Protein kinase A (PKA)-dependent troponin-I phosphorylation and PKA regulatory subunits are decreased in human dilated cardiomyopathy

scientific article published on 01 February 1999

Protein kinase A (PKA)-dependent troponin-I phosphorylation and PKA regulatory subunits are decreased in human dilated cardiomyopathy is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1161/01.CIR.99.4.505
P698PubMed publication ID9927396

P50authorDaniel ZakharyQ73157394
P2093author name stringBond M
Moravec CS
Stewart RW
P433issue4
P921main subjectdilated cardiomyopathyQ283656
P304page(s)505-510
P577publication date1999-02-01
P1433published inCirculationQ578091
P1476titleProtein kinase A (PKA)-dependent troponin-I phosphorylation and PKA regulatory subunits are decreased in human dilated cardiomyopathy
P478volume99

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cites work (P2860)
Q3558819710,000-fold concentration increase in proteins in a cascade microchip using anionic ITP by a 3-D numerical simulation with experimental results
Q3578616510,000-fold concentration increase of the biomarker cardiac troponin I in a reducing union microfluidic chip using cationic isotachophoresis
Q5509220817β-Estradiol and/or estrogen receptor alpha signaling blocks protein phosphatase 1 mediated ISO induced cardiac hypertrophy.
Q366992592-Deoxyadenosine triphosphate restores the contractile function of cardiac myofibril from adult dogs with naturally occurring dilated cardiomyopathy
Q35879498A-kinase anchoring protein targeting of protein kinase A in the heart
Q36003703AMP-activated protein kinase phosphorylates cardiac troponin I at Ser-150 to increase myofilament calcium sensitivity and blunt PKA-dependent function.
Q34982964Activation of cardiac adenylyl cyclase expression increases function of the failing ischemic heart in mice
Q36649084Alpha1 catalytic subunit of AMPK modulates contractile function of cardiomyocytes through phosphorylation of troponin I.
Q44195104An epsilonPKC-selective inhibitor attenuates back phosphorylation of a low molecular weight protein in cardiac myocytes
Q38248672Anchored protein kinase A signalling in cardiac cellular electrophysiology
Q58614496Assessment of PKA and PKC inhibitors on force and kinetics of non-failing and failing human myocardium
Q35315109Biochemical and myofilament responses of the right ventricle to severe pulmonary hypertension
Q42264504Cardiac troponin I tyrosine 26 phosphorylation decreases myofilament Ca2+ sensitivity and accelerates deactivation.
Q24300805Cardiac troponin T isoforms affect the Ca2+ sensitivity and inhibition of force development. Insights into the role of troponin T isoforms in the heart
Q73157396Cyclic AMP-dependent protein kinase binding to A-kinase anchoring proteins in living cells by fluorescence resonance energy transfer of green fluorescent protein fusion proteins
Q36176071Development of dilated cardiomyopathy in Bmal1-deficient mice
Q42123152Disruption of protein kinase A interaction with A-kinase-anchoring proteins in the heart in vivo: effects on cardiac contractility, protein kinase A phosphorylation, and troponin I proteolysis.
Q28512782Disruption of striated preferentially expressed gene locus leads to dilated cardiomyopathy in mice
Q34578568Electrical and structural remodeling of the failing ventricle
Q33622017FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility
Q41265608Force relaxation and thin filament protein phosphorylation during acute myocardial ischemia
Q36369931Functional consequences of sarcomeric protein abnormalities in failing myocardium
Q21129229Gene regulation, alternative splicing, and posttranslational modification of troponin subunits in cardiac development and adaptation: a focused review
Q33396365Genomic selection of reference genes for real-time PCR in human myocardium
Q37427881Human heart failure is accompanied by altered protein kinase A subunit expression and post-translational state
Q34628879Maternal diet-induced obesity programs cardiovascular dysfunction in adult male mouse offspring independent of current body weight
Q33748197Mice lacking the Cβ subunit of PKA are resistant to angiotensin II-induced cardiac hypertrophy and dysfunction
Q43919870Molecular mechanisms of reduced sarcoplasmic reticulum Ca(2+) uptake in human failing left ventricular myocardium
Q39785961Molecular mechanisms of sarcomere dysfunction in dilated and hypertrophic cardiomyopathy
Q30049005Multiple Reaction Monitoring to Identify Site-Specific Troponin I Phosphorylated Residues in the Failing Human Heart
Q36593277Myofibrillar remodeling in cardiac hypertrophy, heart failure and cardiomyopathies
Q44263809Myofibrillar responsiveness to cAMP, PKA, and caffeine in an animal model of heart failure
Q37503779Myofilament Calcium Sensitivity: Mechanistic Insight into TnI Ser-23/24 and Ser-150 Phosphorylation Integration
Q34727604Pathophysiological basis and clinical application of T-wave alternans
Q35600289Preconcentration and detection of the phosphorylated forms of cardiac troponin I in a cascade microchip by cationic isotachophoresis
Q33678033Protein Kinases as Drug Development Targets for Heart Disease Therapy
Q79138553Protein kinase A dependent phosphorylation activates Mg2+ efflux in the basolateral region of the liver
Q33896774Protein kinase A is a target for aging and the aging heart
Q33641335Reduced force production during low blood flow to the heart correlates with altered troponin I phosphorylation
Q43876768Reduced level of serine(16) phosphorylated phospholamban in the failing rat myocardium: a major contributor to reduced SERCA2 activity
Q46600650Reduced troponin I phosphorylation and increased Ca(2+)-dependent ATP-consumption in triton X-skinned fiber preparations from Galphaq overexpressor mice
Q33538026Regulation of fibre contraction in a rat model of myocardial ischemia
Q28295123Removal of the N-terminal extension of cardiac troponin I as a functional compensation for impaired myocardial beta-adrenergic signaling
Q54578401Reorganized PKA-AKAP associations in the failing human heart.
Q64114940Role of β-adrenergic signaling in masseter muscle
Q37200169Sarcomere length dependence of power output is increased after PKA treatment in rat cardiac myocytes
Q102053331Selective changes in cytosolic β-adrenergic cAMP signals and L-type Calcium Channel regulation by Phosphodiesterases during cardiac hypertrophy
Q30380968TNNI1, TNNI2 and TNNI3: Evolution, regulation, and protein structure-function relationships.
Q40243911The contributions of cardiac myosin binding protein C and troponin I phosphorylation to β-adrenergic enhancement of in vivo cardiac function
Q30476199The gene expression fingerprint of human heart failure
Q37239549The role of Akt/GSK-3beta signaling in familial hypertrophic cardiomyopathy
Q79325476Troponin phosphorylation and regulatory function in human heart muscle: dephosphorylation of Ser23/24 on troponin I could account for the contractile defect in end-stage heart failure
Q34281889Type 1 phosphatase, a negative regulator of cardiac function
Q85203592WITHDRAWN: Simvastatin prevents decreased SERCA2a activity in non-ischemic heart failure in rabbits via inhibition of β-adrenergic signaling

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