[Update on pathophysiologic and immunotherapeutic approaches for the treatment of multiple sclerosis]

scientific article published on 01 August 2007

[Update on pathophysiologic and immunotherapeutic approaches for the treatment of multiple sclerosis] is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1036147451
P356DOI10.1007/S00115-007-2261-9
P698PubMed publication ID17551708

P50authorSven G MeuthQ88461559
Heinz WiendlQ27583547
Christoph KleinschnitzQ67221107
P2093author name stringB C Kieseier
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Human nerve growth factor protects common marmosets against autoimmune encephalomyelitis by switching the balance of T helper cell type 1 and 2 cytokines within the central nervous systemQ28144436
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Sensory neuron-specific sodium channel SNS is abnormally expressed in the brains of mice with experimental allergic encephalomyelitis and humans with multiple sclerosisQ35325861
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Lessons learned from anti-CD40L treatment in systemic lupus erythematosus patientsQ35824531
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Na+ channel expression along axons in multiple sclerosis and its modelsQ35921669
New directions in MS therapeutics: vehicles of hopeQ35941887
Regulation of experimental autoimmune encephalomyelitis with insulin-like growth factor (IGF-1) and IGF-1/IGF-binding protein-3 complex (IGF-1/IGFBP3).Q37381231
A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitisQ37611832
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Functional Interactions of Neurotrophins and Neurotrophin ReceptorsQ40441056
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Human T cell autoimmunity against myelin basic protein: CD4+ cells recognizing epitopes of the T cell receptor beta chain from a myelin basic protein-specific T cell clone.Q41577458
A phase I trial of solubilized DR2:MBP84-102 (AG284) in multiple sclerosisQ41728578
Identification of Epstein-Barr virus proteins as putative targets of the immune response in multiple sclerosisQ41788436
Myeloablative and immunosuppressive properties of treosulfan in miceQ42168522
TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ TregsQ42181372
T cell vaccination in multiple sclerosis patients with autologous CSF-derived activated T cells: results from a pilot studyQ42692324
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Autologous hematopoietic stem cell transplantation suppresses Gd-enhanced MRI activity in MS.Q43668453
Multiple sclerosis: altered glutamate homeostasis in lesions correlates with oligodendrocyte and axonal damageQ43708042
Mycophenolate-mofetil in the treatment of refractory multiple sclerosis.Q43746298
Vaccination against experimental allergic encephalomyelitis with T cell receptor peptidesQ43794379
First human trial of FTY720, a novel immunomodulator, in stable renal transplant patientsQ43931513
The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune diseaseQ43934617
Targeting leukocyte MMPs and transmigration: minocycline as a potential therapy for multiple sclerosisQ44002202
The new orally active immunoregulator laquinimod (ABR-215062) effectively inhibits development and relapses of experimental autoimmune encephalomyelitisQ44133715
Statins as immunomodulators: comparison with interferon-beta 1b in MS.Q44172256
The effect of the neuroprotective agent riluzole on MRI parameters in primary progressive multiple sclerosis: a pilot studyQ44244034
Peroxisome proliferator-activated receptor gamma thiazolidinedione agonists increase glucose metabolism in astrocytesQ44251886
Matrix metalloproteinases in the normal human central nervous system, microglial nodules, and multiple sclerosis lesionsQ44310002
Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatmentQ44370378
Abnormal sodium channel distribution in optic nerve axons in a model of inflammatory demyelinationQ44477086
Cladribine in treatment of chronic progressive multiple sclerosisQ44496335
Cannabinoids inhibit neurodegeneration in models of multiple sclerosisQ44522438
Phenytoin protects spinal cord axons and preserves axonal conduction and neurological function in a model of neuroinflammation in vivoQ44540512
Action of treosulfan in myelin-oligodendrocyte-glycoprotein-induced experimental autoimmune encephalomyelitis and human lymphocytesQ44641631
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Circulating CD4+CD25+ T regulatory cells are not altered in multiple sclerosis and unaffected by disease-modulating drugsQ44801480
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Axonal protection using flecainide in experimental autoimmune encephalomyelitis.Q44880213
Minocycline reduces gadolinium-enhancing magnetic resonance imaging lesions in multiple sclerosis.Q44880234
Oral simvastatin treatment in relapsing-remitting multiple sclerosisQ44897670
Calcium channel blockers ameliorate disease in a mouse model of multiple sclerosisQ45008706
Modulation of effector cell functions in experimental autoimmune encephalomyelitis by leflunomide--mechanisms independent of pyrimidine depletionQ45029733
Sodium channels contribute to microglia/macrophage activation and function in EAE and MS.Q45076768
Autologous HSCT for severe progressive multiple sclerosis in a multicenter trial: impact on disease activity and quality of lifeQ45152665
The immunomodulator FTY720 interferes with effector functions of human monocyte-derived dendritic cells.Q45229482
Peroxisome proliferator-activated receptor-gamma agonists inhibit the activation of microglia and astrocytes: implications for multiple sclerosisQ45303266
Epstein-Barr virus and multiple sclerosis: evidence of association from a prospective study with long-term follow-upQ45417845
Intrathecal B-cell clonal expansion, an early sign of humoral immunity, in the cerebrospinal fluid of patients with clinically isolated syndrome suggestive of multiple sclerosisQ46266579
Lipoic acid in multiple sclerosis: a pilot studyQ46407394
Erythropoietin decreases cytotoxicity and nitric oxide formation induced by inflammatory stimuli in rat oligodendrocytesQ46460140
Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune interventionQ46499427
Erythropoietin: novel approaches to neuroprotection in human brain diseaseQ35956310
The promise of minocycline in neurology.Q35958974
Autologous haematopoietic-stem-cell transplantation for multiple sclerosisQ35994389
Other therapy options and future strategies for treating patients with multiple sclerosisQ35995796
Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organsQ36072414
Therapeutic strategies to prevent neurodegeneration and promote regeneration in multiple sclerosis.Q36074419
Therapeutic blockade of TCR signal transduction and co-stimulation in autoimmune diseaseQ36107645
Blocking adhesion molecules as therapy for multiple sclerosis: natalizumabQ36148448
The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanismsQ36205278
Therapeutic targeting of alpha 4-integrins in chronic inflammatory diseases: tipping the scales of risk towards benefit?Q36211855
Intense T cell depletion followed by autologous bone marrow transplantation for severe multiple sclerosisQ36226307
CTLA-4 is a second receptor for the B cell activation antigen B7Q36230356
Natalizumab for the treatment of multiple sclerosis and Crohn's diseaseQ36284072
Cladribine for multiple sclerosis: review and current statusQ36307847
Granulocyte colony-stimulating factor: a novel mediator of T cell toleranceQ36318980
Antigen-specific therapies in multiple sclerosis.Q36327373
Antigen-specific therapies in multiple sclerosis: going beyond proteins and peptidesQ36327377
Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reactionQ36368672
Promotion of remyelination by immunoglobulins: implications for the treatment of multiple sclerosisQ36384922
Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients.Q36402704
Lymphoid neogenesis in chronic inflammatory diseases.Q36405080
Multiple sclerosis--the plaque and its pathogenesisQ36410882
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The value of animal models for drug development in multiple sclerosis.Q36458937
T cell vaccination induces T cell receptor Vbeta-specific Qa-1-restricted regulatory CD8(+) T cellsQ36475992
Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitroQ37126896
Effective combination of minocycline and interferon-beta in a model of multiple sclerosisQ46548808
Graft-versus-host disease prevention by rapamycin: cellular mechanismsQ46600793
Proinflammatory stimulation and pioglitazone treatment regulate peroxisome proliferator-activated receptor gamma levels in peripheral blood mononuclear cells from healthy controls and multiple sclerosis patientsQ46740179
The effect of anti-alpha4 integrin antibody on brain lesion activity in MS. The UK Antegren Study GroupQ48135012
Phase I study of a humanized anti-CD11/CD18 monoclonal antibody in multiple sclerosisQ48383559
A controlled trial of natalizumab for relapsing multiple sclerosisQ48414534
Prevention of experimental autoimmune encephalomyelitis in common marmosets using an anti-IL-12p40 monoclonal antibodyQ48442189
Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitisQ48475566
Oral fumaric acid esters for the treatment of active multiple sclerosis: an open-label, baseline-controlled pilot studyQ48488976
A Phase II study of the safety and efficacy of teriflunomide in multiple sclerosis with relapsesQ48602930
Antibody-mediated suppression of Vbeta5.2/5.3(+) T cells in multiple sclerosis: results from an MRI-monitored phase II clinical trialQ48647481
MK-801 limits neurovascular dysfunction during experimental allergic encephalomyelitisQ48671716
Increased MRI activity and immune activation in two multiple sclerosis patients treated with the monoclonal anti-tumor necrosis factor antibody cA2.Q48851709
A phase II trial of anti-CD4 antibodies in the treatment of multiple sclerosis.Q48967659
Microglial expression of the B7 family member B7 homolog 1 confers strong immune inhibition: implications for immune responses and autoimmunity in the CNS.Q48974951
Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis.Q49014751
Double-Blind Pilot Trial of Oral Tolerization with Myelin Antigens in Multiple SclerosisQ50127386
T cell vaccination in multiple sclerosis relapsing-remitting nonresponders patients.Q50749623
Hormonal treatment with sex steroids in women is associated with lower p105 serum concentrations.Q50930145
Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis.Q51027456
The effect of cladribine on T(1) 'black hole' changes in progressive MS.Q53909697
Biological assessment and MRI monitoring of the therapeutic efficacy of a monoclonal anti-T CD4 antibody in multiple sclerosis patients.Q53991755
Beneficial effect of erythropoietin on experimental allergic encephalomyelitis.Q54128490
Immunity to TCR peptides in multiple sclerosis. I. Successful immunization of patients with synthetic V beta 5.2 and V beta 6.1 CDR2 peptides.Q54481809
The gelatinase inhibitory activity of tetracyclines and chemically modified tetracycline analogues as measured by a novel microtiter assay for inhibitors.Q54585384
Induction of granulocyte colony-stimulating factor mRNA by focal cerebral ischemia and cortical spreading depression.Q54694225
Natalizumab effects on immune cell responses in multiple sclerosisQ57041915
Do myelin-directed antibodies predict multiple sclerosis?Q57042143
Modified anti-CD3 therapy in psoriatic arthritis: a phase I/II clinical trialQ57101760
Mechanisms of axonal dysfunction after spinal cord injury: with an emphasis on the role of voltage-gated potassium channelsQ57839822
Cladribine and progressive MS: Clinical and MRI outcomes of a multicenter controlled trialQ57911989
Induction of a non-encephalitogenic type 2 T helper-cell autoimmune responsein multiple sclerosis after administration of an altered peptide ligand ina placebo-controlled, randomized phase II trialQ57911995
Cytokine production and surface marker expression in acute and stable multiple sclerosis: altered IL-12 production and augmented signaling lymphocytic activation molecule (SLAM)-expressing lymphocytes in acute multiple sclerosisQ57997698
Anti-myelin antibodies do not allow earlier diagnosis of multiple sclerosisQ59273850
Glutamate excitotoxicity in a model of multiple sclerosisQ60450917
Relation between humoral pathological changes in multiple sclerosis and response to therapeutic plasma exchangeQ61709608
Selective and antigen-dependent effects of myelin degeneration on central nervous system inflammationQ61709613
Multiple sclerosis: trapped in deadly glueQ61853106
P433issue8
P921main subjectimmunotherapyQ1427096
multiple sclerosisQ8277
P304page(s)883-911
P577publication date2007-08-01
P1433published inDer NervenarztQ15446312
P1476title[Update on pathophysiologic and immunotherapeutic approaches for the treatment of multiple sclerosis]
P478volume78

Reverse relations

Q51958899[Targeting B cells in multiple sclerosis. Current concepts and strategies].cites workP2860

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