Anti-interleukin-6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen-induced arthritis model

scientific article published on 01 February 2014

Anti-interleukin-6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen-induced arthritis model is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/CEI.12201
P698PubMed publication ID24028747

P2093author name stringYoshihiro Matsumoto
Keisuke Tanaka
Masahiko Mihara
Miho Suzuki
Hiroto Yoshida
Misato Hashizume
P2860cites workIL-6 receptor inhibition positively modulates bone balance in rheumatoid arthritis patients with an inadequate response to anti-tumor necrosis factor therapy: biochemical marker analysis of bone metabolism in the tocilizumab RADIATE study (NCT001065Q83591113
IL-6 blockade preferentially inhibits Th17 differentiation in collagen-induced arthritisQ84593093
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritisQ24564656
RANK is essential for osteoclast and lymph node developmentQ24598872
Enhanced osteoclast development in collagen-induced arthritis in interferon-gamma receptor knock-out mice as related to increased splenic CD11b+ myelopoiesisQ24800726
CCL9/MIP-1gamma and its receptor CCR1 are the major chemokine ligand/receptor species expressed by osteoclastsQ28210471
MCP-1 is induced by receptor activator of nuclear factor-{kappa}B ligand, promotes human osteoclast fusion, and rescues granulocyte macrophage colony-stimulating factor suppression of osteoclast formationQ28236005
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesisQ28589430
Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasisQ28593488
A combination of methotrexate and zoledronic acid prevents bone erosions and systemic bone mass loss in collagen induced arthritisQ34413330
Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivoQ34420830
1,25-Dihydroxyvitamin D3: short- and long-term effects on bone and calcium metabolism in patients with postmenopausal osteoporosisQ36297015
Finding a way out: lymphocyte egress from lymphoid organsQ37008187
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolismQ37108966
Osteoimmunology and the effects of the immune system on boneQ37626412
Stromal cell-derived factor-1 binding to its chemokine receptor CXCR4 on precursor cells promotes the chemotactic recruitment, development and survival of human osteoclastsQ38328790
CXC chemokine ligand 2 induced by receptor activator of NF-kappa B ligand enhances osteoclastogenesisQ39720295
Role of CX3CL1/fractalkine in osteoclast differentiation and bone resorptionQ39773087
High-resolution three-dimensional micro-computed tomography detects bone loss and changes in trabecular architecture early: comparison with DEXA and bone histomorphometry in a rat model of disuse osteoporosis.Q43830666
Interleukin-6 receptor blockade induces limited repair of bone erosions in rheumatoid arthritis: a micro CT studyQ45271842
Impaired skeletal development in interleukin-6-transgenic mice: a model for the impact of chronic inflammation on the growing skeletal systemQ46280827
Cross-sectional and longitudinal study of osteoporosis in patients with rheumatoid arthritis.Q50697468
Effect of raloxifene on arthritis and bone mineral density in rats with collagen-induced arthritis.Q51529501
Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis.Q51746101
Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3.Q53567358
High-resolution micro-CT evaluation of mid- to long-term effects of estrogen deficiency on rat trabecular bone1Q53639300
LPS and TNF-α induce expression of sphingosine-1-phosphate receptor-2 in human microvascular endothelial cells.Q54329465
Higher circulating sphingosine 1-phosphate levels are associated with lower bone mineral density and higher bone resorption marker in humansQ57225024
Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formationQ71437425
A microtomographic system for the nondestructive evaluation of bone architectureQ71576009
Stromal cell-derived factor-1 (SDF-1) recruits osteoclast precursors by inducing chemotaxis, matrix metalloproteinase-9 (MMP-9) activity, and collagen transmigrationQ73831121
A morphometric comparison of trabecular structure of human ilium between microcomputed tomography and conventional histomorphometryQ73909301
Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myelomaQ73971509
Characterization of anti-mouse interleukin-6 receptor antibodyQ78467480
Reciprocal cross-talk between RANKL and interferon-gamma-inducible protein 10 is responsible for bone-erosive experimental arthritisQ81158300
Rapid and sustained improvement in bone and cartilage turnover markers with the anti-interleukin-6 receptor inhibitor tocilizumab plus methotrexate in rheumatoid arthritis patients with an inadequate response to methotrexate: results from a substudyQ82357642
P433issue2
P304page(s)172-180
P577publication date2014-02-01
P1433published inClinical and Experimental ImmunologyQ15716708
P1476titleAnti-interleukin-6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen-induced arthritis model
P478volume175

Reverse relations

cites work (P2860)
Q36302388Adipose-Derived Mesenchymal Stem Cells Prevent Systemic Bone Loss in Collagen-Induced Arthritis
Q26774874Animal Models of Bone Loss in Inflammatory Arthritis: from Cytokines in the Bench to Novel Treatments for Bone Loss in the Bedside-a Comprehensive Review
Q64956206Arsenic Trioxide in Synergy with Vitamin D Rescues the Defective VDR-PPAR-γ Functional Module of Autophagy in Rheumatoid Arthritis.
Q24701763Bindarit, an inhibitor of monocyte chemotactic protein synthesis, protects against bone loss induced by chikungunya virus infection
Q34252489Cytokine-mediated bone destruction in rheumatoid arthritis
Q60916226Interleukin-6 Interweaves the Bone Marrow Microenvironment, Bone Loss, and Multiple Myeloma
Q92646597Mast cells enhance sterile inflammation in chronic nonbacterial osteomyelitis
Q36189808Periodontal inflammation and alveolar bone loss induced by Aggregatibacter actinomycetemcomitans is attenuated in sphingosine kinase 1-deficient mice
Q47881999Sphingosine 1-phosphate (S1P) signalling: Role in bone biology and potential therapeutic target for bone repair.
Q90187449Sphingosine-1-phosphate (S1P) receptors: Promising drug targets for treating bone-related diseases
Q38831693The Impact of Conventional and Biological Disease Modifying Antirheumatic Drugs on Bone Biology. Rheumatoid Arthritis as a Case Study
Q92757089The effect of anti-IL-6 receptor antibody for the treatment of McH-lpr/lpr-RA1 mice that spontaneously developed destructive arthritis and enthesitis
Q46671185Tocilizumab potentially prevents bone loss in patients with anticitrullinated protein antibody-positive rheumatoid arthritis.

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