Structural analysis of protein kinase A mutants with Rho-kinase inhibitor specificity

scientific article published on 12 May 2006

Structural analysis of protein kinase A mutants with Rho-kinase inhibitor specificity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M512374200
P698PubMed publication ID16699172

P50authorStefan BonnQ47152931
P2093author name stringChristine B Breitenlechner
Dirk Bossemeyer
Michael Gassel
Richard A Engh
Saturnino Herrero
Andrea Erlbruch
Wolf Lehmann
P2860cites workRocks: multifunctional kinases in cell behaviourQ24303641
The protein kinase complement of the human genomeQ24324497
Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT)Q27641426
Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivityQ27642704
Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivityQ27733449
Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potentialQ27748804
The protein kinase family: conserved features and deduced phylogeny of the catalytic domainsQ27860528
Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reactionQ27860958
Regulation and functions of Rho-associated kinaseQ28138022
The structure of dimeric ROCK I reveals the mechanism for ligand selectivityQ28279001
Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)Q28609825
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertensionQ29614247
Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signalingQ29617453
Creation and characterization of a new, non-redundant fragment data bankQ30428274
H-series protein kinase inhibitors and potential clinical applicationsQ33716082
Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cellsQ34133985
The protein kinase C inhibitor bisindolyl maleimide 2 binds with reversed orientations to different conformations of protein kinase A.Q34302668
The phosphorylation of proteins: a major mechanism for biological regulation. Fourteenth Sir Frederick Gowland Hopkins memorial lectureQ34564853
K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinasesQ34684562
The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathwayQ34792910
Rho/Rho-kinase mediated signaling in physiology and pathophysiologyQ34978269
Protein kinase inhibitors: insights into drug design from structure.Q35697409
Erlotinib in the treatment of non-small cell lung cancerQ36284485
The Albert Lasker Medical Awards. Role of the cyclic AMP-dependent protein kinase in signal transductionQ38288479
The molecular genetics of cancerQ39753201
Structural bioinformatics-based design of selective, irreversible kinase inhibitorsQ40307105
Characterization and purification of truncated human Rho-kinase II expressed in Sf-21 cellsQ40710968
Inhibition of rho-kinase-induced myristoylated alanine-rich C kinase substrate (MARCKS) phosphorylation in human neuronal cells by H-1152, a novel and specific Rho-kinase inhibitor.Q40724768
Properties and use of H-series compounds as protein kinase inhibitorsQ41913354
Anti-anginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: a multicenter studyQ44200627
Essential role of rho kinase in the Ca2+ sensitization of prostaglandin F(2alpha)-induced contraction of rabbit aortaeQ44300294
Identification of electrostatic interactions that determine the phosphorylation site specificity of the cAMP-dependent protein kinaseQ44364227
Structure-based optimization of novel azepane derivatives as PKB inhibitorsQ44784861
Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutantsQ45212813
Non-proline cis peptide bonds in proteins.Q52225116
Adenosine cyclic 3',5'-monophosphate dependent protein kinase: kinetic mechanism for the bovine skeletal muscle catalytic subunitQ67253716
Signal transduction and growth control in normal and cancer cellsQ72455779
Purification and in vitro activity of Rho-associated kinaseQ73089650
P433issue34
P407language of work or nameEnglishQ1860
P304page(s)24818-24830
P577publication date2006-05-12
P1433published inJournal of Biological ChemistryQ867727
P1476titleStructural analysis of protein kinase A mutants with Rho-kinase inhibitor specificity
P478volume281

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cites work (P2860)
Q46642481A molecular mechanism of P-loop pliability of Rho-kinase investigated by molecular dynamic simulation
Q38552068Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases
Q93137403Cushing's syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity
Q46273820Design and synthesis of potent and selective azaindole-based Rho kinase (ROCK) inhibitors
Q91198095Diamondoid Amino Acid-Based Peptide Kinase A Inhibitor Analogues
Q27667904Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors
Q30363018Outliers in SAR and QSAR: 2. Is a flexible binding site a possible source of outliers?
Q47675076PAK4 crystal structures suggest unusual kinase conformational movements
Q33387038Prediction of specificity-determining residues for small-molecule kinase inhibitors
Q37139305Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease
Q27680079The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design

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