The role of fluorine atoms in a fluorinated prostaglandin agonist

scientific article published on 01 August 2010

The role of fluorine atoms in a fluorinated prostaglandin agonist is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/CMDC.201000174
P698PubMed publication ID20486154

P2093author name stringYoshimasa Sasabuchi
Ken-ichi Fujimura
P2860cites workIdentification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptorQ24529849
Preparation, characterization, and the crystal structure of the inhibitor ZK-807834 (CI-1031) complexed with factor XaQ27627425
Functional role of internal water molecules in rhodopsin revealed by X-ray crystallography.Q27638895
3,5,6-Trisubstituted naphthostyrils as CDK2 inhibitorsQ27641653
Fluorine in pharmaceuticals: looking beyond intuitionQ27648640
The Amber biomolecular simulation programsQ27860745
AL-3138 antagonizes FP prostanoid receptor-mediated inositol phosphates generation: comparison with some purported FP antagonistsQ31986643
Pharmacological characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drugQ33200005
The role of fluorine in medicinal chemistryQ34717922
The many roles for fluorine in medicinal chemistryQ34788078
Discovery of 13-oxa prostaglandin analogs as antiglaucoma agents: synthesis and biological activityQ34909253
The polar hydrophobicity of fluorinated compounds.Q35762540
Orthogonal multipolar interactions in structural chemistry and biologyQ36038598
New fluoroprostaglandin F(2alpha) derivatives with prostanoid FP-receptor agonistic activity as potent ocular-hypotensive agentsQ40545784
Prediction of the 3D structure and dynamics of human DP G-protein coupled receptor bound to an agonist and an antagonistQ41853393
Fluorine interactions at the thrombin active site: protein backbone fragments H-C(alpha)-C=O comprise a favorable C-F environment and interactions of C-F with electrophilesQ44880159
15-Fluoro prostaglandin FP agonists: a new class of topical ocular hypotensivesQ44928725
General atomic and molecular electronic structure systemQ56017006
Synthetic modification of prostaglandin f(2alpha) indicates different structural determinants for binding to the prostaglandin F receptor versus the prostaglandin transporterQ73229804
Pair interaction energy decomposition analysisQ79364310
Fluorine in medicinal chemistryQ80497522
Fluorine bonding--how does it work in protein-ligand interactions?Q84594961
P433issue8
P304page(s)1254-1257
P577publication date2010-08-01
P1433published inChemMedChemQ2962252
P1476titleThe role of fluorine atoms in a fluorinated prostaglandin agonist
P478volume5

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cites work (P2860)
Q39617576In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease.
Q28547166Pharmacophore modeling for anti-Chagas drug design using the fragment molecular orbital method

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