| scholarly article | Q13442814 |
| P356 | DOI | 10.1038/NI1120 |
| P698 | PubMed publication ID | 15378058 |
| P50 | author | Harald von Boehmer | Q98245 |
| P2093 | author name string | Elmar Jaeckel | |
| Myra A Lipes | |||
| P2860 | cites work | Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. | Q55066037 |
| Insulin treatment prevents diabetes mellitus but not thyroiditis in RT6-depleted diabetes resistant BB/Wor rats | Q67931241 | ||
| Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy | Q68527380 | ||
| Insulin Antibodies in Insulin-Dependent Diabetics Before Insulin Treatment | Q70311233 | ||
| Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies | Q71150178 | ||
| Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice | Q71909256 | ||
| A cassette vector for high-level reporter expression driven by a hybrid invariant chain promoter in transgenic mice | Q73103595 | ||
| Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide | Q73688337 | ||
| Origin of regulatory T cells with known specificity for antigen | Q74381747 | ||
| Plasmid vaccination with insulin B chain prevents autoimmune diabetes in nonobese diabetic mice | Q74388336 | ||
| Evidence that a peptide spanning the B-C junction of proinsulin is an early Autoantigen epitope in the pathogenesis of type 1 diabetes | Q74844394 | ||
| Expression of preproinsulin-2 gene shapes the immune response to preproinsulin in normal mice | Q75197362 | ||
| Control of autoimmune diabetes in NOD mice by GAD expression or suppression in beta cells | Q77744347 | ||
| Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes | Q78014697 | ||
| Projection of an immunological self shadow within the thymus by the aire protein | Q28207164 | ||
| T cell response to preproinsulin I and II in the nonobese diabetic mouse | Q30844663 | ||
| Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23) | Q33592891 | ||
| Engineering an intracellular pathway for major histocompatibility complex class II presentation of antigens | Q33714644 | ||
| DNA immunization to prevent autoimmune diabetes | Q33855482 | ||
| Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription | Q34201095 | ||
| International Workshop on Lessons From Animal Models for Human Type 1 Diabetes: identification of insulin but not glutamic acid decarboxylase or IA-2 as specific autoantigens of humoral autoimmunity in nonobese diabetic mice. | Q34419345 | ||
| Insulin-specific tolerance in diabetes | Q34487093 | ||
| In vivo instruction of suppressor commitment in naive T cells | Q34548023 | ||
| Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice | Q34968027 | ||
| Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes | Q34984972 | ||
| In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro | Q35171080 | ||
| Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health | Q35632007 | ||
| Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse | Q35918236 | ||
| T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice | Q36356330 | ||
| Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase | Q36370946 | ||
| CD4(+) T cells from glutamic acid decarboxylase (GAD)65-specific T cell receptor transgenic mice are not diabetogenic and can delay diabetes transfer | Q36376604 | ||
| In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes | Q36399048 | ||
| CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. | Q36399104 | ||
| Interleukin 10 secretion and impaired effector function of major histocompatibility complex class II-restricted T cells anergized in vivo | Q36400127 | ||
| Analysis of the spontaneous T cell response to insulin in NOD mice | Q36719300 | ||
| Insulin-specific T cells are a predominant component of islet infiltrates in pre-diabetic NOD mice | Q36736666 | ||
| Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes | Q37114100 | ||
| Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin | Q37622936 | ||
| T cell autoreactivity to proinsulin epitopes in diabetic patients and healthy subjects | Q40953888 | ||
| Type I diabetes in NOD mice is not associated with insulin-specific, autoreactive T cells | Q41295861 | ||
| Effects of insulin in relatives of patients with type 1 diabetes mellitus | Q44010590 | ||
| Renaturation of human proinsulin--a study on refolding and conversion to insulin | Q44210612 | ||
| Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes | Q46512140 | ||
| The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. | Q52196097 | ||
| Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. | Q52196099 | ||
| P433 | issue | 10 | |
| P921 | main subject | type-1 diabetes | Q124407 |
| P304 | page(s) | 1028-1035 | |
| P577 | publication date | 2004-09-19 | |
| P1433 | published in | Nature Immunology | Q1071725 |
| P1476 | title | Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes | |
| P478 | volume | 5 |
| Q37163535 | Activation of insulin-reactive CD8 T-cells for development of autoimmune diabetes |
| Q36515711 | Adaptive evolution of the insulin two-gene system in mouse |
| Q36448384 | An HLA-Transgenic Mouse Model of Type 1 Diabetes That Incorporates the Reduced but Not Abolished Thymic Insulin Expression Seen in Patients. |
| Q42825394 | An immunologic homunculus for type 1 diabetes. |
| Q35248766 | Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chains |
| Q34113929 | Autoantigens plus interleukin-10 suppress diabetes autoimmunity |
| Q37358987 | Autoimmune diabetes mellitus--much progress, but many challenges |
| Q33750667 | Banting Lecture 2009: An unfinished journey: molecular pathogenesis to prevention of type 1A diabetes |
| Q36155053 | Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells. |
| Q37358997 | CD8+ T cells in type 1 diabetes |
| Q35225450 | Cardiac autoimmunity as a novel biomarker, mediator, and therapeutic target of heart disease in type 1 diabetes |
| Q84483323 | Central tolerance: essential for preventing autoimmune disease? |
| Q37657051 | Checkpoints in lymphocyte development and autoimmune disease |
| Q36766623 | Conserved T cell receptor alpha-chain induces insulin autoantibodies |
| Q64114479 | Determining Antigen Specificity of Human Islet Infiltrating T Cells in Type 1 Diabetes |
| Q92249441 | Development and Characterization of a Preclinical Model for the Evaluation of CD205-Mediated Antigen Delivery Therapeutics in Type 1 Diabetes |
| Q48186081 | Ectopic Expression of Self-Antigen Drives Regulatory T Cell Development and Not Deletion of Autoimmune T Cells |
| Q59060541 | Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope |
| Q33949282 | Extra-thymically induced regulatory T cells: do they have potential in disease prevention? |
| Q80395683 | Foxp3-expressing CD4(+)T cells under the control of INF-gamma promoter prevent diabetes in NOD mice |
| Q35857717 | Germline TRAV5D-4 T-cell receptor sequence targets a primary insulin peptide of NOD mice |
| Q54249678 | Immunology: insulin trigger for diabetes. |
| Q27025619 | Immunotherapy in autoimmune type 1 diabetes |
| Q34755279 | Impaired thymic tolerance to α-myosin directs autoimmunity to the heart in mice and humans |
| Q41952223 | Insufficient autoantigen presentation and failure of tolerance in a mouse model of rheumatoid arthritis |
| Q33712227 | Insulin as a key autoantigen in the development of type 1 diabetes |
| Q36499414 | Insulin as an autoantigen in NOD/human diabetes |
| Q43061716 | Insulin: a critical autoantigen and potential therapeutic agent in Type 1 diabetes |
| Q45048293 | Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes |
| Q37150497 | Modulating the natural history of type 1 diabetes in children at high genetic risk by mucosal insulin immunization |
| Q84385632 | Mouse thymic epithelial cell lines expressing "Aire" and peripheral tissue-specific antigens reproduce in vitro negative selection of T cells |
| Q37954236 | Multiple antigens versus single major antigen in type 1 diabetes: arguing for multiple antigens |
| Q33990970 | Murine high specificity/sensitivity competitive europium insulin autoantibody assay |
| Q29393228 | Opinion: Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes |
| Q37246540 | Pathogenic CD4⁺ T cells recognizing an unstable peptide of insulin are directly recruited into islets bypassing local lymph nodes. |
| Q37088180 | Pathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease |
| Q37277296 | Perinatal tolerance to proinsulin is sufficient to prevent autoimmune diabetes |
| Q81306346 | Positive and negative selection in Basel |
| Q34718795 | Prevention of "Humanized" diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach |
| Q33937758 | Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope |
| Q34345367 | Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice |
| Q35865376 | Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity |
| Q37643235 | Proinsulin Expression Shapes the TCR Repertoire but Fails to Control the Development of Low-Avidity Insulin-Reactive CD8+ T Cells. |
| Q35669113 | Register shifting of an insulin peptide-MHC complex allows diabetogenic T cells to escape thymic deletion |
| Q35191064 | Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP. |
| Q52715431 | Revealing the specificity of regulatory T cells in murine autoimmune diabetes. |
| Q34629092 | Suppression of dendritic cell activation by diabetes autoantigens linked to the cholera toxin B subunit. |
| Q37150506 | T cells in the pathogenesis of type 1 diabetes |
| Q37758077 | The anti-insulin trimolecular complex in type 1 diabetes. |
| Q33986306 | The central role of antigen presentation in islets of Langerhans in autoimmune diabetes |
| Q37811888 | The role of AIRE in human autoimmune disease |
| Q37078234 | The role of islet antigen presenting cells and the presentation of insulin in the initiation of autoimmune diabetes in the NOD mouse |
| Q36885374 | The vicious cycle of apoptotic beta-cell death in type 1 diabetes |
| Q34527281 | Therapeutic opportunities for manipulating T(Reg) cells in autoimmunity and cancer |
| Q34876029 | Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice |
| Q90498144 | Tissue-specific autoimmunity controlled by Aire in thymic and peripheral tolerance mechanisms |
| Q36836700 | Tolerance to MHC class II disparate allografts through genetic modification of bone marrow |
| Q34327132 | Treg vaccination with a strong-agonistic insulin mimetope |
| Q35956678 | Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice. |
| Q28287737 | Type 1 diabetes: translating mechanistic observations into effective clinical outcomes |
| Q84943150 | Unconventional recognition of peptides by T cells and the implications for autoimmunity |
| Q49269317 | Understanding Autoimmune Diabetes through the Prism of the Tri-Molecular Complex |
| Q34831727 | Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes |
| Q36756575 | Weak proinsulin peptide-major histocompatibility complexes are targeted in autoimmune diabetes in mice |
| Q34227916 | ZnT8-reactive T cells are weakly pathogenic in NOD mice but can participate in diabetes under inflammatory conditions |
| Q36176908 | miRNA92a targets KLF2 and the phosphatase PTEN signaling to promote human T follicular helper precursors in T1D islet autoimmunity |
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