PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients

scientific article published on 21 June 2018

PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI.INSIGHT.99114
P932PMC publication ID6124394
P698PubMed publication ID29925691

P2093author name stringHelena Edlund
Jacob Westman
Ingela Bergqvist
Fredrik Backlund
Pär Steneberg
Thomas Edlund
Madelene Ericsson
Emma Lindahl
Ulf Dahl
Björn Eriksson
Elisabet Kjellkvist
Emmelie Lidh
Eva Berggren
Ingela Lundberg
Jurate Straseviciene
Kajsa Linde
P2860cites workAMPK and PPARdelta agonists are exercise mimeticsQ24652674
Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathyQ26775037
Autophagy fights disease through cellular self-digestionQ27860902
Glucose deprivation regulates KATP channel trafficking via AMP-activated protein kinase in pancreatic beta-cellsQ28566857
Exercise and type 2 diabetes: molecular mechanisms regulating glucose uptake in skeletal muscleQ30397046
Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivoQ30618321
TXNIP regulates peripheral glucose metabolism in humansQ33283341
Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicityQ33944212
Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetesQ33944267
Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia.Q34115152
Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol.Q34191173
Assessment and treatment of cardiovascular risk in prediabetes: impaired glucose tolerance and impaired fasting glucoseQ34204855
Arginine is preferred to glucagon for stimulation testing of β-cell functionQ34356000
Islet beta cell failure in type 2 diabetesQ34698810
AMPK in cardiovascular health and diseaseQ34807222
Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1·9 million peopleQ35004093
Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusionsQ35092842
AMP-activated protein kinase and muscle glucose uptakeQ35178589
Multiparametric assessment of vascular function in peripheral artery disease: dynamic measurement of skeletal muscle perfusion, blood-oxygen-level dependent signal, and venous oxygen saturationQ35439029
The unfolded protein response--a stress signaling pathway of the endoplasmic reticulumQ35885345
Pancreatic β-Cell Dysfunction in Diet-Induced Obese Mice: Roles of AMP-Kinase, Protein Kinase Cε, Mitochondrial and Cholesterol Metabolism, and Alterations in Gene ExpressionQ35979184
The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice.Q36038197
GLP-1-Based Therapies Have No Microvascular Effects in Type 2 Diabetes Mellitus: An Acute and 12-Week Randomized, Double-Blind, Placebo-Controlled TrialQ36113842
Mechanism by Which Caloric Restriction Improves Insulin Sensitivity in Sedentary Obese AdultsQ36392864
The pathogenesis of insulin resistance: integrating signaling pathways and substrate fluxQ36430696
Expression and transcriptional profiling of the LKB1 tumor suppressor in cervical cancer cellsQ36459906
Short-term exercise improves beta-cell function and insulin resistance in older people with impaired glucose toleranceQ36459921
The Human Microcirculation: Regulation of Flow and BeyondQ36547176
AMPK and Exercise: Glucose Uptake and Insulin Sensitivity.Q36628896
AMPK, insulin resistance, and the metabolic syndromeQ36966839
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitusQ37141727
PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditureQ37412140
Cardiac energetics, oxygenation, and perfusion during increased workload in patients with type 2 diabetes mellitus.Q37545950
Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function.Q37588539
Skeletal muscle insulin resistance is the primary defect in type 2 diabetesQ37624257
Fighting disease by selective autophagy of aggregate-prone proteinsQ37735987
Islet amyloid polypeptide, islet amyloid, and diabetes mellitusQ37899668
AMP-activated protein kinase: also regulated by ADP?Q37904132
Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy.Q38399909
Regulation of brown fat by AMP-activated protein kinaseQ38566113
Future glucose-lowering drugs for type 2 diabetes.Q38711383
Improving glycaemic control in type 2 diabetes: Stimulate insulin secretion or provide beta-cell rest?Q38744831
Early Combination Therapy with Oral Glucose-Lowering Agents in Type 2 Diabetes.Q38762377
Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed miceQ38799483
Human IAPP-induced pancreatic β cell toxicity and its regulation by autophagyQ38974302
Exercise, fasting, and mimetics: toward beneficial combinations?Q38978278
Pathophysiology of Intermittent Claudication in Peripheral Artery DiseaseQ39103498
AMPK regulates ER morphology and function in stressed pancreatic β-cells via phosphorylation of DRP1.Q39104609
AMPK modulates glucose-sensing in insulin-secreting cells by altered phosphotransfer to KATP channelsQ39168370
Metformin lowers plasma triglycerides by promoting VLDL-triglyceride clearance by brown adipose tissue in miceQ39308812
AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System.Q39331294
AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1.Q39542812
Intensity-controlled treadmill running in mice: cardiac and skeletal muscle hypertrophyQ40633453
The mechanisms of action of metforminQ41353984
AMPK Phosphorylates Desnutrin/ATGL and Hormone-Sensitive Lipase To Regulate Lipolysis and Fatty Acid Oxidation within Adipose TissueQ42429527
Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemiaQ42442810
Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat dietQ42442818
Exercise training before cardiac-specific Serca2 disruption attenuates the decline in cardiac function in miceQ42877943
Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside in the muscle microcirculation increases nitric oxide synthesis and microvascular perfusionQ43132682
Physiological role of AMP-activated protein kinase in the heart: graded activation during exerciseQ44448758
Moderate exercise restores pancreatic beta-cell function and autonomic nervous system activity in obese rats induced by high-fat dietQ46429085
Cold-Induced Thermogenesis Depends on ATGL-Mediated Lipolysis in Cardiac Muscle, but Not Brown Adipose Tissue.Q47141278
Lipolysis in Brown Adipocytes Is Not Essential for Cold-Induced Thermogenesis in Mice.Q47842456
mTORC1 Signaling: A Double-Edged Sword in Diabetic β CellsQ49589205
Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.Q51022456
Assessment of beta-cell function in young patients with type 2 diabetes: arginine-stimulated insulin secretion may reflect beta-cell reserve.Q51327644
Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables.Q52675077
AMP-activated protein kinase activator AICAR acutely lowers blood pressure and relaxes isolated resistance arteries of hypertensive rats.Q54531929
Intensity and duration effects of exercise on heart cAMP, phosphorylase, and glycogenQ70137796
Athlete's heart: right and left ventricular mass and function in male endurance athletes and untrained individuals determined by magnetic resonance imagingQ78555985
P4510describes a project that usesImageJQ1659584
P433issue12
P921main subjecttype 2 diabetesQ3025883
P577publication date2018-06-21
P1433published inJCI insightQ27727187
P1476titlePAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients
P478volume3

Reverse relations

cites work (P2860)
Q92342120AMP-activated protein kinase: the current landscape for drug development
Q61451626Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD
Q91386361New insight into the mechanisms of ectopic fat deposition improvement after bariatric surgery
Q99551357Pyrazolone derivative C29 protects against HFD-induced obesity in mice via activation of AMPK in adipose tissue
Q99560905Role of Skeletal Muscle in Insulin Resistance and Glucose Uptake
Q59793666Structure and Physiological Regulation of AMPK
Q90242473Targeting metabolic dysregulation for fibrosis therapy

Search more.