Identification of T-cell epitopes on U1A protein in MRL/lpr mice: double-negative T cells are the major responsive cells

scientific article published on 01 June 2005

Identification of T-cell epitopes on U1A protein in MRL/lpr mice: double-negative T cells are the major responsive cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1365-2567.2005.02139.X
P698PubMed publication ID15885135

P50authorBor-Luen ChiangQ56550156
Jau-Ling SuenQ59677295
P2093author name stringMei-Hui Yang
Shiao-Lan Li
P2860cites workThe 1982 revised criteria for the classification of systemic lupus erythematosusQ29547225
Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factorQ29619247
Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative diseaseQ34602392
Expansion of cytokine-producing CD4-CD8- T cells associated with abnormal Fas expression and hypereosinophilia.Q36365810
Lack of coreceptor allows survival of chronically stimulated double-negative alpha/beta T cells: implications for autoimmunityQ36368991
Human T-cell receptor (TCR) alpha/beta + CD4-CD8- T cells express oligoclonal TCRs, share junctional motifs across TCR V beta-gene families, and phenotypically resemble memory T cellsQ36726518
Role of intermolecular/intrastructural B- and T-cell determinants in the diversification of autoantibodies to ribonucleoprotein particlesQ36738984
Structural availability influences the capacity of autoantigenic epitopes to induce a widespread lupus-like autoimmune responseQ37074182
Autoantibodies to Nuclear Antigens (ANA): Their Immunobiology and MedicineQ40104710
Human lupus anti-spliceosome A protein autoantibodies bind contiguous surface structures and segregate into two sequential epitope binding patterns.Q42629300
The immune regulatory function of lymphoproliferative double negative T cells in vitro and in vivo.Q42944882
Characterization of CD3+ CD4- CD8- (double negative) T cells in patients with systemic lupus erythematosus: production of IL-4.Q44400621
Infectious Th1 and Th2 autoimmunity in diabetes-prone mice.Q45983475
Enhanced lymphoproliferation and diminished autoimmunity in CD4-deficient MRL/lpr mice.Q46022334
Reciprocal T-B determinant spreading develops spontaneously in murine lupus: implications for pathogenesisQ46066992
Characterization of self-T-cell response and antigenic determinants of U1A protein with bone marrow-derived dendritic cells in NZB x NZW F1 mice.Q49213049
Pattern of anti-small nuclear ribonucleoprotein antibodies in MRL/Mp-lpr/lpr mice suggests that the intact U1 snRNP particle is their autoimmunogenic target.Q53855301
Diversification of response to hsp65 during the course of autoimmune arthritis is regulatory rather than pathogenic.Q54119203
Characterization of CD3+ CD4- CD8- (double negative) T cells in patients with systemic lupus erythematosus: activation markersQ56904721
Autoantibodies to the URNP particles: relationship to clinical diagnosis and nephritisQ67897606
Evidence for in vivo clonal proliferation of unique population of blood CD4-/CD8- T cells bearing T-cell receptor alpha and beta chains in two normal menQ68126483
In vivo CD4+ lymph node T cells from lpr mice generate CD4-CD8-B220+TCR-beta low cellsQ71651086
Do B cells drive the diversification of immune responses?Q72219989
Establishment and characterization of cloned CD4- CD8- alphabeta-T cell receptor (TCR)-bearing autoreactive T cells from autoimmune NZB x NZW F1 miceQ73211891
The primary site of CD4- 8- B220+ alphabeta T cells in lpr mice: the appendix in normal miceQ74336491
Double-negative (CD4-CD8-) TCRalphabeta+ cells in patients with systemic lupus erythematosusQ74510647
The functional significance of epitope spreading and its regulation by co-stimulatory moleculesQ77488334
Peripheral blood lymphocytes in SLE--hyperexpression of CD154 on T and B lymphocytes and increased number of double negative T cellsQ77514534
Development of Autoantibodies before the Clinical Onset of Systemic Lupus ErythematosusQ79171865
P433issue2
P304page(s)279-286
P577publication date2005-06-01
P1433published inImmunologyQ15754984
P1476titleIdentification of T-cell epitopes on U1A protein in MRL/lpr mice: double-negative T cells are the major responsive cells
P478volume115

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cites work (P2860)
Q36401949Importance of spliceosomal RNP1 motif for intermolecular T-B cell spreading and tolerance restoration in lupus
Q34779998The U1-snRNP complex: structural properties relating to autoimmune pathogenesis in rheumatic diseases

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