| scholarly article | Q13442814 |
| P356 | DOI | 10.1074/JBC.M610157200 |
| P698 | PubMed publication ID | 17303574 |
| P50 | author | Lina M. Obeid | Q56565148 |
| P2093 | author name string | Jacek Bielawski | |
| Besim Ogretmen | |||
| Yusuf Baran | |||
| Ufuk Gunduz | |||
| Can E Senkal | |||
| Arelis Salas | |||
| P433 | issue | 15 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | myeloid leukemia | Q11688946 |
| apoptotic process | Q14599311 | ||
| ceramides | Q424213 | ||
| chronic myeloid leukemia | Q729735 | ||
| P304 | page(s) | 10922-10934 | |
| P577 | publication date | 2007-02-15 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells | |
| P478 | volume | 282 |
| Q35991845 | A comparative proteomic study identified LRPPRC and MCM7 as putative actors in imatinib mesylate cross-resistance in Lucena cell line. |
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| Q37444876 | Anti-tumor activity of Eurycoma longifolia root extracts against K-562 cell line: in vitro and in vivo study |
| Q36804936 | Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal |
| Q34736760 | Apoptotic sphingolipid ceramide in cancer therapy |
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| Q33539833 | Caffeic acid phenethyl ester triggers apoptosis through induction of loss of mitochondrial membrane potential in CCRF-CEM cells |
| Q34790629 | Cancer Treatment Strategies Targeting Sphingolipid Metabolism |
| Q33649252 | Celecoxib-mediated activation of endoplasmic reticulum stress induces de novo ceramide biosynthesis and apoptosis in hepatoma HepG2 cells mobilization. |
| Q90642065 | Ceramide Signaling and p53 Pathways |
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| Q24609859 | Ceramide synthases at the centre of sphingolipid metabolism and biology |
| Q38067062 | Ceramide-orchestrated signalling in cancer cells. |
| Q38133575 | Changes in molecular biology of chronic myeloid leukemia in tyrosine kinase inhibitor era. |
| Q36157057 | Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis |
| Q34949678 | Combined anticancer effects of sphingosine kinase inhibitors and sorafenib |
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| Q39054949 | Enhanced expression of transferrin receptor 1 contributes to oncogenic signalling by sphingosine kinase 1. |
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| Q38890714 | FTY720 enhances TRAIL-mediated apoptosis by up-regulating DR5 and down-regulating Mcl-1 in cancer cells |
| Q24650419 | FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells |
| Q37114962 | FTY720 inhibits tumor growth and enhances the tumor-suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathway |
| Q38289974 | Gene array analysis reveals a common Runx transcriptional programme controlling cell adhesion and survival |
| Q24613953 | IRF8 regulates acid ceramidase expression to mediate apoptosis and suppresses myelogeneous leukemia |
| Q39810675 | Imatinib induces apoptosis by inhibiting PDGF- but not insulin-induced PI 3-kinase/Akt survival signaling in RGC-5 retinal ganglion cells. |
| Q82596482 | Imatinib-induced apoptosis: a possible link to topoisomerase enzyme inhibition |
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| Q24633453 | Mammalian ceramide synthases |
| Q92646188 | MiR-659-3p regulates the progression of chronic myeloid leukemia by targeting SPHK1 |
| Q47142782 | Overexpression of ceramide synthase 1 increases C18-ceramide and leads to lethal autophagy in human glioma |
| Q36928954 | Phosphorylation of serine palmitoyltransferase long chain-1 (SPTLC1) on tyrosine 164 inhibits its activity and promotes cell survival. |
| Q37382152 | Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies |
| Q42460848 | Proteasome inhibitor bortezomib increases radiation sensitivity in androgen independent human prostate cancer cells |
| Q33649823 | Re-configuration of sphingolipid metabolism by oncogenic transformation |
| Q90244336 | Repression of sphingosine kinase (SK)-interacting protein (SKIP) in acute myeloid leukemia diminishes SK activity and its re-expression restores SK function |
| Q35653470 | Resveratrol induces apoptosis of leukemia cell line K562 by modulation of sphingosine kinase-1 pathway |
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| Q34879183 | Roles of sphingosine 1-phosphate on tumorigenesis |
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| Q89587308 | S1P Signaling in the Tumor Microenvironment |
| Q92914007 | SGPL1321 mutation: one main trigger for invasiveness of pediatric alveolar rhabdomyosarcoma |
| Q34345362 | Single-cell sphingosine kinase activity measurements in primary leukemia |
| Q35675184 | Sphingolipid signaling and hematopoietic malignancies: to the rheostat and beyond |
| Q37808219 | Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance |
| Q36744139 | Sphingomyelin synthase 1 activity is regulated by the BCR-ABL oncogene |
| Q34121255 | Sphingosine 1-phosphate and cancer |
| Q42593194 | Sphingosine 1-phosphate receptors and sphingosine kinase 1: novel biomarkers for clinical prognosis in breast, prostate, and hematological cancers |
| Q41531207 | Sphingosine Kinases and Sphingosine 1-Phosphate Receptors: Signaling and Actions in the Cardiovascular System |
| Q33727889 | Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitro |
| Q35794452 | Sphingosine kinase 1 as an anticancer therapeutic target |
| Q33853998 | Sphingosine kinase 1 in cancer |
| Q37697046 | Sphingosine kinase 1 is a potential therapeutic target for nasopharyngeal carcinoma. |
| Q50021960 | Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice |
| Q39880179 | Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation. |
| Q35037415 | Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A. |
| Q46653570 | Sphingosine kinase-1 is a downstream regulator of imatinib-induced apoptosis in chronic myeloid leukemia cells |
| Q85356970 | Sphingosine-1-phosphate and ceramide are associated with health and atresia of bovine ovarian antral follicles |
| Q37173184 | Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling |
| Q24321239 | Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing |
| Q39475165 | Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML. |
| Q97524749 | Targeting SphK2 Reverses Acquired Resistance of Regorafenib in Hepatocellular Carcinoma |
| Q50436260 | Targeting glucosylceramide synthase sensitizes imatinib-resistant chronic myeloid leukemia cells via endogenous ceramide accumulation |
| Q90651738 | Targeting sphingolipid metabolism as an approach for combination therapies in haematological malignancies |
| Q36011176 | Targeting sphingosine-1-phosphate in hematologic malignancies |
| Q37894772 | Targeting sphingosine-1-phosphate receptors in cancer |
| Q37122686 | Targeting survival pathways in chronic myeloid leukaemia stem cells |
| Q49913969 | The investigation of ceranib-2 on apoptosis and drug interaction with carboplatin in human non small cell lung cancer cells in vitro. |
| Q37760852 | The role of the ceramide acyl chain length in neurodegeneration: involvement of ceramide synthases |
| Q43094374 | The roles of bioactive sphingolipids in resveratrol-induced apoptosis in HL60: acute myeloid leukemia cells |
| Q38909416 | Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies. |
| Q90246225 | Unbiased Lipidomic Profiling of Triple-Negative Breast Cancer Tissues Reveals the Association of Sphingomyelin Levels with Patient Disease-Free Survival |
| Q37603503 | siRNA-mediated down-regulation of ceramide synthase 1 leads to apoptotic resistance in human head and neck squamous carcinoma cells after photodynamic therapy. |
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