |
| Q52676259 | The role of RyR2 oxidation in the blunted frequency-dependent facilitation of Ca2+ transient amplitude in rabbit failing myocytes. |
| Q37139450 | The role of SERCA2a/PLN complex, Ca(2+) homeostasis, and anti-apoptotic proteins in determining cell fate |
| Q44801077 | Theoretical investigation of the mechanism of heart failure using a canine ventricular cell model: especially the role of up-regulated CaMKII and SR Ca(2+) leak |
| Q35851026 | Transcriptomic profiling of the canine tachycardia-induced heart failure model: global comparison to human and murine heart failure |
| Q34999647 | Transmural heterogeneity and remodeling of ventricular excitation-contraction coupling in human heart failure |
| Q36473374 | Treating heart failure with cardiac contractility modulation electrical signals |
| Q33890891 | Treatment of heart failure by a methanocarba derivative of adenosine monophosphate: implication for a role of cardiac purinergic P2X receptors. |
| Q36786515 | Up-regulation of sarcoplasmic reticulum Ca(2+) uptake leads to cardiac hypertrophy, contractile dysfunction and early mortality in mice deficient in CASQ2. |
| Q30978949 | Using models of the myocyte for functional interpretation of cardiac proteomic data |
| Q42019861 | Voltage noise influences action potential duration in cardiac myocytes |
| Q34296699 | Why isn't endogenous ouabain more widely accepted? |
| Q79397000 | Window Ca2+ current and its modulation by Ca2+ release in hypertrophied cardiac myocytes from dogs with chronic atrioventricular block |
| Q37368682 | [Ca2+]i elevation and oxidative stress induce KCNQ1 protein translocation from the cytosol to the cell surface and increase slow delayed rectifier (IKs) in cardiac myocytes |
| Q37276162 | beta-adrenergic regulation of a novel isoform of NCX: sequence and expression of shark heart NCX in human kidney cells |
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