Mutations of the PTPN11 gene in therapy-related MDS and AML with rare balanced chromosome translocations

scientific article published on 01 June 2007

Mutations of the PTPN11 gene in therapy-related MDS and AML with rare balanced chromosome translocations is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/GCC.20426
P698PubMed publication ID17330262

P2093author name stringMette K Andersen
Debes H Christiansen
Jens Pedersen-Bjergaard
Frehiwet Desta
P2860cites workMutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndromeQ24291893
Diversity and functional consequences of germline and somatic PTPN11 mutations in human diseaseQ24540529
Occurrence of myeloproliferative disorder in patients with Noonan syndromeQ33499657
Genetics of myeloid leukemiasQ34795893
Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cellsQ35847802
The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative diseaseQ35847884
Mutations of the PTPN11 and RAS genes in rhabdomyosarcoma and pediatric hematological malignanciesQ40308333
Hyperactivation of the RAS signaling pathway in myelodysplastic syndrome with AML1/RUNX1 point mutationsQ40318729
Mutations of AML1 are common in therapy-related myelodysplasia following therapy with alkylating agents and are significantly associated with deletion or loss of chromosome arm 7q and with subsequent leukemic transformationQ43824047
Cooperativity between mutations in tyrosine kinases and in hematopoietic transcription factors in AML.Q43963802
Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemiaQ44419404
Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesisQ44673842
Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemiaQ44775999
PTPN11 mutations in pediatric patients with acute myeloid leukemia: results from the Children's Cancer GroupQ45073102
Mutations of genes in the receptor tyrosine kinase (RTK)/RAS-BRAF signal transduction pathway in therapy-related myelodysplasia and acute myeloid leukemiaQ46799049
Cooperation of activating Ras/rtk signal transduction pathway mutations and inactivating myeloid differentiation gene mutations in M0 AML: a study of 45 patientsQ46902751
Noonan's syndrome in association with acute leukemia.Q52012543
Acute lymphoblastic leukemia in Noonan syndrome: report of two casesQ70772106
P433issue6
P304page(s)517-521
P577publication date2007-06-01
P1433published inGenes, Chromosomes and CancerQ5532697
P1476titleMutations of the PTPN11 gene in therapy-related MDS and AML with rare balanced chromosome translocations
P478volume46

Reverse relations

cites work (P2860)
Q38226741-7/7q- syndrome in myeloid-lineage hematopoietic malignancies: attempts to understand this complex disease entity
Q41814200Constitutive activation of SHP2 in mice cooperates with ICSBP deficiency to accelerate progression to acute myeloid leukemia
Q41809918Constitutive activation of SHP2 protein tyrosine phosphatase inhibits ICSBP-induced transcription of the gene encoding gp91PHOX during myeloid differentiation
Q24646924Constitutively active SHP2 cooperates with HoxA10 overexpression to induce acute myeloid leukemia
Q37058777Genetics of therapy-related myelodysplasia and acute myeloid leukemia
Q33377270Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes
Q37688148Mutation profiling of 19 candidate genes in acute myeloid leukemia suggests significance of DNMT3A mutations
Q41299821Mutational profiling of therapy-related myelodysplastic syndromes and acute myeloid leukemia by next generation sequencing, a comparison with de novo diseases
Q44257677NPM1 mutations in therapy-related acute myeloid leukemia with uncharacteristic features
Q44003077Novel oncogenic PTPN11 mutations in myelodysplastic syndrome in Korean patients
Q37865381Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.
Q35825659Shp2 function in hematopoietic stem cell biology and leukemogenesis
Q52870427Slower early response to treatment and distinct expression profile of childhood high hyperdiploid acute lymphoblastic leukaemia with DNA index < 1.16.
Q37009760Therapy-related myeloid leukemia.
Q38611096Therapy-related myeloid neoplasms: when genetics and environment collide
Q86506687[Clinical and cytogenetic study of chromosome 1 abnormality in myelodysplastic syndrome]

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