Evaluating the intestinal and oral absorption of the prodrug valacyclovir in wildtype and huPepT1 transgenic mice

scientific article published on 21 June 2018

Evaluating the intestinal and oral absorption of the prodrug valacyclovir in wildtype and huPepT1 transgenic mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BCP.2018.06.010
P932PMC publication ID6135671
P698PubMed publication ID29935147

P2093author name stringDavid E Smith
Yongjun Hu
Daniel Epling
P2860cites workComparison of the gravimetric, phenol red, and 14C-PEG-3350 methods to determine water absorption in the rat single-pass intestinal perfusion modelQ28366175
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Protein abundance of clinically relevant multidrug transporters along the entire length of the human intestineQ33358999
Significance and regional dependency of peptide transporter (PEPT) 1 in the intestinal permeability of glycylsarcosine: in situ single-pass perfusion studies in wild-type and Pept1 knockout miceQ34211071
Development and characterization of a novel mouse line humanized for the intestinal peptide transporter PEPT1Q34293583
Valacyclovir in the treatment of genital herpes and herpes zosterQ34482036
Pharmacokinetics of the acyclovir pro-drug valaciclovir after escalating single- and multiple-dose administration to normal volunteersQ34729029
Absolute bioavailability and metabolic disposition of valaciclovir, the L-valyl ester of acyclovir, following oral administration to humansQ35120940
Effect of Dose Escalation on the In Vivo Oral Absorption and Disposition of Glycylsarcosine in Wild-Type andPept1Knockout MiceQ35579541
Species-Dependent Uptake of Glycylsarcosine but Not Oseltamivir in Pichia pastoris Expressing the Rat, Mouse, and Human Intestinal Peptide Transporter PEPT1Q36057398
Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model.Q36535786
Significance of Peptide Transporter 1 in the Intestinal Permeability of Valacyclovir in Wild-Type and PepT1 Knockout MiceQ36642360
Species differences in the pharmacokinetics of cefadroxil as determined in wildtype and humanized PepT1 miceQ36767617
Impact of Peptide Transporter 1 on the Intestinal Absorption and Pharmacokinetics of Valacyclovir after Oral Dose Escalation in Wild-Type and PepT1 Knockout MiceQ37193116
In Vivo Absorption and Disposition of Cefadroxil After Escalating Oral Doses in Wild-Type and PepT1 Knockout MiceQ37351275
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Effects of progesterone and norethisterone on cephalexin transport and peptide transporter PEPT1 expression in human intestinal cell line Caco-2.Q40333659
Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2.Q40877910
Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell lineQ40965871
Delineation of human peptide transporter 1 (hPepT1)-mediated uptake and transport of substrates with varying transporter affinities utilizing stably transfected hPepT1/Madin-Darby canine kidney clones and Caco-2 cells.Q42478498
Computational modelling of H+-coupled peptide transport via human PEPT1.Q46414648
Calculation of the aqueous diffusion layer resistance for absorption in a tube: application to intestinal membrane permeability determinationQ46603960
5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporterQ47678868
Metabolic disposition of the acyclovir prodrug valaciclovir in the rat.Q48205154
Direct evidence for peptide transporter (PepT1)-mediated uptake of a nonpeptide prodrug, valacyclovirQ48932058
In Silico Absorption Analysis of Valacyclovir in Wildtype and Pept1 Knockout Mice Following Oral Dose EscalationQ50512905
Effect of ionization on the variable uptake of valacyclovir via the human intestinal peptide transporter (hPepT1) in CHO cellsQ50719104
Modern prodrug design for targeted oral drug delivery.Q51042522
A compartmental absorption and transit model for estimating oral drug absorptionQ52204779
Metabolic fate and pharmacokinetics of the acyclovir prodrug valaciclovir in cynomolgus monkeysQ72345065
Cellular expression of monocarboxylate transporters (MCT) in the digestive tract of the mouse, rat, and humans, with special reference to slc5a8Q79350813
P304page(s)1-7
P577publication date2018-06-21
P1433published inBiochemical PharmacologyQ864229
P1476titleEvaluating the intestinal and oral absorption of the prodrug valacyclovir in wildtype and huPepT1 transgenic mice
P478volume155

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cites work (P2860)
Q93270551Diabetes downregulates peptide transporter 1 in the rat jejunum: possible involvement of cholate-induced FXR activation
Q61451763Structural basis for prodrug recognition by the SLC15 family of proton-coupled peptide transporters

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