Expert consensus document: Mitochondrial function as a therapeutic target in heart failure

scientific article published on 22 December 2016

Expert consensus document: Mitochondrial function as a therapeutic target in heart failure is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1038/NRCARDIO.2016.203
P932PMC publication ID5350035
P698PubMed publication ID28004807

P50authorBrian L. StaufferQ48302717
Mihai GheorghiadeQ60059386
Bertram PittQ63107334
Gerasimos FilippatosQ63107352
Javed ButlerQ63107356
Stefan D. AnkerQ30310195
Burkert PieskeQ79439304
Saame Raza ShaikhQ91208930
Adriaan A VoorsQ91537232
Hani N SabbahQ114291627
Stephen J GreeneQ125217678
Justin B PerryQ125252956
Mitchell E AllenQ125252961
David A BrownQ125252963
John ClelandQ44931654
Wilson S ColucciQ46618620
P2860cites workReversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure.Q46686975
Heart failure: mitochondrial dysfunction and oxidative stress in CHF.Q46810978
Redox-dependent increases in glutathione reductase and exercise preconditioning: role of NADPH oxidase and mitochondriaQ46837795
Altered cardiac expression of peroxisome proliferator-activated receptor-isoforms in patients with hypertensive heart diseaseQ46863176
Detection of low phosphocreatine to ATP ratio in failing hypertrophied human myocardium by 31P magnetic resonance spectroscopyQ46873061
Induction of mitochondrial biogenesis is a maladaptive mechanism in mitochondrial cardiomyopathiesQ46975964
Developing New Treatments for Heart Failure: Focus on the HeartQ48115739
Exercise training improves exercise capacity and diastolic function in patients with heart failure with preserved ejection fraction: results of the Ex-DHF (Exercise training in Diastolic Heart Failure) pilot studyQ48570168
Downregulation of the Na(+)-creatine cotransporter in failing human myocardium and in experimental heart failureQ48748873
NCLX is an essential component of mitochondrial Na+/Ca2+ exchangeQ22254831
2009 focused update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaborationQ22306346
ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the [...]Q22306349
Respiratory complex III is required to maintain complex I in mammalian mitochondriaQ24322645
Opening and closing the metabolite gateQ24569785
How mitochondria produce reactive oxygen speciesQ24643882
Antioxidants prevent health-promoting effects of physical exercise in humansQ24646248
Mitochondrial DNA mutations in human diseaseQ24676881
Contemporary Drug Development in Heart Failure: Call for Hemodynamically Neutral TherapiesQ26801166
Antioxidants improve the phenotypes of dilated cardiomyopathy and muscle fatigue in mitochondrial superoxide dismutase-deficient miceQ26822994
Maternal inheritance of mitochondrial DNA by diverse mechanisms to eliminate paternal mitochondrial DNAQ26849450
Mitochondrial dysfunction in heart failureQ26851293
Idebenone and neuroprotection: antioxidant, pro-oxidant, or electron carrier?Q26853254
Mitochondria as a therapeutic target in heart failureQ27005632
The ADP/ATP translocator is not essential for the mitochondrial permeability transition poreQ28241418
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell deathQ28242653
Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variantsQ28281746
Dimers of mitochondrial ATP synthase form the permeability transition poreQ28287824
Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell deathQ28297152
Opposing effects of beta(1)- and beta(2)-adrenergic receptors on cardiac myocyte apoptosis : role of a pertussis toxin-sensitive G proteinQ28377109
Targeting mitochondrial cardiolipin and the cytochrome c/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesisQ28383442
Individual Cardiac Mitochondria Undergo Rare Transient Permeability Transition Pore OpeningsQ36654820
Ketones Step to the Plate: A Game Changer for Metabolic Remodeling in Heart Failure?Q36783575
Altered sarcoplasmic reticulum calcium cycling--targets for heart failure therapyQ36837270
Perspectives in innate and acquired cardioprotection: cardioprotection acquired through exerciseQ36843601
Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylationQ36870637
Mitochondria-targeted cytoprotective peptides for ischemia-reperfusion injuryQ36999928
Mitochondrial targeted antioxidant Peptide ameliorates hypertensive cardiomyopathyQ37091220
Targeting lipophilic cations to mitochondria.Q37148517
Bendavia restores mitochondrial energy metabolism gene expression and suppresses cardiac fibrosis in the border zone of the infarcted heartQ37151412
Experimentally observed phenomena on cardiac energetics in heart failure emerge from simulations of cardiac metabolismQ37154013
Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice.Q37170429
PGC-1alpha and ERRalpha target gene downregulation is a signature of the failing human heartQ37189947
The molecular composition of the mitochondrial permeability transition poreQ37195017
Mitochondria-targeted antioxidants protect against mechanical ventilation-induced diaphragm weaknessQ37197868
Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trialQ37213020
The cardiac sarcoplasmic/endoplasmic reticulum calcium ATPase: a potent target for cardiovascular diseasesQ37229784
Cyclosporine A attenuates mitochondrial permeability transition and improves mitochondrial respiratory function in cardiomyocytes isolated from dogs with heart failureQ37238298
Mitochondria in cardiac hypertrophy and heart failureQ37246892
(-)-Epicatechin rich cocoa mediated modulation of oxidative stress regulators in skeletal muscle of heart failure and type 2 diabetes patients.Q37248486
Cardiolipin biosynthesis and remodeling enzymes are altered during development of heart failureQ37297827
Mitochondria-targeted antioxidants in the treatment of diseaseQ37348550
An attempt to prevent senescence: a mitochondrial approach.Q37374360
Global proteomics and pathway analysis of pressure-overload-induced heart failure and its attenuation by mitochondrial-targeted peptidesQ37375934
The role of the mitochondrial permeability transition pore in heart disease.Q37376953
Heart failure enhances susceptibility to arrhythmogenic cardiac alternansQ37393007
Cardiolipin remodeling in the heartQ37412214
Mitochondrial calcium transport in the heart: physiological and pathological rolesQ37414637
Redox modification of ryanodine receptors underlies calcium alternans in a canine model of sudden cardiac death.Q37422595
Cardiac metabolism in heart failure: implications beyond ATP production.Q37495811
Why do we still not have cardioprotective drugs?Q37511439
Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesisQ37526796
Human mitochondrial DNA: roles of inherited and somatic mutationsQ37648855
Mitochondrial targeted peptides attenuate residual myocardial damage after reversal of experimental renovascular hypertensionQ37686149
NADPH oxidases and cardiac remodellingQ37775558
Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery disease.Q50519099
Malonyl CoA: A promising target for the treatment of cardiac disease.Q51750613
Novel pathomechanisms of cardiomyocyte dysfunction in a model of heart failure with preserved ejection fraction.Q52852855
Myocardial adenine nucleotide concentrations and myocardial norepinephrine content in patients with heart failure secondary to idiopathic dilated or ischemic cardiomyopathy.Q53025853
Myosin Activator Omecamtiv Mecarbil Increases Myocardial Oxygen Consumption and Impairs Cardiac Efficiency Mediated by Resting Myosin ATPase Activity.Q53486283
Protein kinase A catalytic subunit alters cardiac mitochondrial redox state and membrane potential via the formation of reactive oxygen species.Q53569175
Expression of the cytoplasmic domain of beta1 integrin induces apoptosis in adult rat ventricular myocytes (ARVM) via the involvement of caspase-8 and mitochondrial death pathway.Q53617151
Inhibition of mitochondrial permeability transition pores by cyclosporine A improves cytochrome C oxidase function and increases rate of ATP synthesis in failing cardiomyocytes.Q53629275
Detection of myocardial ischemia by 31P magnetic resonance spectroscopy during handgrip exercise.Q54442411
Mitochondrial production of reactive oxygen species contributes to the β-adrenergic stimulation of mouse cardiomycytes.Q54597053
Effect of N-2-mercaptopropionyl glycine on exercise-induced cardiac adaptations.Q54614124
Mitochondria-Targeted Antioxidant MitoQ 10 Improves Endothelial Function and Attenuates Cardiac HypertrophyQ56970686
Rationale and Design of the MITOCARE Study: A Phase II, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of TRO40303 for the Reduction of Reperfusion Injury in Patients Undergoing Percutaneous CoroQ57572076
Antioxidant, EUK-8, Prevents Murine Dilated CardiomyopathyQ59202829
Chronic formoterol administration reduces cardiac mitochondrial protein synthesis and oxidative capacity in miceQ60324029
EUK-8, a Superoxide Dismutase and Catalase Mimetic, Reduces Cardiac Oxidative Stress and Ameliorates Pressure Overload-Induced Heart Failure in the Harlequin Mouse MutantQ63412945
Serendipity and the discovery of novel compounds that restore mitochondrial plasticityQ28384256
Mitochondria-targeted antioxidant preserves contractile properties and mitochondrial function of skeletal muscle in aged ratsQ28385949
The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipinQ28387020
Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged ratsQ28387024
Mitochondrial Metabolism in Aging HeartQ28388306
Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidationQ28578053
Supercomplex assembly determines electron flux in the mitochondrial electron transport chainQ28590886
Cardiolipin stabilizes respiratory chain supercomplexesQ29615470
Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanismQ29616055
2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice GuidelinesQ29620107
Cardiac involvement in mitochondrial DNA disease: clinical spectrum, diagnosis, and managementQ30459704
Glutathione oxidation as a trigger of mitochondrial depolarization and oscillation in intact heartsQ30485060
Cardiac myosin activation: a potential therapeutic approach for systolic heart failureQ30583292
Impaired mitochondrial network excitability in failing guinea-pig cardiomyocytesQ30692654
Channel formation by yeast F-ATP synthase and the role of dimerization in the mitochondrial permeability transitionQ33718426
ATP flux through creatine kinase in the normal, stressed, and failing human heartQ33756653
Ion transport and energetics during cell death and protectionQ33861202
Reduction of early reperfusion injury with the mitochondria-targeting peptide bendaviaQ33919143
Molecular and cellular basis of viable dysfunctional myocardiumQ33924001
Super-suppression of mitochondrial reactive oxygen species signaling impairs compensatory autophagy in primary mitophagic cardiomyopathyQ33931661
Respiratory chain supercomplexes of mitochondria and bacteriaQ33961173
Gluing the respiratory chain together. Cardiolipin is required for supercomplex formation in the inner mitochondrial membraneQ33961781
Dysregulation of cardiolipin biosynthesis in pediatric heart failureQ33969031
Therapeutic targeting of mitochondrial superoxide in hypertensionQ33981734
The survival of patients with heart failure with preserved or reduced left ventricular ejection fraction: an individual patient data meta-analysis.Q33984662
Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trialQ34046673
Uncoupling to survive? The role of mitochondrial inefficiency in ageingQ34071511
Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENsQ34127971
Mitochondrial protection restores renal function in swine atherosclerotic renovascular diseaseQ34137989
Role of mitochondrial dysfunction in cardiac glycoside toxicityQ34172696
Enhancing the metabolic substrate: PPAR-alpha agonists in heart failureQ37812007
Targeting fatty acid and carbohydrate oxidation--a novel therapeutic intervention in the ischemic and failing heart.Q37831555
Exercise-induced cardiac preconditioning: how exercise protects your achy-breaky heartQ37851768
What are the costs of heart failure?Q37868827
Novel therapies targeting inner mitochondrial membrane--from discovery to clinical developmentQ37884459
Mitochondrial inner membrane lipids and proteins as targets for decreasing cardiac ischemia/reperfusion injuryQ38122609
Mitochondrial autophagy--an essential quality control mechanism for myocardial homeostasisQ38132341
Regulation of mitochondrial dynamics and cell fateQ38197491
Mitochondria-targeted therapies for acute kidney injuryQ38237988
Mitochondrial oxidative metabolism and uncoupling proteins in the failing heartQ38246367
The "Goldilocks Zone" from a redox perspective-Adaptive vs. deleterious responses to oxidative stress in striated muscleQ38256368
Cardiovascular drug development: is it dead or just hibernating?Q38424497
Mitochondrial dynamics: Orchestrating the journey to advanced age.Q38445626
How mitochondrial dynamism orchestrates mitophagyQ38497008
Myocardial Energy Substrate Metabolism in Heart Failure : from Pathways to Therapeutic TargetsQ38545752
Effect of If-channel inhibition on hemodynamic status and exercise tolerance in heart failure with preserved ejection fraction: a randomized trial.Q38548171
Therapeutic potential of resveratrol in heart failureQ38552981
"Targeting the Heart" in Heart Failure: Myocardial Recovery in Heart Failure With Reduced Ejection FractionQ38585269
Mitochondrial Quality Control as a Therapeutic TargetQ38640867
Organization and Regulation of Mitochondrial Protein SynthesisQ38704038
Mitochondrial remodeling: Rearranging, recycling, and reprogrammingQ38821544
Calcium upregulation by percutaneous administration of gene therapy in patients with cardiac disease (CUPID 2): a randomised, multinational, double-blind, placebo-controlled, phase 2b trialQ38916981
Cardiac Myosin Activators in Systolic Heart Failure: More Friend than Foe?Q38939243
Role of microRNA in metabolic shift during heart failureQ38981243
Acute Treatment With Omecamtiv Mecarbil to Increase Contractility in Acute Heart Failure: The ATOMIC-AHF StudyQ39174869
Cardiac arrhythmias induced by glutathione oxidation can be inhibited by preventing mitochondrial depolarization.Q39599713
Improved systolic function of rat cardiocytes during heart failure by overexpression of SERCA2aQ39782569
Respiratory active mitochondrial supercomplexes.Q39913363
Redistribution of accumulated cell iron: a modality of chelation with therapeutic implicationsQ40059081
Symbiotic theory of the origin of eukaryotic organelles; criteria for proofQ40774076
Contributions of 31P-magnetic resonance spectroscopy to the understanding of dilated heart muscle diseaseQ40964153
Redox-optimized ROS balance: a unifying hypothesisQ41441153
Elevated cytosolic Na+ decreases mitochondrial Ca2+ uptake during excitation-contraction coupling and impairs energetic adaptation in cardiac myocytesQ41811834
SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recoveryQ41945438
Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humansQ42247172
Ultrastructural quantitation of mitochondria and myofilaments in cardiac muscle from 10 different animal species including manQ42455774
Rate dependence of [Na+]i and contractility in nonfailing and failing human myocardiumQ42524047
Effect of EPI-743 on the clinical course of the mitochondrial disease Leber hereditary optic neuropathyQ42639640
Mitochondrial respiratory supercomplex association limits production of reactive oxygen species from complex I.Q42678131
Coenzyme Q10, rosuvastatin, and clinical outcomes in heart failure: a pre-specified substudy of CORONA (controlled rosuvastatin multinational study in heart failure).Q42872754
The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial.Q34209536
Mitochondrial permeability transition and oxidative stressQ34232146
Cardiac mitochondria and arrhythmiasQ34307966
Pathophysiological mechanisms of catecholamine and cocaine-mediated cardiotoxicityQ34396286
A new twist on an old idea part 2: cyclosporine preserves normal mitochondrial but not cardiomyocyte function in mini-swine with compensated heart failureQ34399914
The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trialQ34441721
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.Q34447034
Selective elimination of mitochondrial mutations in the germline by genome editingQ34473537
Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approachQ34559786
Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growthQ34623700
What is the mitochondrial permeability transition pore?Q34658211
The mitochondrial dynamism-mitophagy-cell death interactome: multiple roles performed by members of a mitochondrial molecular ensembleQ34807191
Altered myocardial high-energy phosphate metabolites in patients with dilated cardiomyopathyQ34822268
Calcineurin inhibitor nephrotoxicityQ34945314
Cardiac energy metabolism homeostasis: role of cytosolic calciumQ34977128
The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implicationsQ35010370
Mitochondria-targeted peptide accelerates ATP recovery and reduces ischemic kidney injuryQ35012392
Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screeningQ35064609
[Na+]i handling in the failing human heartQ35090046
Altered myocardial calcium cycling and energetics in heart failure--a rational approach for disease treatmentQ35116100
Domestication of the cardiac mitochondrion for energy conversionQ35225761
The role of Ca(2+) signaling in the coordination of mitochondrial ATP production with cardiac workQ35225766
Mechanisms underlying acute protection from cardiac ischemia-reperfusion injuryQ35424798
Mitochondrial-targeted antioxidants protect skeletal muscle against immobilization-induced muscle atrophyQ35562060
Energy metabolism in heart failureQ35602060
Altered creatine kinase adenosine triphosphate kinetics in failing hypertrophied human myocardiumQ35659510
Mitochondrial permeability transition pore opening during myocardial reperfusion--a target for cardioprotectionQ35666876
The novel cardiac myosin activator omecamtiv mecarbil increases the calcium sensitivity of force production in isolated cardiomyocytes and skeletal muscle fibres of the ratQ36036237
Myocardial substrate metabolism in the normal and failing heartQ36179008
Mitochondrial criticality: a new concept at the turning point of life or death.Q36293854
Mechanisms of disease: beta-adrenergic receptors--alterations in signal transduction and pharmacogenomics in heart failureQ36304375
Adenylate kinase phosphotransfer communicates cellular energetic signals to ATP-sensitive potassium channelsQ36319041
Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-CQ36341946
Reduction of ischemia/reperfusion injury with bendavia, a mitochondria-targeting cytoprotective PeptideQ36366202
Adrenaline-induced “oxygen-wastage” and enzyme release from working rat heart. Effects of calcium antagonism, β-blockade, nicotinic acid and coronary artery ligationQ66981532
31P magnetic resonance spectroscopy in dilated cardiomyopathy and coronary artery disease. Altered cardiac high-energy phosphate metabolism in heart failureQ67593279
31P MR spectroscopy in hypertrophic cardiomyopathy: comparison with Tl-201 myocardial perfusion imagingQ70676620
Plasma norepinephrine, plasma renin activity, and congestive heart failure. Relations to survival and the effects of therapy in V-HeFT II. The V-HeFT VA Cooperative Studies GroupQ70733060
Fatty acid oxidation enzyme gene expression is downregulated in the failing heartQ71828329
Effect of pressure development on oxygen consumption by isolated rat heartQ72218889
Quantitative measurements of cardiac phosphorus metabolites in coronary artery disease by 31P magnetic resonance spectroscopyQ72331370
Sodium and the heart: a hidden key factor in cardiac regulationQ73158153
Vitamin E supplementation and cardiovascular events in high-risk patientsQ73365511
Direct evidence for increased hydroxyl radicals originating from superoxide in the failing myocardiumQ73427285
[Cardiac energy metabolism in heart valve diseases with 31P MR spectroscopy]Q73661799
p38 mitogen-activated protein kinase pathway protects adult rat ventricular myocytes against beta -adrenergic receptor-stimulated apoptosis. Evidence for Gi-dependent activationQ73689040
Cardiac high-energy phosphate metabolism in patients with aortic valve disease assessed by 31P-magnetic resonance spectroscopyQ73932420
Human myocardial ATP content and in vivo contractile functionQ74453126
Mitral regurgitation: impaired systolic function, eccentric hypertrophy, and increased severity are linked to lower phosphocreatine/ATP ratios in humansQ74561897
Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, I: experimental studiesQ74615255
31P NMR spectroscopy detects metabolic abnormalities in asymptomatic patients with hypertrophic cardiomyopathyQ74764934
Diastolic dysfunction in hypertensive heart disease is associated with altered myocardial metabolismQ77393474
Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardiumQ78151171
Myocardial fatty acid metabolism: independent predictor of left ventricular mass in hypertensive heart diseaseQ78744696
Influence of beta-adrenoceptor blockade on the myocardial accumulation of fatty acid tracer and its intracellular metabolism in the heart after ischemia-reperfusion injuryQ79297944
The polymorphonuclear leukocyte and the abdominal aortic aneurysm: a neglected cell type and a neglected diseaseQ80357440
Reduced in vivo skeletal muscle oxygen consumption in patients with chronic heart failure--a study using Near Infrared Spectrophotometry (NIRS)Q81502572
Catecholamine-induced cardiac mitochondrial dysfunction and mPTP opening: protective effect of curcuminQ82600646
Cardiac mitochondria in heart failure: normal cardiolipin profile and increased threonine phosphorylation of complex IVQ83409915
Mitochondrial permeability transition in the diabetic heart: contributions of thiol redox state and mitochondrial calcium to augmented reperfusion injuryQ83618914
Novel mitochondria-targeted antioxidants: plastoquinone conjugated with cationic plant alkaloids berberine and palmatineQ84356843
Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heartQ84838077
Heart failure at the crossroads: moving beyond blaming stakeholders to targeting the heartQ85606383
Catechin ameliorates cardiac dysfunction in rats with chronic heart failure by regulating the balance between Th17 and Treg cellsQ87741148
Treatment of mitochondrial disorders: antioxidants and beyondQ88199066
Mitochondria as a drug target in ischemic heart disease and cardiomyopathyQ36426316
Heart failure with preserved ejection fraction: chronic low-intensity interval exercise training preserves myocardial O2 balance and diastolic functionQ36531058
Mitochondrial ROS-induced ROS release: an update and reviewQ36531183
Chronic Therapy With Elamipretide (MTP-131), a Novel Mitochondria-Targeting Peptide, Improves Left Ventricular and Mitochondrial Function in Dogs With Advanced Heart FailureQ36550830
Role of cardiolipin alterations in mitochondrial dysfunction and diseaseQ36561388
Perturbations in the gene regulatory pathways controlling mitochondrial energy production in the failing heartQ36605039
Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure.Q36654675
Effect of cyclosporine on left ventricular remodeling after reperfused myocardial infarctionQ43124905
'Leaky' ryanodine receptors and sudden cardiac deathQ43264886
Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarctionQ43542921
Dramatic improvement in mitochondrial cardiomyopathy following treatment with idebenoneQ43564490
Cardiac metabolism in patients with dilated and hypertrophic cardiomyopathy: assessment with proton-decoupled P-31 MR spectroscopyQ43912543
The effect of prethrombolytic cyclosporine-A injection on clinical outcome of acute anterior ST-elevation myocardial infarctionQ43935007
Intracellular Na(+) concentration is elevated in heart failure but Na/K pump function is unchangedQ44009242
Ultrastructural morphometric analysis of myocardium from dogs, rats, hamsters, mice, and from human heartsQ44071888
Absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium measured noninvasively with (31)P-SLOOP magnetic resonance spectroscopyQ44182277
Beta-adrenergic receptor-stimulated apoptosis in cardiac myocytes is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of the mitochondrial pathwayQ44306725
Hypertrophic cardiomyopathy due to sarcomeric gene mutations is characterized by impaired energy metabolism irrespective of the degree of hypertrophyQ44454565
Exercise training preserves coronary flow and reduces infarct size after ischemia-reperfusion in rat heartQ44560614
Mitochondrial abnormalities in myocardium of dogs with chronic heart failureQ44576578
Effects of edaravone on reperfusion injury in patients with acute myocardial infarctionQ45027825
Intramyocardial injection of SERCA2a-expressing lentivirus improves myocardial function in doxorubicin-induced heart failureQ45886178
Heart failure with preserved ejection fraction is characterized by dynamic impairment of active relaxation and contraction of the left ventricle on exercise and associated with myocardial energy deficiency.Q45921765
Mitochondrial Na+/Ca2+-exchanger blocker CGP37157 protects against chromaffin cell death elicited by veratridine.Q45976080
Safety and tolerability of omecamtiv mecarbil during exercise in patients with ischemic cardiomyopathy and anginaQ46137371
In vivo phosphorus-31 spectroscopic imaging in patients with global myocardial diseaseQ46212051
Coenzyme Q10: an independent predictor of mortality in chronic heart failureQ46239711
Impaired left ventricular energy metabolism in patients with hypertrophic cardiomyopathy is related to the extension of fibrosis at delayed gadolinium-enhanced magnetic resonance imagingQ46425737
Effect of cyclosporine on reperfusion injury in acute myocardial infarctionQ46453592
Metabolic response of the human heart to inotropic stimulation: in vivo phosphorus-31 studies of normal and cardiomyopathic myocardiumQ46508744
Malonyl-CoA decarboxylase inhibition suppresses fatty acid oxidation and reduces lactate production during demand-induced ischemiaQ46650374
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectheart failureQ181754
Kearns-Sayre syndromeQ2605012
mitochondrial myopathyQ6881881
heart mitochondriaQ70188839
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)238-250
P577publication date2016-12-22
2017-04-01
P1433published inNature Reviews CardiologyQ2108444
P1476titleExpert consensus document: Mitochondrial function as a therapeutic target in heart failure
P478volume14

Reverse relations

cites work (P2860)
Q58693386A high-fat diet impairs mitochondrial biogenesis, mitochondrial dynamics, and the respiratory chain complex in rat myocardial tissues
Q47248786AMPKα2 Protects Against the Development of Heart Failure by Enhancing Mitophagy via PINK1 Phosphorylation
Q50860951ATP5J and ATP5H Proactive Expression Correlates with Cardiomyocyte Mitochondrial Dysfunction Induced by Fluoride.
Q52333566Activation of Class I histone deacetylases contributes to mitochondrial dysfunction in cardiomyocytes with altered complex activities.
Q89964336Age and Sex Differences in Hearts of Soluble Epoxide Hydrolase Null Mice
Q41509997Aging: Molecular Pathways and Implications on the Cardiovascular System.
Q89708268Alteration of cardiolipin biosynthesis and remodeling in single right ventricle congenital heart disease
Q39429565Altered Mitochondrial Metabolism and Mechanosensation in the Failing Heart: Focus on Intracellular Calcium Signaling
Q88661222Analyses of Mitochondrial Calcium Influx in Isolated Mitochondria and Cultured Cells
Q61814382AntagomiR-103 and -107 Treatment Affects Cardiac Function and Metabolism
Q42651346Antihypertrophic Effects of Small Molecules that Maintain Mitochondrial ATP Levels Under Hypoxia.
Q64108165Association between admission plasma 2-oxoglutarate levels and short-term outcomes in patients with acute heart failure: a prospective cohort study
Q63352498Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits
Q98568564Bedaquiline inhibits the yeast and human mitochondrial ATP synthases
Q57036069Bid maintains mitochondrial cristae structure and protects against cardiac disease in an integrative genomics study
Q91795773Bioenergetics and translational metabolism: implications for genetics, physiology and precision medicine
Q92890117Cardiac monoamine oxidases: at the heart of mitochondrial dysfunction
Q91625884Cardiac troponin T is associated with mortality in patients admitted to critical care in a UK major trauma centre: a retrospective database analysis
Q58715795Cardiomyocytes cultured on mechanically compliant substrates, but not on conventional culture devices, exhibit prominent mitochondrial dysfunction due to reactive oxygen species and insulin resistance under high glucose
Q64239449Cardiorenal protective effect of sodium-glucose cotransporter 2 inhibitors and mitochondrial function
Q89146570Changes in the activity of some metabolic enzymes in the heart of SHR rat incurred by transgenic expression of CD36
Q88008254Current themes in myocardial and coronary vascular aging
Q94560908Danqi Pill Protects Against Heart Failure Post-Acute Myocardial Infarction via HIF-1α/PGC-1α Mediated Glucose Metabolism Pathway
Q90821719Deficiency of nuclear receptor interaction protein leads to cardiomyopathy by disrupting sarcomere structure and mitochondrial respiration
Q92644691Denervation drives skeletal muscle atrophy and induces mitochondrial dysfunction, mitophagy and apoptosis via miR-142a-5p/MFN1 axis
Q60047543Disease Tolerance and Pathogen Resistance Genes May Underlie Persistence and Differential Progression to Chagas Disease Cardiomyopathy
Q45073605Docosahexaenoic acid lowers cardiac mitochondrial enzyme activity by replacing linoleic acid in the phospholipidome.
Q57293272Drug Targets for Heart Failure with Preserved Ejection Fraction: A Mechanistic Approach and Review of Contemporary Clinical Trials
Q64236310Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production
Q92781615Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial H2 O2 emission during impaired oxidative phosphorylation
Q64081792Elamipretide Improves Mitochondrial Function in the Failing Human Heart
Q93013975Female Heart Health: Is GPER the Missing Link?
Q54088960G protein-coupled estrogen receptor (GPER) deficiency induces cardiac remodeling through oxidative stress.
Q64244369High-resolution respirometry in human endomyocardial biopsies shows reduced ventricular oxidative capacity related to heart failure
Q47141564Human Cardiac 31P-MR Spectroscopy at 3 Tesla Cannot Detect Failing Myocardial Energy Homeostasis during Exercise
Q92895912Human pluripotent stem cell-derived cardiomyocytes for studying energy metabolism
Q51763166Improved Cardiovascular Function in Old Mice after N-Acetyl Cysteine and Glycine Supplemented Diet: Inflammation and Mitochondrial Factors.
Q95325890Increasing carbohydrate oxidation improves contractile reserves and prevents hypertrophy in porcine right heart failure
Q93082044Inflammatory cytokines associated with cancer growth induce mitochondria and cytoskeleton alterations in cardiomyocytes
Q90259003Influence of mitochondrial and systemic iron levels in heart failure pathology
Q49300240Insights from Second-Line Treatments for Idiopathic Dilated Cardiomyopathy
Q50660284Integrating New Pharmacologic Agents into Heart Failure Care: Role of Heart Failure Practice Guidelines in Meeting This Challenge.
Q47158357Integration of miRNA and gene expression profiles suggest a role for miRNAs in the pathobiological processes of acute Trypanosoma cruzi infection
Q92283486Irreversible oxidative post-translational modifications in heart disease
Q90720520Ischemia/Reperfusion Injury Revisited: An Overview of the Latest Pharmacological Strategies
Q64946361Kruppel-Like Factor 4 (KLF4) and its Regulation on Mitochondrial Homeostasis.
Q90744789LAMP-2B regulates human cardiomyocyte function by mediating autophagosome-lysosome fusion
Q91909836Lingguizhugan decoction attenuates doxorubicin-induced heart failure in rats by improving TT-SR microstructural remodeling
Q42373740MMI-0100 Inhibits Cardiac Fibrosis in a Mouse Model Overexpressing Cardiac Myosin Binding Protein C.
Q47163241Melatonin Efficacy in Obese Leptin-Deficient Mice Heart
Q90420571Melatonin in Heart Failure: A Promising Therapeutic Strategy?
Q93192737Metabolic remodeling induced by mitokines in heart failure
Q42333907Metabolomics and Cardiology: Toward the Path of Perinatal Programming and Personalized Medicine
Q93347609Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease
Q103029040MicroRNA-214 contributes to Ang II-induced cardiac hypertrophy by targeting SIRT3 to provoke mitochondrial malfunction
Q58611546Mitochondria as a therapeutic target for common pathologies
Q93385793Mitochondria-Targeted Drugs
Q91826141Mitochondrial 4-HNE derived from MAO-A promotes mitoCa2+ overload in chronic postischemic cardiac remodeling
Q98951973Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy
Q92267248Mitochondrial Dysfunction in Heart Failure With Preserved Ejection Fraction
Q90679359Mitochondrial Quality Control in the Heart: New Drug Targets for Cardiovascular Disease
Q90319225Mitochondrial dysregulation and muscle disuse atrophy
Q89397986Mitochondrial function in the heart: the insight into mechanisms and therapeutic potentials
Q50281263Mitochondrial genome variability: the effect on cellular functional activity.
Q90395114Mitochondrial membrane transporters and metabolic switch in heart failure
Q64058959Mitofusin 2 Participates in Mitophagy and Mitochondrial Fusion Against Angiotensin II-Induced Cardiomyocyte Injury
Q90663952Mitophagy in Cardiovascular Diseases
Q63446889Multiscale structure-function relationships in right ventricular failure due to pressure overload
Q52715720Myocardial Energetics and Heart Failure: a Review of Recent Therapeutic Trials.
Q45064238New and revisited approaches to preserving the reperfused myocardium
Q38671402Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich's ataxia cardiomyopathy model
Q90077681Novel myocardial markers GADD45G and NDUFS5 identified by RNA-sequencing predicts left ventricular reverse remodeling in advanced non-ischemic heart failure: a retrospective cohort study
Q92921857Peripheral Blood Mononuclear Cells and Platelets Mitochondrial Dysfunction, Oxidative Stress, and Circulating mtDNA in Cardiovascular Diseases
Q92356186Perspectives on Directions and Priorities for Future Preclinical Studies in Regenerative Medicine
Q89746482Platelet mitochondrial DNA methylation predicts future cardiovascular outcome in adults with overweight and obesity
Q92063996Potential Role of Antioxidants as Adjunctive Therapy in Chagas Disease
Q91666914Protective transcriptional mechanisms in cardiomyocytes and cardiac fibroblasts
Q47956238Protein turnover in the failing heart: an ever-changing landscape
Q97645720Pyrroloquinoline quinone can prevent chronic heart failure by regulating mitochondrial function
Q64123698Quantitative temporal analysis of protein dynamics in cardiac remodeling
Q92293076Rationale and design of the AFFIRM-AHF trial: a randomised, double-blind, placebo-controlled trial comparing the effect of intravenous ferric carboxymaltose on hospitalisations and mortality in iron-deficient patients admitted for acute heart failur
Q39195160Redefining the role of biomarkers in heart failure trials: expert consensus document
Q55334029Reduced ejection fraction heart failure - new data from multicenter studies and national registries regarding general and elderly populations: hopes and disappointments.
Q47770905Regulation of mitochondrial bioenergetics by the non-canonical roles of mitochondrial dynamics proteins in the heart
Q92702018Sarcopenia and Heart Failure
Q92475887Sodium-glucose co-transporter 2 inhibition as a mitochondrial therapy for atrial fibrillation in patients with diabetes?
Q42371471Spermine and spermidine reversed age-related cardiac deterioration in rats
Q64081816Targeting Mitochondrial Function in Heart Failure: Makes Sense But Will it Work?
Q91276580Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles
Q89641857Targeting the Mitochondria in Heart Failure: A Translational Perspective
Q64084319Telomerase Deficiency Predisposes to Heart Failure and Ischemia-Reperfusion Injury
Q60950146Temporal Frame of Immune Cell Infiltration during Heart Failure Establishment: Lessons from Animal Models
Q41056656The Involvement of Mg2+ in Regulation of Cellular and Mitochondrial Functions
Q92469179The New Promise of Mitochondrial Transplantation for Myocardial Recovery
Q64087497The Role of Pathological Aging in Cardiac and Pulmonary Fibrosis
Q97587345The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats
Q57155941The effects of metabolic substrate availability on human adipose stem cell spheroid survival
Q64084317Three in a Box: Understanding Cardiomyocyte, Fibroblast, and Innate Immune Cell Interactions to Orchestrate Cardiac Repair Processes
Q59136280Transcriptome analysis of human heart failure reveals dysregulated cell adhesion in dilated cardiomyopathy and activated immune pathways in ischemic heart failure
Q90253350TrimetaziDine as a Performance-enhancING drug in heart failure with preserved ejection fraction (DoPING-HFpEF): rationale and design of a placebo-controlled cross-over intervention study
Q97645771Use of cardiac magnetic resonance to detect changes in metabolism in heart failure
Q63976707Variable outcomes of human heart attack recapitulated in genetically diverse mice

Search more.