| scholarly article | Q13442814 |
| review article | Q7318358 |
| P2093 | author name string | Brice Ayissi Owona | |
| Herman J Schluesener | |||
| P2860 | cites work | Nanostructured lipid carriers used for oral delivery of oridonin: an effect of ligand modification on absorption | Q47960609 |
| Oridonin's therapeutic effect: suppressing Th1/Th17 simultaneously in a mouse model of Crohn's disease. | Q50781597 | ||
| Studies on the cell-immunosuppressive mechanism of Oridonin from Isodon serra. | Q51005635 | ||
| Chemical proteomics reveals HSP70 1A as a target for the anticancer diterpene oridonin in Jurkat cells. | Q53119858 | ||
| Proteomic identification of proteins involved in the anticancer activities of oridonin in HepG2 cells. | Q54414795 | ||
| Synergistic effect of oridonin and cisplatin on cytotoxicity and DNA cross-link against mouse sarcoma S180 cells in culture | Q72011939 | ||
| [Chemical constituents of Rabdosia nervosa (Hemsl) C.Y. Wu et H. W. Li] | Q72768574 | ||
| [Effect of N, P, K on yield and quality of Rabdosia rubescens] | Q79820692 | ||
| Fas/FasL signaling allows extracelluar-signal regulated kinase to regulate cytochrome c release in oridonin-induced apoptotic U937 cells | Q80199791 | ||
| [Mechanism of downregulation of apoptosis by autophagy induced by oridonin in HeLa cells] | Q80372916 | ||
| Nitric oxide augments oridonin-induced efferocytosis by human histocytic lymphoma U937 cells via autophagy and the NF-κB-COX-2-IL-1β pathway | Q84304541 | ||
| The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells | Q84434166 | ||
| Galactosylated chitosan nanoparticles for hepatocyte-targeted delivery of oridonin | Q84457118 | ||
| Inhibition of c-Met promoted apoptosis, autophagy and loss of the mitochondrial transmembrane potential in oridonin-induced A549 lung cancer cells | Q86489068 | ||
| Synthesis, characterization, in vitro and in vivo evaluation of PEGylated oridonin conjugates | Q87304686 | ||
| Design, synthesis and antimycobacterial activity evaluation of natural oridonin derivatives | Q87891638 | ||
| Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response | Q28385636 | ||
| Selection for high oridonin yield in the Chinese medicinal plant Isodon (Lamiaceae) using a combined phylogenetics and population genetics approach | Q28485333 | ||
| Oridonin induced A375-S2 cell apoptosis via bax-regulated caspase pathway activation, dependent on the cytochrome c/caspase-9 apoptosome | Q33199100 | ||
| Anti-proliferation effect of oridonin on HL-60 cells and its mechanism. | Q33204669 | ||
| Antiproliferation effects of oridonin on HPB-ALL cells and its mechanisms of action | Q33232382 | ||
| Oridonin induced U937 cell apoptosis through ERK pathway | Q33234701 | ||
| Effective two-dimensional counter-current chromatographic method for simultaneous isolation and purification of oridonin and ponicidin from the crude extract of Rabdosia rubescens | Q33276058 | ||
| Oridonin induces apoptosis via PI3K/Akt pathway in cervical carcinoma HeLa cell line | Q33303792 | ||
| Empirical study of oridonin-induced gastric cancer cells MKN45 apoptosis | Q33516135 | ||
| Autophagy counteracts apoptosis in human multiple myeloma cells exposed to oridonin in vitro via regulating intracellular ROS and SIRT1 | Q33566976 | ||
| Oridonin induces G2/M cell cycle arrest and apoptosis through MAPK and p53 signaling pathways in HepG2 cells | Q33642936 | ||
| Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc | Q33740026 | ||
| Augmentation of oridonin-induced apoptosis observed with reduced autophagy | Q33997847 | ||
| Isolation and purification of oridonin from the whole plant of Isodon rubescens by high-speed counter-current chromatography. | Q34092141 | ||
| Oridonin nanosuspension was more effective than free oridonin on G2/M cell cycle arrest and apoptosis in the human pancreatic cancer PANC-1 cell line | Q34278726 | ||
| Oridonin inhibits hepatic stellate cell proliferation and fibrogenesis | Q34479065 | ||
| Oridonin induces apoptosis in gastric cancer through Apaf-1, cytochrome c and caspase-3 signaling pathway | Q34550650 | ||
| Preparation and evaluation of self-microemulsifying drug delivery system of oridonin | Q34744529 | ||
| Overcoming synthetic challenges of oridonin A-ring structural diversification: regio- and stereoselective installation of azides and 1,2,3-triazoles at the C-1, C-2, or C-3 position | Q34802229 | ||
| Oridonin induces apoptosis and cell cycle arrest of gallbladder cancer cells via the mitochondrial pathway | Q35127404 | ||
| Anti-cancer natural products isolated from chinese medicinal herbs | Q35143916 | ||
| Mechanism concerning antitumor effect of oridonin on multiple myeloma cell line U266 | Q35156854 | ||
| Oridonin in combination with imatinib exerts synergetic anti-leukemia effect in Ph+ acute lymphoblastic leukemia cells in vitro by inhibiting activation of LYN/mTOR signaling pathway | Q36384328 | ||
| Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells | Q36623835 | ||
| Novel nitrogen-enriched oridonin analogues with thiazole-fused A-ring: protecting group-free synthesis, enhanced anticancer profile, and improved aqueous solubility | Q37017307 | ||
| Oridonin ring A-based diverse constructions of enone functionality: identification of novel dienone analogues effective for highly aggressive breast cancer by inducing apoptosis. | Q37432505 | ||
| Oridonin ameliorates neuropathological changes and behavioural deficits in a mouse model of cerebral amyloidosis | Q37557568 | ||
| Resveratrol, a natural stilbene in grapes and wine, enhances intraphagocytosis in human promonocytes: a co-factor in antiinflammatory and anticancer chemopreventive activity. | Q40887580 | ||
| Antibacterial activity of trichorabdal A from Rabdosia trichocarpa against Helicobacter pylori | Q42548430 | ||
| A novel analysis method for diterpenoids in rat plasma by liquid chromatography-electrospray ionization mass spectrometry | Q42965781 | ||
| Induction of G(2)/M phase arrest and apoptosis by oridonin in human laryngeal carcinoma cells | Q43055765 | ||
| Preparation and characteristics of oridonin-loaded nanostructured lipid carriers as a controlled-release delivery system | Q43180565 | ||
| Two en-kaurene diterpenoids from Tibetan medicine Caryopteris toroetii | Q43272102 | ||
| Triggering Fbw7-mediated proteasomal degradation of c-Myc by oridonin induces cell growth inhibition and apoptosis. | Q43508536 | ||
| Oridonin induces apoptosis of HeLa cells via altering expression of Bcl-2/Bax and activating caspase-3/ICAD pathway. | Q44887951 | ||
| Antiproliferation effects of oridonin on HL-60 cells | Q45025753 | ||
| Ent-kauranoids from Isodon rubescens var. taihangensis | Q45203902 | ||
| Regulation of telomerase activity and cell cycle of K562 cells by oridonin | Q45254826 | ||
| The cytostatic and cytotoxic effects of oridonin (Rubescenin), a diterpenoid from Rabdosia rubescens, on tumor cells of different lineage. | Q45259728 | ||
| Oridonin enhances phagocytosis of UV-irradiated apoptotic U937 cells | Q45296035 | ||
| Study on stability of oridonin solution | Q46042773 | ||
| Molecular mechanisms of oridonin-induced apoptosis and autophagy in murine fibrosarcoma L929 cells | Q46128790 | ||
| Multiple-modulation effects of Oridonin on the production of proinflammatory cytokines and neurotrophic factors in LPS-activated microglia | Q46137751 | ||
| Involvement of PKC signal pathways in oridonin-induced autophagy in HeLa cells: a protective mechanism against apoptosis | Q46232893 | ||
| Inhibitory effect of Oridonin injection on heterotransplanted gastric adenocarcinoma in nude mice and its mechanism | Q46469417 | ||
| Oridonin-induced apoptosis in leukemia K562 cells and its mechanism | Q46473086 | ||
| Activation of phosphoinositide 3-kinase, protein kinase C, and extracellular signal-regulated kinase is required for oridonin-enhanced phagocytosis of apoptotic bodies in human macrophage-like U937 cells | Q46633854 | ||
| Oridonin promotes CD4+/CD25+ Treg differentiation, modulates Th1/Th2 balance and induces HO-1 in rat splenic lymphocytes | Q46693452 | ||
| Determination of oridonin and rosemarinic acid in Rabdosia rubescens by HPLC | Q46716301 | ||
| Oridonin induced autophagy in human cervical carcinoma HeLa cells through Ras, JNK, and P38 regulation | Q46840428 | ||
| Roles of Ras and extracellular signal-regulated kinase-dependent IkappaBalpha degradation in oridonin-enhanced phagocytosis of apoptotic cells by human macrophage-like U937 cells | Q46884524 | ||
| Reactive oxygen species H2O2 and •OH, but not O2•(-) promote oridonin-induced phagocytosis of apoptotic cells by human histocytic lymphoma U937 cells | Q46989820 | ||
| Oridonin inhibits BxPC-3 cell growth through cell apoptosis | Q38912986 | ||
| Oridonin induces apoptosis in uveal melanoma cells by upregulation of Bim and downregulation of Fatty Acid Synthase | Q38924884 | ||
| Oridonin inhibits the proliferation of human osteosarcoma cells by suppressing Wnt/β-catenin signaling | Q38991681 | ||
| Intracellular glutathione depletion by oridonin leads to apoptosis in hepatic stellate cells. | Q39013864 | ||
| Oridonin induces apoptosis in SW1990 pancreatic cancer cells via p53- and caspase-dependent induction of p38 MAPK. | Q39051037 | ||
| Oridonin ameliorates lupus-like symptoms of MRL(lpr/lpr) mice by inhibition of B-cell activating factor (BAFF). | Q39146912 | ||
| ER stress and ASK1-JNK activation contribute to oridonin-induced apoptosis and growth inhibition in cultured human hepatoblastoma HuH-6 cells | Q39167609 | ||
| Oridonin induces apoptosis, inhibits migration and invasion on highly-metastatic human breast cancer cells. | Q39207391 | ||
| Hydroxyl radical (·OH) played a pivotal role in oridonin-induced apoptosis and autophagy in human epidermoid carcinoma A431 cells | Q39233348 | ||
| Downregulation of nucleoporin 88 and 214 induced by oridonin may protect OCIM2 acute erythroleukemia cells from apoptosis through regulation of nucleocytoplasmic transport of NF-κB. | Q39309584 | ||
| Interruption of hepatocyte growth factor signaling augmented oridonin-induced death in human non-small cell lung cancer A549 cells via c-met-nuclear factor-κB-cyclooxygenase-2 and c-Met-Bcl-2-caspase-3 pathways | Q39315456 | ||
| Melanogenesis inhibitors from Rabdosia japonica | Q39323409 | ||
| Oridonin enhances antitumor activity of gemcitabine in pancreatic cancer through MAPK-p38 signaling pathway | Q39328944 | ||
| Biodegradable self-assembled MPEG-PCL micelles for hydrophobic oridonin delivery in vitro. | Q39362346 | ||
| Synergistic antitumor activity of oridonin and arsenic trioxide on hepatocellular carcinoma cells | Q39468162 | ||
| Oridonin induced the apoptosis of PC-3 cells and its mechanism | Q39470061 | ||
| Downregulation of AP-1 gene expression is an initial event in the oridonin-mediated inhibition of colorectal cancer: studies in vitro and in vivo | Q39574052 | ||
| Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by oridonin nanosuspension | Q39629849 | ||
| Combined activity of oridonin and wogonin in advanced-stage ovarian cancer cells: sensitivity of ovarian cancer cells to phyto-active chemicals | Q39651374 | ||
| Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways | Q39732329 | ||
| Oridonin induces G2/M arrest and apoptosis via activating ERK-p53 apoptotic pathway and inhibiting PTK-Ras-Raf-JNK survival pathway in murine fibrosarcoma L929 cells | Q39809734 | ||
| Ent-kaurane diterpenoids from Rabdosia rubescens and their cytotoxic effects on human cancer cell lines | Q39817080 | ||
| Comparison of cytotoxicity and DNA damage potential induced by ent-kaurene diterpenoids from Isodon plant | Q39824791 | ||
| Caspase inhibition augmented oridonin-induced cell death in murine fibrosarcoma l929 by enhancing reactive oxygen species generation | Q39935578 | ||
| Reactive oxygen species mediate oridonin-induced HepG2 apoptosis through p53, MAPK, and mitochondrial signaling pathways | Q39948397 | ||
| Oridonin induces human melanoma A375-S2 cell death partially through inhibiting insulin-like growth factor 1 receptor signaling | Q39951528 | ||
| Down-regulation of androgen-receptor and PSA by phytochemicals | Q40023730 | ||
| Oridonin induces human epidermoid carcinoma A431 cell apoptosis through tyrosine kinase and mitochondrial pathway | Q40040281 | ||
| P53-mediated cell cycle arrest and apoptosis through a caspase-3- independent, but caspase-9-dependent pathway in oridonin-treated MCF-7 human breast cancer cells | Q40116029 | ||
| Autophagy preceded apoptosis in oridonin-treated human breast cancer MCF-7 cells | Q40138436 | ||
| Oridonin inhibited the tyrosine kinase activity and induced apoptosis in human epidermoid carcinoma A431 cells | Q40176455 | ||
| Oridonin induced apoptosis through Akt and MAPKs signaling pathways in human osteosarcoma cells | Q40183990 | ||
| Fibroblast growth factor-2 suppresses oridonin-induced L929 apoptosis through extracellular signal-regulated kinase-dependent and phosphatidylinositol 3-kinase-independent pathway | Q40206093 | ||
| A comparison of the signal pathways between the TNF alpha- and oridonin-induced murine L929 fibrosarcoma cell death | Q40328365 | ||
| Bcl-2 up-regulation and P-p53 down-regulation account for the low sensitivity of murine L929 fibrosarcoma cells to oridonin-induced apoptosis | Q40354165 | ||
| Differential control of growth, cell cycle progression, and expression of NF-kappaB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the chinese herb Rabdosia rubescens | Q40370526 | ||
| The effects of oridonin on cell growth, cell cycle, cell migration and differentiation in melanoma cells | Q40372132 | ||
| Two novel ent-kauranoid diterpenoids from Isodon japonica leaves | Q40377104 | ||
| Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways | Q40435902 | ||
| Anti-proliferative effects of oridonin on SPC-A-1 cells and its mechanism of action. | Q40482988 | ||
| Cytochrome c release from oridonin-treated apoptotic A375-S2 cells is dependent on p53 and extracellular signal-regulated kinase activation | Q40502547 | ||
| Oridonin induces a caspase-independent but mitochondria- and MAPK-dependent cell death in the murine fibrosarcoma cell line L929. | Q40507634 | ||
| Cytotoxic ent-kauranoids from Isodon leucophyllus | Q40580898 | ||
| P275 | copyright license | Creative Commons Attribution-NonCommercial | Q6936496 |
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | hydrocarbon | Q43648 |
| signal transduction | Q828130 | ||
| P304 | page(s) | 233-44 | |
| P577 | publication date | 2015-09-01 | |
| P1433 | published in | Drugs in R & D | Q26842117 |
| P1476 | title | Molecular Insight in the Multifunctional Effects of Oridonin | |
| P478 | volume | 15 |
| Q28387804 | Discovery and development of natural product oridonin-inspired anticancer agents |
| Q37699216 | Induction of the mitochondria-mediated apoptosis in human esophageal cancer cells by DS2, a newly synthetic diterpenoid analog, is regulated by Bax and caused by generation of reactive oxygen species |
| Q57061981 | Natural molecules induce and synergize to boost expression of the human antimicrobial peptide β-defensin-3 |
| Q98205366 | Oridonin ameliorates inflammation-induced bone loss in mice via suppressing DC-STAMP expression |
| Q47738850 | Oridonin exerts anticancer effect on osteosarcoma by activating PPAR-γ and inhibiting Nrf2 pathway |
| Q41145034 | Oridonin induces apoptosis and reverses drug resistance in cisplatin resistant human gastric cancer cells |
| Q90304420 | Oridonin inhibits the migration and epithelial-to-mesenchymal transition of small cell lung cancer cells by suppressing FAK-ERK1/2 signalling pathway |
| Q26738633 | Oridonin, a Promising ent-Kaurane Diterpenoid Lead Compound |
| Q47400524 | Phytotherapeutics Oridonin and Ponicidin show Additive Effects Combined with Irradiation in Pancreatic Cancer in Vitro |
| Q38707589 | Single molecule force spectroscopy for in-situ probing oridonin inhibited ROS-mediated EGF-EGFR interactions in living KYSE-150 cells. |
| Q37745377 | Targeting 3-phosphoinositide-dependent protein kinase 1 associated with drug-resistant renal cell carcinoma using new oridonin analogs |
| Q52716625 | Targeting AKT with oridonin inhibits growth of esophageal squamous cell carcinoma in vitro and patient derived xenografts in vivo. |
| Q37636708 | Targeting XBP1-mediated β-catenin expression associated with bladder cancer with newly synthetic Oridonin analogues. |
| Q59335282 | The anti-tumor diterpene oridonin is a direct inhibitor of Nucleolin in cancer cells |
| Q61947589 | Therapeutic Potential of Oridonin and Its Analogs: From Anticancer and Antiinflammation to Neuroprotection |
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