Pharmacokinetic drug interactions between apigenin, rutin and paclitaxel mediated by P-glycoprotein in rats

scientific article published on 29 May 2014

Pharmacokinetic drug interactions between apigenin, rutin and paclitaxel mediated by P-glycoprotein in rats is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S13318-014-0203-Z
P698PubMed publication ID24871039

P2093author name stringS Sujatha
P Ravindra Babu
K Kishore Kumar
K Gnananath
Leena Priyanka
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Co-administration of cyclosporin enables oral therapy with paclitaxelQ95807142
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Inhibitory effects of polyphenols on human cytochrome P450 3A4 and 2C9 activityQ28263349
Anti-asthmatic action of quercetin and rutin in conscious guinea-pigs challenged with aerosolized ovalbuminQ28267509
Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450.Q34501881
Emerging significance of flavonoids as P-glycoprotein inhibitors in cancer chemotherapy.Q34983061
Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestineQ36031211
Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoproteinQ36277561
Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833.Q36431370
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Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways.Q40450886
Neuroprotective effects of flavones on hydrogen peroxide-induced apoptosis in SH-SY5Y neuroblostoma cellsQ40567527
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Clinical toxicities encountered with paclitaxel (Taxol).Q40711497
Oral chemotherapy: rationale and future directionsQ40851033
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Apigenin suppresses insulin-like growth factor I receptor signaling in human prostate cancer: an in vitro and in vivo studyQ42001138
Inhibition of protein-tyrosine kinase activity by flavanoids and related compoundsQ43804196
A painful peripheral neuropathy in the rat produced by the chemotherapeutic drug, paclitaxelQ43814061
Enhanced oral bioavailability of paclitaxel by coadministration of the P-glycoprotein inhibitor KR30031.Q44330532
Quantitation of paclitaxel in micro-sample rat plasma by a sensitive reversed-phase HPLC assayQ44332558
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Enhanced bioavailability of paclitaxel after oral coadministration with flavone in ratsQ44841876
The effect of verapamil on the pharmacokinetics of paclitaxel in ratsQ45207270
Enhanced paclitaxel bioavailability after oral coadministration of paclitaxel prodrug with naringin to ratsQ45278500
Apigenin protects endothelium-dependent relaxation of rat aorta against oxidative stress.Q45956534
Effects of quercetin on the pharmacokinetics of Etoposide after oral or intravenous administration of etoposide in rats.Q46026038
Pharmacokinetic interaction study between quercetin and valsartan in rats and in vitro modelsQ46063158
Pharmacokinetic and pharmacodynamic interactions of morin and cyclosporinQ46483175
Effects of oral kaempferol on the pharmacokinetics of tamoxifen and one of its metabolites, 4-hydroxytamoxifen, after oral administration of tamoxifen to ratsQ46704237
Role of p-glycoprotein inhibition for drug interactions: evidence from in vitro and pharmacoepidemiological studiesQ46890019
Rutin improves the antioxidant status in streptozotocin-induced diabetic rat tissuesQ48492620
Enhanced paclitaxel bioavailability after oral administration of pegylated paclitaxel prodrug for oral delivery in rats.Q51643335
Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesionsQ62950307
Effect of R-verapamil on the pharmacokinetics of paclitaxel in women with breast cancerQ71961929
Specific CYP3A4 inhibitors in grapefruit juice: furocoumarin dimers as components of drug interactionQ73834871
P433issue3
P921main subjectpharmacokineticsQ323936
paclitaxelQ423762
P304page(s)267-276
P577publication date2014-05-29
P1433published inEuropean Journal of Drug Metabolism and PharmacokineticsQ15757261
P1476titlePharmacokinetic drug interactions between apigenin, rutin and paclitaxel mediated by P-glycoprotein in rats
P478volume40

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cites work (P2860)
Q47096159Dietary polyphenols influence antimetabolite agents: methotrexate, 6-mercaptopurine and 5-fluorouracil in leukemia cell lines.
Q36712831Effects of Jia-Wei-Xiao-Yao-San on the Peripheral and Lymphatic Pharmacokinetics of Paclitaxel in Rats.
Q26800893Interactions between CYP3A4 and Dietary Polyphenols
Q38330349Relevance of P-glycoprotein in stroke prevention with dabigatran, rivaroxaban, and apixaban
Q39201434The Pharmacological Potential of Rutin.