Glutathione: an overview of biosynthesis and modulation

scientific article published on 01 April 1998

Glutathione: an overview of biosynthesis and modulation is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1016/S0009-2797(97)00146-4
P698PubMed publication ID9679538

P2093author name stringM E Anderson
P2860cites workTransport into brain of buthionine sulfoximine, an inhibitor of glutathione synthesis, is facilitated by esterification and administration of dimethylsulfoxideQ48952676
Intracellular cysteine and glutathione delivery systems.Q54435685
Flexible loop that is novel catalytic machinery in a ligase. Atomic structure and function of the loopless glutathione synthetase.Q54633627
Glutathione monoethyl ester: preparation, uptake by tissues, and conversion to glutathione.Q54649522
Mutational and proteolytic studies on a flexible loop in glutathione synthetase from Escherichia coli B: the loop and arginine 233 are critical for the catalytic reaction.Q54682237
Comparison of the delivery of reduced glutathione into P388D1 cells by reduced glutathione and its mono- and diethyl ester derivativesQ60786673
Intracellular delivery of cysteineQ68190463
Cytotoxicity of cysteine in culture mediaQ68291890
The effect of L-2-oxothiazolidine on glutathione levels in cultured mammalian cellsQ69238418
Glutathione metabolism at the blood-cerebrospinal fluid barrierQ69375295
Crystallization and preliminary X-ray studies of glutathione synthetase from Escherichia coli BQ69555581
Near-total glutathione depletion and age-specific cataracts induced by buthionine sulfoximine in miceQ69557556
Glutathione synthetase from rat kidneyQ69926310
Marked increase of cysteine levels in many regions of the brain after administration of 2-oxothiazolidine-4-carboxylateQ69953474
Preparation and use of glutathione monoestersQ72377059
Preparation and properties of glutathione diethyl ester and related derivativesQ72377064
Missense mutations in the human glutathione synthetase gene result in severe metabolic acidosis, 5-oxoprolinuria, hemolytic anemia and neurological dysfunctionQ73494424
Three-dimensional structure of the glutathione synthetase from Escherichia coli B at 2.0 A resolutionQ27732100
Sequencing and expression of a cDNA for human glutathione synthetaseQ28114781
Hydrolysis and transfer reactions catalyzed by γ-glutamyl transpeptidase; Evidence for separate substrate sites and for high affinity of L-cystineQ28118353
Cloning and nucleotide sequence of a full-length cDNA for human liver gamma-glutamylcysteine synthetaseQ28182247
GlutathioneQ28261279
Amino acid sequence of rat kidney glutathione synthetaseQ28580171
Cloning and sequencing of the gene encoding the large subunit of glutathione synthetase of Schizosaccharomyces pombeQ33479074
Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigensQ33557888
On the active site thiol of gamma-glutamylcysteine synthetase: relationships to catalysis, inhibition, and regulationQ33566233
The gamma-glutamyl cycle: a possible transport system for amino acidsQ33708826
High-affinity transport of glutathione is part of a multicomponent system essential for mitochondrial functionQ33797751
Mitochondrial damage in muscle occurs after marked depletion of glutathione and is prevented by giving glutathione monoesterQ33831082
Glutathione metabolism in the lung: inhibition of its synthesis leads to lamellar body and mitochondrial defectsQ34289792
Glutathione ester prevents buthionine sulfoximine-induced cataracts and lens epithelial cell damageQ34318593
Increase in rat brain glutathione following intracerebroventricular administration of gamma-glutamylcysteineQ34340546
Stimulation of hepatic glutathione formation by administration of L-2-oxothiazolidine-4-carboxylate, a 5-oxo-L-prolinase substrateQ35419704
Intracellular cysteine delivery system that protects against toxicity by promoting glutathione synthesisQ36316242
Transport of glutathione diethyl ester into human cellsQ36576562
Molecular cloning of the large subunit of glutathione synthetase from Xenopus laevis embryosQ36722306
Glutathione deficiency produced by inhibition of its synthesis, and its reversal; Applications in research and therapyQ36936660
Ascorbic acid prevents oxidative stress in glutathione-deficient mice: effects on lung type 2 cell lamellar bodies, lung surfactant, and skeletal muscleQ37043755
Transport of glutathione, as gamma-glutamylcysteinylglycyl ester, into liver and kidneyQ37347247
Glutathione synthetase deficiency, an inborn error of metabolism involving the gamma-glutamyl cycle in patients with 5-oxoprolinuria (pyroglutamic aciduria).Q37449843
Glutathione deficiency decreases tissue ascorbate levels in newborn rats: ascorbate spares glutathione and protectsQ37519555
Origin and turnover of mitochondrial glutathioneQ37523709
Transport and direct utilization of gamma-glutamylcyst(e)ine for glutathione synthesisQ37602746
Inhibition of glutathione synthesis in the newborn rat: a model for endogenously produced oxidative stressQ37610486
Inhibition of γ-glutamylcysteine synthetase by cystamine; An approach to a therapy of 5-oxoprolinuria (pyroglutamic aciduria)Q39178139
The nucleotide sequence of the gene for gamma-glutamylcysteine synthetase of Escherichia coliQ40416941
Complete nucleotide sequence of the E. coli glutathione synthetase gsh-II.Q40463350
Identification of an essential cysteine residue in human glutathione synthaseQ42153619
Flexibility impaired by mutations revealed the multifunctional roles of the loop in glutathione synthetase.Q42609261
Studies on the inhibition of glutamine synthetase by methionine sulfoneQ48665156
P921main subjectglutathioneQ116907
P304page(s)1-14
P577publication date1998-04-01
P1433published inChemico-biological InteractionsQ14923137
P1476titleGlutathione: an overview of biosynthesis and modulation
P478volume111-112

Reverse relations

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Q39368995Synthesis of a smart gold nano-vehicle for liver specific drug delivery
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Q36875656TRX-1 Regulates SKN-1 Nuclear Localization Cell Non-autonomously in Caenorhabditis elegans
Q38182358Targeting the epigenetic machinery of cancer cells
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Q38956970The Architecture of Thiol Antioxidant Systems among Invertebrate Parasites.
Q92697975The Effect of Exhaustive Exercise on Plasma Metabolic Profiles of Male and Female Rats
Q42598700The Glutathione Synthetase of Schizosaccharomyces pombe Is Synthesized as a Homodimer but Retains Full Activity When Present as a Heterotetramer
Q37376013The Paradox of Oestradiol-Induced Breast Cancer Cell Growth and Apoptosis
Q41898788The effect of BSO-induced oxidative stress on histologic feature of testis: testosterone secretion and semen parameters in mice
Q41916312The effect of combined treatment with cisplatin and histone deacetylase inhibitors on HeLa cells
Q92814874The effect of omega-3 and vitamin E on oxidative stress and inflammation: Systematic review and meta-analysis of randomized controlled trials
Q28474389The effect of oxidant and the non-oxidant alteration of cellular thiol concentration on the formation of protein mixed-disulfides in HEK 293 cells
Q35669489The effect of raw soybean on oxidative status of digestive organs in mice
Q35733315The effects of glutathione, insulin and oxidative stress on cultured spermatogenic cysts.
Q28180886The importance of glutathione in human disease
Q35747310The molecular basis that unifies the metabolism, cellular uptake and chemopreventive activities of dietary isothiocyanates.
Q33902816The role of intracellular glutathione in inorganic mercury-induced toxicity in neuroblastoma cells.
Q92461310The role of low molecular weight thiols in Mycobacterium tuberculosis
Q42704684The role of the glycine triad in human glutathione synthetase
Q90669787The roles of S-nitrosylation and S-glutathionylation in Alzheimer's disease
Q85173935Tinospora cordifolia ameliorates urotoxic effect of cyclophosphamide by modulating GSH and cytokine levels
Q38155500Triggered Nanoparticles as Therapeutics.
Q36061797Tumor Xenograft Response to Redox-Active Therapies Assessed by Magnetic Resonance Imaging Using a Thiol-Bearing DOTA Complex of Gadolinium
Q43290420Tyrosine administration decreases glutathione and stimulates lipid and protein oxidation in rat cerebral cortex.
Q91690576Unraveling the Potential Role of Glutathione in Multiple Forms of Cell Death in Cancer Therapy
Q37709545Upregulation of capacity for glutathione synthesis in response to amino acid deprivation: regulation of glutamate-cysteine ligase subunits.
Q36096948Vine nitrogen status and volatile thiols and their precursors from plot to transcriptome level.
Q35291859cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.

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