A speed-fidelity trade-off determines the mutation rate and virulence of an RNA virus

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A speed-fidelity trade-off determines the mutation rate and virulence of an RNA virus is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PBIO.2006459
P932PMC publication ID6040757
P698PubMed publication ID29953453

P50authorWilliam FitzsimmonsQ96249405
Adam S. LauringQ56869110
Andrew WoodmanQ87698898
P2093author name stringRobert J Woods
Craig E Cameron
Jamie J Arnold
Richard Evans
John T McCrone
Madhumita Yennawar
P2860cites workLimited trafficking of a neurotropic virus through inefficient retrograde axonal transport and the type I interferon responseQ21131564
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Speed, dissipation, and error in kinetic proofreadingQ24625696
Arbovirus high fidelity variant loses fitness in mosquitoes and miceQ24635860
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Increased fidelity reduces poliovirus fitness and virulence under selective pressure in miceQ24817069
Guanidine-selected mutants of poliovirus: mapping of point mutations to polypeptide 2CQ27486796
Site-directed mutagenesis by overlap extension using the polymerase chain reactionQ27860503
From molecular genetics to phylodynamics: evolutionary relevance of mutation rates across virusesQ28483231
Variation in RNA virus mutation rates across host cellsQ28539101
Foot-and-mouth disease virus mutant with decreased sensitivity to ribavirin: implications for error catastropheQ40199734
RNA Recombination Enhances Adaptability and Is Required for Virus Spread and VirulenceQ40492307
Elongation-Competent Pauses Govern the Fidelity of a Viral RNA-Dependent RNA PolymeraseQ42164522
The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagenQ43545743
Production of "authentic" poliovirus RNA-dependent RNA polymerase (3D(pol)) by ubiquitin-protease-mediated cleavage in Escherichia coli.Q44407927
Elucidating interplay of speed and accuracy in biological error correctionQ45233061
Engineering attenuated virus vaccines by controlling replication fidelityQ45397402
Aspects of the synthesis of poliovirus RNA and the formation of virus particlesQ45824924
Spontaneous mutators in bacteria: insights into pathways of mutagenesis and repairQ46617407
Reliable detection of subclonal single-nucleotide variants in tumour cell populations.Q51372620
Genetic control of mutation rates in bacteriophageT4.Q53766791
The cost of replication fidelity in human immunodeficiency virus type 1.Q55430533
Pacing a small cage: mutation and RNA virusesQ56384384
Sequence-Specific Fidelity Alterations Associated with West Nile Virus Attenuation in MosquitoesQ28545853
Rates of evolutionary change in viruses: patterns and determinantsQ29616174
Quasispecies diversity determines pathogenesis through cooperative interactions in a viral populationQ29616266
Influenza A virus transmission bottlenecks are defined by infection route and recipient host.Q30369231
The fittest versus the flattest: experimental confirmation of the quasispecies effect with subviral pathogens.Q33267906
Multiple host barriers restrict poliovirus trafficking in miceQ33340964
Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencingQ33576672
Fidelity variants of RNA dependent RNA polymerases uncover an indirect, mutagenic activity of amiloride compoundsQ33741951
The cost of replication fidelity in an RNA virusQ33900476
Evolvability of an RNA virus is determined by its mutational neighbourhoodQ33914492
The evolution of mutation rates: separating causes from consequencesQ33925698
Production of guanidine-resistant and -dependent poliovirus mutants from cloned cDNA: mutations in polypeptide 2C are directly responsible for altered guanidine sensitivityQ33929618
Mutational and fitness landscapes of an RNA virus revealed through population sequencingQ33953331
Generation and characterization of influenza A viruses with altered polymerase fidelityQ34137544
RNA virus population diversity, an optimum for maximal fitness and virulenceQ34396730
Bottleneck-mediated quasispecies restriction during spread of an RNA virus from inoculation site to brainQ34481724
Reduction of the rate of poliovirus protein synthesis through large-scale codon deoptimization causes attenuation of viral virulence by lowering specific infectivityQ34566179
Antimutator mutants in bacteriophage T4 and Escherichia coliQ34603796
Structure-function relationships underlying the replication fidelity of viral RNA-dependent RNA polymerases.Q34992586
Remote site control of an active site fidelity checkpoint in a viral RNA-dependent RNA polymeraseQ35012405
A single mutation in poliovirus RNA-dependent RNA polymerase confers resistance to mutagenic nucleotide analogs via increased fidelityQ35163547
Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerasesQ35721277
Measurements of Intrahost Viral Diversity Are Extremely Sensitive to Systematic Errors in Variant CallingQ36021962
The Mutational Robustness of Influenza A VirusQ36116006
Small ubiquitin-like modifying protein isopeptidase assay based on poliovirus RNA polymerase activityQ36168994
Coxsackievirus B3 mutator strains are attenuated in vivoQ36187182
A Polymerase mechanism-based strategy for viral attenuation and vaccine developmentQ36234666
Adaptive value of high mutation rates of RNA viruses: separating causes from consequencesQ36248500
A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal diseaseQ36456720
Guanidine-resistant mutants of poliovirus have distinct mutations in peptide 2C.Q36831256
Alphavirus mutator variants present host-specific defects and attenuation in mammalian and insect modelsQ37488102
Viral quasispeciesQ38396578
Thinking Outside the Triangle: Replication Fidelity of the Largest RNA VirusesQ38766598
Matters of Size: Genetic Bottlenecks in Virus Infection and Their Potential Impact on Evolution.Q38766697
Codon usage determines the mutational robustness, evolutionary capacity, and virulence of an RNA virusQ39243651
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)e2006459
P577publication date2018-06-28
P1433published inPLOS BiologyQ1771695
P1476titleA speed-fidelity trade-off determines the mutation rate and virulence of an RNA virus
P478volume16

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cites work (P2860)
Q93064899A proofreading-impaired herpesvirus generates populations with quasispecies-like structure
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Q60345946Evolutionary Virology at 40
Q93088963Evolutionary and Structural Overview of Human Picornavirus Capsid Antibody Evasion
Q84315481Fitness Barriers Limit Reversion of a Proofreading-Deficient Coronavirus
Q90227175Impact of RNA Virus Evolution on Quasispecies Formation and Virulence
Q98196740Mutational signature SBS8 predominantly arises due to late replication errors in cancer
Q107138033Mutations in SARS-CoV-2 nsp7 and nsp8 proteins and their predicted impact on replication/transcription complex structure
Q90008053Obesity-Related Microenvironment Promotes Emergence of Virulent Influenza Virus Strains
Q59349688Predicting Intraserotypic Recombination in Enterovirus 71
Q58580111RNA Virus Fidelity Mutants: A Useful Tool for Evolutionary Biology or a Complex Challenge?
Q90193407Recombination in Enteroviruses, a Multi-Step Modular Evolutionary Process
Q58785293Why are RNA virus mutation rates so damn high?

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