Fitness Barriers Limit Reversion of a Proofreading-Deficient Coronavirus

scientific article published on 15 October 2019

Fitness Barriers Limit Reversion of a Proofreading-Deficient Coronavirus is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/JVI.00711-19
P932PMC publication ID6798108
P698PubMed publication ID31341046

P50authorMark R. DenisonQ56426185
Maria Luisa AgostiniQ96383853
P2093author name stringXiaotao Lu
Nicole R Sexton
Kevin W Graepel
P2860cites workA general two-metal-ion mechanism for catalytic RNAQ24562157
Viral mutation ratesQ24611162
Viral quasispecies evolutionQ27013917
Site-directed mutagenesis by overlap extension using the polymerase chain reactionQ27860503
Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeuticsQ28535361
Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineageQ29615331
Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencingQ33576672
Coronaviruses post-SARS: update on replication and pathogenesisQ33694361
Systematic assembly of a full-length infectious cDNA of mouse hepatitis virus strain A59.Q34348993
Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA synthesisQ34596952
Remote site control of an active site fidelity checkpoint in a viral RNA-dependent RNA polymeraseQ35012405
Mutations in coronavirus nonstructural protein 10 decrease virus replication fidelityQ35760472
Molecular anatomy of mouse hepatitis virus persistence: coevolution of increased host cell resistance and virus virulenceQ35861907
Structural basis and functional analysis of the SARS coronavirus nsp14-nsp10 complexQ35910211
The 3'-5' exonuclease of DNA polymerase I of Escherichia coli: contribution of each amino acid at the active site to the reactionQ35919753
RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complexQ36066229
Adaptive value of high mutation rates of RNA viruses: separating causes from consequencesQ36248500
High fidelity of murine hepatitis virus replication is decreased in nsp14 exoribonuclease mutants.Q36315521
A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal diseaseQ36456720
Mutagenesis of Coronavirus nsp14 Reveals Its Potential Role in Modulation of the Innate Immune Response.Q37069821
Defining influenza A virus hemagglutinin antigenic drift by sequential monoclonal antibody selectionQ37104756
Homology-Based Identification of a Mutation in the Coronavirus RNA-Dependent RNA Polymerase That Confers Resistance to Multiple MutagensQ37174459
The Evolutionary Pathway to Virulence of an RNA VirusQ38740160
Mutagenesis of S-Adenosyl-l-Methionine-Binding Residues in Coronavirus nsp14 N7-Methyltransferase Demonstrates Differing Requirements for Genome Translation and Resistance to Innate Immunity.Q39716333
Accumulation of amino acid substitutions promotes irreversible structural changes in the hemagglutinin of human influenza AH3 virus during evolutionQ42162909
Biochemical characterization of exoribonuclease encoded by SARS coronavirusQ44542066
Murine hepatitis virus nsp14 exoribonuclease activity is required for resistance to innate immunityQ45326084
Role of methionine 184 of human immunodeficiency virus type-1 reverse transcriptase in the polymerase function and fidelity of DNA synthesis.Q45770339
Proofreading-Deficient Coronaviruses Adapt for Increased Fitness over Long-Term Passage without Reversion of Exoribonuclease-Inactivating Mutations.Q46655978
Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA.Q47560362
Viral mutation rates: modelling the roles of within-host viral dynamics and the trade-off between replication fidelity and speed.Q51302402
Mapping the Evolutionary Potential of RNA Viruses.Q52591749
Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease.Q53704198
Combination Attenuation Offers Strategy for Live Attenuated Coronavirus VaccinesQ56781312
A speed-fidelity trade-off determines the mutation rate and virulence of an RNA virusQ57000842
Mechanisms and Concepts in RNA Virus Population Dynamics and EvolutionQ59355959
Epistatic interactions can moderate the antigenic effect of substitutions in haemagglutinin of influenza H3N2 virusQ90269046
P433issue20
P407language of work or nameEnglishQ1860
P921main subjectCoronavirusQ290805
RNA virusesQ751911
exoribonucleaseQ3062052
Adaptive evolutionQ57555958
P577publication date2019-10-15
P1433published inJournal of VirologyQ1251128
P1476titleFitness Barriers Limit Reversion of a Proofreading-Deficient Coronavirus
P478volume93

Reverse relations

cites work (P2860)
Q107341981The coronavirus proofreading exoribonuclease mediates extensive viral recombination
Q99557062The enzymatic activity of the nsp14 exoribonuclease is critical for replication of MERS-CoV and SARS-CoV-2

Search more.