New developments in the molecular pharmacology of the myo-inositol 1,4,5-trisphosphate receptor

scientific article published on 01 November 1998

New developments in the molecular pharmacology of the myo-inositol 1,4,5-trisphosphate receptor is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0165-6147(98)01260-7
P698PubMed publication ID9850611

P2093author name stringR A Challiss
S R Nahorski
R A Wilcox
W U Primrose
P2860cites workPhosphorylation of inositol 1,4,5-trisphosphate receptors by cAMP-dependent protein kinase. Type I, II, and III receptors are differentially susceptible to phosphorylation and are phosphorylated in intact cellsQ27867708
Inositol trisphosphate and calcium signallingQ28262867
Mutational analysis of the ligand binding site of the inositol 1,4,5-trisphosphate receptorQ28586214
Inhibition of nuclear vesicle fusion by antibodies that block activation of inositol 1,4,5-trisphosphate receptorsQ33912926
Activation of the calcium release channel (ryanodine receptor) by heparin and other polyanions is calcium dependent.Q34436186
Catalytic properties of inositol trisphosphate kinase: activation by Ca2+ and calmodulinQ34552219
Kinetics of smooth and skeletal muscle activation by laser pulse photolysis of caged inositol 1,4,5-trisphosphateQ36460397
Quantal puffs of intracellular Ca2+ evoked by inositol trisphosphate in Xenopus oocytesQ36702655
Plasma membrane inositol 1,4,5-trisphosphate receptor of lymphocytes: selective enrichment in sialic acid and unique binding specificityQ36924230
Molecular recognition of inositol polyphosphates by intracellular receptors and metabolic enzymesQ38281029
Intracellular channelsQ40392897
Inositol 1,4,5-trisphosphate receptor subtypes differentially recognize regioisomers of D-myo-inositol 1,4,5-trisphosphateQ40873367
Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expressionQ41044051
Differential regulation of types-1 and -3 inositol trisphosphate receptors by cytosolic Ca2+Q41067966
The inositol triphosphate receptor familyQ41087607
Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptorQ41105707
Stable overexpression of the type-1 inositol 1,4,5-trisphosphate receptor in L fibroblasts: subcellular distribution and functional consequencesQ41167472
Type-I, Type-II and Type-III Inositol 1,4,5-Trisphosphate Receptor Co-Immunoprecipitation as Evidence for the Existence of Heterotetrameric Receptor ComplexesQ41313286
Heterotetrameric complex formation of inositol 1,4,5-trisphosphate receptor subunitsQ41334433
Type I, II, and III inositol 1,4,5-trisphosphate receptors are unequally susceptible to down-regulation and are expressed in markedly different proportions in different cell typesQ41345900
The InsP3 receptor and intracellular Ca2+ signalingQ41541429
Interactions between inositol tris- and tetrakis-phosphates. Effects on intracellular Ca2+ mobilization in SH-SY5Y cellsQ41684296
Ca2+ differentially regulates the ligand-affinity states of type 1 and type 3 inositol 1,4,5-trisphosphate receptorsQ41856637
Inositol 1:2-cyclic,4,5-trisphosphate is only a weak agonist at inositol 1,4,5-trisphosphate receptorsQ41908498
Conformational changes in plant Ins(1,4,5)P3 receptor on interaction with different myo-inositol trisphosphates and its effect on Ca2+ release from microsomal fraction and liposomesQ42123248
Rapid kinetic measurements of 45Ca2+ mobilization reveal that Ins(2,4,5)P3 is a partial agonist at hepatic InsP3 receptors.Q42159863
Involvement of the C-terminus of the inositol 1,4,5-trisphosphate receptor in Ca2+ release analysed using region-specific monoclonal antibodiesQ42161881
Evidence for lithium-sensitive inositol 4,5-bisphosphate accumulation in muscarinic cholinoceptor-stimulated cerebral-cortex slicesQ42175853
Characterization of the inositol 1,4,5-trisphosphate-induced calcium release from permeabilized endocrine cells and its inhibition by decavanadate and p-hydroxymercuribenzoateQ42802129
Inositol 1,4,5-trisphosphorothioate, a stable analogue of inositol trisphosphate which mobilizes intracellular calcium.Q42836088
Single-channel kinetics, inactivation, and spatial distribution of inositol trisphosphate (IP3) receptors in Xenopus oocyte nucleus.Q42977389
Ins(1,3,4,5)P4 is effective in mobilizing Ca2+ in mouse exocrine pancreatic acinar cells if phospholipase A2 is inhibitedQ42984416
Xestospongins: potent membrane permeable blockers of the inositol 1,4,5-trisphosphate receptorQ46074332
The novel Ins(1,4,5)P3 analogue 3-amino-3-deoxy-Ins(1,4,5)P3: a pH-dependent Ins(1,4,5)P3 receptor partial agonist in SH-SY5Y neuroblastoma cellsQ48155829
Disaccharide polyphosphates based upon adenophostin A activate hepatic D-myo-inositol 1,4,5-trisphosphate receptorsQ48568062
2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+ releaseQ48605432
Structural analogues of D-myo-inositol-1,4,5-trisphosphate and adenophostin A: recognition by cerebellar and platelet inositol-1,4,5-trisphosphate receptorsQ48619300
D-[35S(U)]inositol 1,4,5-trisphosphorothioate, a novel radioligand for the inositol 1,4,5-trisphosphate receptor. Complex binding to rat cerebellar membranesQ48740561
The effects of inositol 1,4,5-trisphosphate (InsP3) analogues on the transient kinetics of Ca2+ release from cerebellar microsomes. InsP3 analogues act as partial agonistsQ48830363
Inositol 1,4,5-trisphosphate affinity chromatographyQ49020059
Role of inositol 1,4,5-trisphosphate receptor in ventral signaling in Xenopus embryos.Q52191620
Modification at C2 of myo-inositol 1,4,5-trisphosphate produces inositol trisphosphates and tetrakisphosphates with potent biological activities.Q54199952
3-position modification of myo-inositol 1,4,5-trisphosphate: consequences for intracellular Ca2+ mobilisation and enzyme recognition.Q54267874
Structure and Function of Inositol 1,4,5-Trisphosphate ReceptorQ56482244
Binding and activity of the nine possible regioisomers of myo-inositol tetrakisphosphate at the inositol 1,4,5-trisphosphate receptor.Q64956913
Interaction of synthetic D-6-deoxy-myo-inositol 1,4,5-trisphosphate with the Ca2(+)-releasing D-myo-inositol 1,4,5-trisphosphate receptor, and the metabolic enzymes 5-phosphatase and 3-kinaseQ67912703
Heparin inhibits inositol trisphosphate-induced calcium release from permeabilized rat liver cellsQ69815830
Synthesis of methyl 2-O-allyl-(and 3-O-allyl)-5-O-benzyl-beta-D- ribofuranosideQ70983278
Regulation of the inositol 1,4,5-trisphosphate receptor by tyrosine phosphorylationQ71084759
A Ca(2+)-mobilising carbohydrate-based polyphosphate: synthesis of 2-hydroxyethyl alpha-D-glucopyranoside 2',3,4-trisphosphateQ71424690
Adenophostin-medicated quantal Ca2+ release in the purified and reconstituted inositol 1,4,5-trisphosphate receptor type 1Q71940805
Inositol 1,4,5-trisphosphate receptors: labeling the inositol 1,4,5-trisphosphate binding site with photoaffinity ligandsQ72951660
Defining the minimal structural requirements for partial agonism at the type I myo-inositol 1,4,5-trisphosphate receptorQ73082603
Structure and function of inositol 1,4,5-trisphosphate receptorQ73311223
Molecular and functional evidence for multiple Ca2+-binding domains in the type 1 inositol 1,4,5-trisphosphate receptorQ73770572
Differences among type I, II, and III inositol-1,4,5-trisphosphate receptors in ligand-binding affinity influence the sensitivity of calcium stores to inositol-1,4,5-trisphosphateQ74454404
P433issue11
P921main subjectpharmacologyQ128406
P304page(s)467-475
P577publication date1998-11-01
P1433published inTrends in Pharmacological SciencesQ2451474
P1476titleNew developments in the molecular pharmacology of the myo-inositol 1,4,5-trisphosphate receptor
P478volume19

Reverse relations

cites work (P2860)
Q83483032Adenophostins: High-Affinity Agonists of IP(3) Receptors
Q31585475C-glycoside based mimics of D-myo-inositol 1,4,5-trisphosphate.
Q36256801Cardiac expression of ryanodine receptor subtype 3; a strategic component in the intracellular Ca2+ release system of Purkinje fibers in large mammalian heart.
Q34537344Defining the neuromolecular action of myo-inositol: application to obsessive-compulsive disorder
Q58798779Drosophila CaV2 channels harboring human migraine mutations cause synapse hyperexcitability that can be suppressed by inhibition of a Ca2+ store release pathway
Q43962778Hydrophobic modifications at 1-phosphate of inositol 1,4,5-trisphosphate analogues enhance receptor binding
Q40873028Inhibition of Ca(2+) signalling by p130, a phospholipase-C-related catalytically inactive protein: critical role of the p130 pleckstrin homology domain
Q31803134Inhibitory effects of ruthenium red on inositol 1,4, 5-trisphosphate-induced responses in rat megakaryocytes
Q42012083Inhibitory mechanism of xestospongin-C on contraction and ion channels in the intestinal smooth muscle
Q33279720Inositol-1,4,5-trisphosphate-mediated spontaneous activity in mouse embryonic stem cell-derived cardiomyocytes
Q73115075Involvement of nitric oxide/cyclic GMP signaling pathway in the regulation of fatty acid metabolism in rat hepatocytes
Q64986819Maintenance of homeostatic plasticity at the Drosophila neuromuscular synapse requires continuous IP3-directed signaling.
Q21284458Mechanisms mediating the biologic activity of synthetic proline, glycine, and hydroxyproline polypeptides in human neutrophils
Q28366084Mechanisms underlying reduced responsiveness of neonatal neutrophils to distinct chemoattractants
Q33756111New Ca2+-releasing messengers: are they important in the nervous system?
Q36364436Pharmacology of intracellular signalling pathways
Q38547135Regulation of calcium clock-mediated pacemaking by inositol-1,4,5-trisphosphate receptors in mouse sinoatrial nodal cells.
Q28360600Selective recognition of inositol phosphates by subtypes of the inositol trisphosphate receptor
Q30653049Small molecule-based laser inactivation of inositol 1,4,5-trisphosphate receptor
Q30956351Spatiotemporal laser inactivation of inositol 1,4,5-trisphosphate receptors using synthetic small-molecule probes
Q34612793Stimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by adenophostin A and its analogues
Q34571414Stimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by analogues of IP3
Q27639992Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand
Q44066986Sympathoexcitation by bradykinin involves Ca2+-independent protein kinase C.
Q44636378Synthesis and Ca2+-Mobilizing Activity of Purine-Modified Mimics of Adenophostin A: A Model for the Adenophostin−Ins(1,4,5)P3 Receptor Interaction
Q44216590Synthesis of D- and L-myo-inositol 2,4,5-trisphosphate and trisphosphorothioate: structural analogues of D-myo-inositol 1,4,5-trisphosphate
Q73221746The mycotoxin paxilline inhibits the cerebellar inositol 1,4, 5-trisphosphate receptor
Q34089878Three-dimensional structure of the type 1 inositol 1,4,5-trisphosphate receptor at 24 A resolution
Q43264712Xestospongin C, a selective and membrane-permeable inhibitor of IP(3) receptor, attenuates the positive inotropic effect of alpha-adrenergic stimulation in guinea-pig papillary muscle
Q43637492Xylopyranoside-based agonists of D-myo-inositol 1,4,5-trisphosphate receptors: synthesis and effect of stereochemistry on biological activity

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