Cancer as a robust system: implications for anticancer therapy

scientific article published on 01 March 2004

Cancer as a robust system: implications for anticancer therapy is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1015732303
P356DOI10.1038/NRC1300
P698PubMed publication ID14993904

P2093author name stringHiroaki Kitano
P2860cites workInvolvement of chemokine receptors in breast cancer metastasisQ24290909
Negative control of p53 by Sir2alpha promotes cell survival under stressQ24291828
Metapopulation dynamics and spatial heterogeneity in cancerQ24538673
Targeting HIF-1 for cancer therapyQ27860504
A genetic model for colorectal tumorigenesisQ27860582
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylaseQ27860668
Stem cells, cancer, and cancer stem cellsQ27860878
Surfing the p53 networkQ28032484
Genetic instabilities in human cancersQ28131826
A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damageQ28138556
Tumor hypoxia: definitions and current clinical, biologic, and molecular aspectsQ28200181
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogeneQ28202069
Putting tumours in contextQ28207789
The complexity of p53 modulation: emerging patterns from divergent signalsQ28284854
Sustained loss of a neoplastic phenotype by brief inactivation of MYCQ74413944
Extensive cytogenetic heterogeneity in a benign retroperitoneal schwannomaQ95721482
Error and attack tolerance of complex networksQ29547268
Hypoxia--a key regulatory factor in tumour growthQ29547318
The large-scale organization of metabolic networksQ29547498
Systems biology: a brief overviewQ29547514
Cancer. Addiction to oncogenes--the Achilles heal of cancerQ29614243
Computational systems biologyQ29616655
Stochastic mechanisms in gene expressionQ29617407
Robustness in bacterial chemotaxisQ29617495
Robustness in simple biochemical networksQ29617496
The segment polarity network is a robust developmental moduleQ29618600
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplificationQ29618788
The microenvironment of the tumour-host interfaceQ29620375
Human Sir2 and the 'silencing' of p53 activityQ30309900
Aneuploidy vs. gene mutation hypothesis of cancer: recent study claims mutation but is found to support aneuploidyQ30587566
Phase II study of combining vinblastine and cyclosporin-A to circumvent multidrug resistance in renal cell cancerQ33357640
A phase II study of epidoxorubicin in colorectal cancer and the use of cyclosporin-A in an attempt to reverse multidrug resistanceQ33377470
It's a noisy business! Genetic regulation at the nanomolar scaleQ33546905
Genetic instability and darwinian selection in tumoursQ33804007
Disorders in cell circuitry during multistage carcinogenesis: the role of homeostasisQ33900139
MDM2 oncogene as a novel target for human cancer therapyQ33902429
Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugsQ34060806
Tumor reversion: Correction of malignant behavior by microenvironmental cuesQ34103266
Complexity and robustnessQ34138870
Error catastrophe and antiviral strategyQ34153584
How does calorie restriction work?Q34175282
Tumors are unique organs defined by abnormal signaling and contextQ34231927
Biological consequences of tumor hypoxiaQ34275624
Multiple mutations and cancerQ34327554
Solitary cancer cells as a possible source of tumour dormancy?Q34341754
T-cell immunity in the induction and maintenance of a tumour dormant stateQ34341769
"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normallyQ34369829
A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutantsQ34488592
Reverse engineering of biological complexityQ34548755
Chemokines: agents for the immunotherapy of cancer?Q34576416
Tumor progression: a brief historical perspectiveQ34766105
Hypoxia-induced pathways in breast cancerQ34872665
Engineered gene circuits.Q34997456
Control, exploitation and tolerance of intracellular noiseQ34997459
T cell memory, anergy and immunotherapy in breast cancerQ35015669
Cancer chronotherapy: principles, applications, and perspectivesQ35030286
Linking chromatin function with metabolic networks: Sir2 family of NAD(+)-dependent deacetylasesQ35040959
Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humansQ35044170
Promises and pitfalls of anti-angiogenic therapy in clinical trialsQ35076995
Cancer immunotherapy: the past, the present and the futureQ35083647
Modulation of P-glycoprotein (PGP) mediated multidrug resistance (MDR) using chemosensitizers: recent advances in the design of selective MDR modulatorsQ35100585
The p53-Mdm2 pathway: targets for the development of new anticancer therapeutics.Q35108617
Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental studyQ35268497
Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo.Q35581806
Tumor hypoxia: a target for selective cancer therapyQ35602696
Robust perfect adaptation in bacterial chemotaxis through integral feedback controlQ35689729
Metastatic variants are generated spontaneously at a high rate in mouse KHT tumorQ36312026
Less efficacy with alternating regimen as adjuvant chemotherapy in stage II node-positive breast cancer: results at 8 years (Pronacam 85)Q36430928
Multidrug resistance (mdr) genes in human cancerQ36495579
Activator-protein-1 binding potentiates the hypoxia-induciblefactor-1-mediated hypoxia-induced transcriptional activation of vascular-endothelial growth factor expression in C6 glioma cellsQ38341890
Hypoxia-inducible protein binding to vascular endothelial growth factor mRNA and its modulation by the von Hippel-Lindau proteinQ38352366
Toward a chronotherapy of neoplasia: Tolerance of treatment depends upon host rhythmsQ39931271
Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL.Q40633683
Viral quasispecies.Q40828271
Cancer dormancy: opportunities for new therapeutic approachesQ41463105
Robustness of a gene regulatory circuitQ41842616
Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signalingQ42478267
Roots of clinical resistance to STI-571 cancer therapyQ43744914
Robustness as a measure of plausibility in models of biochemical networksQ44036135
Cytogenetic and molecular mechanisms of resistance to imatinibQ44463519
Bifurcation analysis of a model of mitotic control in frog eggsQ45114625
Aneuploidy theory explains tumor formation, the absence of immune surveillance, and the failure of chemotherapyQ45288287
Simulation of prokaryotic genetic circuitsQ46714216
Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance.Q50626711
Robust oscillations within the interlocked feedback model of Drosophila circadian rhythm.Q52061014
A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity.Q52548391
Robustness, flexibility, and the role of lateral inhibition in the neurogenic network.Q52596238
Intratumor genetic heterogeneity in advanced human colorectal adenocarcinoma.Q53397513
Cytogenetic analysis of pancreatic carcinomas: intratumor heterogeneity and nonrandom pattern of chromosome aberrations.Q53431099
Somatic recombination redux.Q55036287
Cancer robustness: Tumour tacticsQ59086311
Dynamic heterogeneity: rapid generation of metastatic variants in mouse B16 melanoma cellsQ62498340
Angiostatin induces and sustains dormancy of human primary tumors in miceQ71101907
Tumour dormancy: not so sleepy after allQ71802890
Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppressionQ71802927
Circadian clocks limited by noiseQ73412329
Lack of effectiveness of adjuvant alternating chemotherapy in node-positive, estrogen-receptor-negative premenopausal breast cancer patients: results of a multicentric Italian study. The Breast Cancer Adjuvant Chemo-Hormone Therapy Cooperative GroupQ73977659
P433issue3
P304page(s)227-235
P577publication date2004-03-01
P1433published inNature Reviews CancerQ641657
P1476titleCancer as a robust system: implications for anticancer therapy
P478volume4