| review article | Q7318358 |
| scholarly article | Q13442814 |
| P2093 | author name string | Jian-Ping Jin | |
| Juan-Juan Sheng | |||
| P2860 | cites work | Gene regulation, alternative splicing, and posttranslational modification of troponin subunits in cardiac development and adaptation: a focused review | Q21129229 |
| Idiopathic restrictive cardiomyopathy is part of the clinical expression of cardiac troponin I mutations | Q24292763 | ||
| Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form | Q24306847 | ||
| Fast skeletal muscle troponin I is a co-activator of estrogen receptor-related receptor alpha | Q24309327 | ||
| Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1 | Q24312146 | ||
| Mutations in fast skeletal troponin I, troponin T, and beta-tropomyosin that cause distal arthrogryposis all increase contractile function | Q24338449 | ||
| Polycystin-2 interacts with troponin I, an angiogenesis inhibitor | Q24338627 | ||
| Mutations in genes encoding fast-twitch contractile proteins cause distal arthrogryposis syndromes | Q24531960 | ||
| Troponin I is present in human cartilage and inhibits angiogenesis | Q24674047 | ||
| Preserved close linkage between the genes encoding troponin I and troponin T, reflecting an evolution of adapter proteins coupling the Ca(2+) signaling of contractility | Q28140053 | ||
| Troponin I: inhibitor or facilitator | Q28140058 | ||
| Additional PKA phosphorylation sites in human cardiac troponin I | Q28140579 | ||
| Cardiac troponin I is modified in the myocardium of bypass patients | Q28141483 | ||
| Transgenic mouse model of stunned myocardium | Q28142983 | ||
| A novel mechanism for myocardial stunning involving impaired Ca(2+) handling | Q77069121 | ||
| Impaired cardiomyocyte relaxation and diastolic function in transgenic mice expressing slow skeletal troponin I in the heart | Q77393681 | ||
| Protein kinase A (PKA)-dependent troponin-I phosphorylation and PKA regulatory subunits are decreased in human dilated cardiomyopathy | Q77932851 | ||
| C-terminal truncation of cardiac troponin I causes divergent effects on ATPase and force: implications for the pathophysiology of myocardial stunning | Q79150632 | ||
| PKC-betaII sensitizes cardiac myofilaments to Ca2+ by phosphorylating troponin I on threonine-144 | Q79162724 | ||
| Troponin phosphorylation and regulatory function in human heart muscle: dephosphorylation of Ser23/24 on troponin I could account for the contractile defect in end-stage heart failure | Q79325476 | ||
| Differential roles of cardiac myosin-binding protein C and cardiac troponin I in the myofibrillar force responses to protein kinase A phosphorylation | Q80642359 | ||
| Clinical and mutational spectrum in a cohort of 105 unrelated patients with dilated cardiomyopathy | Q84775782 | ||
| Specific degradation of troponin T and I by mu-calpain and its modulation by substrate phosphorylation. | Q42826423 | ||
| Phosphorylation of troponin I controls cardiac twitch dynamics: evidence from phosphorylation site mutants expressed on a troponin I-null background in mice | Q43948817 | ||
| Role of cyclic GMP-dependent protein kinase in the contractile response to exogenous nitric oxide in rat cardiac myocytes | Q43961407 | ||
| p21-activated kinase increases the calcium sensitivity of rat triton-skinned cardiac muscle fiber bundles via a mechanism potentially involving novel phosphorylation of troponin I. | Q44145598 | ||
| N-terminal phosphorylation of cardiac troponin-I reduces length-dependent calcium sensitivity of contraction in cardiac muscle | Q44281385 | ||
| Protein kinase C and A sites on troponin I regulate myofilament Ca2+ sensitivity and ATPase activity in the mouse myocardium | Q44552168 | ||
| Restrictive cardiomyopathy mutations demonstrate functions of the C-terminal end-segment of troponin I. | Q44675443 | ||
| Phosphorylation and mutation of human cardiac troponin I deferentially destabilize the interaction of the functional regions of troponin I with troponin C. | Q44684364 | ||
| Alterations in myofilament function contribute to left ventricular dysfunction in pigs early after myocardial infarction | Q45140735 | ||
| Lys184 deletion in troponin I impairs relaxation kinetics and induces hypercontractility in murine cardiac myofibrils. | Q46445601 | ||
| Hydroxyl radical and glutathione interactions alter calcium sensitivity and maximum force of the contractile apparatus in rat skeletal muscle fibres. | Q46726955 | ||
| RNA expression of cardiac troponin T isoforms in diseased human skeletal muscle. | Q47904036 | ||
| Protein kinase D selectively targets cardiac troponin I and regulates myofilament Ca2+ sensitivity in ventricular myocytes. | Q50695684 | ||
| Myofibrillar disruption in hypocontractile myocardium showing perfusion-contraction matches and mismatches. | Q52538651 | ||
| Cardiac troponin I mutations in Australian families with hypertrophic cardiomyopathy: clinical, genetic and functional consequences. | Q52562573 | ||
| Elevation of cardiac troponin T, but not cardiac troponin I, in patients with neuromuscular diseases: implications for the diagnosis of myocardial infarction. | Q54358875 | ||
| Phosphorylation of both serine residues in cardiac troponin I is required to decrease the Ca2+ affinity of cardiac troponin C. | Q54598150 | ||
| Pure restrictive cardiomyopathy associated with cardiac troponin I gene mutation: mismatch between the lack of hypertrophy and the presence of disarray | Q58910341 | ||
| Absence of Troponin I Degradation or Altered Sarcoplasmic Reticulum Uptake Protein Expression After Reversible Ischemia in Swine | Q60144128 | ||
| O-LinkedN-Acetylglucosaminylation Is Involved in the Ca2+Activation Properties of Rat Skeletal Muscle | Q60403389 | ||
| Chimera analysis of troponin I domains that influence Ca(2+)-activated myofilament tension in adult cardiac myocytes | Q64380931 | ||
| Functional analysis of troponin I regulatory domains in the intact myofilament of adult single cardiac myocytes | Q64381377 | ||
| Sequential phosphorylation of adjacent serine residues on the N‐terminal region of cardiac troponin‐I: structure‐activity implications of ordered phosphorylation | Q72015214 | ||
| Cardiac troponin I phosphorylation increases the rate of cardiac muscle relaxation | Q72256359 | ||
| Expression of messenger RNA of the cardiac isoforms of troponin T and I in myopathic skeletal muscle | Q73063806 | ||
| Cardiac troponin T composition in normal and regenerating human skeletal muscle | Q73151700 | ||
| Troponin I phosphorylation in the normal and failing adult human heart | Q73744397 | ||
| Independent prognostic value of cardiac troponin T in patients with confirmed pulmonary embolism | Q73977711 | ||
| Biochemical mechanism(s) of stunning in conscious dogs | Q74014347 | ||
| The highly conserved COOH terminus of troponin I forms a Ca2+-modulated allosteric domain in the troponin complex | Q28186310 | ||
| Effects of T142 phosphorylation and mutation R145G on the interaction of the inhibitory region of human cardiac troponin I with the C-domain of human cardiac troponin C | Q28202179 | ||
| The slow isoform of Xenopus troponin I is expressed in developing skeletal muscle but not in the heart | Q28202644 | ||
| The genetic basis for cardiomyopathy: from mutation identification to mechanistic paradigms | Q28203734 | ||
| Phosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocity | Q28205242 | ||
| A proteolytic NH2-terminal truncation of cardiac troponin I that is up-regulated in simulated microgravity | Q28208345 | ||
| Characteristics of the human ocular surface epithelium | Q28208434 | ||
| Time-dependent changes in expression of troponin subunit isoforms in unloaded rat soleus muscle | Q28213658 | ||
| Structural based insights into the role of troponin in cardiac muscle pathophysiology | Q28235083 | ||
| Molecular evolution of the vertebrate troponin I gene family | Q28235725 | ||
| Troponin T isoform expression in humans. A comparison among normal and failing adult heart, fetal heart, and adult and fetal skeletal muscle | Q28240311 | ||
| To investigate protein evolution by detecting suppressed epitope structures | Q28241204 | ||
| Ca(2+)-regulated structural changes in troponin | Q28241337 | ||
| Long term ablation of protein kinase A (PKA)-mediated cardiac troponin I phosphorylation leads to excitation-contraction uncoupling and diastolic dysfunction in a knock-in mouse model of hypertrophic cardiomyopathy | Q28242903 | ||
| Calcium-regulated conformational change in the C-terminal end segment of troponin I and its binding to tropomyosin | Q28243781 | ||
| Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy | Q28244969 | ||
| Fast and slow skeletal troponin I in serum from patients with various skeletal muscle disorders: a pilot study | Q28245469 | ||
| A novel deletion in TNNI2 causes distal arthrogryposis in a large Chinese family with marked variability of expression | Q28248649 | ||
| Structure and expression of the human slow twitch skeletal muscle troponin I gene | Q28251386 | ||
| The molecular structures and expression patterns of zebrafish troponin I genes | Q28251951 | ||
| Cardiac troponin I as a prognostic factor in critically ill pneumonia patients in the absence of acute coronary syndrome | Q28254453 | ||
| The heart-specific NH2-terminal extension regulates the molecular conformation and function of cardiac troponin I | Q28254601 | ||
| S-glutathionylation of troponin I (fast) increases contractile apparatus Ca2+ sensitivity in fast-twitch muscle fibres of rats and humans | Q28257610 | ||
| A mutation in the fast skeletal muscle troponin I gene causes myopathy and distal arthrogryposis | Q28259210 | ||
| Spectrum and clinical manifestations of mutations in genes responsible for hypertrophic cardiomyopathy | Q28262963 | ||
| Mutations in Troponin that cause HCM, DCM AND RCM: what can we learn about thin filament function? | Q28264798 | ||
| Impaired diastolic function after exchange of endogenous troponin I with C-terminal truncated troponin I in human cardiac muscle | Q28267178 | ||
| Raised serum cardiac troponin I concentrations predict hospital mortality in intensive care unit patients | Q28267249 | ||
| Distinct sarcomeric substrates are responsible for protein kinase D-mediated regulation of cardiac myofilament Ca2+ sensitivity and cross-bridge cycling | Q28268017 | ||
| Troponin I gene expression during human cardiac development and in end-stage heart failure | Q28268307 | ||
| The C terminus of cardiac troponin I stabilizes the Ca2+-activated state of tropomyosin on actin filaments | Q28268783 | ||
| Troponin elevation in patients with heart failure: on behalf of the third Universal Definition of Myocardial Infarction Global Task Force: Heart Failure Section | Q28269814 | ||
| Isoform diversity, regulation, and functional adaptation of troponin and calponin | Q28270406 | ||
| AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes | Q34211072 | ||
| New concepts in diastolic dysfunction and diastolic heart failure: Part II: causal mechanisms and treatment | Q34577241 | ||
| Protein phosphorylation and signal transduction in cardiac thin filaments | Q34696197 | ||
| Distinct conformational and functional effects of two adjacent pathogenic mutations in cardiac troponin I at the interface with troponin T. | Q35075012 | ||
| Ablation of p21-activated kinase-1 in mice promotes isoproterenol-induced cardiac hypertrophy in association with activation of Erk1/2 and inhibition of protein phosphatase 2A | Q35529137 | ||
| Generation and functional characterization of knock-in mice harboring the cardiac troponin I-R21C mutation associated with hypertrophic cardiomyopathy | Q35694064 | ||
| Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic mice | Q36761860 | ||
| Slow skeletal troponin I gene transfer, expression, and myofilament incorporation enhances adult cardiac myocyte contractile function | Q36773429 | ||
| O-linked GlcNAc modification of cardiac myofilament proteins: a novel regulator of myocardial contractile function | Q37040657 | ||
| The unique functions of cardiac troponin I in the control of cardiac muscle contraction and relaxation | Q37045891 | ||
| Impaired relaxation is the main manifestation in transgenic mice expressing a restrictive cardiomyopathy mutation, R193H, in cardiac TnI. | Q37403663 | ||
| Acute effects of reactive oxygen and nitrogen species on the contractile function of skeletal muscle. | Q37805925 | ||
| Cardiac troponin I tyrosine 26 phosphorylation decreases myofilament Ca2+ sensitivity and accelerates deactivation. | Q42264504 | ||
| Thin filament disinhibition by restrictive cardiomyopathy mutant R193H troponin I induces Ca2+-independent mechanical tone and acute myocyte remodeling | Q42511843 | ||
| Functional effects of a restrictive-cardiomyopathy-linked cardiac troponin I mutation (R145W) in transgenic mice | Q42625188 | ||
| Changes in serum fast and slow skeletal troponin I concentration following maximal eccentric contractions | Q28271089 | ||
| Why does troponin I have so many phosphorylation sites? Fact and fancy | Q28274412 | ||
| Impact of Type 2 diabetes and aging on cardiomyocyte function and O-linked N-acetylglucosamine levels in the heart | Q28276371 | ||
| Troponin I switching in the developing heart | Q28279315 | ||
| Structural dynamics of troponin I during Ca2+-activation of cardiac thin filaments: a multi-site Förster resonance energy transfer study | Q28281188 | ||
| Expression of the fast twitch troponin complex, fTnT, fTnI and fTnC, in vascular smooth muscle | Q28283608 | ||
| Cardiac troponin-I is not expressed in fetal and healthy or diseased adult human skeletal muscle tissue | Q28284855 | ||
| Alternative RNA splicing-generated cardiac troponin T isoform switching: a non-heart-restricted genetic programming synchronized in developing cardiac and skeletal muscles | Q28288140 | ||
| Protein kinase D is a novel mediator of cardiac troponin I phosphorylation and regulates myofilament function | Q28290449 | ||
| Effects of acidosis on ventricular muscle from adult and neonatal rats | Q28291935 | ||
| Troponin T3 expression in skeletal and smooth muscle is required for growth and postnatal survival: characterization of Tnnt3(tm2a(KOMP)Wtsi) mice | Q28293004 | ||
| Troponin I degradation and covalent complex formation accompanies myocardial ischemia/reperfusion injury | Q28294888 | ||
| Removal of the N-terminal extension of cardiac troponin I as a functional compensation for impaired myocardial beta-adrenergic signaling | Q28295123 | ||
| Troponin T isoforms and posttranscriptional modifications: Evolution, regulation and function | Q28296309 | ||
| Proteolytic N-terminal truncation of cardiac troponin I enhances ventricular diastolic function | Q28299362 | ||
| A non-equilibrium isoelectric focusing method to determine states of phosphorylation of cardiac troponin I: identification of Ser-23 and Ser-24 as significant sites of phosphorylation by protein kinase C | Q28300371 | ||
| A preferred AMPK phosphorylation site adjacent to the inhibitory loop of cardiac and skeletal troponin I | Q28307636 | ||
| Ischemic dysfunction in transgenic mice expressing troponin I lacking protein kinase C phosphorylation sites | Q28505911 | ||
| Intracellular localization and functional effects of P21-activated kinase-1 (Pak1) in cardiac myocytes | Q28565246 | ||
| Differential contribution of troponin I phosphorylation sites to the endothelin-modulated contractile response | Q28569756 | ||
| Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs | Q28607749 | ||
| A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis | Q28910472 | ||
| Regulation of cardiac contractile function by troponin I phosphorylation | Q29028920 | ||
| The Genetic Basis for Cardiomyopathy | Q29300961 | ||
| Multiple Reaction Monitoring to Identify Site-Specific Troponin I Phosphorylated Residues in the Failing Human Heart | Q30049005 | ||
| Structure and developmental expression of troponin I isoforms. cDNA clone analysis of avian cardiac troponin I mRNA. | Q30374624 | ||
| Structure, evolution, and regulation of a fast skeletal muscle troponin I gene | Q30449683 | ||
| cDNA clone analysis of six co-regulated mRNAs encoding skeletal muscle contractile proteins | Q30450035 | ||
| Removal of the cardiac troponin I N-terminal extension improves cardiac function in aged mice | Q30475106 | ||
| Pathogenic peptide deviations support a model of adaptive evolution of chordate cardiac performance by troponin mutations. | Q30498065 | ||
| Correcting diastolic dysfunction by Ca2+ desensitizing troponin in a transgenic mouse model of restrictive cardiomyopathy | Q33573193 | ||
| Phosphorylation of cardiac troponin I at protein kinase C site threonine 144 depresses cooperative activation of thin filaments | Q33782408 | ||
| Combined troponin I Ser-150 and Ser-23/24 phosphorylation sustains thin filament Ca(2+) sensitivity and accelerates deactivation in an acidic environment. | Q33821210 | ||
| Mutual rescues between two dominant negative mutations in cardiac troponin I and cardiac troponin T | Q34107292 | ||
| PKA phosphorylation of cardiac troponin I modulates activation and relaxation kinetics of ventricular myofibrils | Q34144046 | ||
| P433 | issue | 1 Pt 3 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | protein evolution | Q59870539 |
| P304 | page(s) | 385-394 | |
| P179 | part of the series | Gene Wiki Review Series | Q108807010 |
| P577 | publication date | 2015-10-22 | |
| P1433 | published in | Gene | Q5531065 |
| P1476 | title | TNNI1, TNNI2 and TNNI3: Evolution, regulation, and protein structure-function relationships. | |
| P478 | volume | 576 |
| Q42174834 | Amino Acid Changes at Arginine 204 of Troponin I Result in Increased Calcium Sensitivity of Force Development |
| Q49271261 | Cardiac protein expression patterns are associated with distinct inborn exercise capacity in non-selectively bred rats |
| Q38403227 | Deep RNA sequencing of pectoralis muscle transcriptomes during late-term embryonic to neonatal development in indigenous Chinese duck breeds |
| Q42987220 | Deletion of Pofut1 in Mouse Skeletal Myofibers Induces Muscle Aging-Related Phenotypes in cis and in trans |
| Q91362486 | Dysregulation of lipid metabolism and appearance of slow myofiber-specific isoforms accompany the development of Wooden Breast myopathy in modern broiler chickens |
| Q89692126 | Effect of Grilled Nux Vomica on Differential RNA Expression Profile of Gastrocnemius Muscle and Toll‑Like Receptor 4 (TLR-4)/Nuclear Factor kappa B (NF-κB) Signaling in Experimental Autoimmune Myasthenia Gravis Rats |
| Q64966691 | Endurance training slows breast tumor growth in mice by suppressing Treg cells recruitment to tumors. |
| Q43278193 | Experimental preeclampsia in rats affects vascular gene expression patterns |
| Q90146045 | Isolation and characterization of three skeletal troponin genes and association with growth-related traits in Exopalaemon carinicauda |
| Q97523836 | RNA-Seq transcriptome reveals different molecular responses during human and mouse oocyte maturation and fertilization |
| Q46446019 | S-nitrosylation and S-glutathionylation of Cys134 on troponin I have opposing competitive actions on Ca2+ sensitivity in rat fast-twitch muscle fibers. |
| Q36689767 | Structural determinants of muscle thin filament cooperativity |
| Q90033635 | The evolutionarily conserved C-terminal peptide of troponin I is an independently configured regulatory structure to function as a myofilament Ca2+-desensitizer |
| Q91597359 | Thin filament dysfunctions caused by mutations in tropomyosin Tpm3.12 and Tpm1.1. |
| Q49376239 | Troponin through the looking-glass: emerging roles beyond regulation of striated muscle contraction |
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