CTSL2 is a pro-apoptotic target of E2F1 and a modulator of histone deacetylase inhibitor and DNA damage-induced apoptosis

scientific article published on 01 April 2013

CTSL2 is a pro-apoptotic target of E2F1 and a modulator of histone deacetylase inhibitor and DNA damage-induced apoptosis is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1000380449
P356DOI10.1038/ONC.2013.72
P698PubMed publication ID23542171

P2093author name stringQ Yu
Z Wu
C H Wong
P2860cites workDACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modificationsQ24319915
Anticancer activities of histone deacetylase inhibitorsQ29616624
Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim.Q34115920
(-)-Epigallocatechin-3-gallate induces non-apoptotic cell death in human cancer cells via ROS-mediated lysosomal membrane permeabilizationQ34442037
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cellsQ34619655
Histone-deacetylase inhibitors: novel drugs for the treatment of cancerQ34743301
E2F1 pathways to apoptosisQ34922303
Intrinsic tumour suppressionQ35953133
Life and death decisions by the E2F transcription factorsQ36499727
E2F1 death pathways as targets for cancer therapyQ36815342
Lysosomes in apoptosisQ37228891
E2F - at the crossroads of life and deathQ37274580
The E2F family and the role of E2F1 in apoptosisQ37524916
Role of the p53-homologue p73 in E2F1-induced apoptosisQ38306110
Polycomb protein EZH2 regulates E2F1-dependent apoptosis through epigenetically modulating Bim expressionQ38349096
An E2F1-dependent gene expression program that determines the balance between proliferation and cell deathQ40029015
Apoptosis signal-regulating kinase 1 is a direct target of E2F1 and contributes to histone deacetylase inhibitor-induced apoptosis through positive feedback regulation of E2F1 apoptotic activityQ40316748
Direct coupling of the cell cycle and cell death machinery by E2F.Q40695864
Role for the p53 homologue p73 in E2F-1-induced apoptosisQ40848736
Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosisQ42833059
Expression of human cathepsin L or human cathepsin V in mouse thymus mediates positive selection of T helper cells in cathepsin L knock-out miceQ43116887
Differential regulation of E2F1 apoptotic target genes in response to DNA damage.Q44453757
Improved safety through tamoxifen-regulated induction of cytotoxic genes delivered by Ad vectors for cancer gene therapyQ45869660
Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologuesQ46603171
Live or let die: E2F1 and PI3K pathways intersect to make life or death decisionsQ46826670
Stat3 controls lysosomal-mediated cell death in vivoQ48530601
Lysosomes and mitochondria in the commitment to apoptosis: a potential role for cathepsin D and AIF.Q51013717
Cathepsin-cleaved Bid promotes apoptosis in human neutrophils via oxidative stress-induced lysosomal membrane permeabilization.Q53574092
p14ARF links the tumour suppressors RB and p53.Q55067966
Apaf-1 is a transcriptional target for E2F and p53Q57274134
P433issue10
P921main subjectapoptotic processQ14599311
P304page(s)1249-1257
P577publication date2013-04-01
P1433published inOncogeneQ1568657
P1476titleCTSL2 is a pro-apoptotic target of E2F1 and a modulator of histone deacetylase inhibitor and DNA damage-induced apoptosis
P478volume33

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cites work (P2860)
Q47154025Characterization of epithelial-mesenchymal transition intermediate/hybrid phenotypes associated to resistance to EGFR inhibitors in non-small cell lung cancer cell lines
Q92715444Elevated CTSL2 expression is associated with an adverse prognosis in hepatocellular carcinoma

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