Pharmacogenetic screening for polymorphisms in drug-metabolizing enzymes and drug transporters in a Dutch population

scientific article published on 01 January 2006

Pharmacogenetic screening for polymorphisms in drug-metabolizing enzymes and drug transporters in a Dutch population is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1001679241
P356DOI10.1007/BF03256456
P2888exact matchhttps://scigraph.springernature.com/pub.10.1007/bf03256456
P698PubMed publication ID16771603

P50authorJos BeijnenQ23771643
P2093author name stringJ H M Schellens
I Meijerman
P H M Smits
V D Doodeman
T M Bosch
P2860cites workGenomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndromeQ24540140
UGT1A1 gene variations and irinotecan treatment in patients with metastatic colorectal cancerQ24648015
Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism?Q24670527
Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjectsQ28206464
Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndromeQ28209501
Mutations in the canilicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndromeQ28258556
Rapid and simple method for purification of nucleic acidsQ29615124
Genetic variability in CYP3A5 and its possible consequences.Q30341330
Polymorphisms in the ABCC2 (cMOAT/MRP2) gene found in 72 established cell lines derived from Japanese individuals: an association between single nucleotide polymorphisms in the 5'-untranslated region and exon 28.Q31043181
Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data.Q32072529
Multidrug resistance-associated protein subfamily transporters and drug resistanceQ33686909
A systematic review of genetic polymorphisms and breast cancer risk.Q33766628
Genetic polymorphism of CYP genes, alone or in combination, as a risk modifier of tobacco-related cancers.Q33833585
ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2.Q33938893
Polymorphisms of UDP-glucuronosyltransferase gene and irinotecan toxicity: a pharmacogenetic analysis.Q34130450
Genotyping of cytochrome P450 2D6*3 and *4 mutations using conventional PCR.Q34285997
The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphismQ34735686
Genetic polymorphisms of the human MDR1 drug transporterQ34931160
Pharmacogenetics of the major polymorphic metabolizing enzymes.Q35067187
Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivoQ35113118
Variations of the bilirubin uridine-diphosphoglucuronosyl transferase 1A1 gene in healthy TaiwaneseQ74278947
Susceptibility to childhood acute lymphoblastic leukemia: influence of CYP1A1, CYP2D6, GSTM1, and GSTT1 genetic polymorphismsQ74462951
Distinct haplotype profiles and strong linkage disequilibrium at the MDR1 multidrug transporter gene locus in three ethnic Asian populationsQ74598011
MDR1 genotype-related pharmacokinetics of digoxin after single oral administration in healthy Japanese subjectsQ77133730
CYP3A5 variant allele frequencies in Dutch CaucasiansQ77221613
Mutation analysis of the human CYP3A4 gene 5' regulatory region: population screening using non-radioactive SSCPQ77758106
Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphismQ77788818
UDP-glucuronosyltransferase (UGT1A1*28 and UGT1A6*2) polymorphisms in Caucasians and Asians: relationships to serum bilirubin concentrationsQ78201971
Dihydropyrimidine dehydrogenase and the efficacy and toxicity of 5-fluorouracilQ35749424
Relationship between proguanil metabolic ratio and CYP2C19 genotype in a Caucasian populationQ35802629
MDR1 genotypes do not influence the absorption of a single oral dose of 1 mg digoxin in healthy white malesQ35804210
Genetic polymorphism of cytochrome P450 2C9 in a Caucasian and a black African population.Q36054252
CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activityQ38315596
Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecanQ38347530
Homozygous mutation Arg768Trp in the ABC-transporter encoding gene MRP2/cMOAT/ABCC2 causes Dubin-Johnson syndrome in a Caucasian patientQ38351098
Profound dihydropyrimidine dehydrogenase deficiency resulting from a novel compound heterozygote genotype.Q38457450
Allele and genotype frequencies of CYP2C9, CYP2C19 and CYP2D6 in an Italian population.Q40506352
Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14+1G>A mutation causing DPD deficiency.Q43606229
No influence of the MDR-1 C3435T polymorphism or a CYP3A4 promoter polymorphism (CYP3A4-V allele) on dose-adjusted cyclosporin A trough concentrations or rejection incidence in stable renal transplant recipientsQ43618856
Identification and functional characterization of eight CYP3A4 protein variantsQ43686375
Frequency of C3435T polymorphism of MDR1 gene in African peopleQ43705274
Identification of functionally variant MDR1 alleles among European Americans and African AmericansQ43705904
Genetic polymorphism of CYP1A1, GSTM1 and GSTT1 genes in Indian oral cancerQ43743146
Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos.Q43803779
CYP3A4 variant alleles in white individuals with low CYP3A4 enzyme activityQ43926477
I105V polymorphism and promoter methylation of the GSTP1 gene in prostate adenocarcinomaQ43993684
Analysis of GSTP1-1 polymorphism using real-time polymerase chain reactionQ44317905
Genetic findings and functional studies of human CYP3A5 single nucleotide polymorphisms in different ethnic groupsQ44534413
CYP3A5 and MDR1 genetic polymorphisms and cyclosporine pharmacokinetics after renal transplantationQ44872808
An MDR1-3435 variant is associated with higher plasma nelfinavir levels and more rapid virologic response in HIV-1 infected childrenQ45305768
Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populationsQ46141212
Characterization of an allelic variant in the nifedipine-specific element of CYP3A4: ethnic distribution and implications for prostate cancer risk. Mutations in brief no. 191. OnlineQ46164950
A mutation in the drug transporter gene ABCC2 associated with impaired methotrexate eliminationQ46466430
Genomic evidence for recent positive selection at the human MDR1 gene locusQ46509410
Single nucleotide polymorphisms of ABCB1 (MDR1) gene and distinct haplotype profile in a West Black African populationQ46681441
Metabolic gene polymorphism frequencies in control populationsQ46857953
Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population.Q47296992
Frequencies of UDP-glucuronosyltransferase 1 (UGT1A1) gene promoter polymorphisms among distinct ethnic groups from BrazilQ47582860
Polymorphisms of drug-metabolizing enzymes CYP2C9, CYP2C19, CYP2D6, CYP1A1, NAT2 and of P-glycoprotein in a Russian population.Q47738894
Polymorphism in the P-glycoprotein drug transporter MDR1 gene: a possible link between environmental and genetic factors in Parkinson's diseaseQ48320745
Expression polymorphism of the blood-brain barrier component P-glycoprotein (MDR1) in relation to Parkinson's disease.Q48476423
A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility.Q50995791
Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects.Q52965959
Influence of functional polymorphisms of the MDR1 gene on vincristine pharmacokinetics in childhood acute lymphoblastic leukemia.Q54701330
Validation of methods for CYP2C9 genotyping: frequencies of mutant alleles in a Swedish population.Q64923947
Genetic tests which identify the principal defects in CYP2C19 responsible for the polymorphism in mephenytoin metabolismQ71497765
Population distribution and effects on drug metabolism of a genetic variant in the 5' promoter region of CYP3A4Q73052606
CYP3A4-V polymorphism detection by PCR-restriction fragment length polymorphism analysis and its allelic frequency among 199 Dutch CaucasiansQ73162883
Allelic, genotypic and phenotypic distributions of S-mephenytoin 4'-hydroxylase (CYP2C19) in healthy Caucasian populations of European descent throughout the worldQ73257076
Influence of GSTM1, GSTT1, GSTP1, and EPHX gene polymorphisms on DNA adduct level and HPRT mutant frequency in coke-oven workersQ73355668
Clinical implications of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: identification of new mutations in the DPD geneQ73393155
Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) geneQ73740950
Known variant DPYD alleles do not explain DPD deficiency in cancer patientsQ73769582
The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cellsQ74127572
P433issue3
P304page(s)175-185
P577publication date2006-01-01
P1433published inMolecular Diagnosis and TherapyQ15758832
P1476titlePharmacogenetic screening for polymorphisms in drug-metabolizing enzymes and drug transporters in a Dutch population
P478volume10

Reverse relations

cites work (P2860)
Q35062331ABCB1 genotypes and haplotypes in patients with dementia and age-matched non-demented control patients
Q50758475An iterative searching and ranking algorithm for prioritising pharmacogenomics genes.
Q37345974Can UGT1A1 genotyping reduce morbidity and mortality in patients with metastatic colorectal cancer treated with irinotecan? An evidence-based review
Q30939373Characterisation of CYP2C8, CYP2C9 and CYP2C19 polymorphisms in a Ghanaian population
Q37818297Finasteride metabolism and pharmacogenetics: new approaches to personalized prevention of prostate cancer.
Q33632608Genetic polymorphisms in MDR1, CYP3A4 and CYP3A5 genes in a Ghanaian population: a plausible explanation for altered metabolism of ivermectin in humans?
Q80068795Rapid detection of the DPYD IVS14+1G>A mutation for screening patients to prevent fluorouracil-related toxicity

Search more.