Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress

scientific article published on 22 November 2012

Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.YJMCC.2012.11.006
P698PubMed publication ID23178899

P50authorMaria F. GomezQ57236613
Ivar SjaastadQ65675496
P2093author name stringGeir Christensen
Cathrine R Carlson
Geir Florholmen
Ida G Lunde
Kate M Herum
Biljana Skrbic
Dina Behmen
P2860cites workMatrix stiffness-induced myofibroblast differentiation is mediated by intrinsic mechanotransductionQ36370200
Therapeutic strategies against TGF-beta signaling pathway in hepatic fibrosisQ36371664
Emerging new drugs for scar reductionQ36407401
Mechanical induction of gene expression in connective tissue cellsQ37785159
Transforming growth factor (TGF)-β signaling in cardiac remodeling.Q37808014
DSCR1 gene expression is dependent on NFATc1 during cardiac valve formation and colocalizes with anomalous organ development in trisomy 16 miceQ40596613
Adhesion signalling complexesQ41864387
Syndecan-4 modulates focal adhesion kinase phosphorylationQ44043440
Angiotensin II and norepinephrine activate specific calcineurin-dependent NFAT transcription factor isoforms in cardiomyocytes.Q45970904
Increased syndecan expression following myocardial infarction indicates a role in cardiac remodelingQ48935393
Syndecan-4 Deficiency Impairs Focal Adhesion Formation Only under Restricted ConditionsQ58211929
Calcineurin plays a critical role in pressure overload-induced cardiac hypertrophyQ73267718
Molecular mechanisms of myocardial remodelingQ77918078
NFATc2 is a necessary mediator of calcineurin-dependent cardiac hypertrophy and heart failureQ81269550
Serum syndecan-4 is a novel biomarker for patients with chronic heart failureQ83598067
Syndecan-4 prevents cardiac rupture and dysfunction after myocardial infarctionQ83866038
Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growthQ24309615
Smoothelin, a novel cytoskeletal protein specific for smooth muscle cellsQ24313011
Delayed wound repair and impaired angiogenesis in mice lacking syndecan-4Q24681644
Syndecan-4 is essential for development of concentric myocardial hypertrophy via stretch-induced activation of the calcineurin-NFAT pathwayQ27311486
A calcineurin-dependent transcriptional pathway for cardiac hypertrophyQ28269300
Force activates smooth muscle alpha-actin promoter activity through the Rho signaling pathwayQ28566405
Myocardin: a component of a molecular switch for smooth muscle differentiationQ28566619
Syndecan-4 binding to the high affinity heparin-binding domain of fibronectin drives focal adhesion formation in fibroblastsQ28576503
Scleraxis and NFATc regulate the expression of the pro-alpha1(I) collagen gene in tendon fibroblastsQ28592074
Actin dynamics control SRF activity by regulation of its coactivator MALQ28646140
Transmembrane signaling proteoglycansQ30390527
Integrative genomics identifies DSCR1 (RCAN1) as a novel NFAT-dependent mediator of phenotypic modulation in vascular smooth muscle cellsQ30433341
Smoothelin is a specific marker for smooth muscle neoplasms of the gastrointestinal tract.Q30934163
NFAT and Osterix cooperatively regulate bone formationQ31813054
Defining the role of syndecan-4 in mechanotransduction using surface-modification approachesQ33552237
Inhibition of transforming growth factor-beta signaling induces left ventricular dilation and dysfunction in the pressure-overloaded heartQ33656046
Heparan sulfate chain valency controls syndecan-4 function in cell adhesionQ33825117
Role of mechanical factors in modulating cardiac fibroblast function and extracellular matrix synthesisQ33895485
Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophyQ33974366
Calcineurin signaling and NFAT activation in cardiovascular and skeletal muscle developmentQ33975200
Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarctionQ34066752
Exploring the neighborhood: adhesion-coupled cell mechanosensors.Q34768683
The role of modulatory calcineurin-interacting proteins in calcineurin signalingQ35055274
Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic diseaseQ35094477
Reversibility of adverse, calcineurin-dependent cardiac remodelingQ35189672
Mechanical tension controls granulation tissue contractile activity and myofibroblast differentiationQ35746732
Interaction between NFκB and NFAT coordinates cardiac hypertrophy and pathological remodelingQ35926510
Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblastsQ36232642
The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1.Q36288284
P304page(s)73-81
P577publication date2012-11-22
P1433published inJournal of Molecular and Cellular CardiologyQ2061932
P1476titleSyndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress
P478volume54

Reverse relations

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