The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells

scientific article published on 23 June 2012

The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S00535-012-0612-1
P698PubMed publication ID22722903

P50authorZhiling YuQ45745355
Zhijun YangQ55153261
Hiu Yee KwanQ57320304
P2093author name stringWang-Fun Fong
Yong-Mei Hu
Wen-Luan Wendy Hsiao
P2860cites workInhibitory effects of flavonoids on animal fatty acid synthaseQ44785449
Fatty acid synthase inhibitors are chemopreventive for mammary cancer in neu-N transgenic miceQ45111063
Co-ordinate activation of lipogenic enzymes in hepatocellular carcinomaQ46470997
Proteomic identification of proteins involved in the anticancer activities of oridonin in HepG2 cells.Q54414795
Fatty acid synthase (FAS): a target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cellsQ71079799
Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancerQ71102430
Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cellsQ71148397
Sterol regulatory element-binding protein-1 participates in the regulation of fatty acid synthase expression in colorectal neoplasiaQ73199524
Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenograftsQ73430491
Fas/FasL signaling allows extracelluar-signal regulated kinase to regulate cytochrome c release in oridonin-induced apoptotic U937 cellsQ80199791
A role of DNA-PK for the metabolic gene regulation in response to insulinQ24323112
Fatty acid synthesis: a potential selective target for antineoplastic therapyQ24561903
Fatty acid synthase, a proficient multifunctional enzymeQ28271458
Direct interaction between USF and SREBP-1c mediates synergistic activation of the fatty-acid synthase promoterQ28281340
Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathwaysQ28646508
Oridonin induced A375-S2 cell apoptosis via bax-regulated caspase pathway activation, dependent on the cytochrome c/caspase-9 apoptosomeQ33199100
Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genesQ33354965
Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-mycQ33740026
Fatty-acid synthase and human cancer: new perspectives on its role in tumor biologyQ33855476
Metabolism and proliferation share common regulatory pathways in cancer cellsQ34419460
ATP citrate lyase is an important component of cell growth and transformationQ34432794
ATP citrate lyase inhibition can suppress tumor cell growthQ34651116
ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer.Q34657399
Synthesis and antitumor activity of an inhibitor of fatty acid synthaseQ35112277
Genetic epidemiology of mutated K-ras proto-oncogene, altered suppressor genes, and microsatellite instability in colorectal adenomasQ35355359
Elevated expression of fatty acid synthase and fatty acid synthetic activity in colorectal neoplasia.Q35765259
Increased expression of fatty acid synthase in human aberrant crypt foci: possible target for colorectal cancer preventionQ37386674
De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapyQ37437194
Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifsQ39087484
Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathwaysQ39732329
CNGA2 contributes to ATP-induced noncapacitative Ca2+ influx in vascular endothelial cells.Q39803787
Sp1 coordinately regulates de novo lipogenesis and proliferation in cancer cellsQ39822654
Control of cell growth and survival by enzymes of the fatty acid synthesis pathway in HCT-116 colon cancer cells.Q39939634
Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1.Q40012178
Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells.Q40174155
Oridonin induced apoptosis through Akt and MAPKs signaling pathways in human osteosarcoma cellsQ40183990
Up-regulation of fatty acid synthase promoter by hepatitis C virus core protein: genotype-3a core has a stronger effect than genotype-1b coreQ40190516
Mechanism of apoptosis induced by the inhibition of fatty acid synthase in breast cancer cellsQ40272708
Acetyl-CoA carboxylase alpha is essential to breast cancer cell survivalQ40278693
Apoptosis of androgen-independent prostate cell line induced by inhibition of fatty acid synthesisQ41060920
Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP.Q41120850
Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthaseQ43130305
Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicityQ43667789
Androgens stimulate lipogenic gene expression in prostate cancer cells by activation of the sterol regulatory element-binding protein cleavage activating protein/sterol regulatory element-binding protein pathwayQ43752406
Role of glucose-6-phosphate dehydrogenase on enhanced proliferation of pre-neoplastic and neoplastic cells in rat liver induced by N-nitrosomorpholineQ44315263
P433issue2
P921main subjectcolorectal cancerQ188874
colorectal carcinomaQ25493920
P304page(s)182-192
P577publication date2012-06-23
P1433published inJournal of GastroenterologyQ15764399
P1476titleThe anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells
P478volume48

Reverse relations

cites work (P2860)
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